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    • 9. 发明申请
    • PREPARATION METHOD OF (3S,4S)-3-HEXYL-4-((R)-2-HYDROXYTRIDECYL)-OXETAN-2-0NE AND THE PRODUCT OF THAT METHOD
    • (3S,4S)-3-甲基-4 - ((R)-2-羟基吡啶基) - 异-2-烯的制备方法及其制法
    • US20110046400A1
    • 2011-02-24
    • US12990111
    • 2008-05-26
    • Yong QinXianglin DengXuan ZhouGuofeng YuKe WangHao SongXiaolin WangShan Huang
    • Yong QinXianglin DengXuan ZhouGuofeng YuKe WangHao SongXiaolin WangShan Huang
    • C07D305/12
    • C07D305/12C07D213/70
    • The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.
    • 本发明涉及制备(3S,4S)-3-己基-4 - ((R)-2-羟基十三烷基)氧杂环丁烷-2-酮的方法和该方法的产物。 该方法包括以下步骤:a)还原由式(II)表示的物质以获得由式(III)表示的物质,然后氧化由式(III)表示的物质以形成由式(IV)表示的物质, ; b)用正辛酸酰化得到正辛酰氯,然后在碱性条件下将所得的正辛酰氯与2-巯基 - 吡啶缩合形成式(Ⅴ)表示的物质,然后转化成物质 由式(Ⅴ)代表由式(Ⅵ)表示的物质; c)在路易斯酸的催化条件下,使步骤a)中获得的物质与步骤b)中获得的物质反应,生成由式(Ⅶ)表示的物质,然后与路易斯酸反应。 这些公式中的符号的含义与描述中的符号的含义相同。