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    • 8. 发明申请
    • SPIROCHROMANON DERIVATIVES
    • 螺吡喃衍生物
    • US20090270436A1
    • 2009-10-29
    • US12518466
    • 2008-01-08
    • Tomoharu IinoHideki JonaHideki KuriharaMasayuki NakamuraKenji NiiyamaJun ShibataTadashi ShimamuraHitomi WatanabeTakeru YamakawaLihu Yang
    • Tomoharu IinoHideki JonaHideki KuriharaMasayuki NakamuraKenji NiiyamaJun ShibataTadashi ShimamuraHitomi WatanabeTakeru YamakawaLihu Yang
    • A61K31/438C07D401/14A61P3/00A61P35/00A61P31/00
    • C07D491/107C07D491/20C07D519/00
    • The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-b]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3: R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a machine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
    • 本发明涉及通式(I)的化合物:其中Ar 1表示由选自苯,吡唑,异恶唑,吡啶,吲哚,1H-吲唑,1H-呋喃并[ 3-c]吡唑,1H-噻吩并[2,3-c]吡唑,苯并咪唑,1,2-苯并异恶唑,咪唑并[1,2-a]吡啶,咪唑并[1,5-a]吡啶和1H-吡唑并[ 具有Ar 2且任选具有一个或两个以上选自R 3:R 1和R 2的取代基的3,4-b]吡啶各自独立地表示氢原子,卤素原子,氰基,C 2 -C 6烯基, C1-C6烷氧基,C2-C7烷酰基,C2-C7烷氧基羰基,芳烷氧基羰基,氨基甲酰基C1-C6烷氧基,羧基-C2-C6链烯基或-Q1-N (Ra)-Q2-Rb; 或任选具有取代基的C1-C6烷基; 或任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或机组; V表示氧原子或硫原子。 本发明的化合物可用作各种ACC相关疾病的治疗剂。
    • 9. 发明授权
    • Spirochromanon derivatives
    • 螺二色素衍生物
    • US08138197B2
    • 2012-03-20
    • US12518466
    • 2008-01-08
    • Tomoharu IinoHideki JonaHideki KuriharaMasayuki NakamuraKenji NiiyamaJun ShibataTadashi ShimamuraHitomi WatanabeTakeru YamakawaLihu Yang
    • Tomoharu IinoHideki JonaHideki KuriharaMasayuki NakamuraKenji NiiyamaJun ShibataTadashi ShimamuraHitomi WatanabeTakeru YamakawaLihu Yang
    • A61K31/438C07D221/20
    • C07D491/107C07D491/20C07D519/00
    • The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of benzene, pyrazole, isoxazole, pyridine, indole, 1H-indazole, 1H-furo[2,3-c]pyrazole, 1H-thieno[2,3-c]pyrazole, benzimidazole, 1,2-benzisoxazole, imidazo[1,2-a]pyridine, imidazo[1,5-a]pyridine and 1H-pyrazolo[3,4-a]pyridine, having Ar2, and optionally having one or two or more substituents selected from R3; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; or a C1-C6 alkyl group optionally having a substituent; or an aryl or heterocyclic group optionally having a substituent; or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
    • 本发明涉及通式(I)的化合物:其中Ar 1表示由选自苯,吡唑,异恶唑,吡啶,吲哚,1H-吲唑,1H-呋喃并[ 3-c]吡唑,1H-噻吩并[2,3-c]吡唑,苯并咪唑,1,2-苯并异恶唑,咪唑并[1,2-a]吡啶,咪唑并[1,5-a]吡啶和1H-吡唑并[ 3,4-a]吡啶,其具有Ar 2,并且任选具有一个或两个或更多个选自R 3的取代基; R 1和R 2各自独立地表示氢原子,卤素原子,氰基,C 2 -C 6烯基,C 1 -C 6烷氧基,C 2 -C 7烷酰基,C 2 -C 7烷氧基羰基,芳烷氧基羰基, 氨基甲酰基-C 1 -C 6烷氧基,羧基-C 2 -C 6烯基或-Q 1 -N(R a)-Q 2 -R b的基团; 或任选具有取代基的C1-C6烷基; 或任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子或硫原子。 本发明的化合物可用作各种ACC相关疾病的治疗剂。
    • 10. 发明授权
    • Substituted spirochromanone derivatives
    • 取代的螺二氢茚酮衍生物
    • US08093389B2
    • 2012-01-10
    • US12007000
    • 2008-01-08
    • Tomoharu IinoHideki JonaJun ShibataTadashi ShimamuraTakeru YamakawaLihu Yang
    • Tomoharu IinoHideki JonaJun ShibataTadashi ShimamuraTakeru YamakawaLihu Yang
    • C07D413/06C07D405/04A61K31/438
    • C07D519/00C07D491/10
    • The invention relates to a compound of a general formula (I): wherein Ar1 represents a group formed from an aromatic ring selected from a group consisting of indole, 1H-indazole, 2H-indazole, 1H-thieno[2,3-c]pyrazole, 1H-pyrazolo[3,4-b]pyridine, benzo[b]furan, benzimidazole, benzoxazole, 1,2-benzisoxazole and imidazo[1,2-a]pyridine; R1 and R2 each represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; an optionally-substituted C1-C6 alkyl, aryl or heterocyclic group; or a C1-C6 alkyl or C2-C6 alkenyl group having the aryl or heterocyclic group; R3 and R4 each represent a hydrogen atom, a halogen atom, a nitro group, a cyclo-C3-C6 alkyl group, a carbamoyl group optionally substituted with a C1-C6 alkyl or cyclo-C3-C6 alkyl group, or a group of —N(Re)Rf; an optionally-substituted C2-C7 alkanoyl, C1-C6 alkoxy, C2-C7 alkoxycarbonyl, cyclo-C3-C6 alkyloxycarbonyl, C1-C6 alkylsulfonyl, C1-C6 alkylthio, cyclo-C3-C6 alkyloxy, cyclo-C3-C6 alkyl-C1-C6 alkoxy, cyclo-C3-C6 alkylsulfonyl, cyclo-C3-C6 alkylthio or cyclo-C3-C6 alkyl-C1-C6 alkylthio group; or an optionally-substituted C1-C6 alkyl group; T and U each represent a nitrogen atom or a methine group; and V represents an oxygen atom or a sulfur atom. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.
    • 本发明涉及通式(I)的化合物:其中Ar1表示由选自吲哚,1H-吲唑,2H-吲唑,1H-噻吩并[2,3-c]所示的芳环形成的基团, 吡唑,1H-吡唑并[3,4-b]吡啶,苯并[b]呋喃,苯并咪唑,苯并恶唑,1,2-苯并异恶唑和咪唑并[1,2-a] R 1和R 2各自表示氢原子,卤素原子,氰基,C 2 -C 6烯基,C 1 -C 6烷氧基,卤代-C 1 -C 6烷氧基,环-C 3 -C 6烷氧基, C2-C7烷酰基,卤代-C2-C7烷酰基,C2-C7烷氧基羰基,卤代-C2-C7烷氧基羰基,环-C3-C6烷氧基羰基,芳烷氧基羰基,氨基甲酰基-C1-C6 烷氧基,羧基-C2-C6烯基或-Q1-N(Ra)-Q2-Rb的基团; 任选取代的C 1 -C 6烷基,芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; R 3和R 4各自表示氢原子,卤素原子,硝基,环-C 3 -C 6烷基,任选被C 1 -C 6烷基或环-C 3 -C 6烷基取代的氨基甲酰基,或者 -N(R f)R f; 任选取代的C 2 -C 7烷酰基,C 1 -C 6烷氧基,C 2 -C 7烷氧基羰基,环C 3 -C 6烷氧基羰基,C 1 -C 6烷基磺酰基,C 1 -C 6烷硫基,环C 3 -C 6烷氧基,环C 3 -C 6烷基 - C 1 -C 6烷氧基,环-C 3 -C 6烷基磺酰基,环-C 3 -C 6烷硫基或环-C 3 -C 6烷基-C 1 -C 6烷硫基; 或任选取代的C 1 -C 6烷基; T和U各自表示氮原子或次甲基; V表示氧原子或硫原子。 本发明的化合物可用作各种ACC相关疾病的治疗剂。