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1. 发明授权

US08039492B2 Substituted cyclic compound, its preparation process and its medical use 失效
标题翻译：取代的环状化合物，其制备方法及其医疗用途
公开(公告)号：US08039492B2
公开(公告)日：2011-10-18
申请号：US11993440
申请日：2006-06-21
申请人： Mingwei Wang , Na Li , Xin Xie , Qing Liu , Caihong Zhou , Fajun Nan , Guangxing Wang
发明人： Mingwei Wang , Na Li , Xin Xie , Qing Liu , Caihong Zhou , Fajun Nan , Guangxing Wang
IPC分类号： A01N43/40
CPC分类号： C07D333/38
摘要： The present invention provides a substituted cyclic compound of the following general formula I or II: its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.
摘要翻译：本发明提供以下通式I或II的取代的环状化合物：其制备方法及其作为胰高血糖素样肽-1受体调节剂用于预防或治疗代谢紊乱的用途，包括但不限于糖尿病，胰岛素抵抗肥胖等

2. 发明申请

US20100168183A1 SUBSITUTED CYCLIC COMPOUND, ITS PREPARATION PROCESS AND ITS MEDICAL USE 失效
标题翻译：替代周期化合物，其制备方法及其医疗用途
公开(公告)号：US20100168183A1
公开(公告)日：2010-07-01
申请号：US11993440
申请日：2006-06-21
申请人： Mingwei Wang , Na Li , Xin Xie , Qing Liu , Caihong Zhou , Fajun Nan
发明人： Mingwei Wang , Na Li , Xin Xie , Qing Liu , Caihong Zhou , Fajun Nan
IPC分类号： A61K31/381 , C07D409/12 , A61K31/4439 , A61P3/04 , A61P5/50 , A61P3/10
CPC分类号： C07D333/38
摘要： The present invention provides a substituted cyclic compound of the following general formula I or II: its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.
摘要翻译：本发明提供以下通式I或II的取代的环状化合物：其制备方法及其作为胰高血糖素样肽-1受体调节剂用于预防或治疗代谢紊乱的用途，包括但不限于糖尿病，胰岛素抵抗肥胖等

3. 发明授权

US07838682B2 Glucagon-like peptide-1 receptor agonists, the preparation and the use of the same 失效
标题翻译：胰高血糖素样肽-1受体激动剂，其制备和使用相同
公开(公告)号：US07838682B2
公开(公告)日：2010-11-23
申请号：US10582580
申请日：2003-12-25
申请人： Fajun Nan , Mingwei Wang , Wenlong Wang , Caihong Zhou
发明人： Fajun Nan , Mingwei Wang , Wenlong Wang , Caihong Zhou
IPC分类号： C07D263/08 , A61K31/42
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention provides the glucagon-like peptide-1 receptor agonists. It is indicated that the agonists have good binding capability to glucagon-like peptide-1 receptor by pharmacological tests. The present invention also provides the preparation of the agonists.
摘要翻译：本发明提供了胰高血糖素样肽-1受体激动剂。表明激动剂通过药理学试验具有对胰高血糖素样肽-1受体的良好结合能力。本发明还提供了激动剂的制备。

4. 发明申请

US20070043093A1 Glucagon-like peptide-1 receptor agonists, the preparation and the use of the same 失效
标题翻译：胰高血糖素样肽-1受体激动剂，其制备和使用相同
公开(公告)号：US20070043093A1
公开(公告)日：2007-02-22
申请号：US10582580
申请日：2003-12-25
申请人： Fajun Nan , Mingwei Wang , Wenlong Wang , Caihong Zhou
发明人： Fajun Nan , Mingwei Wang , Wenlong Wang , Caihong Zhou
IPC分类号： A61K31/426 , A61K31/421 , A61K31/4164
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention provides the glucagon-like peptide-1 receptor agonists. It is indicated that the agonists have good binding capability to glucagon-like peptide-1 receptor by pharmacological tests. The present invention also provides the preparation of the agonists.
摘要翻译：本发明提供了胰高血糖素样肽-1受体激动剂。表明通过药理学试验，激动剂对胰高血糖素样肽-1受体具有良好的结合能力。本发明还提供了激动剂的制备。

5. 发明授权

US07737288B2 Non-steroidal androgen receptor modulators, preparation process, pharmaceutical composition and use thereof 失效
标题翻译：非甾体雄激素受体调节剂，制备方法，药物组合物及其用途
公开(公告)号：US07737288B2
公开(公告)日：2010-06-15
申请号：US11921088
申请日：2006-05-26
申请人： Mingwei Wang , Caihong Zhou , Xin Hui , Haoran Su , Jie Gao , Yong Deng , Dacheng Yang
发明人： Mingwei Wang , Caihong Zhou , Xin Hui , Haoran Su , Jie Gao , Yong Deng , Dacheng Yang
IPC分类号： C07D307/02 , C07C223/00 , A61K31/34 , A61K31/135
CPC分类号： C07D211/32 , C07C225/22 , C07C229/60 , C07D295/104 , C07D307/52
摘要： Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities.
摘要翻译：公开了通式（I）的非甾体雄激素受体调节化合物，其药学上可接受的盐，制备方法和含有所述化合物的药物组合物。通式（I）的化合物或其药学上可接受的盐可用于制备非甾体药物以治疗和/或预防诸如前列腺增生症，前列腺癌，多毛症，严重激素依赖性脱发或痤疮的病症或疾病，作为雄激素受体拮抗活性的结果。

6. 发明申请

US20080293808A1 Non-Steroidal Androgen Receptor Modulators, Preparation Process, Pharmaceutical Composition and Use Thereof 失效
标题翻译：非甾体雄激素受体调节剂，制备方法，药物组合物及其用途
公开(公告)号：US20080293808A1
公开(公告)日：2008-11-27
申请号：US11921088
申请日：2006-05-26
申请人： Mingwei Wang , Caihong Zhou , Xin Hui , Haoran Su , Jie Gao , Yong Deng , Dacheng Yang
发明人： Mingwei Wang , Caihong Zhou , Xin Hui , Haoran Su , Jie Gao , Yong Deng , Dacheng Yang
IPC分类号： A61K31/341 , C07C225/16 , A61K31/137 , C07C221/00 , A61P35/00 , C07D307/52
CPC分类号： C07D211/32 , C07C225/22 , C07C229/60 , C07D295/104 , C07D307/52
摘要： Non-steroidal androgen receptor modulating compounds of the general formula (I), their pharmaceutically acceptable salts, preparation process and pharmaceutically compositions containing the said compounds are disclosed. Such compounds of the general formula (I) or their pharmaceutically acceptable salts can be used for preparing non-steroidal medicines to treat and/or prevent conditions or diseases such as prostatic hyperplasia, prostate cancer, hirsutism, severe hormone-dependent alopecia or acne, etc. as a result of androgen receptor antagonistic activities.
摘要翻译：公开了通式（I）的非甾体雄激素受体调节化合物，其药学上可接受的盐，制备方法和含有所述化合物的药物组合物。通式（I）的化合物或其药学上可接受的盐可用于制备非甾体药物以治疗和/或预防诸如前列腺增生症，前列腺癌，多毛症，严重激素依赖性脱发或痤疮的病症或疾病，作为雄激素受体拮抗活性的结果。

7. 发明申请

US20090111781A1 Use of Cymipristone Type Compounds in Aids Treatment 审中-公开
标题翻译：使用Cymipristone类化合物在艾滋病治疗
公开(公告)号：US20090111781A1
公开(公告)日：2009-04-30
申请号：US11989076
申请日：2006-07-21
申请人： Mingwei Wang , Lin Zuo , Minghua Ying
发明人： Mingwei Wang , Lin Zuo , Minghua Ying
IPC分类号： A61K31/575
CPC分类号： A61K31/565
摘要： This invention refers to use of cymipristone type compounds of formula (I), salt or solvate thereof in preparation of medicament for treating AIDS. Cymipristone type compounds are a new type glucocorticoid receptor antagonist. Pharmacological test shows that cymipristone has anti-glucocorticoid activity and very strong affinity with glucocorticoid receptor. Test indicates that cymipristone is a glucocorticoid antagonist on receptor level and can block the function of glucocorticoid receptor. The inventor uses cymipristone to test the inhibition on the growth of AIDS virus in vitro and finds that cymipristone has significant growth inhibition action on AIDS pathogen HIV-1.
摘要翻译：本发明涉及式（I）的替米司他酮型化合物，其盐或溶剂化物在制备用于治疗AIDS的药物中的用途。 Cymipristone型化合物是新型糖皮质激素受体拮抗剂。药理试验表明，cymipristone具有抗糖皮质激素活性，与糖皮质激素受体非常强烈的亲和力。测试表明cymipristone是受体水平的糖皮质激素拮抗剂，可以阻断糖皮质激素受体的功能。本发明人利用cymipristone检测对体外艾滋病病毒生长的抑制作用，发现cymipristone对艾滋病病毒HIV-1具有显着的生长抑制作用。

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