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1. 发明申请

WO2008066854A3 METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS IN CANCER CELLS 审中-公开
标题翻译：诱导癌细胞凋亡的方法和组合物
公开(公告)号：WO2008066854A3
公开(公告)日：2009-08-13
申请号：PCT/US2007024518
申请日：2007-11-28
申请人： NOVARTIS AG , LI JING , STOVER DAVID RAYMOND
发明人： LI JING , STOVER DAVID RAYMOND
IPC分类号： A61K45/06 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2878 , A61K45/06 , A61K2039/505 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C12N15/111 , C12N15/1135 , C12N2310/14 , C12N2320/12
摘要： Anti-DR4 or Anti-DR5 antibody agonists, combined with apoptosis-inducing agents, synergistically induce apoptosis in cancer cells. A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with: an Anti-DR5 antibody agonists; and one or more pharmaceutically active agents.
摘要翻译：抗DR4或抗DR5抗体激动剂与细胞凋亡诱导剂联合，协同诱导癌细胞凋亡。公开了用于治疗患有与持续血管发生相关的增殖性疾病或疾病的患者的联合疗法。治疗患者：抗DR5抗体激动剂; 和一种或多种药物活性剂。

2. 发明申请

WO2007126799A3 COMPOSITIONS AND METHODS OF USE FOR ANTIBODIES OF C-MET 审中-公开
标题翻译：用于C-MET抗体的组合物和方法
公开(公告)号：WO2007126799A3
公开(公告)日：2008-04-03
申请号：PCT/US2007007543
申请日：2007-03-29
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , STOVER DAVID RAYMOND , PRASSLER JOSEF , BERGER CATRIN , BROCKS BODO
发明人： STOVER DAVID RAYMOND , PRASSLER JOSEF , BERGER CATRIN , BROCKS BODO
IPC分类号： C07K16/28 , A61K31/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P35/00 , C12N15/13 , C12N15/85 , G01N33/00
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： Antibodies and fragments that bind to the protein target c Met, particularly to epitopes located in the c Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c Met-related condition such as a cancer, a metastasis, or an inflammatory condition.
摘要翻译：提供了结合蛋白质靶标c Met的抗体和片段，特别是位于c Met细胞外结构域中的表位，以及使用抗体和试剂盒的方法，用于治疗不想要的细胞，特别是与 ac Met相关病症如癌症，转移或炎性病症。

3. 发明专利

AU2013201789B2 Compositions and methods of use for antibodies of c-Met 未知
公开(公告)号：AU2013201789B2
公开(公告)日：2015-12-24
申请号：AU2013201789
申请日：2013-03-21
申请人： NOVARTIS AG
发明人： BROCKS BODO , PRASSLER JOSEF , STOVER DAVID RAYMOND , BERGER CATRIN
IPC分类号： C07K16/28 , A61K31/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P35/00 , C12N15/13 , C12N15/85 , G01N33/00
摘要： l: \kll\Interwoven\NRPortbl\DCC\KLL\500364_I.DOC-21 03/2013 Antibodies and fragments that bind to the protein target c-Met, particularly to epitopes located in the c-Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c-Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

4. 发明专利

AU2010245833B2 Compositions and methods of use for binding molecules to Dickkopf-1 or Dickkopf-4 or both 未知
公开(公告)号：AU2010245833B2
公开(公告)日：2014-03-27
申请号：AU2010245833
申请日：2010-05-06
申请人： NOVARTIS AG
发明人： BRAENDLE EDGAR , RAE PATRICIA , RANGWALA SHAMINA M , STOVER DAVID RAYMOND , TAYLOR ANN
IPC分类号： C07K16/18 , A61P3/10 , A61P35/00
摘要： Methods of using binding molecules and fragments thereof that bind to the protein target Dickkopf -1 (DKK1), Dickkopf-4 (DKK4) or both (wherein specificity to DKK1 or DKK4 or both is herein denoted as "DKK1/4") are provided.

5. 发明专利

AU2013201789A1 Compositions and methods of use for antibodies of c-Met 未知
公开(公告)号：AU2013201789A1
公开(公告)日：2013-04-11
申请号：AU2013201789
申请日：2013-03-21
申请人： NOVARTIS AG
发明人： BROCKS BODO , PRASSLER JOSEF , STOVER DAVID RAYMOND , BERGER CATRIN
IPC分类号： C07K16/28 , A61K31/00 , A61K38/00 , A61K39/395 , A61K47/48 , A61P29/00 , A61P35/00 , C12N15/13 , C12N15/85 , G01N33/00
摘要： l: \kll\Interwoven\NRPortbl\DCC\KLL\500364_I.DOC-21 03/2013 Antibodies and fragments that bind to the protein target c-Met, particularly to epitopes located in the c-Met extracellular domain, are provided, as are methods of use of the antibodies and kits, for treating an unwanted cell, in particular, a cell associated with a c-Met-related condition such as a cancer, a metastasis, or an inflammatory condition.

6. 发明专利

MA34053B1 Polypeptides agonistes de liaison à dr5 未知
公开(公告)号：MA34053B1
公开(公告)日：2013-03-05
申请号：MA35190
申请日：2012-09-06
申请人： NOVARTIS AG , ABLYNX NV
发明人： CROMIE KAREN , DOMBRECHT BRUNO , ETTENBERG SETH , KOLKMAN JOOST , LI JING , MEERSCHAERT KRIS , STOVER DAVID RAYMOND , ZHANG JINGXIN
IPC分类号： C07K16/28 , A61K39/395
摘要： La présente invention concerne des séquences d'acides aminés qui sont dirigées contre le récepteur 2 de surface cellulaire trail (ci-inclus également appelé « dr5 »), ainsi que des composés ou des produits de construction de ceux-ci et en particulier des protéines et des polypeptides et des nucléotides qui codent pour eux (présentement désignés dans leur intégralité par « agents nb ») et des fragments de ceux-ci, et des variants pharmaceutiquement efficaces de ceux-ci, et leur utilisation dans le diagnostic et le traitement de maladies et de troubles associés à dr5.

7. 发明专利

CA2789251A1 AGONIST DR5 BINDING POLYPEPTIDES 未知
公开(公告)号：CA2789251A1
公开(公告)日：2011-08-18
申请号：CA2789251
申请日：2011-02-10
申请人： NOVARTIS AG , ABLYNX NV
发明人： CROMIE KAREN , DOMBRECHT BRUNO , ETTENBERG SETH , KOLKMAN JOOST , LI JING , MEERSCHAERT KRIS , STOVER DAVID RAYMOND , ZHANG JINGXIN
IPC分类号： C07K16/28 , A61K39/395
摘要： The present invention relates to amino acid sequences that are directed against TRAIL cell surface receptor 2 (herein also "DR5"), as well as to compounds or constructs thereof, and in particular proteins and polypeptides and nucleotides that encode them (referred to herein in their entirety as "NB agents") and fragments thereof, and pharmaceutically effective variants thereof, and their use in the diagnosis and treatment of DR5 associated diseases and disorders.

8. 发明专利

ES2234097T3 FTALAZINAS CON ACTIVIDAD INHIBIDORA DE LA ANGIOGENESIS. 未知
公开(公告)号：ES2234097T3
公开(公告)日：2005-06-16
申请号：ES98908086
申请日：1998-02-11
申请人： NOVARTIS AG
发明人： BOLD GUIDO , FREI JORG , TRAXLER PETER , ALTMANN KARL-HEINZ , METT HELMUT , STOVER DAVID RAYMOND
IPC分类号： A61K31/50 , A61K31/502 , A61P35/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D471/04 , C07F5/02
摘要： La invención se refiere a compuestos de fórmula (I) *fórmula*, en la que r es de 0 a 2, n es de 0 a 2; m es de 0 a 4; R{sub,1} y R{sub,2} (i) son en cada caso un alquilo inferior, o (ii) forman Conjuntamente un puente en la subfórmula (I*) *fórmula* o (iii) forman Conjuntamente un puente en la subfórmula (I**) *fórmula*, siendo nitrógeno uno o dos de los miembros del anillo T{sub,1}, T{sub,2}, T{sub,3}, y T{sub,4}, y siendo el resto en cada caso CH; A, B, D, y E son N o CH, no siendo N más de 2 de estos radicales; G es alquileno inferior, aciloxialquileno o hidroxialquileno inferiores, -CH{sub,2}-O-, -CH{sub,2}-S-, - CH{sub,2}-NH-, oxa, tia, o imino; Q es metilo; R es H o alquilo inferior; X es imino, oxa, o tia; Y es arilo, piridilo o cicloalquilo (no) sustituido; y Z es amino mono o disustituido, halógeno, alquilo, alquilo sustituido, hidroxi, hidroxi eterificado o esterificado, nitro, ciano, carboxi, carboxi esterificado, alcanoílo, carbamoílo, carbamoílo N-monosustituido o N,N-disustituido, amidino, guanidino, mercapto, sulfo, feniltio, fenilalquiltio inferior, alquilfeniltio, fenilsulfinilo, fenilalquilsulfinilo inferior, alquilfenilsulfinilo, fenilsulfonilo, fenilalquilsulfonilo inferior o alquilfenilsulfonilo; y siendo los enlaces caracterizados por una línea ondulada enlaces sencillos o dobles enlaces; o un N-oxido del citado compuesto con la condición de que, si Y es piridilo o cicloalquilo no sustituido, X es imino, y los radicales restantes son como se definieron, entonces G se selecciona del grupo constituido por alquileno inferior, -CH{sub,2}-O-, -CH{sub,2}-S-, oxa y tia; o una sal de éstos. Los compuestos inhiben la angiogénesis.

9. 发明专利

NO317367B1 未知
公开(公告)号：NO317367B1
公开(公告)日：2004-10-18
申请号：NO993888
申请日：1999-08-12
申请人： NOVARTIS AG
发明人： BOLD GUIDO , WOOD JEANETTE MARJORIE , FREI JORG , TRAXLER PETER , ALTMANN KARL-HEINZ , METT HELMUT , STOVER DAVID RAYMOND
IPC分类号： A61K31/50 , A61K31/502 , A61P35/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D471/04 , C07F5/02
摘要： The invention relates to compounds of formula I,wherein r is 0 to 2, n is 0 to 2; m is 0 to 4; R1 and R2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I*or (iii) together form a bridge in subformula I**wherein one or two of the ring members T1, T2, T3, and T4 are nitrogen, and the remainder are in each case CH; A, B, D, and E are N or CH, wherein not more than 2 of these radicals are N; G is lower alkylene, acyloxy- or hydroxy-lower alkylene, -CH2-O-, -CH2-S-, -CH2-NH-, oxa, thia, or imino; Q is methyl; R is H or lower alkyl; X is imino, oxa, or thia; Y is aryl, pyridyl, or (un)substituted cycloalkyl; and Z is mono- or disubstited amino, halogen, alkyl, substituted alkyl, hydroxy, etheritied or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N-mono- or N,N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl-lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl-lower alkylsulfonyl, or alkylphenylsulfony; and wherein the bonds characterized by a wavy line are either single or double bonds; or an N-oxide of said compound with the stipulation that, if Y is pyridyl or unsubstituted cycloalkyl, X is imino, and the remaining radicals are as defined, then G is selected from the group comprising lower alkylene, -CH2-O-, -CH2-S-, oxa and thia; or a salt thereof. The compounds inhibit angiogenesis.

10. 发明专利

CO4950519A1 FTALAZINAS, PREPARACIONES FARMACEUTICAS QUE LAS COMPRENDEN Y PROCESO PARA SU PREPARACION 未知
公开(公告)号：CO4950519A1
公开(公告)日：2000-09-01
申请号：CO98005806
申请日：1998-02-05
申请人： NOVARTIS AG
发明人： BOLD GUIDO , FREI JORG , TRAXLER PETER , KRARL-HEINZ ALTMANN , METT HELMUT , STOVER DAVID RAYMOND , WOOD JEANETTE
IPC分类号： A61K31/495 , A61K31/50 , A61K31/502 , A61P35/00 , A61P43/00 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/14 , C07D413/14 , C07D471/04 , C07F5/02
摘要： La presente invención se relaciona con un compuesto de lafórmula I: en donde: r es de 0 a 2, n es de 0 a 2, m es de 0 a 4, R1 y R2 (i) son alquilo inferior, o (ii) forman juntos un puente en la subfórmula I*: lográndose el enlace por medio de los átomos de carbono terminales, o (iii) forman juntos un puente en la subfórmula I **:en donde uno o dos de los miembros del anillo T1 , T2 , T3 , y T4 son hidrógeno, y los otros son en cada caso CH, y el enlace se logra por medio de T1 y T4 ; A, B, D, y E son, independientemente unos de otros, N ó CH, con la estipulación de que no más de dos de estos radicales sean N;G es alquileno inferior, alquileno inferior sustituido por aciloxi o hidroxi, -CH2 -O-, -CH2 -S-, -CH2 -NH-, oxa(-O-), tia (-S-), ó imino (-NH-); Q es alquilo inferior, R es H o alquilo inferior; X es imino, oxa, ó tia;...

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