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1. 发明申请

WO2008124801A3 ORTHOVOLTAGE RADIOSURGERY 审中-公开
公开(公告)号：WO2008124801A3
公开(公告)日：2008-12-31
申请号：PCT/US2008059808
申请日：2008-04-09
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , HANSEN STEVEN D
发明人： GERTNER MICHAEL , HANSEN STEVEN D
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。在一些实施方案中，使用基准标记来鉴定靶组织的位置。在一些实施例中，眼睛被保持并且与系统对准。在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后随同伴随地递送。

2. 发明申请

WO2009085204A2 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 审中-公开
标题翻译：用于检测，控制和预测辐射传送的方法和装置
公开(公告)号：WO2009085204A2
公开(公告)日：2009-07-09
申请号：PCT/US2008013886
申请日：2008-12-18
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
IPC分类号： A61F9/00 , A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供了基于图像的方法和系统，用于相对于辐射束轴对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

3. 发明申请

WO2008118198A3 OCULAR RADIOSURGERY 审中-公开
标题翻译：眼科放射科医师
公开(公告)号：WO2008118198A3
公开(公告)日：2009-02-19
申请号：PCT/US2007081569
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL
发明人： GERTNER MICHAEL
IPC分类号： A61N5/10 , A61B5/00
CPC分类号： A61N5/1049 , A61B6/506 , A61B2017/306 , A61F9/009 , A61N5/1017 , A61N5/103 , A61N2005/105 , A61N2005/1056 , A61N2005/1091
摘要： A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：放射外科系统描述了对患者的靶结构的治疗性辐射递送。放射外科系统治疗炎症性眼部疾病; 将眼部结构置于基于眼睛成像的全局坐标系中; 将全局坐标系内的眼结构自动化到基于坐标系内眼睛结构的定位系统的方向; 跟踪并将眼部结构的位置与放射外科手术系统的状态相关联; 确定要治疗的特定疾病和/或要避免的结构的束能量和治疗时间的方向和持续时间; 轨道结构的眼睛; 保持和修复眼睛到位; 放置基准在眼睛上帮助定位; 将眼睛放在反光面上; 并结合其他治疗方法，并可在其他治疗之前，之前或之后进行交付。

4. 发明专利

JP2014039867A Device and assembly for positioning, stabilizing and treating an eye 有权
标题翻译：用于定位，稳定和治疗眼睛的装置和装置
公开(公告)号：JP2014039867A
公开(公告)日：2014-03-06
申请号：JP2013220447
申请日：2013-10-23
申请人： Oraya Therapeutics Inc , オラヤセラピューティクス,インコーポレーテッドOraya Therapeutics, Inc.
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , MATT HERRON
IPC分类号： A61F9/007 , A61F9/008
摘要： PROBLEM TO BE SOLVED: To provide an eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system.SOLUTION: The device includes an eye-contact member 120 having an inner contact surface for contacting a front surface of an eye, and a vacuum port 210 formed within the eye-contact member and communicating with the eye-contact member's contact surfaces, by which a negative pressure can be applied between the eye 130 and the contact surface, to stabilize the position of the eye with respect to the device 110. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm 180, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.
摘要翻译：要解决的问题：提供一种用于在外部坐标系中的选定位置稳定人眼的眼睛接触装置和组件。解决方案：该装置包括眼睛接触构件120，其具有内接触表面，用于接触眼睛和真空端口210，其形成在眼睛接触构件内并与眼睛接触构件的接触表面连通，由此可以在眼睛130和接触表面之间施加负压，以稳定眼睛的位置该装置适于被偏压抵靠患者的眼睛，以将装置固定到眼睛上，可枢转地联接到定位臂180，并且可以通过以下方式携带一个或多个光束引导元件：可以确定装置在外部坐标系中的位置。

5. 发明专利

JP2014113502A Ocular radiosurgery 有权
标题翻译：眼科放射科医师
公开(公告)号：JP2014113502A
公开(公告)日：2014-06-26
申请号：JP2014018375
申请日：2014-02-03
申请人： Oraya Therapeutics Inc , オラヤセラピューティクス,インコーポレーテッドOraya Therapeutics, Inc.
发明人： GERTNER MICHAEL , ERIK CHELL , STEVEN D HANSEN , MARK ARNOLDUSSEN , MATT HERRON , PAN KWAN HAN
IPC分类号： A61N5/10 , A61F9/008 , A61N5/067
CPC分类号： A61N5/1049 , A61B6/506 , A61B2017/306 , A61F9/009 , A61N5/1017 , A61N5/103 , A61N2005/105 , A61N2005/1056 , A61N2005/1091
摘要： PROBLEM TO BE SOLVED: To provide a system, a method, and an apparatus for treatment of an ocular disorder by radiation to a specific region.SOLUTION: An ocular structure is placed in a global coordinate system on the basis of ocular imaging. The ocular structure 210 in the global coordinate system leads to a direction of an automated positioning system oriented on the basis of the ocular structure in the coordinate system. The position of the ocular structure is tracked and related to a state of a radiosurgery system 10. A treatment plan to be used for beam energy, a beam direction, or a treatment period determines at least one of a specific disease to be treated and a structure to be avoided. A structure is an ocular structure, and an eye is tracked by the system 10. In some embodiments, the eye held in a specified location, and in some embodiments, the eye is fixated by the patient. A fiducial marker is disposed on an eye for positioning, and a reflection from the eye is used for positioning.
摘要翻译：要解决的问题：提供一种通过放射到特定区域来治疗眼部疾病的系统，方法和装置。解决方案：基于眼睛成像将眼部结构放置在全局坐标系中。全局坐标系中的目镜结构210导向基于坐标系中的目镜结构定向的自动定位系统的方向。跟踪眼结构的位置并与放射外科系统10的状态相关。用于束能，束方向或治疗周期的治疗计划确定待治疗的特定疾病和结构要避免。结构是眼部结构，并且眼睛被系统10跟踪。在一些实施例中，眼睛保持在指定位置，并且在一些实施例中，眼睛被患者固定。将基准标记设置在眼睛上用于定位，并且来自眼睛的反射用于定位。

6. 发明专利

HK1219912A1 眼放射外科未知
公开(公告)号：HK1219912A1
公开(公告)日：2017-04-21
申请号：HK16108015
申请日：2016-07-08
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N20060101

7. 发明专利

HK1219863A1 眼放射外科未知
公开(公告)号：HK1219863A1
公开(公告)日：2017-04-21
申请号：HK16108013
申请日：2016-07-08
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61F20060101 , A61B20060101

8. 发明专利

ES2556615T3 Dispositivo para alineación ocular y acoplamiento de estructuras oculares 未知
公开(公告)号：ES2556615T3
公开(公告)日：2016-01-19
申请号：ES13155533
申请日：2008-04-17
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , HERRON MATT , LIANG JUNZHONG
IPC分类号： A61N5/10
摘要： Un sistema (100) de definición de un eje de referencia (18) de un ojo (10) de un paciente en un sistema de coordenadas externo, caracterizado por que comprende: (a) una fuente de luz (108) para dirigir un haz de luz coherente o enfocado sobre una superficie reflectora (16) asociada con el ojo del paciente, (b) un sistema (102) de formación de imágenes para registrar una imagen de un limbo (26) del ojo del paciente y una imagen formada por una reflexión del haz de luz desde la córnea (12) del ojo del paciente, y (c) un procesador conectado operativamente al sistema (102) de formación de imágenes para (i) a partir de la imagen del limbo (26), determinar el centro (30) del limbo del ojo (10) del paciente en el sistema de coordenadas externo, y (ii) a partir de la imagen de la reflexión, determinar cuando la posición de la reflexión es coincidente con el centro (30) del limbo, en qué posición un eje (18) normal a la córnea (12) en el centro corneal define el eje de referencia.

9. 发明专利

ES2553187T3 Radiocirugía ocular 未知
公开(公告)号：ES2553187T3
公开(公告)日：2015-12-04
申请号：ES07873549
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN D , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N5/10
摘要： Un sistema (10), para administrar radiación a un ojo (210, 2720), que comprende: un modelo de ojo derivado de los datos anatómicos del ojo de un paciente: un emisor (200) adaptado para administrar al ojo un haz de rayos X que tiene una energía máxima de 10 keV a 500 keV; una guía de posición, acoplada al emisor que, basándose en el modelo de ojo, posiciona el emisor con respecto a una localización sobre o en el ojo, para administrar el haz de rayos X a un objetivo sobre o en el ojo; un colimador (1030, 1040, 1052, 3315) adaptado para colimar el haz de radiación hasta una anchura de 0,5 mm a 6 mm, en donde el haz de radiación tiene una penumbra inferior al diez por ciento a una distancia de hasta 50 cm desde el colimador; y un módulo de planificación (800) que se adapta para (i) determinar, basándose en el modelo de ojo, al menos dos entre objetivo del haz, intensidad del haz, energía del haz, trayectoria del haz, tamaño del campo de tratamiento, forma del campo de tratamiento, distancia desde el emisor al objetivo, tiempo de exposición, y dosis, y (ii) enviar información a la guía de posición; en donde la guía de posición, en base a la información, se adapta para mover al emisor alrededor de un eje de tratamiento y ajusta un ángulo de administración del haz de rayos X mediante el emisor con respecto al eje de tratamiento de tal modo que el haz de rayos X se administra al objetivo.

10. 发明专利

BRPI0717529A2 未知
公开(公告)号：BRPI0717529A2
公开(公告)日：2013-10-22
申请号：BRPI0717529
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL
IPC分类号： A61N5/10 , A61B5/00
摘要： A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.

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