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1. 发明申请

WO2008124801A3 ORTHOVOLTAGE RADIOSURGERY 审中-公开
公开(公告)号：WO2008124801A3
公开(公告)日：2008-12-31
申请号：PCT/US2008059808
申请日：2008-04-09
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , HANSEN STEVEN D
发明人： GERTNER MICHAEL , HANSEN STEVEN D
IPC分类号： A61N5/10
CPC分类号： A61N5/1067 , A61B6/506 , A61B6/508 , A61N5/10 , A61N5/1001 , A61N5/1017 , A61N5/1045 , A61N5/1048 , A61N5/1049 , A61N5/1064 , A61N5/1065 , A61N5/1077 , A61N5/1084 , A61N2005/1019 , A61N2005/1022 , A61N2005/105 , A61N2005/1051 , A61N2005/1059 , A61N2005/1091 , A61N2005/1097
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues. In some embodiments, an eye is held with force and in alignment with the system. In some embodiments, the device automatically turns off with excessive movement outside of alignment along an axis of the eye. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
摘要翻译：描述了放射外科系统，其被配置为将治疗剂量的辐射递送到患者中的目标结构。在一些实施方案中，治疗炎症性眼部疾病，特别是黄斑变性。在一些实施方案中，身体的其它病症或组织用辐射剂量治疗。在一些实施例中，目标组织基于眼睛成像被放置在全局坐标系中。在一些实施例中，全局坐标系统内的目标组织导致基于坐标系统内的目标组织定向的自动定位系统的方向。在一些实施例中，使用治疗计划，其中针对要治疗的特定疾病和/或要避免的结构确定束能量和治疗时间的方向和持续时间。在一些实施方案中，使用基准标记来鉴定靶组织的位置。在一些实施例中，眼睛被保持并且与系统对准。在一些实施例中，设备沿着眼睛的轴线的对准内部的过度运动自动关闭。在一些实施例中，描述了放射外科手术与其他治疗组合使用的放射治疗疗法，并且可以在其它治疗之前，之前或之后随同伴随地递送。

2. 发明申请

WO2009085204A2 METHODS AND DEVICES FOR DETECTING, CONTROLLING, AND PREDICTING RADIATION DELIVERY 审中-公开
标题翻译：用于检测，控制和预测辐射传送的方法和装置
公开(公告)号：WO2009085204A2
公开(公告)日：2009-07-09
申请号：PCT/US2008013886
申请日：2008-12-18
申请人： ORAYA THERAPEUTICS INC , GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , KORUGA IGOR , LIANG JUNZHONG
IPC分类号： A61F9/00 , A61N5/10
CPC分类号： A61N5/1067 , A61F9/008 , A61F2009/00844 , A61F2009/00863 , A61N5/1017 , A61N5/1049 , A61N2005/1059 , A61N2005/1072 , A61N2005/1091
摘要： Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina. Particular methods for controlling radiation in response to motion of the target during treatment are described, such as algorithms for gating or interrupting radiation emission, both to ensure treatment goals and to avoid exposure to sensitive structures.
摘要翻译：实施例提供了用于确定诸如眼睛的患者身体部位（例如眼睛）在诸如放射治疗装置的治疗或诊断装置的外部坐标系中的对准的方法和系统，以便限定用于引导装置操作的参考轴。另外的实施例提供了基于图像的方法和系统，用于相对于辐射束轴对准，跟踪和监测身体部位和治疗目标的运动。特别的眼科实施例提供了包括眼睛接触引导装置和成像系统的方法和系统，用于对准和跟踪眼睛和眼部治疗目标相对于正电压X射线束轴线的运动，以便监测辐射对病变的应用，如视网膜的黄斑病变。描述了在处理期间响应于靶的运动来控制辐射的特定方法，例如用于门控或中断辐射发射的算法，以确保治疗目标并避免暴露于敏感结构。

3. 发明专利

ES2553187T3 Radiocirugía ocular 未知
公开(公告)号：ES2553187T3
公开(公告)日：2015-12-04
申请号：ES07873549
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN D , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N5/10
摘要： Un sistema (10), para administrar radiación a un ojo (210, 2720), que comprende: un modelo de ojo derivado de los datos anatómicos del ojo de un paciente: un emisor (200) adaptado para administrar al ojo un haz de rayos X que tiene una energía máxima de 10 keV a 500 keV; una guía de posición, acoplada al emisor que, basándose en el modelo de ojo, posiciona el emisor con respecto a una localización sobre o en el ojo, para administrar el haz de rayos X a un objetivo sobre o en el ojo; un colimador (1030, 1040, 1052, 3315) adaptado para colimar el haz de radiación hasta una anchura de 0,5 mm a 6 mm, en donde el haz de radiación tiene una penumbra inferior al diez por ciento a una distancia de hasta 50 cm desde el colimador; y un módulo de planificación (800) que se adapta para (i) determinar, basándose en el modelo de ojo, al menos dos entre objetivo del haz, intensidad del haz, energía del haz, trayectoria del haz, tamaño del campo de tratamiento, forma del campo de tratamiento, distancia desde el emisor al objetivo, tiempo de exposición, y dosis, y (ii) enviar información a la guía de posición; en donde la guía de posición, en base a la información, se adapta para mover al emisor alrededor de un eje de tratamiento y ajusta un ángulo de administración del haz de rayos X mediante el emisor con respecto al eje de tratamiento de tal modo que el haz de rayos X se administra al objetivo.

4. 发明专利

CA2709233A1 METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 未知
公开(公告)号：CA2709233A1
公开(公告)日：2009-06-18
申请号：CA2709233
申请日：2008-10-31
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , LIANG JUNZHONG
IPC分类号： A61N5/10
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

5. 发明专利

MX2009003961A RADIOCIRUGIA OCULAR. 未知
公开(公告)号：MX2009003961A
公开(公告)日：2009-07-03
申请号：MX2009003961
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN D , HERRON MATT , PAN KUANG-HUNG , ARNOLDUSSEN MARK
IPC分类号： A61N5/00
摘要： Se describe un sistema de radiocirugía que se configura para suministrar una dosis terapéutica de radiación a una estructura objetivo en un paciente. En algunas modalidades, se tratan los padecimientos oculares inflamatorios, específicamente la degeneración macular. En algunas modalidades, las estructuras oculares se colocan en un sistema global coordinado o de coordenadas basado en la formación de imágenes oculares. En algunas modalidades, las estructuras oculares dentro del sistema global de coordenadas llevan a la dirección de un sistema de posicionamiento automatizado que se dirige, basado en las estructuras oculares dentro del sistema de coordenadas. En algunas modalidades, la posición de la estructura ocular se rastrea y refiere al estado del sistema de radiocirugía. En algunas modalidades, se utiliza un plan de tratamiento en que se determina la energía y dirección del haz y la duración del tiempo para el tratamiento para un padecimiento específico a ser tratado y/o las estructuras que van a evitarse. En algunas modalidades, la estructura es un ojo y el ojo se rastrea por el sistema. En algunas modalidades, el ojo se mantiene en su lugar y en algunas modalidades, el ojo se fija por el paciente. En algunas modalidades, se coloca una marca en el ojo para ayudar en el posicionamiento. En algunas modalidades, se usa una reflexión fuera del ojo para ayudar en el posicionamiento. En algunas modalidades, se describe la terapia radiodinámica en que se usa la radiocirugía en combinación con otros tratamientos y se puede suministrar concomitante con, antes de, o después de otros tratamientos.

6. 发明专利

CA2709233C METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 未知
公开(公告)号：CA2709233C
公开(公告)日：2016-11-29
申请号：CA2709233
申请日：2008-10-31
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , CHELL ERIK , HANSEN STEVEN D , LIANG JUNZHONG
IPC分类号： A61N5/10 , A61F9/007
摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and in-tensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye po-sition, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the ir-radiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

7. 发明专利

CA2666366C OCULAR RADIOSURGERY 未知
公开(公告)号：CA2666366C
公开(公告)日：2016-06-07
申请号：CA2666366
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN D , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N5/10 , A61B6/00 , A61N5/067
摘要： A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the refelction; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.

8. 发明专利

AU2016201833A1 OCULAR RADIOSURGERY 未知
公开(公告)号：AU2016201833A1
公开(公告)日：2016-04-14
申请号：AU2016201833
申请日：2016-03-23
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , ARNOLDUSSEN MARK , HERRON MATT , CHELL ERIK , KUANG-HUNG PAN , HANSEN STEVEN D
IPC分类号： A61N5/10 , A61B5/00
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the 5 ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system, hi some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In 10 some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system, hi some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial 15 is placed on the eye to aid in positioning, hi some embodiments, a reflection off the eye is used to aid in positioning, hi some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments. Page 1 of 35 --- - - - 210--- ' 3 u140

9. 发明专利

AU2012261645A1 OCULAR RADIOSURGERY 未知
公开(公告)号：AU2012261645A1
公开(公告)日：2013-01-10
申请号：AU2012261645
申请日：2012-12-06
申请人： ORAYA THERAPEUTICS INC
发明人： ERIK CHELL , PAN KUANG-HUNG , ARNOLDUSSEN MARK , HERRON MATT , GERTNER MICHAEL , HANSEN STEVEN D
IPC分类号： A61N5/10 , A61B5/00
摘要： A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the 5 ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system, hi some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In 10 some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system, hi some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial 15 is placed on the eye to aid in positioning, hi some embodiments, a reflection off the eye is used to aid in positioning, hi some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments. Page 1 of 35 - -- -400

10. 发明专利

CA2925590A1 OCULAR RADIOSURGERY 未知
公开(公告)号：CA2925590A1
公开(公告)日：2008-10-02
申请号：CA2925590
申请日：2007-10-16
申请人： ORAYA THERAPEUTICS INC
发明人： GERTNER MICHAEL , CHELL ERIK , HANSEN STEVEN D , ARNOLDUSSEN MARK , HERRON MATT , PAN KUANG-HUNG
IPC分类号： A61N5/00 , A61B6/00 , A61F9/007 , A61N5/10
摘要： A radiosurgery system describes a therapeutic radiation delivery to a target structure in a patient. The radiosurgery system treats inflammatory ocular disorders; places ocular structures in a global coordinate system based on ocular imaging; automates ocular structures inside the global coordinate system to direction of a positioning system that is directed based on ocular structures within the coordinate system; tracks and relates the position of ocular structures to the status of the radiosurgery system; determines beam energy and direction and duration of time for treatment for a specific disease to be treated and/or structures to be avoided; tracks structure of an eye; holds and fixes the eye is in place; places a fiducial is on the eye to aid in positioning; positions the eye off the reflection; and combines with other treatments and can be delivered concomitant with, prior to, or following other treatments.

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