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1. 发明授权

US08679518B2 Antimicrobial compounds having protective or therapeutic leaving groups 有权
标题翻译：具有保护性或治疗性离去基团的抗微生物化合物
公开(公告)号：US08679518B2
公开(公告)日：2014-03-25
申请号：US13407961
申请日：2012-02-29
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61F2/00 , A61L27/54 , A61L27/44
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物在不离开基团的情况下的挥发性。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

2. 发明申请

US20120157373A1 ANTIMICROBIAL COMPOUNDS HAVING PROTECTIVE OR THERAPEUTIC LEAVING GROUPS 有权
标题翻译：具有保护性或治疗性组合的抗微生物化合物
公开(公告)号：US20120157373A1
公开(公告)日：2012-06-21
申请号：US13407961
申请日：2012-02-29
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61K31/695 , A61K31/216 , A61K31/65 , A61K31/496 , A61K31/7048 , A61K31/43 , A61K31/546 , A61K31/407 , A61K31/427 , A61K31/7036 , A61K38/02 , A61K31/28 , A61K31/573 , A61K31/58 , C07C69/92 , C07D307/54 , C07D333/24 , C07D207/337 , C07J5/00 , C07J71/00 , C07D307/42 , C07D333/16 , A61P31/00 , A61P29/00 , A61P9/12 , A61P35/00 , A61L33/00 , A61K31/24
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

3. 发明授权

US08173622B2 Antimicrobial compounds having protective or therapeutic leaving groups 有权
标题翻译：具有保护性或治疗性离去基团的抗微生物化合物
公开(公告)号：US08173622B2
公开(公告)日：2012-05-08
申请号：US12192268
申请日：2008-08-15
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A01N55/00
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

4. 发明申请

US20090047321A1 ANTIMICROBIAL COMPOUNDS HAVING PROTECTIVE OR THERAPEUTIC LEAVING GROUPS 有权
标题翻译：具有保护性或治疗性组合的抗微生物化合物
公开(公告)号：US20090047321A1
公开(公告)日：2009-02-19
申请号：US12192268
申请日：2008-08-15
申请人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
发明人： Paul Hsien-Fu Wu , Catherine E. Taylor , Linnus Cheruiyot , Jianwei Li , Terese A. Bartlett , Matt Bergan
IPC分类号： A61K31/695 , A61K31/575 , A61P31/00 , A61K9/00 , C07F7/08
CPC分类号： A61L27/54 , A61K31/575 , A61K31/695 , A61K47/6957 , A61L27/443 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/216 , A61L2300/222 , A61L2300/404 , A61L2300/41 , A61L2300/416 , C07F7/1804
摘要： Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
摘要翻译：抗微生物化合物，例如硅烷醇或醇，包括保护或离去基团，其可以在制备含有化合物的医疗装置的过程中保护化合物免于降解，或降低化合物相对于其对应物的挥发性而不用离去基团。可以使用几乎任何可水解的离去基团。除了保护或保留抗微生物剂之外，离去基团可以是可以起到治疗功能的药剂。

5. 发明授权

US08551113B2 Method and apparatus for fixating an implantable medical device 有权
标题翻译：用于固定可植入医疗装置的方法和装置
公开(公告)号：US08551113B2
公开(公告)日：2013-10-08
申请号：US13277813
申请日：2011-10-20
申请人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
发明人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
IPC分类号： A61B19/00
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A fixation mechanism coupled to an implantable device body extends from a proximal portion of the body to a distal portion of the body and includes a fixation element and a push tube segment. A push tube segment of the mechanism extends proximally from the fixation mechanism to the proximal portion of the body and is adapted to deploy the mechanism.
摘要翻译：耦合到可植入装置主体的固定机构从主体的近侧部分延伸到主体的远侧部分，并且包括固定元件和推管段。机构的推管段从固定机构向近侧延伸到身体的近端部分，并且适于部署该机构。

6. 发明申请

US20120035699A1 METHOD AND APPARATUS FOR FIXATING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：用于固定可植入医疗装置的方法和装置
公开(公告)号：US20120035699A1
公开(公告)日：2012-02-09
申请号：US13277813
申请日：2011-10-20
申请人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
发明人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A fixation mechanism coupled to an implantable device body extends from a proximal portion of the body to a distal portion of the body and includes a fixation element and a push tube segment. A push tube segment of the mechanism extends proximally from the fixation mechanism to the proximal portion of the body and is adapted to deploy the mechanism.
摘要翻译：耦合到可植入装置主体的固定机构从主体的近侧部分延伸到主体的远侧部分，并且包括固定元件和推管段。机构的推管段从固定机构向近侧延伸到身体的近端部分，并且适于部署该机构。

7. 发明授权

US08052711B2 Method and apparatus for fixating an implantable medical device 有权
标题翻译：用于固定可植入医疗装置的方法和装置
公开(公告)号：US08052711B2
公开(公告)日：2011-11-08
申请号：US10792413
申请日：2004-03-03
申请人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
发明人： Gary H. Hanse , Matthew A. Bergan , Terese A. Bartlett , Ryan T. Bauer , Vicki L. Bjorklund , Richard D. Sandstrom
IPC分类号： A61M29/00
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A fixation mechanism coupled to an implantable device body extends from a proximal portion of the body to a distal portion of the body and includes a fixation element and a push tube segment. A push tube segment of the mechanism extends proximally from the fixation mechanism to the proximal portion of the body and is adapted to deploy the mechanism.
摘要翻译：耦合到可植入装置主体的固定机构从主体的近侧部分延伸到主体的远侧部分，并且包括固定元件和推管段。机构的推管段从固定机构向近侧延伸到身体的近端部分，并且适于部署该机构。

8. 发明授权

US5173302A Hydrophilic pressure sensitive adhesive for topical administration of hydrophobic drugs 失效
标题翻译：疏水性压敏胶粘剂用于静脉注射药物的局部给药
公开(公告)号：US5173302A
公开(公告)日：1992-12-22
申请号：US590648
申请日：1990-09-28
申请人： Carolann M. Holmblad , Joan M. Bergstrom , Terese A. Bartlett
发明人： Carolann M. Holmblad , Joan M. Bergstrom , Terese A. Bartlett
IPC分类号： A61K9/70 , A61L15/44 , A61L15/58
CPC分类号： A61K9/7061 , A61L15/58
摘要： Novel hydrogel formulations useful as adhesive reservoirs for topical or transdermal drugs employ as the polymer base a crosslinked polymer or copolymer of 2-acrylamido-2-methylpropanesulfonic acid or a salt thereof. The gels are prepared from polymerizable compositions comprising:20%-50% of a monofunctional monomer component, at least 75% of said component comprising 2-acrylamido-2-methylpropane sulfonic acid or a salt thereof, the balance being selected from the group consisting of acrylic acid, water soluble acrylic functional monomers and vinyl pyrrolidone;30%-50% of a glycol component selected from the group consisting of compounds of the formulaHO--(C.sub.2 H.sub.4 O).sub.n --H,HO--(C.sub.3 H.sub.6 O).sub.m --H and mixtures thereof, where n is in the range of about 4 to about 16 and m is 1-4;between about 0.02% and about 0.20% of a crosslinking monomer;an amount of a free radical polymerization initiator effective for initiating polymerization of said monofunctional monomer and crosslinking monomer components; anda therapeutically effective amount of a topically or transdermally deliverable drug, at least about 60% of said drug being dissolved in the formulation.
摘要翻译：用作局部或透皮药物的粘合剂储存器的新型水凝胶制剂使用2-丙烯酰胺基-2-甲基丙磺酸或其盐的交联聚合物或共聚物作为聚合物基质。凝胶由可聚合组合物制备，包括：20％-50％的单官能单体组分，至少75％的所述组分包含2-丙烯酰氨基-2-甲基丙磺酸或其盐，余量选自的丙烯酸，水溶性丙烯酸官能单体和乙烯基吡咯烷酮; 30％-50％的选自式HO-（C 2 H 4 O）n H，HO-（C 3 H 6 O）m H的化合物及其混合物的二醇组分，其中n在约4至约16的范围内，m 是1-4; 约0.02％至约0.20％的交联单体; 一定量的自由基聚合引发剂，用于引发所述单官能单体和交联单体组分的聚合; 和治疗有效量的局部或透皮递送的药物，至少约60％的所述药物溶解在制剂中。

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