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1. 发明授权

US06923978B2 Multilayer materials 失效
标题翻译：多层材料
公开(公告)号：US06923978B2
公开(公告)日：2005-08-02
申请号：US10368693
申请日：2003-02-19
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
IPC分类号： A61L27/00 , A61L27/34 , C08L101/16 , G02B1/04 , G02C7/04 , A61F2/00 , C08F8/00
CPC分类号： G02B1/043 , A61L27/34 , C08L5/00
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.
摘要翻译：本发明涉及复合材料，特别是生物医学装置，例如，眼科装置，优选隐形眼镜，具有能够在其上容纳水性流体的连续层的一个或多个可润湿表面，所述复合材料包括本体材料和亲水涂层，其特征在于，所述亲水性涂层由共价连接到反应性的碳水化合物在本体材料表面的基团，直接地或通过低官能化合物的官能团，所述低官能化合物又具有能够与本体材料的表面与碳水化合物的所述反应性基团反应的官能团，其中所述反应性基团本质上（先验地）存在于本体材料中，或者其中所述反应性基团已经通过等离子体表面制备被附着到散装材料的表面，以及制造这种复合材料的方法。

2. 发明授权

US06623747B1 Multilayer materials 失效
公开(公告)号：US06623747B1
公开(公告)日：2003-09-23
申请号：US08601420
申请日：1996-02-14
申请人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
发明人： Ronald Christopher Chatelier , Liming Dai , Hans Jörg Griesser , Sheng Li , Paul Zientek , Dieter Lohmann , Peter Chabrecek
IPC分类号： A61F200
CPC分类号： G02B1/043 , A61L27/34 , C08L5/00
摘要： The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continous layer of aqueous fluid thereon which composite material comprises a bulk material and a hydrophilic coating characterized in that the hydrophilic coating consists of a carbohydrate attached covalently to reactive groups at the surface of the bulk material, either directly or via functional groups of an oligofunctional compound, said oligofunctional compound in turn having functional groups being capable of reacting with said reactive groups at the surface of the bulk material and with the carbohydrate, wherein said reactive groups are either inherently (a priori) present in the bulk material or wherein said reactive groups have been attached to the surface of the bulk material by a plasma surface preparation, as well as to a process of manufacture of such a composite material.

3. 发明授权

US06951894B1 Extended wear ophthalmic lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US06951894B1
公开(公告)日：2005-10-04
申请号：US09640526
申请日：2000-08-17
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Höpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Höpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号： G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有很大的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

4. 发明申请

US20100238398A1 Extended Wear Ophthalmic Lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US20100238398A1
公开(公告)日：2010-09-23
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。

5. 发明授权

US07538146B2 Extended wear ophthalmic lens 失效
公开(公告)号：US07538146B2
公开(公告)日：2009-05-26
申请号：US11618800
申请日：2006-12-30
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： C08F290/06
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.

6. 发明授权

US07468398B2 Extended wear ophthalmic lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US07468398B2
公开(公告)日：2008-12-23
申请号：US11146586
申请日：2005-06-07
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： C08F290/06
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

7. 发明授权

US06730366B2 Process for modifying a surface 有权
标题翻译：改变表面的工艺
公开(公告)号：US06730366B2
公开(公告)日：2004-05-04
申请号：US10056168
申请日：2002-01-24
申请人： Dieter Lohmann , Peter Chabrecek , Jörg Leukel
发明人： Dieter Lohmann , Peter Chabrecek , Jörg Leukel
IPC分类号： C23C1428
CPC分类号： C08J7/047 , Y10T428/31504 , Y10T428/31623
摘要： The invention relates to a process for coating a material surface comprising the steps of: (a) applying to the material surface one or more different comb-type polymers comprising a polymer backbone and side chains pendently attached thereto, wherein at least a part of the side chains carry a triggerable precursor for carbene or nitrene formation; and (b) fixing the polymer(s) onto the material surface using heat or radiation, in particular radiation such as UV or visible light. The polymers of the invention are useful for the modification of material surfaces and are particularly suitable for providing biomedical articles such as contact lenses with a hydrophilic coating.
摘要翻译：本发明涉及一种用于涂覆材料表面的方法，包括以下步骤：（a）向材料表面施加一种或多种不同的梳型聚合物，其包含聚合物主链和侧链附着于其上，其中至少一部分侧链携带可触发的卡宾或者氮烯形成前体; 和（b）使用热或辐射，特别是诸如UV或可见光的辐射将聚合物固定在材料表面上。本发明的聚合物可用于改性材料表面，并且特别适用于提供生物医学制品例如具有亲水涂层的隐形眼镜。

8. 发明授权

US5939466A Poly-unsaturated carbohydrate derivatives, polymers thereof and their use 失效
标题翻译：多不饱和碳水化合物衍生物及其用途及其用途
公开(公告)号：US5939466A
公开(公告)日：1999-08-17
申请号：US817044
申请日：1997-04-04
申请人： Frank Bachmann , Dieter Lohmann , Peter Chabrecek
发明人： Frank Bachmann , Dieter Lohmann , Peter Chabrecek
IPC分类号： G02C7/04 , A61K9/00 , A61K47/36 , C07D493/04 , C07H13/12 , C07H15/04 , C08B37/00 , C08B37/16 , C08F12/00 , C08F18/00 , C08F20/36 , C08F220/36 , G02B1/04 , G02B1/10 , C07H15/02 , C07H265/04
CPC分类号： C07D493/04 , C07H13/12 , C07H15/04 , C08B37/0012 , C08F220/36 , G02B1/043
摘要： The present invention relates to polymerizable derivatives of carbohydrates comprising a carbohydrate radical and more than one radically polymerizable hydrocarbon group which is linked optionally via a spacer to the carbohydrate radical, to homopolymers, copolymers, block copolymers, graft copolymers and polymeric networks thereof, to capsules, fibers, films and coatings having water-binding and biocompatible properties, and to molded articles, for example contact lenses or biomedicinal articles, comprising the mentioned polymers, as well as to processes for the preparation of the mentioned polymers and articles.
摘要翻译： PCT No.PCT / EP95 / 04052 Sec。 371日期1997年04月4日 102（e）日期1997年4月4日PCT提交1995年10月16日PCT公布。第WO96 / 13511号公报日期1996年5月9日本发明涉及碳水化合物的可聚合衍生物，其包含碳水化合物基团和多于一个可自由基聚合的烃基，其任选经由间隔基连接至碳水化合物基团，至均聚物，共聚物，嵌段共聚物，接枝共聚物和聚合物网络具有水结合和生物相容性质的胶囊，纤维，膜和涂层，以及包含所述聚合物的模制品，例如隐形眼镜或生物医学制品，以及制备所述聚合物和制品的方法。

9. 发明授权

US5612391A Functionalized photoinitiators, macromers thereof, and the use thereof for contact lens 失效
标题翻译：官能化光引发剂，其大分子单体及其用于隐形眼镜的用途
公开(公告)号：US5612391A
公开(公告)日：1997-03-18
申请号：US469399
申请日：1995-06-06
申请人： Peter Chabrecek , Dieter Lohmann
发明人： Peter Chabrecek , Dieter Lohmann
IPC分类号： G02C7/04 , C07C49/76 , C07C49/82 , C07C271/20 , C07C271/24 , C07C271/28 , C07C271/32 , C07C271/38 , C07D317/26 , C07F7/10 , C08B31/00 , C08B33/00 , C08B37/00 , C08B37/08 , C08B37/16 , C08F2/48 , C08F2/50 , C08F8/30 , C08F16/36 , C08G18/00 , C08G18/08 , C08G18/71 , C08G77/04 , C08G77/38 , C08J3/28 , C08J7/12 , C08J7/18 , C08L101/02 , G02B1/04 , G03F7/031 , G03F7/075 , C08J5/00 , C08J5/18 , C08J7/04
CPC分类号： G03F7/075 , C07C271/20 , C07C271/24 , C07C271/28 , C07C271/38 , C08B37/0012 , C08B37/0072 , C08F2/50 , C08F8/30 , C08G77/38 , C08J7/12 , C08J7/18 , G02B1/043 , G03F7/031 , C07C2101/14 , Y10S522/904 , Y10S522/905 , Y10T428/31645 , Y10T428/31663 , Y10T428/31667 , Y10T428/31855 , Y10T428/31971
摘要： Contact lenses formed from compounds of formula I: ##STR1## are disclosed. The compounds are photoinitiators which can be functionalized by means of ethylenic groups or can be bonded to H-active substances, in order, for example, to modify surfaces by means of photopolymerizable substances. The compounds are especially useful in the manufacture of contact lenses.
摘要翻译：公开了由式I化合物形成的隐形眼镜：。这些化合物是可以通过烯属基官能化或可以与H-活性物质结合的光引发剂，以便例如通过可光聚合物质来修饰表面。这些化合物在隐形眼镜的制造中特别有用。

10. 发明授权

US07553880B2 Extended wear ophthalmic lens 失效
标题翻译：延长佩戴眼科镜片
公开(公告)号：US07553880B2
公开(公告)日：2009-06-30
申请号：US11618798
申请日：2006-12-30
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译：一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。透镜具有透氧性和离子或水渗透性的平衡，离子或水渗透性足以提供良好的眼内运动，使得透镜和眼睛之间发生良好的泪液交换。优选的透镜是含氧大分子单体和离子单体单体的共聚产物。本发明包括长期佩戴的隐形眼镜，其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。

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