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1. 发明申请

US20080300299A1 Application of Eriocalyxin B in the Manufacture of Medicaments For Treating Leukemia 审中-公开
标题翻译：胭脂红素B在制造治疗白血病药物中的应用
公开(公告)号：US20080300299A1
公开(公告)日：2008-12-04
申请号：US12092914
申请日：2006-10-08
申请人： Sai-juan Chen , Zhu Chen , Lan Wang , Wei-li Zhao , Han-dong Sun
发明人： Sai-juan Chen , Zhu Chen , Lan Wang , Wei-li Zhao , Han-dong Sun
IPC分类号： A61K31/352 , A61P35/02
CPC分类号： A61K31/352
摘要： The use of eriocalyxin B in the manufacture of medicaments for treating leukemia, wherein the leukemia include leukemia containing AML1-ETO fusion protein, acute promyelocytic leukemia, acute myelocytic leukemia and lymphocytic leukemia. Eriocalyxin B increases the level of peroxidate and influences the phosphorylation and degradation of IκBα to prevent NF-κB from getting into the nucleus in order to inhibition NF-κB pathway. Eriocalyxin B can decrease the phosphorylation of ERI1/2 and inhibit MAPK pathway. Eriocalyxin B can extend the life span of mice and decrease tumor volume in mice model of C57 leukemia and tumor transplantation.
摘要翻译：在制备用于治疗白血病的药物中使用调色素B，其中白血病包括含有AML1-ETO融合蛋白的白血病，急性早幼粒细胞白血病，急性骨髓性白血病和淋巴细胞性白血病。 Eriocalyxin B增加过氧化物的水平，并影响IkappaBalpha的磷酸化和降解，以防止NF-κB进入细胞核以抑制NF-κB通路。 Eriocalyxin B可以减少ERI1 / 2的磷酸化并抑制MAPK通路。 Eriocalyxin B可以延长小鼠的寿命，并减少C57白血病和肿瘤移植的小鼠模型中的肿瘤体积。

2. 发明授权

US6165461A Tao protein kinases and methods of use therefor 失效
标题翻译：陶蛋白激酶及其使用方法
公开(公告)号：US6165461A
公开(公告)日：2000-12-26
申请号：US60410
申请日：1998-04-14
申请人： Melanie Cobb , Michele Hutchison , Zhu Chen , Kevin Berman
发明人： Melanie Cobb , Michele Hutchison , Zhu Chen , Kevin Berman
IPC分类号： G01N33/50 , A61K31/711 , A61K38/00 , A61K39/395 , A61P35/00 , A61P37/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/09 , C12N15/54 , C12P21/08 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/577 , A61K38/51
CPC分类号： C12N9/1205 , A61K38/00
摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
摘要翻译：提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体。这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

3. 发明授权

US08385661B2 Hand-held mobile apparatus and method of quckly displaying online community friends' images applicable thereto 有权
标题翻译：手持式移动装置及其应用于在线社区朋友的图像的方法
公开(公告)号：US08385661B2
公开(公告)日：2013-02-26
申请号：US13043896
申请日：2011-03-09
申请人： Zhu Chen , Gang Chen , Qi Guo
发明人： Zhu Chen , Gang Chen , Qi Guo
IPC分类号： G06K9/62 , G06K9/68 , G06K9/70 , G06K9/32 , G06K9/60
CPC分类号： G06F17/30902
摘要： A hand-held mobile apparatus and method of quickly displaying online community friends' images applicable thereto are disclosed. The hand-held mobile apparatus includes a network communication module for linking to an online community server; a comparison module for comparing and determining whether data of a web image in the online community server matches data of a local image in a storage unit of the apparatus; a recognition module for determining an image type of the web image when the web image data is different from the local image data; a processing unit for downloading the web image of a first type in a smallest image size or the web image of a second type in an image size matching a screen resolution of the apparatus, and storing the web image in the storage unit as the local image; and a display unit for displaying the local image.
摘要翻译：公开了一种快速显示在线社区朋友的图像的手持移动装置和方法。手持移动装置包括用于链接到在线社区服务器的网络通信模块; 用于比较和确定在线社区服务器中的网络图像的数据是否匹配设备的存储单元中的本地图像的数据的比较模块; 识别模块，用于当网页图像数据与本地图像数据不同时，确定网页图像的图像类型; 处理单元，用于以与所述装置的屏幕分辨率相匹配的图像大小中以最小图像大小的第一类型的网页图像或第二类型的网页图像下载，并将所述网络图像存储在所述存储单元中作为所述局部图像 ; 以及显示单元，用于显示本地图像。

4. 发明授权

US09590253B2 Core-shell structured bifunctional catalysts for metal air battery/fuel cell 有权
标题翻译：用于金属空气电池/燃料电池的核壳结构双功能催化剂
公开(公告)号：US09590253B2
公开(公告)日：2017-03-07
申请号：US13941139
申请日：2013-07-12
申请人： Zhongwei Chen , Zhu Chen
发明人： Zhongwei Chen , Zhu Chen
IPC分类号： H01M4/90 , H01M4/86 , H01M4/96 , H01M12/06
CPC分类号： H01M4/9016 , H01M4/8615 , H01M4/96 , H01M12/06 , Y02E60/50
摘要： The present invention relates to a bifunctional catalyst for use with air metal batteries and fuel cell. The bifunctional catalyst comprising a core and a shell, where the core comprises a metal oxide and the shell comprises a carbon nanostructure. In a further aspect the bifunctional catalyst is catalytically active for oxygen reduction and oxygen evolution reactions.
摘要翻译：本发明涉及一种用于空气金属电池和燃料电池的双功能催化剂。包含核和壳的双功能催化剂，其中芯包含金属氧化物，壳包含碳纳米结构。在另一方面，双功能催化剂对氧还原和析氧反应具有催化活性。

5. 发明申请

US20130033611A1 Search System of Face Recognition and Method Thereof, Computer Readable Storage Media and Computer Program Product 审中-公开
标题翻译：人脸识别及其方法搜索系统，计算机可读存储媒体和计算机程序产品
公开(公告)号：US20130033611A1
公开(公告)日：2013-02-07
申请号：US13218032
申请日：2011-08-25
申请人： Zhu Chen
发明人： Zhu Chen
IPC分类号： H04N5/225
CPC分类号： G06K9/00288 , G06F16/583 , G06Q50/01 , H04M1/27455 , H04M1/576 , H04N7/141
摘要： A search system of face recognition and a method thereof, a computer readable storage media and a computer program product. The search method of face recognition comprises of: capturing a human face image by an image capturing unit; recognizing a first face information of the human face image via a face recognition unit; controlling a first communication unit to transmit the first face information by a first processing unit; storing a plurality piece of personal information and a second face information corresponding to each personal information by a storage unit; comparing the first face information and the plurality piece of second face information by a matching unit; and controlling a second communication unit to provide the personal information corresponding to the second face information to a portable electronic device by a second processing unit when the first face information matches one of the second face information.
摘要翻译：人脸识别搜索系统及其方法，计算机可读存储介质和计算机程序产品。面部识别的搜索方法包括：通过图像捕获单元捕获人脸图像; 通过面部识别单元识别人脸图像的第一面部信息; 控制第一通信单元通过第一处理单元发送第一面部信息; 通过存储单元存储多个个人信息和与每个个人信息相对应的第二面部信息; 通过匹配单元比较第一面部信息和多个第二面部信息; 以及当所述第一面部信息与所述第二面部信息中的一个相匹配时，控制第二通信单元以通过第二处理单元将与所述第二面部信息相对应的个人信息提供给便携式电子设备。

6. 发明申请

US20140023939A1 CORE-SHELL STRUCTURED BIFUNCTIONAL CATALYSTS FOR METAL AIR BATTERY/FUEL CELL 审中-公开
标题翻译：金属空气电池/燃料电池的核壳结构化双功能催化剂
公开(公告)号：US20140023939A1
公开(公告)日：2014-01-23
申请号：US13941139
申请日：2013-07-12
申请人： Zhongwei Chen , Zhu Chen
发明人： Zhongwei Chen , Zhu Chen
IPC分类号： H01M4/90 , H01M4/86
CPC分类号： H01M4/9016 , H01M4/8615 , H01M4/96 , H01M12/06 , Y02E60/50
摘要： The present invention relates to a bifunctional catalyst for use with air metal batteries and fuel cell. The bifunctional catalyst comprising a core and a shell, where the core comprises a metal oxide and the shell comprises a carbon nanostructure. In a further aspect the bifunctional catalyst is catalytically active for oxygen reduction and oxygen evolution reactions.
摘要翻译：本发明涉及一种用于空气金属电池和燃料电池的双功能催化剂。包含核和壳的双功能催化剂，其中芯包含金属氧化物，壳包含碳纳米结构。在另一方面，双功能催化剂对氧还原和析氧反应具有催化活性。

7. 发明授权

US07153683B2 TAO protein kinase polypeptides and methods of use therefor 失效
公开(公告)号：US07153683B2
公开(公告)日：2006-12-26
申请号：US10445735
申请日：2003-05-27
申请人： Melaine Cobb , Michelle Hutchinson , Zhu Chen , Kevin Berman
发明人： Melaine Cobb , Michelle Hutchinson , Zhu Chen , Kevin Berman
IPC分类号： C12N15/00 , C12N9/12 , C12N1/20 , A61K38/00 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00
摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.

8. 发明授权

US07078182B1 TAO protein kinase polypeptides and methods of use therefor 失效
标题翻译： TAO蛋白激酶多肽及其使用方法
公开(公告)号：US07078182B1
公开(公告)日：2006-07-18
申请号：US09686346
申请日：2000-10-10
申请人： Melanie Cobb , Michelle Hutchinson , Zhu Chen , Kevin Berman
发明人： Melanie Cobb , Michelle Hutchinson , Zhu Chen , Kevin Berman
IPC分类号： C12Q1/48 , C12N15/00 , C12N5/00 , C12N9/12 , C07K1/00
CPC分类号： C12N9/1205 , A61K38/00
摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
摘要翻译：提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体。这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

9. 发明授权

US06586242B1 TAO protein kinases and methods of use therefor 失效
标题翻译： TAO蛋白激酶及其使用方法
公开(公告)号：US06586242B1
公开(公告)日：2003-07-01
申请号：US09723458
申请日：2000-11-27
申请人： Melanie H. Cobb , Michele Hutchison , Zhu Chen , Kevin Scott Berman
发明人： Melanie H. Cobb , Michele Hutchison , Zhu Chen , Kevin Scott Berman
IPC分类号： C12N500
CPC分类号： C12N9/1205 , A61K38/00
摘要： Compositions and methods are provided for potentiating the activity of the mitogen-activated protein kinase p38. In particular the mitogen-activated protein kinase kinase MEK6, and variants thereof that stimulate phosphorylation of p38 are provided. Such compounds may be used, for example, for therapy of diseases associated with the p38 cascade and to identify antibodies and other agents that inhibit or activate signal transduction via p38.
摘要翻译：提供组合物和方法来增强丝裂原活化蛋白激酶p38的活性。特别地提供了刺激磷酸化p38的丝裂原活化蛋白激酶激酶MEK6及其变体。这样的化合物可用于例如治疗与p38级联相关的疾病，并鉴定通过p38抑制或激活信号转导的抗体和其它试剂。

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