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1. 发明授权

US07763441B2 Modulators of gluconeogenesis 失效
标题翻译：糖异生的调节剂
公开(公告)号：US07763441B2
公开(公告)日：2010-07-27
申请号：US11717426
申请日：2007-03-13
申请人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
发明人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
IPC分类号： C12Q1/42 , C12N9/16 , G01N33/53 , A61K38/17
CPC分类号： C07K14/4702 , A61K38/1709 , C12N9/16
摘要： The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译：本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。还公开了包含或编码糖异生的调节剂的药物组合物。

2. 发明授权

US06548257B2 Methods of identifying nucleic acid probes to quantify the expression of a target nucleic acid 有权
标题翻译：鉴定核酸探针以量化靶核酸的表达的方法
公开(公告)号：US06548257B2
公开(公告)日：2003-04-15
申请号：US09935365
申请日：2001-08-22
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与RNA转录物互补衍生自RNA转录物的核酸; 并定量阵列中的杂交核酸。

3. 发明授权

US6022714A Methods for attachment of a polynucleotide to a preselected material 失效
标题翻译：将多核苷酸连接到预选材料的方法
公开(公告)号：US6022714A
公开(公告)日：2000-02-08
申请号：US574860
申请日：1995-12-19
申请人： Eugene L. Brown , Joseph P. Dougherty , Mary Collins
发明人： Eugene L. Brown , Joseph P. Dougherty , Mary Collins
IPC分类号： C07B61/00 , C07H21/00 , C12Q1/68 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： C07H21/00 , C12Q1/6834 , C07B2200/11 , C40B40/00 , Y10S435/81
摘要： Compositions and methods for selectively linking a polynucleotide through its 5' or 3' end to one or more preselected materials such as insoluble matrices, solid supports, proteins, small molecular or labels are disclosed. Use of these compositions and methods in the production of diagnostic and affinity reagents are also disclosed.
摘要翻译：公开了将多核苷酸通过其5'或3'端选择性连接到一种或多种预选物质如不溶性基质，固体支持物，蛋白质，小分子或标记物的组合物和方法。还公开了这些组合物和方法在制备诊断和亲和试剂中的用途。

4. 发明授权

US06927032B2 Expression monitoring by hybridization to high density oligonucleotide arrays 失效
标题翻译：通过与高密度寡核苷酸阵列杂交进行表达监测
公开(公告)号：US06927032B2
公开(公告)日：2005-08-09
申请号：US10353792
申请日：2003-01-28
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark Chee , Thomas R. Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与衍生自RNA转录物的RNA转录物或核酸互补; 并定量阵列中的杂交核酸。

5. 发明授权

US5084556A Composition of M-CSF conjugated to cytotoxic agents and a method for treating cancers characterized by over-expression of the c-fms proto-oncogene 失效
标题翻译：与细胞毒素偶联的M-CSF的组成和用于治疗以c-fms原癌基因过度表达为特征的癌症的方法
公开(公告)号：US5084556A
公开(公告)日：1992-01-28
申请号：US545678
申请日：1990-06-28
申请人： Eugene L. Brown
发明人： Eugene L. Brown
IPC分类号： A61K47/48 , C07K14/82
CPC分类号： A61K47/48276 , C07K14/82
摘要： A composition and method for treating cancers characterized by over-expression of the c-fms proto-oncogene/M-CSF receptor protein are provided. The composition involves a M-CSF polypeptide cross-linked to a cytotoxic agent capable of crossing into the cytoplasm of the cell bearing the receptor and killing the cell.
摘要翻译：提供了以c-fms原癌基因/ M-CSF受体蛋白质过度表达为特征的治疗癌症的组合物和方法。该组合物包含与能够穿过带有受体的细胞的细胞质并杀死细胞的细胞毒性剂交联的M-CSF多肽。

6. 发明授权

US06410229B1 Expression monitoring by hybridization to high density nucleic acid arrays 有权
标题翻译：通过与高密度核酸阵列杂交进行表达监测
公开(公告)号：US06410229B1
公开(公告)日：2002-06-25
申请号：US09212004
申请日：1998-12-14
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
IPC分类号： C12Q168
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475 , C12Q2565/507
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.
摘要翻译：本发明提供监测多种基因的表达水平的方法。所述方法包括将核酸样品与寡核苷酸探针的高密度阵列杂交，其中高密度阵列含有与核酸样品中靶核酸的子序列互补的寡核苷酸探针。在一个实施方案中，所述方法包括提供包含一个或多个靶基因的RNA转录物或衍生自RNA转录物的核酸的靶核酸库，将所述核酸库与固定在表面上的寡核苷酸探针阵列杂交，其中包含超过100种不同寡核苷酸的阵列和每种不同的寡核苷酸被定位在表面的预定区域中，不同寡核苷酸的密度大于每1cm 2大约60个不同的寡核苷酸，并且寡核苷酸探针与RNA转录物互补衍生自RNA转录物的核酸; 并定量阵列中的杂交核酸。

7. 发明授权

US6040138A Expression monitoring by hybridization to high density oligonucleotide arrays 失效
公开(公告)号：US6040138A
公开(公告)日：2000-03-21
申请号：US529115
申请日：1995-09-15
申请人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
发明人： David J. Lockhart , Eugene L. Brown , Gordon G. Wong , Mark S. Chee , Thomas R. Gingeras
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N15/14 , G01N37/00 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6809 , C12Q1/6837 , G01N15/1475
摘要： This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample. In one embodiment, the method involves providing a pool of target nucleic acids comprising RNA transcripts of one or more target genes, or nucleic acids derived from the RNA transcripts, hybridizing said pool of nucleic acids to an array of oligonucleotide probes immobilized on surface, where the array comprising more than 100 different oligonucleotides and each different oligonucleotide is localized in a predetermined region of the surface, the density of the different oligonucleotides is greater than about 60 different oligonucleotides per 1 cm.sup.2, and the olignucleotide probes are complementary to the RNA transcripts or nucleic acids derived from the RNA transcripts; and quantifying the hybridized nucleic acids in the array.

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