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1. 发明授权

US07763441B2 Modulators of gluconeogenesis 失效
标题翻译：糖异生的调节剂
公开(公告)号：US07763441B2
公开(公告)日：2010-07-27
申请号：US11717426
申请日：2007-03-13
申请人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
发明人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene L. Brown , Ruth Gimeno , Robert Martinez
IPC分类号： C12Q1/42 , C12N9/16 , G01N33/53 , A61K38/17
CPC分类号： C07K14/4702 , A61K38/1709 , C12N9/16
摘要： The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译：本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。还公开了包含或编码糖异生的调节剂的药物组合物。

2. 发明申请

US20070270331A1 Modulators of gluconeogenesis 失效
标题翻译：糖异生的调节剂
公开(公告)号：US20070270331A1
公开(公告)日：2007-11-22
申请号：US11717426
申请日：2007-03-13
申请人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
发明人： Stephen Berasi , Christine Huard , Dongmei Li , Heather Shih , Ying Sun , Janet Paulsen , Eugene Brown , Ruth Gimeno , Robert Martinez
IPC分类号： A61K38/02 , A61K31/7052 , A61P3/08 , C12N5/02
CPC分类号： C07K14/4702 , A61K38/1709 , C12N9/16
摘要： The present invention provides methods of affecting gluconeogenesis by altering the levels or activity of DUSP4 and/or EGR1. Pharmaceutical compositions comprising or encoding modulators of gluconeogenesis are also disclosed.
摘要翻译：本发明提供通过改变DUSP4和/或EGR1的水平或活性来影响糖异生的方法。还公开了包含或编码糖异生的调节剂的药物组合物。

3. 发明申请

US20070014776A1 Identification of adiponutrin-related proteins as esterases and methods of use for the same 审中-公开
标题翻译：脂肪素相关蛋白鉴定为酯酶及其使用方法
公开(公告)号：US20070014776A1
公开(公告)日：2007-01-18
申请号：US11450935
申请日：2006-06-09
申请人： Ruth Gimeno , Janet Paulsen , Jian-Liang Li , Andrew Lake , Wei Liu , Jae Eun Kim
发明人： Ruth Gimeno , Janet Paulsen , Jian-Liang Li , Andrew Lake , Wei Liu , Jae Eun Kim
IPC分类号： A61K38/54 , C12Q1/34 , C07H21/04 , C12P21/06 , C12N9/99
CPC分类号： C12Q1/44 , A61K38/28 , C12N9/20 , G01N33/543 , G01N2333/918 , G01N2500/00 , G01N2800/04 , G01N2800/32
摘要： The present invention provides methods of identifying polypeptides that have enzymatic activity associated with nutrient and/or energy homeostasis, and thus, are involved in the development of one or more cardiovascular and metabolic disorders, e.g., cardiovascular disease, obesity, insulin resistance, type 2 diabetes, dyslipidemia, nonalcoholic fatty liver disease, and metabolic syndrome. One such method comprises identifying a polypeptide as a member of the adiponutrin family of proteins. As such, the invention is related to the polynucleotides and polypeptides belonging to the adiponutrin family, and provides novel isolated and purified polynucleotides and polypeptides of a novel member of the adiponutrin family, patatin-like phospholipase domain 1 (PNPLA1). Also provided are methods of using the polynucleotides and polypeptides related to or provided by the invention for screening a test compound, e.g., a small molecule, antibody, etc., for the ability of the test compound to detect and/or modulate the activity of one or more members of the adiponutrin family of proteins. The present invention also is directed to novel methods for diagnosing, prognosing, and monitoring the progress of at least one cardiovascular and metabolic disorder using polynucleotides or polypeptides belonging to the adiponutrin family, and/or modulators of one or more members of the adiponutrin family. The present invention is further directed to novel therapeutics and therapeutic targets for the intervention (treatment) and prevention of cardiovascular and metabolic disorders arising from dysregulated energy homeostasis, as related to one or more members of the adiponutrin family of proteins.
摘要翻译：本发明提供了鉴定具有与营养和/或能量内稳态相关的酶活性的多肽的方法，因此涉及一种或多种心血管和代谢疾病的发展，例如心血管疾病，肥胖症，胰岛素抵抗，2型糖尿病，血脂异常，非酒精性脂肪性肝病和代谢综合征。一种这样的方法包括鉴定多肽作为脂肪细胞蛋白家族的成员。因此，本发明涉及属于脂肪调素素家族的多核苷酸和多肽，并且提供脂肪分泌素家族的新成员的新分离和纯化的多核苷酸和多肽，类似蛋白样磷脂酶结构域1（PNPLA1）。还提供了使用与本发明相关或由本发明提供的多核苷酸和多肽用于筛选测试化合物（例如小分子，抗体等）以测试化合物检测和/或调节活性的能力的方法脂肪蛋白家族蛋白的一个或多个成员。本发明还涉及使用属于脂肪素家族的多核苷酸或多肽和/或脂肪素家族的一个或多个成员的调节剂来诊断，预测和监测至少一种心血管和代谢紊乱进展的新方法。本发明进一步涉及用于干预（治疗）的新型治疗学和治疗靶标，以及与由脂肪蛋白家族蛋白质的一个或多个成员相关的由失调的能量稳态引起的心血管和代谢紊乱的预防。

4. 发明申请

US20100092941A1 32142,21481,25964,21686, Novel dehydrogenase molecules and uses therefor 审中-公开
标题翻译： 32142,21481,25964,21686，新型脱氢酶分子及其用途
公开(公告)号：US20100092941A1
公开(公告)日：2010-04-15
申请号：US12316383
申请日：2008-12-10
申请人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
发明人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
IPC分类号： C12Q1/70 , C07H21/00 , C12N15/63 , C12N5/00 , C12N1/00 , C12P21/00 , C07K7/08 , C07K14/00 , C07K16/00 , G01N33/53 , G01N33/68 , C12Q1/02
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。还提供了利用本发明组合物的诊断方法。

5. 发明申请

US20080038278A1 GPAT3 encodes a mammalian, microsomal acyl-coa:glycerol 3- phosphate acyltransferase 审中-公开
标题翻译： GPAT3编码哺乳动物，微粒体酰基-CoA：甘油3-磷酸酰基转移酶
公开(公告)号：US20080038278A1
公开(公告)日：2008-02-14
申请号：US11711577
申请日：2007-02-26
申请人： Jingsong Cao , Ruth Gimeno , Jian-Liang Li
发明人： Jingsong Cao , Ruth Gimeno , Jian-Liang Li
IPC分类号： A61K39/395 , A61K31/7088 , C07K16/40 , C12Q1/48 , C12N5/00 , A61K38/00
CPC分类号： C12Q1/48 , A61K31/7088 , A61K38/00 , C12N9/1029
摘要： The present invention provides isolated and purified polynucleotides and polypeptides related to mouse and human microsomal acyl-CoA:glycerol 3-phosphate acyltransferase 3 (GPAT3) and their uses in modulating triacylglycerol (TAG) levels in a cell or sample of interest. The invention also provides GPAT3 agonists and antagonists, e.g., GPAT3 polynucleotides and polypeptides, antibodies to GPAT3 (agonistic and antagonistic antibodies), GPAT3 inhibitory polypeptides, and GPAT3 inhibitory polynucleotides. The present invention is also directed to novel methods for diagnosing, prognosing, monitoring, treating, ameliorating and/or preventing conditions related to GPAT3, TAG synthesis (or accumulation), or the synthesis (or accumulation) of TAG precursors (e.g., MAG, LPA, PA, and/or G3P). These GPAT3-associated conditions include, but are not limited to, dyslipidemia (e.g., hyperlipidemia, hypertriglyceridemia, Type III hyperlipidemia), obesity, hypercholesterolemia, hepatic steatosis, cancer, skin disorders associated with altered lipid metabolism (e.g., acne vulgaris, dry skin), adiposity, type 2 diabetes (and complications associated therewith, such as dermopathy, retinopathy, neuropathy, and nephropathy), insulin resistance, hyperinsulinemia, hypertension, cardiovascular disease, atherosclerosis, stroke, thrombosis, lipodystrophy, lipopenia, Reye's syndrome, Cushing's syndrome, metabolic syndrome (e.g., syndrome X), eating disorders (e.g., anorexia, bulimia), skin homeostasis, disorders related to energy storage, nutrient absorption, and lipid metabolism, reduced or absent lactation, and low preterm birth weight (and complications thereof, such as defects in neural development).
摘要翻译：本发明提供与小鼠和人微粒体酰基辅酶A：甘油3-磷酸酰基转移酶3（GPAT3）相关的分离和纯化的多核苷酸和多肽及其在调节感兴趣的细胞或样品中的三酰基甘油（TAG）水平的用途。本发明还提供GPAT3激动剂和拮抗剂，例如GPAT3多核苷酸和多肽，GPAT3抗体（激动剂和拮抗性抗体），GPAT3抑制性多肽和GPAT3抑制性多核苷酸。本发明还涉及用于诊断，预后，监测，治疗，改善和/或预防与GPAT3相关的病症，TAG合成（或积累）或TAG前体的合成（或积累）的新方法（例如MAG， LPA，PA和/或G3P）。这些GPAT3相关病症包括但不限于血脂异常（例如，高脂血症，高甘油三酯血症，III型高脂血症），肥胖症，高胆固醇血症，肝脂肪变性，癌症，与脂质代谢改变相关的皮肤病症（例如寻常痤疮，干性皮肤），肥胖，2型糖尿病（以及与其相关的并发症，如皮肤病，视网膜病变，神经病变和肾病），胰岛素抵抗，高胰岛素血症，高血压，心血管疾病，动脉粥样硬化，中风，血栓形成，脂肪营养不良，脂肪减少，雷氏综合征，库欣综合征，代谢综合征（例如综合征X），进食障碍（例如厌食症，贪食症），皮肤内稳态，与储能相关的疾病，营养吸收和脂质代谢，减少或不存在的泌乳，以及早产儿的体重（及其并发症），如神经发育缺陷）。

6. 发明授权

US07045325B2 32142, 21481, 25964, 21686, novel dehydrogenase molecules and uses therefor 有权
公开(公告)号：US07045325B2
公开(公告)日：2006-05-16
申请号：US10664506
申请日：2003-09-17
申请人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
发明人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
IPC分类号： C12N9/04 , C12N1/20 , C12N15/00 , C12P21/04 , C07H21/04
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

7. 发明授权

US06627423B2 21481, a novel dehydrogenase molecule and uses therefor 有权
标题翻译： 21481，一种新的脱氢酶分子并用于此
公开(公告)号：US06627423B2
公开(公告)日：2003-09-30
申请号：US09838561
申请日：2001-04-18
申请人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
发明人： Rachel Meyers , William James Cook , Mark Williamson , Laura A. Rudolph-Owen , Ruth Gimeno
IPC分类号： C12N904
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型DHDR相关脱氢酶分子的分离的核酸分子，命名为DHDR核酸分子。本发明还提供了反义核酸分子，含有DHDR核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及DHDR基因导入或破坏的非人类转基因动物。本发明还进一步提供了分离的DHDR蛋白，融合蛋白，抗原肽和抗DHDR抗体。还提供了利用本发明组合物的诊断方法。

8. 发明申请

US20060166326A1 32142, 21481, 25964, 21686, novel dehydrogenase molecules and uses therefor 失效
公开(公告)号：US20060166326A1
公开(公告)日：2006-07-27
申请号：US11335810
申请日：2006-01-19
申请人： Rachel Meyers , William Cook , Mark Williamson , Laura Rudolph-Owen , Ruth Gimeno
发明人： Rachel Meyers , William Cook , Mark Williamson , Laura Rudolph-Owen , Ruth Gimeno
IPC分类号： C07H21/04 , C12P21/06 , C12N9/04
CPC分类号： C12N9/0004 , C07K2319/00 , C12N9/0006
摘要： The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

9. 发明申请

US20050054022A1 Methods and compositions comprising FATP5 for use in the diagnosis and treatment of metabolic disorders 审中-公开
标题翻译：包含用于诊断和治疗代谢紊乱的FATP5的方法和组合物
公开(公告)号：US20050054022A1
公开(公告)日：2005-03-10
申请号：US10919608
申请日：2004-08-17
申请人： Ruth Gimeno , Brian Hubbard
发明人： Ruth Gimeno , Brian Hubbard
IPC分类号： C12N20060101 , C12Q1/25 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/68 , G01N33/92
CPC分类号： G01N33/6893 , C12Q1/25 , G01N33/92 , G01N2333/9015 , G01N2500/04 , G01N2800/042 , G01N2800/044
摘要： The present invention provides methods for the identification of agents, e.g., therapeutic agents, that inhibit Fatty Acid Transport 5 (FATP5) activity, and methods of treating diseases or conditions associated with FATP5 function, e.g., obesity, insulin resistance, type 2 diabetes, dyslipidemia, fatty liver disease, and cardiovascular disease. Further aspects of the invention provide a transgenic FATP5 non-human knockout mammal, e.g., mouse, useful for elucidating the function of FATP5 in intact animals whose genomes comprise a wild-type FATP5 gene.
摘要翻译：本发明提供了用于鉴定抑制脂肪酸转运5（FATP5）活性的药剂，例如治疗剂的方法，以及治疗与FATP5功能相关的疾病或病症的方法，例如肥胖，胰岛素抵抗，2型糖尿病，血脂异常，脂肪肝疾病和心血管疾病。本发明的其它方面提供了转基因FATP5非人敲除哺乳动物（例如小鼠），其用于阐明在其基因组包含野生型FATP5基因的完整动物中FATP5的功能。

10. 发明申请

US20060183210A1 Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor 有权
公开(公告)号：US20060183210A1
公开(公告)日：2006-08-17
申请号：US11296615
申请日：2005-12-07
申请人： Ruth Gimeno , Zhidan Wu , Rosana Kapeller-Libermann , Brian Hubbard
发明人： Ruth Gimeno , Zhidan Wu , Rosana Kapeller-Libermann , Brian Hubbard
IPC分类号： C12P21/06
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.

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