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    • 4. 发明授权
    • Remote administration in a distributed system
    • US06993681B2
    • 2006-01-31
    • US10122133
    • 2002-04-15
    • Leon E. HaynesDavid N. Johnson
    • Leon E. HaynesDavid N. Johnson
    • G06F11/00
    • G06F11/0793G06F11/0715G06F11/076G06F11/324G06F11/3409G06F11/3495G06F2201/81G06F2201/86
    • A method and system for remote administration of clients performing critical processes are disclosed herein. A client management module is used to monitor a subset of processes performed by a client. When the client management module detects that a process of the subset has terminated or become inoperable, the client management module can restart the process, as well as notify a remote system manager. Additionally, the client management module is adapted to monitor the consumption of system resources by one or more processes. Using fuzzy logic to evaluate the system resource consumptions of one or more system resource types, the client management module can select an appropriate action response to improve the performance of the process and/or notify an administrator of a status of the process. The remote system manager is adapted to monitor a connection with the client. When a connection failure is detected, the system manager can diagnose a cause of the connection failure and take action accordingly, such as by resetting the client management module, resetting the client, or cycling power to the client using a power distribution unit. Additionally, the remote system manager provides various graphical user interfaces to a user or administrator to allow the administrator to assess the condition of the client and/or remotely control the operation of the one or more processes performed by the client.
    • 8. 发明授权
    • Substituted heterocyclic compounds and methods of use
    • 取代的杂环化合物及其使用方法
    • US07504396B2
    • 2009-03-17
    • US10875896
    • 2004-06-23
    • Joseph J. NunesXiaotian ZhuPatricia AmouzeghChiara GhironDavid N. JohnsonEoin Christopher Power
    • Joseph J. NunesXiaotian ZhuPatricia AmouzeghChiara GhironDavid N. JohnsonEoin Christopher Power
    • C07D239/48C07D403/12A61K31/505
    • C07D213/82C07D239/47C07D239/48
    • The present invention relates to pyrimidine or pyridine carboxamides or pharmaceutically-acceptable salts thereof. Also included is a method of treatment of inflammation, inhibition of T cell activation and proliferation, arthritis, rheumatoid arthritis, psoriatic arthritis, osteoarthritis, organ transplant, acute transplant or heterograft or homograft rejection, transplantation tolerance induction, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, including ulcerative colitis, Crohn's disease, lupus, contact hypersensitivity, delayed-type hypersensitivity, and gluten-sensitive enteropathy, type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, glomerulonephritis, serum sickness, uticaria, allergic diseases, asthma, hayfever, allergic rhinitis, scleracielma, mycosis fungoides, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, atopic dermatitis, colon carcinoma or thymoma in a mammal comprising administering a therapeutically-effective amount a compound as described above.
    • 本发明涉及嘧啶或吡啶甲酰胺或其药学上可接受的盐。 还包括治疗炎症,抑制T细胞活化和增殖,关节炎,类风湿性关节炎,银屑病关节炎,骨关节炎,器官移植,急性移植或异种移植或同种移植物排斥,移植耐受性诱导,缺血或再灌注损伤,心肌梗死的方法 ,中风,多发性硬化,炎症性肠病,包括溃疡性结肠炎,克罗恩病,狼疮,接触性超敏反应,迟发型超敏反应和麸质敏感性肠病,1型糖尿病,牛皮癣,接触性皮炎,桥本氏甲状腺炎,干燥综合征,自身免疫性甲状腺功能亢进 ,艾迪生病,自身免疫性多腺病,自身免疫性脱发,恶性贫血,白癜风,自身免疫性低位症,吉兰巴利综合征,肾小球性肾炎,血清病,荨麻疹,过敏性疾病,哮喘,高粱,过敏性鼻炎,巩膜瘤,蕈样真菌病,皮肌炎,斑秃 ,慢性交感 包括给予治疗有效量的如上所述的化合物,包括给予治疗有效量的上述化合物,其中,所述治疗有效量的治疗有效量的药物组合物包括给予治疗有效量的上述化合物。