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1. 发明授权

US08481283B2 Pressure-assisted molecular recovery (PAMR) of biomolecules, pressure-assisted antigen retrieval (PAAR), and pressure-assisted tissue histology (PATH) 有权
标题翻译：生物分子的压力辅助分子回收（PAMR），压力辅助抗原回收（PAAR）和压力辅助组织组织学（PATH）
公开(公告)号：US08481283B2
公开(公告)日：2013-07-09
申请号：US13613618
申请日：2012-09-13
申请人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
发明人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译：公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。

2. 发明申请

US20130011854A1 PRESSURE-ASSISTED MOLECULAR RECOVERY (PAMR) OF BIOMOLECULES, PRESSURE-ASSISTED ANTIGEN RETRIEVAL (PAAR), AND PRESSURE-ASSISTED TISSUE HISTOLOGY (PATH) 有权
标题翻译：生物分子的压力辅助分子恢复（PAMR），压力辅助抗体检索（PAAR）和压力协助组织学（PATH）
公开(公告)号：US20130011854A1
公开(公告)日：2013-01-10
申请号：US13613618
申请日：2012-09-13
申请人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
发明人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译：公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。

3. 发明授权

US08288122B2 Pressure-assisted molecular recovery (PAMR) of biomolecules, pressure-assisted antigen retrieval (PAAR), and pressure-assisted tissue histology (PATH) 有权
标题翻译：生物分子的压力辅助分子回收（PAMR），压力辅助抗原回收（PAAR）和压力辅助组织组织学（PATH）
公开(公告)号：US08288122B2
公开(公告)日：2012-10-16
申请号：US12630746
申请日：2009-12-03
申请人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
发明人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
IPC分类号： G01N1/30
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译：公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。

4. 发明申请

US20100136613A1 PRESSURE-ASSISTED MOLECULAR RECOVERY (PAMR) OF BIOMOLECULES, PRESSURE-ASSISTED ANTIGEN RETRIEVAL (PAAR), AND PRESSURE-ASSISTED TISSUE HISTOLOGY (PATH) 有权
标题翻译：生物分子的压力辅助分子恢复（PAMR），压力辅助抗体检索（PAAR）和压力协助组织学（PATH）
公开(公告)号：US20100136613A1
公开(公告)日：2010-06-03
申请号：US12630746
申请日：2009-12-03
申请人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
发明人： Timothy J. O'Leary , Jeffrey T. Mason , Carol B. Fowler , Robert E. Cunningham
IPC分类号： G01N1/28
CPC分类号： A01N1/0231 , G01N1/30
摘要： A method is disclosed for reversing fixation-induced cross-linking in tissue specimens that have been preserved for histological examination. The method involves placing the fixed tissue in a liquid under elevated temperature and pressure conditions that are sufficient to reverse the fixation-induced cross-linking, restore antigenicity to proteins, and permit improved molecular and proteomic analysis of the preserved tissue specimen. Methods are also disclosed for processing tissues for histological examination under elevated pressure conditions that enhance the perfusion of liquid reagents into the tissue and reduce overall processing times.
摘要翻译：公开了一种用于逆转已经保留用于组织学检查的组织标本中固定诱导交联的方法。该方法包括将固定组织置于液体中，该温度和压力条件足以逆转固定诱导的交联，恢复对蛋白质的抗原性，并允许改进保藏组织标本的分子和蛋白质组学分析。还公开了用于处理在升高的压力条件下进行组织学检查的组织的方法，其增强液体试剂灌注到组织中并减少总体加工时间。

5. 发明申请

US20090176250A1 Immunoliposome-Nucleic Acid Amplification (ILNAA) Assay 失效
标题翻译：免疫脂质体 - 核酸扩增（ILNAA）测定
公开(公告)号：US20090176250A1
公开(公告)日：2009-07-09
申请号：US12399060
申请日：2009-03-06
申请人： Timothy J. O'Leary , Jeffrey T. Mason
发明人： Timothy J. O'Leary , Jeffrey T. Mason
IPC分类号： G01N33/53
CPC分类号： A61K9/127 , C12Q1/6806 , C12Q2563/161
摘要： Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a liposome after a receptor on the liposome couples with a targeted analyte/antigen immobilized on a select surface. The immunoliposome nucleic acid amplification assay permits both quantitative and qualitative analyte detection.
摘要翻译：免疫脂质体及其在高度特异性和灵敏的核酸扩增测定中的应用，其依赖于在脂质体上的受体之后从脂质体中的包封释放的特异性核酸序列的扩增与固定在选择表面上的靶向分析物/抗原相结合。免疫脂质体核酸扩增测定允许定量和定性分析物检测。

6. 发明授权

US07662568B2 Immunoliposome-nucleic acid amplification (ILNAA) assay 失效
标题翻译：免疫脂质体 - 核酸扩增（ILNAA）检测
公开(公告)号：US07662568B2
公开(公告)日：2010-02-16
申请号：US12399060
申请日：2009-03-06
申请人： Timothy J. O'Leary , Jeffrey T. Mason
发明人： Timothy J. O'Leary , Jeffrey T. Mason
IPC分类号： C12Q1/68
CPC分类号： A61K9/127 , C12Q1/6806 , C12Q2563/161
摘要： Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a liposome after a receptor on the liposome couples with a targeted analyte/antigen immobilized on a select surface. The immunoliposome nucleic acid amplification assay permits both quantitative and qualitative analyte detection.
摘要翻译：免疫脂质体及其在高度特异性和灵敏的核酸扩增测定中的应用，其依赖于在脂质体上的受体之后从包封在脂质体内释放的特异性核酸序列的扩增与固定在选择表面上的靶向分析物/抗原相结合。免疫脂质体核酸扩增测定允许定量和定性分析物检测。

7. 发明授权

US07582430B2 Immunoliposome-nucleic acid amplification (ILNAA) assay 失效
标题翻译：免疫脂质体 - 核酸扩增（ILNAA）检测
公开(公告)号：US07582430B2
公开(公告)日：2009-09-01
申请号：US10759099
申请日：2004-01-20
申请人： Timothy J. O'Leary , Jeffrey T. Mason
发明人： Timothy J. O'Leary , Jeffrey T. Mason
IPC分类号： C12Q1/68
CPC分类号： A61K9/127 , C12Q1/6806 , C12Q2563/161
摘要： Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a liposome after a receptor on the liposome couples with a targeted analyte/antigen immobilized on a select surface. The immunoliposome nucleic acid amplification assay permits both quantitative and qualitative analyte detection.
摘要翻译：免疫脂质体及其在高度特异性和灵敏的核酸扩增测定中的应用，其依赖于在脂质体上的受体之后从包封在脂质体内释放的特异性核酸序列的扩增与固定在选择表面上的靶向分析物/抗原相结合。免疫脂质体核酸扩增测定允许定量和定性分析物检测。

8. 外观设计

USD555735S1 Dispenser for flags 有权
公开(公告)号：USD555735S1
公开(公告)日：2007-11-20
申请号：US29263060
申请日：2006-07-14
申请人： James E. Nash , Peter J. Newbould , Timothy J. O'Leary
设计人： James E. Nash , Peter J. Newbould , Timothy J. O'Leary

9. 发明授权

US5747107A Method of applying a hot melt coating 失效
标题翻译：施加热熔涂层的方法
公开(公告)号：US5747107A
公开(公告)日：1998-05-05
申请号：US548897
申请日：1995-10-26
申请人： Glen H. Bayer, Jr. , Timothy J. O'Leary
发明人： Glen H. Bayer, Jr. , Timothy J. O'Leary
IPC分类号： B05D1/26 , B05C1/08 , D21H23/56 , B05D5/10
CPC分类号： B32B37/153 , B05C1/0813 , B05C1/083 , B32B37/1284 , D21H23/56 , B32B2037/1215 , B32B2317/12
摘要： A method of applying a coating of hot melt polymeric material from a die to a substrate. Hot melt polymeric material is extruded through the die onto the peripheral surface of a rotating application roller to provide a coating layer along that peripheral surface. A substrate is conveyed past the peripheral surface of the application roller at an application interface to cause transfer of the first coating layer to the substrate and shearing and thinning of the coating layer because the substrate is conveyed faster than the peripheral speed of the application roller. The velocity of the peripheral surface and spacing between the die and the application interface along are selected to provide a time interval of at least 0.12 second for movement of portions of the coating layer from the die to the application interface, thereby affording relaxation and molecular reorientation of the hot melt polymeric material after the extruding step to facilitate shearing of the first coating layer at the application interface without causing ribbing or breaking of the coating layer.
摘要翻译：将热熔聚合物材料的涂层从模具施加到基底上的方法。将热熔聚合物材料通过模具挤出到旋转施加辊的外围表面上，以沿着该外围表面提供涂层。衬底在应用界面处被传送通过施加辊的外周表面，从而使第一涂层转移到衬底上，并且由于衬底的输送速度比施加辊的圆周速度更快，所以涂层的剪切和变薄。选择周边表面的速度和模具与应用界面之间的间距，以提供至少0.12秒的时间间隔，用于将涂层的一部分从模具移动到施加界面，由此提供松弛和分子重新取向的挤出步骤之后的热熔聚合物材料，以便于施加界面处的第一涂层的剪切，而不会引起涂层的破裂或破裂。

10. 发明授权

US5528033A Automatic surface profiling for submicron device 失效
标题翻译：亚微米器件的自动表面轮廓
公开(公告)号：US5528033A
公开(公告)日：1996-06-18
申请号：US413070
申请日：1995-03-29
申请人： Jiann-Chang Lo , Timothy J. O'Leary
发明人： Jiann-Chang Lo , Timothy J. O'Leary
IPC分类号： G01B11/02 , G01B7/34 , G01B11/26 , G01B21/30 , G01Q30/04 , G01Q30/06 , G01Q60/38 , H01J37/00 , H01J37/26
CPC分类号： G01Q60/38 , B82Y35/00 , G01B7/34 , G01Q30/04 , G01Q30/06 , Y10S977/839 , Y10S977/85 , Y10S977/852 , Y10S977/863
摘要： A method for automatically providing a surface profile analysis of a submicron device using a microscope system typically used to measure critical dimensions of the submicron device is disclosed. The method generates a data point array that is linearly interpolated along a particular scan line measured. The system then calculates an angle for performing a rotational correlation then rotates the measurement profile from the scan line to an absolute horizontal position based on this rotational correlation angle. Next, the system separates the scan line into independent subset features having line and trench features. The number of these line and trench features are then determined in the scan line and using the data point array, the system then calculates the height, width, and angle for each subset feature in that scan line.
摘要翻译：公开了一种用于使用通常用于测量亚微米器件的临界尺寸的显微镜系统自动提供亚微米器件的表面轮廓分析的方法。该方法产生沿所测量的特定扫描线线性内插的数据点阵列。然后，该系统计算用于执行旋转相关的角度，然后基于该旋转相关角度将测量轮廓从扫描线旋转到绝对水平位置。接下来，系统将扫描线分成具有线和沟槽特征的独立子集特征。然后在扫描线中确定这些线和沟槽特征的数量，并使用数据点阵列，系统然后计算该扫描线中每个子集特征的高度，宽度和角度。

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