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1. 发明申请

WO2015181564A1 IMPROVEMENTS IN AND RELATING TO MASS SPECTROMETRY 审中-公开
标题翻译：改进和相关质谱
公开(公告)号：WO2015181564A1
公开(公告)日：2015-12-03
申请号：PCT/GB2015/051569
申请日：2015-05-29
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： RAPTAKIS, Emmanuel , PAPANASTASIOU, Dimitris , NIKOLOS, loannis K. , GILES, Roger
IPC分类号： H01J49/24 , H01J49/06
CPC分类号： H01J49/067 , H01J49/24
摘要： An ion transfer apparatus for transferring ions from an ion source at a first pressure, which first pressure is >500 mbar, suitably atmospheric pressure, along a path towards a mass spectrometer at a lower second pressure, comprising a plurality of pressure- control chambers each comprising an ion inlet opening for receiving therein ions from said ion source on said path and an ion outlet opening for outputting said ions on said path; wherein said plurality of pressure-control chambers are arranged in succession along said path whereby a said ion outlet opening of each pressure-control chamber is in flow communication with a said ion inlet opening of a successive adjacent pressure- control chamber; a pump apparatus in flow communication with each said pressure- control chamber via a respective plurality of pressure exhaust openings formed within each said pressure-control chamber, and arranged to control the pressure in each respective pressure-control chamber to be lower than the pressure in a preceding adjacent pressure-control chamber such that the pressure in a last of said pressure- control chambers is the lowest amongst the plurality of pressure-control chambers.
摘要翻译：一种离子转移装置，用于在第一压力（第一压力> 500mbar）适当地大气压下将离子从离子源转移到沿质子分析仪的较低的第二压力的路径，每个压力控制室包括多个压力控制室包括用于从所述路径上的所述离子源接收离子的离子入口和用于在所述路径上输出所述离子的离子出口; 其特征在于，所述多个压力控制室沿着所述路径连续布置，由此每个压力控制室的所述离子出口与所述相邻的压力控制室的所述离子入口开口流动连通; 一个与每个所述压力控制室经由形成在每个所述压力控制室内的相应多个压力排气开口流动连通的泵装置，并被布置成将每个压力控制室中的压力控制在低于前一相邻的压力控制室，使得最后的压力控制室中的压力在多个压力控制室中是最低的。

2. 发明申请

WO2017089044A1 ION TRANSFER APPARATUS 审中-公开
标题翻译：离子传输设备
公开(公告)号：WO2017089044A1
公开(公告)日：2017-06-01
申请号：PCT/EP2016/075274
申请日：2016-10-20
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： GILES, Roger , GILES, Alina
IPC分类号： H01J49/06 , H01J49/24
CPC分类号： H01J49/24
摘要： An ion transfer apparatus for transferring ions from a first pressure controlled chamber at a first pressure, which first pressure is lower than 10000 Pa, along a path to an adjacent second pressure controlled chamber at a second pressure that is lower than the first pressure. The ion transfer apparatus includes: the first pressure controlled chamber and the second pressure controlled chamber, wherein each pressure controlled chamber includes an ion inlet opening for receiving ions on the path and an ion outlet opening for outputting the ions on the path, wherein the ion outlet opening of the first pressure controlled chamber is in flow communication with the ion inlet opening of a the second pressure controlled chamber; and an RF focusing device configured to focus ions towards the path, the RF focusing device including a plurality of RF focusing electrodes, wherein each RF focusing electrode of the RF focusing device is configured to receive an RF voltage so as to produce an electric field that acts to focus ions towards the path, wherein each RF focusing electrode of the RF focusing device has a shape that extends circumferentially around the path. The first and second pressure controlled chambers each include RF focusing electrodes of the RF focusing device. Each RF focusing electrode of the RF focusing device has a thickness in the direction of the path and a thickness in a direction radial to the path that is less than a distance separating the RF focusing electrode from an adjacent RF focusing electrode of the RF focusing device.
摘要翻译：用于在第一压力下将第一压力低于10000Pa的来自第一压力控制室的离子沿着通向邻近的第二压力控制室的路径以第二压力传输离子传输设备，低于第一压力。离子传输装置包括：第一压力控制室和第二压力控制室，其中每个压力控制室包括用于接收路径上的离子的离子入口和用于输出路径上的离子的离子出口，其中离子第一压力控制室的出口开口与第二压力控制室的离子入口开口流动连通; 以及配置成将离子聚焦在所述路径上的RF聚焦装置，所述RF聚焦装置包括多个RF聚焦电极，其中所述RF聚焦装置的每个RF聚焦电极被配置为接收RF电压以便产生电场，用于将离子聚焦在路径上，其中RF聚焦装置的每个RF聚焦电极具有围绕路径周向延伸的形状。第一和第二压力控制室各自包括RF聚焦装置的RF聚焦电极。 RF聚焦装置的每个RF聚焦电极在路径方向上具有厚度，并且在径向于路径的方向上的厚度小于将RF聚焦电极与RF聚焦装置的相邻RF聚焦电极分开的距离

3. 发明申请

WO2021038091A1 MASS ANALYSIS APPARATUSES AND METHODS 审中-公开
公开(公告)号：WO2021038091A1
公开(公告)日：2021-03-04
申请号：PCT/EP2020/074163
申请日：2020-08-28
申请人： WEBSTER, Jeremy , SHIMADZU CORPORATION
发明人： GILES, Roger , GILES, Alina
IPC分类号： H01J49/06 , H01J49/40
摘要： A device (1) for manipulating charged particles, the device comprising a series of electrodes (2, 3) disposed so as to form a channel for transportation of the charged particles. A power supply unit (5) provides a first supply voltage (7) which changes according to a waveform having a period (T), to axially segmented bunching electrodes (3) to create an electric field within the channel. The potential of the electric field defines a potential well which is translated along the length of the channel such that the potential well is translated a distance substantially equal to its length in an interval of time substantially equal to the period (T). The waveform is substantially continuously smooth throughout its period (T); and, substantially constant in value throughout a finite duration of time (TL(FR) L'invention concerne un dispositif (1) pour manipuler des particules chargées, le dispositif comprenant une série d'électrodes (2, 3) disposées de façon à former un canal pour le transport des particules chargées. Une unité d'alimentation électrique (5) fournit une première tension d'alimentation (7) qui change selon une forme d'onde ayant une période (T), à des électrodes à regroupement axialement segmentés (3) pour créer un champ électrique à l'intérieur du canal. Le potentiel du champ électrique définit un puits de potentiel qui est translaté le long de la longueur du canal de telle sorte que le puits de potentiel est translaté à une distance sensiblement égale à sa longueur dans un intervalle de temps sensiblement égal à la période (T). La forme d'onde est sensiblement lisse en continu pendant toute sa période (T) ; et, sensiblement constante en valeur pendant une durée de temps finie (TL

4. 发明申请

WO2020109091A1 APPARATUS FOR ANALYSING IONS 审中-公开
公开(公告)号：WO2020109091A1
公开(公告)日：2020-06-04
申请号：PCT/EP2019/081834
申请日：2019-11-19
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： GILES, Alina , GILES, Roger
IPC分类号： H01J49/06 , H01J49/00
摘要： An apparatus for analysing ions, the apparatus including: a first mass analyser configured to eject groups of ions from the first mass analyser in a predetermined sequence such that each group of ions is ejected during a different time window and is initially formed from precursor ions having m/z values in a respective m/z value window, wherein the first mass analyser is configured to, when ejecting each group of ions, retain at least some of any other ions contained in the first mass analyser prior to the group of ions being ejected; an ion transport device having a plurality of electrodes arranged around a transport channel, wherein the ion transport device is configured to receive at least some groups of ions ejected from the first mass analyser; control means configured to control voltages applied to the electrodes of the ion transport device to generate a transport potential in the transport channel, the transport potential having a plurality of potential wells which are configured to move along the transport channel, the control unit being configured to generate the transport potential such that each group of ions received by the ion transport device is respectively transported along the transport channel by one or more selected potential wells in the transport potential; fragmentation means configured to fragment precursor ions in each group of ions so as to produce product ions; a second mass analyser configured to produce a respective mass spectrum using each group of ions after the group of ions has been fragmented by the fragmentation means and transported along the transport channel.

5. 发明申请

WO2017089045A1 ION TRANSFER APPARATUS 审中-公开
标题翻译：离子传输设备
公开(公告)号：WO2017089045A1
公开(公告)日：2017-06-01
申请号：PCT/EP2016/075275
申请日：2016-10-20
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： GILES, Roger , GILES, Alina
IPC分类号： H01J49/24
CPC分类号： H01J49/24
摘要： An ion transfer apparatus for transferring ions from an ion source at an ion source pressure, which ion source pressure is greater than 500mbar, along a path towards a mass analyser at a mass analyser pressure that is lower than the ion source pressure. The apparatus includes a plurality of pressure controlled chambers, wherein each pressure controlled chamber in the ion transfer apparatus includes an ion inlet opening for receiving ions from the ion source on the path and an ion outlet opening for outputting the ions on the path. The plurality of pressure controlled chambers are arranged in succession along the path from an initial pressure controlled chamber to a final pressure controlled chamber, wherein an ion outlet opening of each pressure controlled chamber other than the final pressure controlled chamber is in flow communication with the ion inlet opening of a successive adjacent pressure controlled chamber. The ion transfer apparatus is configured to have, in use, at least one pair of adjacent pressure controlled chambers for which a ratio of pressure in an upstream pressure controlled chamber to pressure in a downstream pressure controlled chamber is set such that there is substantially subsonic gas flow in the downstream pressure controlled chamber.
摘要翻译：用于在离子源压力下从离子源转移离子的离子转移设备，离子源压力大于500mbar，沿质量分析器的质量分析器压力低于离子源压力。该设备包括多个压力控制腔室，其中离子转移设备中的每个压力控制腔室包括用于从路径上的离子源接收离子的离子入口开口和用于输出路径上的离子的离子出口开口。多个压力控制室沿着从初始压力控制室到最终压力控制室的路径连续布置，其中除最终压力控制室之外的每个压力控制室的离子出口开口与离子流相通连续相邻的压力控制室的入口开口。离子转移设备被构造成在使用中具有至少一对相邻的压力控制室，对于该对压力控制室，上游压力控制室中的压力与下游压力控制室中的压力的比率被设定为使得基本上存在亚音速气体流入下游压力控制室。

6. 发明申请

WO2021038092A1 MASS ANALYSIS APPARATUSES AND METHODS 审中-公开
公开(公告)号：WO2021038092A1
公开(公告)日：2021-03-04
申请号：PCT/EP2020/074164
申请日：2020-08-28
申请人： WEBSTER, Jeremy , SHIMADZU CORPORATION
发明人： GILES, Roger , GILES, Alina
IPC分类号： H01J49/06 , H01J49/40
摘要： A device (1) for manipulating charged particles, the device comprising a series of electrodes (2, 3) that form a channel for transportation of the charged particles. A power supply unit (5, 6) provides a voltage to axially segmented bunching electrodes to create a potential well within the channel having one or more local minima between local maxima (50, 51). The well is translated along the channel. An axial extraction region (54) comprises electrodes defining an end of the channel. They receive a supply voltage to create a pseudo-potential within the channel such that the depth of the potential well varies according to the mass-to-charge ratio (m/z) of the charged particles transported therein and reduces as a local maxima of the potential well is translated axially towards the axial extraction region thereby to release the transported charged particles of different mass-to-charge ratio (m/z) at different respective times.

7. 发明申请

WO2018114442A1 A TRANSPORT DEVICE FOR TRANSPORTING CHARGED PARTICLES 审中-公开
公开(公告)号：WO2018114442A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/082286
申请日：2017-12-11
申请人： SHIMADZU CORPORATION , WEBSTER, Jeremy
发明人： GILL, Matthew , GILES, Roger , GILES, Alina
IPC分类号： H01J49/06
摘要： An apparatus for transporting charged particles. The apparatus includes a control unit and a transport device having a plurality of electrodes arranged around a transport channel, wherein the transport channel includes a bunch forming region configured to receive charged particles received by the transport device. The control unit is configured to control voltages applied to the electrodes to generate a transport potential in the transport channel, the transport potential having a plurality of potential wells which are configured to move so as to transport charged particles along the transport channel in one or more bunches. The control unit is further configured to control voltages applied to the electrodes: temporarily generate a gathering potential in the bunch forming region so that charged particles received by the transport device are gathered in the bunch forming region; and then generate the transport potential in the bunch forming region so that a selected potential well is formed in the bunch forming region with the selected potential well receiving a bunch of charged particles formed from the charged particles gathered in the bunch forming region by the gathering potential.

8. 发明申请

WO2007057623A1 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007057623A1
公开(公告)日：2007-05-24
申请号：PCT/GB2005/004408
申请日：2005-11-16
申请人： SHIMADZU CORPORATION , TAKEUCHI, Sadao , WAKI, Hiroaki , DING, Li , GILES, Roger
发明人： TAKEUCHI, Sadao , WAKI, Hiroaki , DING, Li , GILES, Roger
IPC分类号： H01J49/04 , H01J49/40
CPC分类号： H01J49/067 , H01J49/066
摘要： The present invention provides a mass spectrometer having an ion lens capable of transporting an ion having a large mass to charge ratio with a high level of ion-passing efficiency even under a low-vacuum atmosphere. In conventional atmospheric pressure ionization mass spectrometers or similar mass spectrometers, applying an excessively high voltage to the ion lens undesirably causes an electric discharge. Therefore, the passing efficiency for an ion having a large mass to charge ratio cannot be adequately improved, which leads to a poor detection sensitivity. To solve this problem, the mass spectrometer according to the present invention includes a voltage controller (21) that controls a variable radiofrequency (RF) voltage generator (24) so that both the amplitude and the frequency of the RF voltage applied to the lens electrodes of an ion lens (5) are changed according to the mass to charge ratio of an ion to be analyzed. This control enables the ion lens (5) to focus an ion and transport it to the subsequent stage with a high level of passing efficiency even in the case of analyzing an ion having a large mass to charge ratio. Thus, the detection sensitivity is improved. The aforementioned control is conducted on the basis of the control data stored in a voltage control data storage (22). These data are obtained in advance by a measurement of a sample containing a substance having a known mass to charge ratio, in which the intensity of the signal of an ion detector is maintained while the analysis conditions are changed.
摘要翻译：本发明提供一种质谱仪，其具有能够即使在低真空气氛下也能以高水平的离子通过效率将具有大质荷比的离子输送的离子透镜。在传统的大气压电离质谱仪或类似的质谱仪中，对离子透镜施加过高的电压会导致放电。因此，不能充分提高质荷比大的离子的通过效率，导致检测灵敏度差。为了解决这个问题，根据本发明的质谱仪包括控制可变射频（RF）电压发生器（24）的电压控制器（21），使得施加到透镜电极的RF电压的幅度和频率的离子透镜（5）根据要分析的离子的质荷比而改变。这种控制使得离子透镜（5）能够聚焦离子并且即使在分析具有大质荷比的离子的情况下也能以高水平的通过效率将其输送到后续阶段。因此，提高了检测灵敏度。上述控制是根据存储在电压控制数据存储器（22）中的控制数据进行的。通过测量包含具有已知质荷比的物质的样品，预先获得这些数据，其中在分析条件改变的同时保持离子检测器的信号强度。

9. 发明申请

WO2008071923A2 A TIME-OF-FLIGHT MASS SPECTROMETER AND A METHOD OF ANALYSING IONS IN A TIME-OF-FLIGHT MASS SPECTROMETER 审中-公开
标题翻译：飞行时间质谱仪及其在飞行时间质谱仪中分析离子的方法
公开(公告)号：WO2008071923A2
公开(公告)日：2008-06-19
申请号：PCT/GB2007/004689
申请日：2007-12-07
申请人： SHIMADZU CORPORATION , GILES, Roger , SUDAKOV, Michael , WOLLNIK, Hermann
发明人： GILES, Roger , SUDAKOV, Michael , WOLLNIK, Hermann
CPC分类号： H01J49/403 , H01J49/4295
摘要： A time-of-flight mass spectrometer (1) comprises an ion source a segmented linear ion device (10) for receiving sample ions supplied by the ion source and a time-of-flight mass analyser for analysing ions ejected from the segmented device. A trapping voltage is applied to the segmented device to trap ions initially into a group of two or more adjacent segments and subsequently to trap them in a region of the segmented device shorter than the group of segments. The trapping voltage may also be effective to provide a uniform trapping field along the length of the device (10).
摘要翻译：飞行时间质谱仪（1）包括离子源，用于接收由离子源提供的样品离子的分段线性离子装置（10）和用于分析从分段装置喷射的离子的飞行时间质量分析器。捕获电压被施加到分段器件，以将离子初始化为两个或更多个相邻段的一组，并且随后将它们捕获在分段器件的比段组短的区域中。捕获电压也可以有效地沿着装置（10）的长度提供均匀的捕获场。

10. 发明申请

WO2013057505A2 MASS ANALYSER, MASS SPECTROMETER AND ASSOCIATED METHODS 审中-公开
标题翻译：质量分析仪，质谱分析仪和相关方法
公开(公告)号：WO2013057505A2
公开(公告)日：2013-04-25
申请号：PCT/GB2012/052593
申请日：2012-10-19
申请人： SHIMADZU CORPORATION , SHCHEPUNOV, Vyacheslav , GILES, Roger
发明人： SHCHEPUNOV, Vyacheslav , GILES, Roger
CPC分类号： H01J49/062 , H01J49/40 , H01J49/408 , H01J49/4245
摘要： A mass analyser for use in a mass spectrometer. The mass analyser has a set of electrodes including electrodes arranged to form at least one electrostatic sector, the set of electrodes being spatially arranged to be capable of providing an electrostatic field in a reference plane suitable for guiding ions along a closed orbit in the reference plane, wherein the set of electrodes extend along a drift path that is locally orthogonal to the reference plane and that curves around a reference axis so that, in use, the set of electrodes provide a 3D electrostatic field region. The mass analyser is configured so that, in use, the 3D electrostatic field region provided by the set of electrodes guides ions having different initial coordinates and velocities along a single predetermined 3D reference trajectory that curves around the reference axis.
摘要翻译：用于质谱仪的质量分析仪。质量分析器具有一组电极，其包括设置为形成至少一个静电扇区的电极，该组电极在空间上布置为能够在适于沿着参考平面中的闭合轨道引导离子的参考平面中提供静电场其中所述一组电极沿着漂移路径延伸，所述漂移路径局部正交于所述参考平面并围绕参考轴线弯曲，使得在使用中，所述一组电极提供3D静电场区域。质量分析器被配置为使得在使用中，由该组电极提供的3D静电场区域沿着围绕参考轴线弯曲的单个预定3D参考轨迹引导具有不同初始坐标和速度的离子。

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