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1. 发明授权

US08697129B2 Stable colloidal gold nanoparticles with controllable surface modification and functionalization 有权
标题翻译：稳定的胶体金纳米粒子具有可控的表面改性和功能化
公开(公告)号：US08697129B2
公开(公告)日：2014-04-15
申请号：US13038788
申请日：2011-03-02
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K9/14 , A61K33/24
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

2. 发明申请

US20140170070A1 STABLE COLLOIDAL GOLD NANOPARTICLES WITH CONTROLLABLE SURFACE MODIFICATION AND FUNCTIONALIZATION 审中-公开
标题翻译：具有可控表面改性和功能化的稳定的胶体金纳米颗粒
公开(公告)号：US20140170070A1
公开(公告)日：2014-06-19
申请号：US14187416
申请日：2014-02-24
申请人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
发明人： Wei Qian , Makoto Murakami , Yuki Ichikawa , Yong Che
IPC分类号： A61K49/00 , A61K47/10 , A61K41/00 , G01N21/65
CPC分类号： A61K49/0002 , A61K9/0019 , A61K9/1688 , A61K41/0057 , A61K47/10 , B01J13/0034 , B01J13/0043 , B82Y5/00 , B82Y30/00 , B82Y40/00 , G01N21/64 , G01N21/658 , G01N33/531 , G01N33/54346 , G01N2021/3595
摘要： In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.
摘要翻译：在本发明中，公开了一种制备稳定的裸胶体金纳米颗粒的方法。随后可以对纳米颗粒进行部分或全面修饰。该方法包括使用以大块金为原料的自顶向下纳米制造方法在液体中制备胶体金纳米颗粒。这些纳米颗粒的表面改性是通过添加一种或多种类型的配体，每个配体包含对金纳米颗粒表面具有亲和性以产生共轭物的官能团。由于通过该方法制备的纳米颗粒的高效率和优异的稳定性，所制备的金纳米颗粒共轭物可以具有表面覆盖的功能性配体，其可被调整为0至100％之间的任何百分比值。

3. 发明授权

US08836941B2 Method and apparatus to prepare a substrate for molecular detection 有权
标题翻译：制备用于分子检测的底物的方法和装置
公开(公告)号：US08836941B2
公开(公告)日：2014-09-16
申请号：US12951524
申请日：2010-11-22
申请人： Makoto Murakami , Yong Che , Bing Liu , Yuki Ichikawa
发明人： Makoto Murakami , Yong Che , Bing Liu , Yuki Ichikawa
IPC分类号： G01J3/44 , C23C14/08 , B82Y30/00 , C23C14/34 , G01N21/65 , B82Y40/00
CPC分类号： G01N21/658 , B82Y30/00 , B82Y40/00 , C23C14/083 , C23C14/3435
摘要： An device for Raman spectroscopy such as surface enhanced Raman spectroscopy (SERS) is disclosed herein. Various embodiments may be utilized to prepare a SERS substrate using several deposition techniques such as pulsed laser deposition. Some embodiments optimize coverage, volume, or elements of SERS active metals. The method is a single step inexpensive method for preparing a SERS active substrate. In some embodiments a coating layer underneath the SERS active metals is utilized for additional enhancements.
摘要翻译：本文公开了一种用于拉曼光谱的装置，例如表面增强拉曼光谱（SERS）。可以使用多种沉积技术例如脉冲激光沉积来制备SERS衬底的各种实施例。一些实施例优化SERS活性金属的覆盖，体积或元素。该方法是用于制备SERS活性基底的单步廉价方法。在一些实施方案中，SERS活性金属下面的涂层用于额外的增强。

4. 发明申请

US20110194106A1 METHOD AND APPARATUS TO PREPARE A SUBSTRATE FOR MOLECULAR DETECTION 有权
标题翻译：制备用于分子检测的底物的方法和装置
公开(公告)号：US20110194106A1
公开(公告)日：2011-08-11
申请号：US12951524
申请日：2010-11-22
申请人： Makoto MURAKAMI , Yong Che , Bing Liu , Yuki Ichikawa
发明人： Makoto MURAKAMI , Yong Che , Bing Liu , Yuki Ichikawa
IPC分类号： G01J3/44 , C23C14/28 , C23C14/34 , G01N21/65 , B82Y99/00 , B82Y30/00
CPC分类号： G01N21/658 , B82Y30/00 , B82Y40/00 , C23C14/083 , C23C14/3435
摘要： An device for Raman spectroscopy such as surface enhanced Raman spectroscopy (SERS) is disclosed herein. Various embodiments may be utilized to prepare a SERS substrate using several deposition techniques such as pulsed laser deposition. Some embodiments optimize coverage, volume, or elements of SERS active metals. The method is a single step inexpensive method for preparing a SERS active substrate. In some embodiments a coating layer underneath the SERS active metals is utilized for additional enhancements.
摘要翻译：本文公开了一种用于拉曼光谱的装置，例如表面增强拉曼光谱（SERS）。可以使用多种沉积技术例如脉冲激光沉积来制备SERS衬底的各种实施例。一些实施例优化SERS活性金属的覆盖，体积或元素。该方法是用于制备SERS活性基底的单步廉价方法。在一些实施方案中，SERS活性金属下面的涂层用于额外的增强。

5. 发明授权

US08540173B2 Production of fine particles of functional ceramic by using pulsed laser 有权
标题翻译：使用脉冲激光生产功能性陶瓷微粒
公开(公告)号：US08540173B2
公开(公告)日：2013-09-24
申请号：US12951557
申请日：2010-11-22
申请人： Yuki Ichikawa , Zhengong Hu , Bing Liu , Yong Che
发明人： Yuki Ichikawa , Zhengong Hu , Bing Liu , Yong Che
IPC分类号： B02C19/18
CPC分类号： C09K11/025 , C09K11/08 , Y10T428/2982
摘要： A method of forming nanometer sized fine particles of functional ceramic from a bulk functional ceramic, particularly fine particles of phosphorous ceramics from a bulk phosphor material is disclosed. The method relies on irradiation of a bulk phosphorous ceramic in a liquid with an ultrashort-pulsed-laser-fragmentation beam to thereby form nanometer sized particles of the phosphorous ceramic. The method is unique in that the generated particles retain the chemical and crystalline properties of the bulk phosphorous ceramic. The generated solutions are stable colloids from which the particles can be isolated or used as is.
摘要翻译：公开了一种从体积功能陶瓷形成纳米尺寸的功能性陶瓷微粒的方法，特别是来自块状磷光体材料的磷陶瓷的细颗粒的方法。该方法依赖于用超短脉冲激光破碎光束在液体中照射大块磷陶瓷，从而形成纳米尺寸的磷陶瓷颗粒。该方法的独特之处在于所产生的颗粒保留了大块磷陶瓷的化学和结晶性质。产生的溶液是稳定的胶体，颗粒可从其中分离或原样使用。

6. 发明申请

US20140213807A1 Methods For Preparing Aqueous Suspension Of Precious Metal Nanoparticles 审中-公开
标题翻译：制备贵金属纳米粒子水悬浮液的方法
公开(公告)号：US20140213807A1
公开(公告)日：2014-07-31
申请号：US14161773
申请日：2014-01-23
申请人： Yuki Ichikawa , Andrius Marcinkevicus , Masayuki Ito , Wei Qian
发明人： Yuki Ichikawa , Andrius Marcinkevicus , Masayuki Ito , Wei Qian
IPC分类号： C08G65/328 , B82Y30/00
CPC分类号： C08G65/328 , B01J13/0043 , B82Y30/00
摘要： The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.
摘要翻译：本公开涉及制备贵金属纳米颗粒的稳定悬浮液的方法和将生物分子附着到纳米颗粒的方法。纳米颗粒的形成可以通过液体中的化学合成或脉冲激光烧蚀来实现。本公开揭示了在液体中的脉冲激光烧蚀期间控制分散介质的电导率以控制纳米颗粒的粒度的重要性。本公开还揭示了在纳米颗粒储存期间和刚好在进行生物共轭反应之前调节和保持电导率在25μS/ cm以下范围内的重要性。导电性的控制是将纳米颗粒保持在分散介质中作为稳定的非聚集胶体悬浮液的重要方法。

7. 发明申请

US20140106122A1 OPTICAL LAYERED BODY, METHOD FOR PRODUCING OPTICAL LAYERED BODY, POLARIZER AND IMAGE DISPLAY DEVICE 有权
标题翻译：光学层，用于制造光学层的方法，极化器和图像显示装置
公开(公告)号：US20140106122A1
公开(公告)日：2014-04-17
申请号：US13697462
申请日：2011-05-12
申请人： Junya Eguchi , Tasuku Kitamura , Yuki Ichikawa , Takashi Kodama
发明人： Junya Eguchi , Tasuku Kitamura , Yuki Ichikawa , Takashi Kodama
IPC分类号： G02B1/08
CPC分类号： G02B1/16 , G02B1/04 , G02B1/08 , G02B1/11 , G02B5/3025 , Y10T428/24364 , Y10T428/256 , Y10T428/31533
摘要： The present invention provides an optical layered body which stably keeps light resistance such as ultraviolet resistance and oxidation resistance while keeping conventional physical properties and optical properties as the outermost surface material of an image display device, which is excellent in an antistatic property and which is capable of providing high image contrast when employed for an image display device. The optical layered body has a light transmitting substrate and a resin layer formed on one surface of the light transmitting substrate and is characterized in that the resin layer contains a binder resin, a polythiophene, an auxiliary conductive agent, and a leveling agent.
摘要翻译：本发明提供了一种光学层叠体，其在保持作为图像显示装置的最外表面材料的常规物理性能和光学性能的同时稳定地保持耐紫外线性和抗氧化性，其抗静电性优异，并且能够当用于图像显示装置时提供高图像对比度。光学层叠体具有形成在透光基板的一个表面上的透光基板和树脂层，其特征在于，树脂层含有粘合剂树脂，聚噻吩，辅助导电剂和流平剂。

8. 发明授权

US08450689B2 Device and method for measuring thickness of paint film in non-contacting manner 有权
标题翻译：以非接触方式测量漆膜厚度的装置和方法
公开(公告)号：US08450689B2
公开(公告)日：2013-05-28
申请号：US12635339
申请日：2009-12-10
申请人： Hideyuki Ohtake , Yuki Ichikawa
发明人： Hideyuki Ohtake , Yuki Ichikawa
IPC分类号： G01B15/02
CPC分类号： G01B11/0633
摘要： A non-contacting type paint film thickness measuring device includes a generating portion for generating a terahertz pulse light, a detecting portion for detecting the terahertz pulse light, a measured wave form in time-series obtaining portion for obtaining a measured wave form indicating an electric field intensity of a terahertz echo pulse light, and an intrinsic wave form in time-series obtaining portion, having an intrinsic electric field spectrum calculating portion and an intrinsic wave form in time-series calculating portion, for calculating an intrinsic wave form in time-series of an object.
摘要翻译：非接触型涂膜厚度测量装置包括用于产生太赫兹脉冲光的产生部分，用于检测太赫兹脉冲光的检测部分，用于获得指示电力的测量波形的时间序列获得部分中的测量波形在时间序列获取部分中具有太赫兹回波脉冲光的场强和本征波形，在时间序列计算部分中具有固有电场光谱计算部分和固有波形，用于计算时间序列获得部分中的固有波形，系列的一个对象。

9. 发明授权

US09463243B2 Amorphous medicinal fine particles produced by pulsed laser ablation in liquid and the production method thereof 有权
标题翻译：液态脉冲激光烧蚀制备的无定形药用细粒及其制备方法
公开(公告)号：US09463243B2
公开(公告)日：2016-10-11
申请号：US13765769
申请日：2013-02-13
申请人： Yuki Ichikawa , Andrius Marcinkevicus
发明人： Yuki Ichikawa , Andrius Marcinkevicus
IPC分类号： A61K9/00 , A61K41/00 , A61J3/02 , A61K9/50 , A61K9/51
CPC分类号： A61K41/00 , A61J3/02 , A61K9/50 , A61K9/51 , Y10T428/2982
摘要： The present disclosure is directed to an in-liquid laser-based method for fabricating a solution of fine particles of amorphous solid medicinal compounds, a solution of fine particles of amorphous medicinal agents made with the method, and fine particles made with the method. By using a target solidified via a phase transition process to covert an initial crystalline structure into an amorphous solid, technical difficulties with handling a hydraulically-pressed target are overcome. The laser-based ablation process produces amorphous solid medicinal compound fine particles, which improves the bioavailability and solubility of the medicinal compound. The improvement results from a combination of: disordered crystalline structure and enlarged relative surface area by particle size reduction. The laser based method may be carried out with ultrashort pulsed laser systems, or with UV nanosecond lasers. Results obtained with an ultrashort near IR laser and a UV nanosecond laser show formation of amorphous solid curcumin fine particles.
摘要翻译：本公开涉及一种用于制造无定形固体药物化合物的细颗粒溶液的液体内基于激光的方法，用该方法制备的非晶医药的微粒溶液和用该方法制备的微粒。通过使用通过相变过程固化的靶将初始晶体结构转变为无定形固体，克服了处理液压压制靶的技术困难。基于激光的消融过程产生无定形固体药物复合细颗粒，其改善药物化合物的生物利用度和溶解度。通过以下组合的改进结果：无序的结晶结构和通过粒径减小扩大的相对表面积。基于激光的方法可以用超短脉冲激光系统或UV纳秒激光器进行。用超短距离近红外激光和UV纳秒激光显示的结果显示无定形固体姜黄素细颗粒的形成。

10. 发明授权

US09310522B2 Optical layered body, method for producing optical layered body, polarizer and image display device 有权
标题翻译：光学层叠体，光学层叠体的制造方法，偏振片及图像显示装置
公开(公告)号：US09310522B2
公开(公告)日：2016-04-12
申请号：US13697462
申请日：2011-05-12
申请人： Junya Eguchi , Tasuku Kitamura , Yuki Ichikawa , Takashi Kodama
发明人： Junya Eguchi , Tasuku Kitamura , Yuki Ichikawa , Takashi Kodama
IPC分类号： G02B1/08 , G02B5/30
CPC分类号： G02B1/16 , G02B1/04 , G02B1/08 , G02B1/11 , G02B5/3025 , Y10T428/24364 , Y10T428/256 , Y10T428/31533
摘要： The present invention provides an optical layered body which stably keeps light resistance such as ultraviolet resistance and oxidation resistance while keeping conventional physical properties and optical properties as the outermost surface material of an image display device, which is excellent in an antistatic property and which is capable of providing high image contrast when employed for an image display device. The optical layered body has a light transmitting substrate and a resin layer formed on one surface of the light transmitting substrate and is characterized in that the resin layer contains a binder resin, a polythiophene, an auxiliary conductive agent, and a leveling agent.
摘要翻译：本发明提供了一种光学层叠体，其在保持作为图像显示装置的最外表面材料的常规物理性能和光学性能的同时稳定地保持耐紫外线性和抗氧化性，其抗静电性优异，并且能够当用于图像显示装置时提供高图像对比度。光学层叠体具有形成在透光基板的一个表面上的透光基板和树脂层，其特征在于，树脂层含有粘合剂树脂，聚噻吩，辅助导电剂和流平剂。

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