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1. 发明申请

US20100204513A1 Preparation process of a complex oxide catalyst and application thereof to the synthesis of the acrylic acid 有权
标题翻译：复合氧化物催化剂的制备方法及其在丙烯酸合成中的应用
公开(公告)号：US20100204513A1
公开(公告)日：2010-08-12
申请号：US12690662
申请日：2010-01-20
申请人： Xuemei Li , Chunhua Qin , Kun Jiao , Shiqiang Feng , Yan Zhuang , Jianxue Ma , Xiaodong Zhu , Jingming Shao
发明人： Xuemei Li , Chunhua Qin , Kun Jiao , Shiqiang Feng , Yan Zhuang , Jianxue Ma , Xiaodong Zhu , Jingming Shao
IPC分类号： B01J31/02 , B01J21/06 , B01J23/28 , B01J23/22 , B01J23/30 , B01J23/72 , C07C51/16
CPC分类号： B01J23/002 , B01J21/08 , B01J23/8885 , B01J31/0202 , B01J37/0018 , B01J37/16 , B01J2523/00 , C07C51/235 , C07C57/04 , B01J2523/17 , B01J2523/25 , B01J2523/3706 , B01J2523/55 , B01J2523/68 , B01J2523/69 , B01J2523/56 , B01J2523/3712 , B01J2523/24 , B01J2523/3725
摘要： The present invention provides a complex oxide catalyst whose general formula is Mo12VaCubWcXdYeOf/Z. reducing agent needs to be added into the catalyst during the preparation process of the active component of the catalyst and (or) molding process of the catalyst. Specifically, X is at least one selected from a group consisting of Nb, Sb, Sr, Ba and Te; Y is at least one selected from a group consisting of La, Ce, Nd, Sm and Cs; “a” is ranging from 2 to 8; “b” is ranging from 1 to 6; “c” is ranging from 0.5 to 5; “d” is ranging from 0.01 to 4; “e” is ranging from 0.01 to 4; f is determined by the oxidation state of the component element; Z is silicon powder; the reducing agent is C2˜C6 diol or polyol.
摘要翻译：本发明提供一种复合氧化物催化剂，其通式为Mo12VaCubWcXdYeOf / Z。在催化剂的活性组分的制备过程和（或）催化剂的（或）模制过程中，需要将还原剂加入到催化剂中。具体地，X是选自Nb，Sb，Sr，Ba和Te中的至少一种; Y是选自La，Ce，Nd，Sm和Cs中的至少一种; “a”的范围从2到8; “b”范围从1到6; “c”范围从0.5到5; “d”范围从0.01到4; “e”范围从0.01到4; f由成分元素的氧化态决定; Z是硅粉; 还原剂为C 2〜C 6二醇或多元醇。

2. 发明授权

US09371304B2 Compound separated from monascus-fermented rice,the preparation method and uses thereof 有权
标题翻译：与红曲霉发酵水稻分离的化合物及其制备方法及用途
公开(公告)号：US09371304B2
公开(公告)日：2016-06-21
申请号：US13983048
申请日：2012-01-10
申请人： Zhenwen Duan , Shuren Guo , Xuemei Li , Chunli Liu
发明人： Zhenwen Duan , Shuren Guo , Xuemei Li , Chunli Liu
IPC分类号： A61K31/35 , C07D309/30 , A61K31/366 , A61K36/062 , C07D309/32 , A61K36/899
CPC分类号： C07D309/30 , A61K31/366 , A61K36/062 , A61K36/899 , A61K2236/19 , C07D309/32 , A61K2300/00
摘要： The present invention discloses a compound separated from Monascus-fermented rice, the preparation method and uses thereof. Specifically, the present invention discloses a compound represented by the Formula I, or a pharmaceutically acceptable salt thereof, wherein, R1 is selected from the group consisting of hydrogen, hydroxyl, C1-6 straight or branched alkoxyl, (II), (III) and (IV); R2 is hydrogen or C1-6 alkyl; R3 is selected from the group consisting of hydrogen, hydroxyl and C1-6 straight or branched alkoxyl. The present invention further discloses a pharmaceutical composition containing the compound. The compound of the present invention has HMG-CoA reductase inhibition effects.
摘要翻译：本发明公开了从红曲霉发酵水稻分离出的化合物及其制备方法和用途。具体地说，本发明公开了式I化合物或其药学上可接受的盐，其中R 1选自氢，羟基，C 1-6直链或支链烷氧基，（II），（III）和（IV）; R2是氢或C1-6烷基; R 3选自氢，羟基和C 1-6直链或支链烷氧基。本发明还公开了含有该化合物的药物组合物。本发明的化合物具有HMG-CoA还原酶抑制作用。

3. 外观设计

USD984508S1 Magnifying glass 有权
公开(公告)号：USD984508S1
公开(公告)日：2023-04-25
申请号：US29884687
申请日：2023-02-15
申请人： Xuemei Li
设计人： Xuemei Li

4. 发明申请

US20130309705A1 METHOD FOR DETERMINING THE CONCENTRATION OF HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译：测定HMG-COA还原酶抑制剂浓度的方法
公开(公告)号：US20130309705A1
公开(公告)日：2013-11-21
申请号：US13983044
申请日：2012-01-12
申请人： Zhenwen Duan , Shuren Guo , Xuemei Li
发明人： Zhenwen Duan , Shuren Guo , Xuemei Li
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26
摘要： The invention, which belongs to the field of enzymology and pharmaceutical chemistry, relates to a method for determining the concentration of a HMG-CoA reductase inhibitor, and to a method for determining the inhibition rate of HMG-CoA reductase. In particular, the method for determining the inhibition rate of HMG-CoA reductase comprises the following steps: 1) establishing the following enzymatic reaction systems for HMG-CoA reductase: a reaction system for a sample to be tested, to which a sample to be tested is added, and a negative control reaction system, to which deionized water in the same volume as a sample to be tested is added; 2) determining the MVAL concentration in a negative control reaction system and in a reaction system for a sample to be tested by HPLC-MS/MS method, respectively; 3) calculating the inhibition rate of HMG-CoA reductase according to the formula: inhibition rate of HMG-CoA reductase=[(MVAL concentration in a negative control reaction system−MVAL concentration in a reaction system for a sample to be tested)/MVAL concentration in a negative control reaction system]×100%. The inhibition rate of HMG-CoA reductase can be accurately determined by the method.
摘要翻译：属于酶学和药物化学领域的本发明涉及确定HMG-CoA还原酶抑制剂浓度的方法以及确定HMG-CoA还原酶抑制率的方法。具体而言，HMG-CoA还原酶的抑制率的测定方法包括以下步骤：1）建立HMG-CoA还原酶的下述酶反应体系：待测样品的反应体系，加入测试的阴性对照反应体系，加入与待测试样品相同体积的去离子水; 2）分别通过HPLC-MS / MS方法确定阴性对照反应体系和待测试样品的反应体系中的MVAL浓度; 3）根据以下公式计算HMG-CoA还原酶的抑制率：HMG-CoA还原酶的抑制率= [（（对于待测试样品的反应体系中阴性对照反应体系中的MVAL浓度 - MVAL浓度）/ MVAL 阴性对照反应体系中的浓度]×100％。 HMG-CoA还原酶的抑制率可以通过该方法准确测定。

5. 发明申请

US20110295041A1 CATALYST FOR PRODUCING UNSATURATED ALDEHYDE BY OXIDATION OF LOWER OLEFIN AT HIGH SPACE VELOCITY 有权
标题翻译：用于通过在高空间速度下氧化低烯烃来生产不饱和二胺的催化剂
公开(公告)号：US20110295041A1
公开(公告)日：2011-12-01
申请号：US13116309
申请日：2011-05-26
申请人： Jian Wang , Xuemei Li , Yan Zhuang , Kaimin Shi , Kun Jiao , Jianxue Ma , Xiaodong Chu , Jingming Shao
发明人： Jian Wang , Xuemei Li , Yan Zhuang , Kaimin Shi , Kun Jiao , Jianxue Ma , Xiaodong Chu , Jingming Shao
IPC分类号： C07C45/27 , B01J27/192 , B01J21/06 , B01J23/887 , C07C45/37 , B01J37/08 , B01J21/10 , B01J23/89 , B01J23/889 , B01J23/888 , B01J37/03 , B01J35/08 , C07C45/35
CPC分类号： B01J23/002 , B01J21/08 , B01J23/8876 , B01J23/8885 , B01J37/0009 , B01J37/031 , B01J2523/00 , C07C45/35 , C07C47/22 , B01J2523/13 , B01J2523/54 , B01J2523/67 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/27 , B01J2523/69 , B01J2523/847
摘要： A method of preparing a catalyst for producing acrolein by oxidation of propylene at high space velocity, said catalyst is a Mo—Bi—Fe—Co based composite metal oxide. Producing unsaturated aldehyde via partial oxidation of lower unsaturated olefin at high space velocity using said catalyst is suitable for process with or without off-gas recirculating. Said catalyst is prepared by co-precipitation, the reaction conditions for using said catalyst to produce unsaturated aldehyde are, the space velocity of unsaturated lower olefin relative to catalyst being 120˜200 h-1(STP), reaction temperature being 300˜420° C. and absolute pressure being 0.1˜0.5 MPa; a single-stage unsaturated lower olefin conversion ratio of greater than 98.0% and carbon oxide yield of less than 3.3% with an overall yield of unsaturated lower aldehyde and acid of greater than 94.0% are obtained. The process to prepare the said catalyst is simple, easy to be repeated, and capable of industrial scale-up.
摘要翻译：一种通过丙烯以高空间速度氧化制备丙烯醛的催化剂的方法，所述催化剂是Mo-Bi-Fe-Co系复合金属氧化物。通过使用所述催化剂以高空间速度部分氧化低级不饱和烯烃来生产不饱和醛适用于有或没有废气再循环的方法。所述催化剂通过共沉淀制备，使用所述催化剂生成不饱和醛的反应条件是，不饱和低级烯烃相对于催化剂的空速为120〜200h -1（STP），反应温度为300〜420℃ C.绝对压力为0.1〜0.5MPa; 获得大于98.0％的单级不饱和低级烯烃转化率和小于3.3％的碳氧化物产率，不饱和低级醛和酸的总收率大于94.0％。制备所述催化剂的方法简单，易于重复，并能够进行工业放大。

6. 发明授权

US07586016B2 Method for producing 1,2-propylene glycol using bio-based glycerol 失效
标题翻译：使用生物基甘油生产1,2-丙二醇的方法
公开(公告)号：US07586016B2
公开(公告)日：2009-09-08
申请号：US12232982
申请日：2008-09-26
申请人： Fang Cui , Jing Chen , Chungu Xia , Haixiao Kang , Xinzhi Zhang , Jin Tong , Xuemei Li
发明人： Fang Cui , Jing Chen , Chungu Xia , Haixiao Kang , Xinzhi Zhang , Jin Tong , Xuemei Li
IPC分类号： C07C29/132
CPC分类号： B01J37/18 , B01J23/83 , B01J37/03 , C07C29/60 , C07C31/205
摘要： This invention disclosed a method for producing 1,2-propylene glycol from bio-based glycerol. In this method, a CuO—CeO2—SiO2 catalyst is filled into a fixed bed reactor, a glycerol solution is flowed into the reactor together with hydrogen gas in a manner of top feeding, and controlling the reaction temperature to be 170˜200° C., the reaction pressure to be 1.0˜5.0 MPa, so as to realize the production of 1,2-propylene glycol from the hydrogenation of glycerol. The catalyst used in this invention can sustain a high selectivity for the target product and a high conversion for glycerol for 500 hours.
摘要翻译：本发明公开了一种从生物基甘油生产1,2-丙二醇的方法。在该方法中，将CuO-CeO 2 -SiO 2催化剂填充到固定床反应器中，以顶部进料的方式将甘油溶液与氢气一起流入反应器，控制反应温度为170〜200℃ 反应压力为1.0〜5.0MPa，从而实现甘油氢化制备1,2-丙二醇。用于本发明的催化剂可以维持目标产物的高选择性和甘油的高转化率500小时。

7. 发明授权

US08481790B2 Catalyst for producing unsaturated aldehyde by oxidation of lower olefin at high space velocity 有权
标题翻译：用于通过以高空间速度氧化低级烯烃生产不饱和醛的催化剂
公开(公告)号：US08481790B2
公开(公告)日：2013-07-09
申请号：US13116309
申请日：2011-05-26
申请人： Jian Wang , Xuemei Li , Yan Zhuang , Kaimin Shi , Kun Jiao , Jianxue Ma , Xiaodong Chu , Jingming Shao
发明人： Jian Wang , Xuemei Li , Yan Zhuang , Kaimin Shi , Kun Jiao , Jianxue Ma , Xiaodong Chu , Jingming Shao
IPC分类号： C07C45/27 , B01J27/192 , B01J21/06 , B01J23/00
CPC分类号： B01J23/002 , B01J21/08 , B01J23/8876 , B01J23/8885 , B01J37/0009 , B01J37/031 , B01J2523/00 , C07C45/35 , C07C47/22 , B01J2523/13 , B01J2523/54 , B01J2523/67 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/27 , B01J2523/69 , B01J2523/847
摘要： A method of preparing a catalyst for producing acrolein by oxidation of propylene at high space velocity, said catalyst is a Mo—Bi—Fe—Co based composite metal oxide. Producing unsaturated aldehyde via partial oxidation of lower unsaturated olefin at high space velocity using said catalyst is suitable for process with or without off-gas recirculating. Said catalyst is prepared by co-precipitation, the reaction conditions for using said catalyst to produce unsaturated aldehyde are, the space velocity of unsaturated lower olefin relative to catalyst being 120˜200 h-1(STP), reaction temperature being 300˜420° C. and absolute pressure being 0.1˜0.5 MPa; a single-stage unsaturated lower olefin conversion ratio of greater than 98.0% and carbon oxide yield of less than 3.3% with an overall yield of unsaturated lower aldehyde and acid of greater than 94.0% are obtained. The process to prepare the said catalyst is simple, easy to be repeated, and capable of industrial scale-up.
摘要翻译：一种通过丙烯以高空间速度氧化制备丙烯醛的催化剂的方法，所述催化剂是Mo-Bi-Fe-Co系复合金属氧化物。通过使用所述催化剂以高空间速度部分氧化低级不饱和烯烃来生产不饱和醛适用于有或没有废气再循环的方法。所述催化剂通过共沉淀制备，使用所述催化剂生成不饱和醛的反应条件是，不饱和低级烯烃相对于催化剂的空速为120〜200h-1（STP），反应温度为300〜420℃ C.绝对压力为0.1〜0.5MPa; 获得大于98.0％的单级不饱和低级烯烃转化率和小于3.3％的碳氧化物产率，不饱和低级醛和酸的总收率大于94.0％。制备所述催化剂的方法简单，易于重复，并能够进行工业放大。

8. 发明授权

US08288306B2 Preparation process of a catalyst used for gas phase oxidation of light alkenes to unsaturated aldehydes 有权
标题翻译：用于将轻烯烃气相氧化成不饱和醛的催化剂的制备方法
公开(公告)号：US08288306B2
公开(公告)日：2012-10-16
申请号：US12690764
申请日：2010-01-20
申请人： Ge Luo , Xin Wen , Xiaoqi Zhao , Xuemei Li , Yan Zhuang , Jianxue Ma , Jingming Shao
发明人： Ge Luo , Xin Wen , Xiaoqi Zhao , Xuemei Li , Yan Zhuang , Jianxue Ma , Jingming Shao
IPC分类号： B01J27/228 , B01J21/02 , B01J21/00 , B01J23/00 , B01J23/02 , B01J23/06
CPC分类号： B01J23/8892 , B01J21/18 , B01J23/002 , B01J23/8876 , B01J27/224 , B01J2523/00 , C07C45/35 , C07C45/37 , C07C47/22 , B01J2523/15 , B01J2523/43 , B01J2523/54 , B01J2523/68 , B01J2523/842 , B01J2523/845 , B01J2523/13 , B01J2523/72 , B01J2523/847 , B01J2523/27 , B01J2523/14
摘要： The present invention provides a preparation process of complex oxides catalyst containing Mo, Bi, Fe and Co, which comprising steps as following: dissolving precursor compounds of the components for catalyst and complexing agent in water to obtain a solution, and then drying, molding and calcining the solution to obtain catalyst. The catalyst is used for gas phase oxidation of light alkenes to unsaturated aldehydes. The catalyst has high activity, selectivity and stability. The reaction condition is mild. The preparation process of the catalyst is easy to operate and can be used for mass production.
摘要翻译：本发明提供含有Mo，Bi，Fe和Co的复合氧化物催化剂的制备方法，其包括以下步骤：将催化剂和络合剂组分的前体化合物溶解在水中，得到溶液，然后干燥，成型和煅烧溶液以获得催化剂。催化剂用于将轻烯烃气相氧化成不饱和醛。该催化剂具有高活性，选择性和稳定性。反应条件温和。催化剂的制备方法易于操作，可用于批量生产。

9. 发明授权

US08623780B2 Preparation process of a complex oxide catalyst and application thereof to the synthesis of the acrylic acid 有权
标题翻译：复合氧化物催化剂的制备方法及其在丙烯酸合成中的应用
公开(公告)号：US08623780B2
公开(公告)日：2014-01-07
申请号：US12690662
申请日：2010-01-20
申请人： Xuemei Li , Chunhua Qin , Kun Jiao , Shiqiang Feng , Yan Zhuang , Jianxue Ma , Xiaodong Zhu , Jingming Shao
发明人： Xuemei Li , Chunhua Qin , Kun Jiao , Shiqiang Feng , Yan Zhuang , Jianxue Ma , Xiaodong Zhu , Jingming Shao
IPC分类号： B01J23/00
CPC分类号： B01J23/002 , B01J21/08 , B01J23/8885 , B01J31/0202 , B01J37/0018 , B01J37/16 , B01J2523/00 , C07C51/235 , C07C57/04 , B01J2523/17 , B01J2523/25 , B01J2523/3706 , B01J2523/55 , B01J2523/68 , B01J2523/69 , B01J2523/56 , B01J2523/3712 , B01J2523/24 , B01J2523/3725
摘要： The present invention provides a complex oxide catalyst whose general formula is Mo12VaCubWcXdYeOf/Z. reducing agent needs to be added into the catalyst during the preparation process of the active component of the catalyst and (or) molding process of the catalyst. Specifically, X is at least one selected from a group consisting of Nb, Sb, Sr, Ba and Te; Y is at least one selected from a group consisting of La, Ce, Nd, Sm and Cs; “a” is ranging from 2 to 8; “b” is ranging from 1 to 6; “c” is ranging from 0.5 to 5; “d” is ranging from 0.01 to 4; “e” is ranging from 0.01 to 4; f is determined by the oxidation state of the component element; Z is silicon powder; the reducing agent is C2˜C6 diol or polyol.
摘要翻译：本发明提供一种复合氧化物催化剂，其通式为Mo12VaCubWcXdYeOf / Z。在催化剂的活性组分的制备过程和（或）催化剂的（或）模制过程中，需要将还原剂加入到催化剂中。具体地，X是选自Nb，Sb，Sr，Ba和Te中的至少一种; Y是选自La，Ce，Nd，Sm和Cs中的至少一种; “a”的范围从2到8; “b”范围从1到6; “c”范围从0.5到5; “d”范围从0.01到4; “e”范围从0.01到4; f由成分元素的氧化态决定; Z是硅粉; 还原剂是C 2〜C 6二醇或多元醇。

10. 发明申请

US20130310450A1 Compound Separated from Monascus-Fermented Rice,The Preparation Method and Uses Thereof 有权
标题翻译：与红曲霉发酵水稻分离的化合物，其制备方法及用途
公开(公告)号：US20130310450A1
公开(公告)日：2013-11-21
申请号：US13983048
申请日：2012-01-10
申请人： Zhenwen Duan , Shuren Guo , Xuemei Li , Chunli Liu
发明人： Zhenwen Duan , Shuren Guo , Xuemei Li , Chunli Liu
IPC分类号： C07D309/30
CPC分类号： C07D309/30 , A61K31/366 , A61K36/062 , A61K36/899 , A61K2236/19 , C07D309/32 , A61K2300/00
摘要： The present invention discloses a compound separated from Monascus-fermented rice, the preparation method and uses thereof. Specifically, the present invention discloses a compound represented by the Formula I, or a pharmaceutically acceptable salt thereof, wherein, R1 is selected from the group consisting of hydrogen, hydroxyl, C1-6 straight or branched alkoxyl, (II), (III) and (IV); R2 is hydrogen or C1-6 alkyl; R3 is selected from the group consisting of hydrogen, hydroxyl and C1-6 straight or branched alkoxyl. The present invention further discloses a pharmaceutical composition containing the compound. The compound of the present invention has HMG-CoA reductase inhibition effects.
摘要翻译：本发明公开了从红曲霉发酵水稻分离出的化合物及其制备方法和用途。具体地说，本发明公开了式I化合物或其药学上可接受的盐，其中R 1选自氢，羟基，C 1-6直链或支链烷氧基，（II），（III）和（IV）; R2是氢或C1-6烷基; R 3选自氢，羟基和C 1-6直链或支链烷氧基。本发明还公开了含有该化合物的药物组合物。本发明的化合物具有HMG-CoA还原酶抑制作用。

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