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1. 发明申请

US20120322050A1 USING IMPEDANCE-BASED CELL RESPONSE PROFILING TO IDENTIFY PUTATIVE INHIBITORS FOR ONCOGENE ADDICTED TARGETS OR PATHWAYS 审中-公开
标题翻译：使用基于阻抗的细胞响应分析来识别针对ONCOGENE添加的目标或途径的诱导性抑制剂
公开(公告)号：US20120322050A1
公开(公告)日：2012-12-20
申请号：US13403976
申请日：2012-02-23
申请人： Yama A. Abassi , Li Zhao , Ning Ke , Xiabo Wang , Xiao Xu
发明人： Yama A. Abassi , Li Zhao , Ning Ke , Xiabo Wang , Xiao Xu
IPC分类号： G01N27/02
CPC分类号： G01N33/5014 , C12Q1/002 , C40B30/04 , G01N33/5011 , G01N33/5041 , G01N33/5438 , G01N2333/4716
摘要： Use of impedance devices in methods of generating a time dependent cellular profiles (TCRP) for the modulation of oncogene addicted cells and comparing the impedance-based TCRP to controls or knowns to identify signature time dependent cellular profiles.
摘要翻译：在产生用于调节致癌基因成瘾细胞的时间依赖性细胞谱（TCRP）的方法中使用阻抗装置，并将基于阻抗的TCRP与对照或已知的基因进行比较，以鉴定签名时间依赖性细胞谱。

2. 发明授权

US08263375B2 Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology 有权
标题翻译：使用实时微电子传感技术动态监测活细胞中G蛋白偶联受体（GPCR）和受体酪氨酸激酶（RTK）的活化
公开(公告)号：US08263375B2
公开(公告)日：2012-09-11
申请号：US11198831
申请日：2005-08-04
申请人： Yama A. Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
发明人： Yama A. Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
IPC分类号： C12N13/00 , C07H31/04
CPC分类号： G01N33/5041 , C12Q1/002 , G01N27/021 , G01N33/5014 , G01N33/5438 , G01N2333/4716 , G01N2333/705 , G01N2333/91205 , G01N2500/04 , G01N2500/10
摘要： The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control well, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index of the compound well and the control well.
摘要翻译：本申请包括用于鉴定能够与G-蛋白偶联受体（GPCR）或受体酪氨酸激酶（RTK）相互作用的化合物的系统和方法，包括提供能够测量可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，将表达GPCR或RTK的测试细胞测量到所述装置的孔中，测量所述孔的第一阻抗并任选地从所述第一阻抗确定第一细胞指数，向至少一个含有测试细胞的孔中加入化合物以形成至少一种化合物，以及向至少另一个含有测试单元的井添加车辆控制以形成至少一个控制井，测量化合物井和控制井的第二阻抗，并且可选地从第二阻抗确定第二细胞指数，确定阻抗或细胞的变化指数为复合井和一个对照孔，比较了阻抗或细胞指数的变化如果比较表明化合物井和对照孔的阻抗变化或细胞指数之间存在显着差异，则鉴定化合物与GPCR或RTK相互作用。

3. 发明申请

US20060050596A1 Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology 有权
标题翻译：使用实时微电子传感技术动态监测活细胞中G蛋白偶联受体（GPCR）和受体酪氨酸激酶（RTK）的活化
公开(公告)号：US20060050596A1
公开(公告)日：2006-03-09
申请号：US11198831
申请日：2005-08-04
申请人： Yama Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
发明人： Yama Abassi , Naichen Yu , Josephine Atienza , Xiao Xu , Xiabo Wang
IPC分类号： G11C8/00
CPC分类号： G01N33/5041 , C12Q1/002 , G01N27/021 , G01N33/5014 , G01N33/5438 , G01N2333/4716 , G01N2333/705 , G01N2333/91205 , G01N2500/04 , G01N2500/10
摘要： The present application includes systems and methods for identifying a compound capable of interacting with a G-Protein Coupled Receptor (GPCR) or Receptor Tyrosine Kinase (RTK) including providing a device capable of measuring cell-substrate impedance operably connected to an impedance analyzer, adding test cells expressing a GPCR or a RTK to wells of the device, measuring first impedances of the wells and optionally determining first cell indices from the first impedances, adding a compound to at least one well containing test cells to form at least one compound well and adding a vehicle control to at least another well containing test cells to form at least one control well, measuring second impedances of the compound well and the control well and optionally determining second cell indices from the second impedances, determining the change in the impedance or cell index for the compound well and the one control well, comparing the change in impedance or cell index between the compound well and the control well, and identifying the compound interacts with the GPCR or RTK if the comparison demonstrates a significant difference between the change in impedance or cell index of the compound well and the control well.
摘要翻译：本申请包括用于鉴定能够与G-蛋白偶联受体（GPCR）或受体酪氨酸激酶（RTK）相互作用的化合物的系统和方法，包括提供能够测量可操作地连接到阻抗分析仪的细胞 - 基底阻抗的装置，将表达GPCR或RTK的测试细胞测量到所述装置的孔中，测量所述孔的第一阻抗并任选地从所述第一阻抗确定第一细胞指数，向至少一个含有测试细胞的孔中加入化合物以形成至少一种化合物，以及向至少另一个含有测试单元的井添加车辆控制以形成至少一个控制井，测量化合物井和控制井的第二阻抗，并且可选地从第二阻抗确定第二细胞指数，确定阻抗或细胞的变化指数为复合井和一个对照孔，比较了阻抗或细胞指数的变化如果比较表明化合物井和对照孔的阻抗变化或细胞指数之间存在显着差异，则鉴定化合物与GPCR或RTK相互作用。

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