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1. 发明公开

EP3271021A2 TAT-INDUCED CRISPR/ENDONUCLEASE-BASED GENE EDITING 审中-公开
标题翻译： TAT诱导的基于CRISPR /内切核酸酶的基因编辑
公开(公告)号：EP3271021A2
公开(公告)日：2018-01-24
申请号：EP16769422.3
申请日：2016-03-18
申请人： Temple University Of The Commonwealth System Of Higher Education
发明人： KHALILI, Kamel
IPC分类号： A61P31/12 , A61P31/18 , C12N9/22 , C12N15/63 , C12N15/49
CPC分类号： C12N15/111 , A61K45/06 , A61K48/005 , A61K48/0075 , C12N7/00 , C12N9/22 , C12N15/11 , C12N15/1132 , C12N15/86 , C12N2310/20 , C12N2310/3519 , C12N2320/30 , C12N2740/16062 , C12N2800/107 , C12N2800/22 , C12N2830/00 , C12N2830/30 , C12N2830/60
摘要： Compositions and methods are provided for Tat-inducible expression of a CRISPR-associated endonuclease by a truncated HIV LTR promoter containing at least a core region and a TAR region of a HIV LTR promoter. The compositions may be used as a therapeutic treatment for the treatment and/or prevention of HIV.

2. 发明公开

EP3250231A1 CYTOMEGALOVIRUS-BASED VACCINE EXPRESSING EBOLA VIRUS GLYCOPROTEIN 审中-公开
标题翻译：基于细胞病毒的疫苗表达埃博拉病毒糖蛋白
公开(公告)号：EP3250231A1
公开(公告)日：2017-12-06
申请号：EP16701948.8
申请日：2016-01-28
申请人： University Of Plymouth , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , Office of Technology Transfer, National Institutes of Health
发明人： JARVIS, Michael Arthur , MURPHY, Aisling Aoife , FELDMANN, Heinrich , MARZI, Andrea , POWERS, Ilhem Messaoudi
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5256 , A61K2039/57 , A61K2039/575 , C12N7/00 , C12N2710/16121 , C12N2710/16141 , C12N2710/16143 , C12N2760/14134 , C12N2830/00 , Y02A50/383 , Y02A50/386 , Y02A50/394 , Y02A50/466
摘要： A recombinant herpesvirus-based vector comprising a nucleic acid sequence encoding a heterologous antigen and a promoter for controlling the expression of the antigen, in which the promoter is expressed at a time selected to provide a required immune response in a subject.

3. 发明公开

EP2956557A4 COMPOSITIONS AND METHODS OF USE THEREOF FOR IDENTIFYING ANTI-VIRAL AGENTS 有权
标题翻译：组合物和它们的用途用于鉴定杀病毒
公开(公告)号：EP2956557A4
公开(公告)日：2016-09-14
申请号：EP14751523
申请日：2014-02-13
申请人： DAVID GLADSTONE INST
发明人： WEINBERGER LEOR S
IPC分类号： C12Q1/70
CPC分类号： C12N15/86 , C12N2710/16122 , C12N2710/16143 , C12N2740/15043 , C12N2830/00 , C12N2830/48 , C12N2830/60 , C12N2840/203 , G01N33/5023
摘要： The present disclosure provides a recombinant expression vector comprising a nucleotide sequence encoding a herpesvirus transactivator, where the nucleotide sequence is operably linked to a herpesvirus control element. The present disclosure provides cell lines genetically modified to express a herpesvirus transactivator under the control of a herpesvirus control element. The present disclosure provides methods of identifying agents that disrupt feedback regulation of a herpesvirus transcriptional control element by a herpesvirus transactivator.
摘要翻译：本公开内容提供了包含编码疱疹病毒反式激活，其中所述核苷酸序列可操作地连接到一个控制疱疹病毒元件的核苷酸序列的重组表达载体。本发明提供了细胞系遗传修饰以表达疱疹病毒控制元件的控制下的反式激活的疱疹病毒。本发明提供了鉴定剂的方法确实由疱疹病毒反式干扰疱疹病毒的转录控制元件的反馈调节。

4. 发明授权

EP2752112B1 TRANSGENIC BIRD EXPRESSING FOREIGN GENE USING ENDOPLASMIC RETICULUM CHAPERONE PROMOTER 有权
标题翻译：外国GEN表达转基因的鸟，内质网分子伴侣启动
公开(公告)号：EP2752112B1
公开(公告)日：2016-04-27
申请号：EP12827380.2
申请日：2012-08-27
申请人： Kaneka Corporation
发明人： KYOGOKU Kenji , WATANABE Hiroyuki
IPC分类号： A01K67/027 , C12N15/09 , C07K14/505
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C07K14/505 , C12N2740/13043 , C12N2830/00 , C12N2830/90

5. 发明公开

EP2922962A1 OPTIMIZED EXPRESSION CASSETTE FOR EXPRESSING A POLYPEPTIDE WITH HIGH YIELD 有权
标题翻译：优化表达盒进行表达的高产栽培多肽
公开(公告)号：EP2922962A1
公开(公告)日：2015-09-30
申请号：EP13792030.2
申请日：2013-11-18
申请人： Novartis AG
发明人： DRAGIC, Zorica , SCHMITZ, Rita , WILMS, Burkhard , GEISSE, Sabine
IPC分类号： C12N15/85 , C12N5/10
CPC分类号： C12N15/85 , C07K16/00 , C12N2830/00 , C12N2830/30
摘要： The present invention is based on the finding that the combination of a specific 5′UTR polynucleotide sequence (see SEQ ID NO 1) and the hCD33 secretory leader sequence in an expression cassette for expressing a polypeptide of interest results in a surprisingly better expression level of the polypeptide of interest compared to prior art expression cassettes. Based on this finding, the present invention inter alia provides novel expression cassettes, expression vectors and methods for producing a polypeptide of interest with high yield.

6. 发明公开

EP2752112A4 TRANSGENIC BIRD EXPRESSING FOREIGN GENE USING ENDOPLASMIC RETICULUM CHAPERONE PROMOTER 有权
标题翻译：外国GEN表达转基因的鸟，内质网分子伴侣启动
公开(公告)号：EP2752112A4
公开(公告)日：2015-03-04
申请号：EP12827380
申请日：2012-08-27
申请人： KANEKA CORP
发明人： KYOGOKU KENJI , WATANABE HIROYUKI
IPC分类号： A01K67/027 , C07K14/505 , C12N15/09
CPC分类号： A01K67/0275 , A01K2217/052 , A01K2227/30 , A01K2267/01 , C07K14/505 , C12N2740/13043 , C12N2830/00 , C12N2830/90

7. 发明授权

EP2147121B1 Synthetic expression vectors for insect cells 有权
标题翻译：用于昆虫细胞的合成的表达载体
公开(公告)号：EP2147121B1
公开(公告)日：2014-12-17
申请号：EP08754138.9
申请日：2008-04-28
申请人： Merck Sharp & Dohme Corp.
发明人： WANG, Gordon, V., L. , CLEMENTS, David, E. , WEEKS-LEVY, Carolyn
IPC分类号： C12Q1/68 , C12N15/85
CPC分类号： C12N15/85 , C12N2800/105 , C12N2830/00 , C12N2830/15 , C12N2830/75

8. 发明授权

EP2007895B1 COMPOSITIONS AND METHODS FOR THERAPY OF CYSTIC FIBROSIS 有权
标题翻译：组合物和方法囊性纤维化治疗
公开(公告)号：EP2007895B1
公开(公告)日：2014-11-26
申请号：EP07732165.1
申请日：2007-03-28
申请人： Imperial Innovations Ltd
发明人： HYDE, Stephen , GILL, Deborah
IPC分类号： C12N15/85 , A61K48/00
CPC分类号： C12N15/67 , A61K48/0058 , C12N15/85 , C12N2830/00

9. 发明公开

EP2794651A2 EXPRESSION VECTOR ELEMENT COMBINATIONS, NOVEL PRODUCTION CELL GENERATION METHODS AND THEIR USE FOR THE RECOMBINANT PRODUCTION OF POLYPEPTIDES 审中-公开
标题翻译：表达载体的元素组合，生产电池生产及新方法它们在重组多肽生产
公开(公告)号：EP2794651A2
公开(公告)日：2014-10-29
申请号：EP12810245.6
申请日：2012-12-19
申请人： F.Hoffmann-La Roche AG
发明人： HUELSMANN, Peter Michael , KNOETGEN, Hendrik
IPC分类号： C07K16/00 , C12N15/67
CPC分类号： C12N15/85 , C07K16/00 , C07K16/2854 , C07K16/468 , C07K2317/14 , C12N2830/00 , C12N2830/36 , C12N2830/42 , C12N2840/203
摘要： Herein is reported that for transient transfections the use of the human elongation factor 1 alpha promoter (with Intron A) provides for an enhanced productivity (in LC-HC-SM organization), the use of the bovine growth hormone polyA signal sequence provides for an enhanced productivity compared to use of the SV40 polyA signal sequence, the addition of the HGT to the bGH PolyA signal sequence results in an increased productivity in vectors containing the hCMV promoter and the vector organization LC(3′-5′)-HC-SM results in improved expression. For stable pools it is reported that pools generated with vectors containing the hEF1α promoter show an enhanced productivity in batch analysis, clones generated with vectors containing the hEF1α promoter show a reduced number of low producing clones, and clones generated with vectors containing the hEF1α promoter show a higher stability of IgG expression. For single clones it is reported that the vector organization with downstream position of selection marker (LC-HC-SM) has a positive effect on productivity of single clones and that clones generated with vectors containing the bGH polyA signal sequence and the hGT have higher productivities.
摘要翻译：在报道没有为瞬时转染使用人延伸因子1α启动子（内含子A）的提供用于上提高生产率（在LC-HC-SM组织），使用牛生长激素多聚腺苷酸信号序列提供了用于相比于使用SV40的增强生产力多聚A信号序列，添加HGT到的bGH polyA信号序列中的生产力提高导致在含有hCMV启动子与矢量组织LC（3'-5“）载体 - HC-SM 导致改进的表达。对于稳定池有报道并与载体通过含有HEF1α启动子节目以提高生产率在分批分析产生池，用含有HEF1α启动子显示出低生产克隆的数量减少的矢量产生的克隆，并用载体通过含有HEF1α启动子节目产生克隆 IgG表达的更高的稳定性。对于单克隆有报告做了与选择标记物（LC-HC-SM）的下游位置的矢量组织对单个克隆的生产率具有积极作用，并用含有所述的bGH polyA信号序列和HGT矢量生成并克隆具有更高的生产率，

10. 发明公开

EP2655636A4 MODIFIED HUMAN CMV PROMOTERS THAT ARE RESISTANT TO GENE SILENCING 有权
标题翻译：修饰的人类巨细胞病毒的推动者与抗病性的精确的电路
公开(公告)号：EP2655636A4
公开(公告)日：2014-06-11
申请号：EP11850231
申请日：2011-12-22
申请人： AGENCY SCIENCE TECH & RES
发明人： YANG YUANSHENG , MARIATI MARIATI
IPC分类号： C12N15/869
CPC分类号： C12N15/86 , A61K48/00 , C12N9/1077 , C12N15/67 , C12N15/85 , C12N2710/16122 , C12N2830/00 , C12N2830/46 , C12N2830/60 , C12N2830/85 , C12Y204/02007

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