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1. 发明授权

EP2791685B1 NOUVELLE UTILISATION D'UN MATÉRIAU CAPABLE DE LIER LA PROTÉINE PRION 有权
公开(公告)号：EP2791685B1
公开(公告)日：2018-10-24
申请号：EP12813912.8
申请日：2012-12-12
申请人： Maco Pharma
发明人： COMOY, Emmanuel , SUMIAN, Chryslain , LESCOUTRA, Nathalie , JAFFRE, Nina , DESLYS, Jean-Philippe
IPC分类号： G01N33/68 , A61L2/00 , A61M1/02
CPC分类号： G01N33/6896 , G01N2800/2828

2. 发明授权

EP2723379B1 ANTI-ALPHA SYNUCLEIN BINDING MOLECULES 有权转让
公开(公告)号：EP2723379B1
公开(公告)日：2018-09-12
申请号：EP12802721.6
申请日：2012-06-22
申请人： Biogen International Neuroscience GmbH , University of Zürich
发明人： WEIHOFEN, Andreas , GRIMM, Jan , HOCK, Christoph , NITSCH, Roger , SU, Lihe , WEINREB, Paul
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K47/6849 , C07K2317/34 , C07K2317/565 , G01N33/6896 , G01N2333/47 , G01N2800/28 , G01N2800/2828 , G01N2800/2835
摘要： Provided are anti-human α-synuclein-specific binding molecules, e.g., antibodies or antigen-binding fragments, variants or derivatives thereof, as methods related thereto. Further provided are anti-human α-synuclein binding molecules which bind to specific N-terminal and C-terminal epitopes on human α-synuclein. The binding molecules described herein can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.

3. 发明公开

EP3110974A4 METHODS OF USING AN ACTIVATOR OF CEREBLON FOR NEURAL CELL EXPANSION AND THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS 审中-公开
公开(公告)号：EP3110974A4
公开(公告)日：2018-01-24
申请号：EP15752120
申请日：2015-02-23
申请人： CELGENE CORP
发明人： HANDA HIROSHI , ANDO HIDEKI , ITO TAKUMI
IPC分类号： C12Q1/68 , A61K35/30 , A61K35/545 , A61K38/17 , A61K48/00 , C12N5/079 , C12N5/0797 , C12N15/113 , G01N33/50
CPC分类号： A61K35/30 , A61K35/545 , A61K38/1709 , A61K48/00 , C12N5/0618 , C12N5/0623 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/3233 , C12N2320/30 , C12N2501/60 , C12N2501/70 , C12N2501/998 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/5088 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835 , G01N2800/52
摘要： Provided herein, for example, are methods generally relating to the expansion and/or regeneration of central nervous system (CNS) cells, such as nerve cells, astrocytes and oligodendrocytes, using an activator of cereblon (CRBN), such as an inhibitor of a CRBN substrate or downstream protein. Also provided herein, for example, are methods related to the expansion of neural stem cells, neural progenitor cells, or neural precursor cells and/or differentiation of these cells into CNS cells using a BRD7 antagonist, Ikaros antagonist, or CRBN activator. In certain embodiments, the methods further comprise differentiation of certain stem cells into the neural stem cells, neural progenitor cells, or neural precursor cells using a BRD7 antagonist, Ikaros antagonist, or CRBN activator. Also provided herein, for example, are methods of preventing or treating a CNS cell defective disease, disorder or condition, or a symptom thereof, using a BRD7 antagonist, Ikaros antagonist, or CRBN activator.

4. 发明公开

EP3161482A1 METHOD FOR ENRICHING CNS-DERIVED EXOSOMES 有权
标题翻译：增强CNS衍生外体的方法
公开(公告)号：EP3161482A1
公开(公告)日：2017-05-03
申请号：EP15811137.7
申请日：2015-06-26
申请人： XY Evergreen Technology Company
发明人： ZHANG, Jing
IPC分类号： G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/2828 , G01N2800/2835
摘要： The present invention relates to a method for enriching CNS-derived exosomes from a biological fluid such as blood, serum, plasma, or saliva. The method comprises: contacting a biological fluid containing CNS-derived exosomes with an anti-L1CAM antibody to form an immunocomplex, binding CNS-derived exosomes in the biological fluid to a solid phase through the immunocomplex; and separating the solid phase bound exosomes from the biological fluid to enrich the CNS-derived exosomes. Biomarkers from the CNS-derived exosomes can be measured for detecting a neurological disease, differentiating among different neurological diseases, monitoring disease progression or objectively assessing existing and future medical treatments.
摘要翻译：本申请涉及用于从生物流体例如血液，血清，血浆或唾液中富集CNS衍生的外泌体的方法。该方法包括：将含有CNS衍生的外泌体的生物流体与抗-L1CAM抗体接触以形成免疫复合物，通过免疫复合物将生物流体中的CNS衍生的外泌体与固相结合; 并从生物流体中分离固相结合的外来体以富集CNS衍生的外泌体。可以测量来自CNS衍生的外泌体的生物标志物用于检测神经疾病，区分不同的神经疾病，监测疾病进展或客观评估现有和未来的药物治疗。

5. 发明公开

EP3088899A1 BIOMARKERS FOR PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT AND METHODS FOR DETECTING PSYCHIATRIC DISEASES INCLUDING COGNITIVE IMPAIRMENT USING THE BIOMARKERS 有权
标题翻译：生物标志物与用生物标志物认知干扰于检测精神疾病的认知障碍和方法的精神障碍
公开(公告)号：EP3088899A1
公开(公告)日：2016-11-02
申请号：EP16171946.3
申请日：2010-05-17
申请人： Mcbi Inc.
发明人： UCHIDA, Kazuhiko , ISHII, Takashi , MENO, Kohji , SUZUKI, Hideaki
IPC分类号： G01N33/68 , G01N21/78 , G01N27/62 , G01N33/53 , G01N33/543 , C07K14/47
CPC分类号： G01N33/6896 , C07K14/47 , G01N2333/705 , G01N2333/974 , G01N2560/00 , G01N2800/2814 , G01N2800/2828
摘要： The present invention aims to present methods to detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence, or in quantity between non-cognitive impairment and patients with cognitive impairment and further aims to present biomarkers comprising said protein and said partial peptide to be used to detect cognitive impairment including mild cognitive impairment and Alzheimer disease. Simultaneously, the present invention aims to present novel biomarkers for cognitive impairment and non-psychiatry disease and methods for detecting cognitive impairment using such biomarkers.
Specifically, a biomarker for diagnosis of psychiatry disease or cognitive impairment comprising protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, and 20 and selected from the group of partial peptide in these proteins consisting of amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, and 21. And further aims to present diagnostic method using these biomarker, and further aims to present synthesis antigen peptide expressed by SEQ ID NO: 22 for preparation of peptide specific antibody for use in diagnostic method.
摘要翻译：本发明目的是提出的方法来检测的认知缺损包括轻度认知障碍和阿尔茨海默氏病，通过使用蛋白质或它的部分肽没有不同之处存在或不存在，或在非认知障碍和患者的认知障碍和进一步的目的，以间量包含所述蛋白和所述部分肽本生物标记可以用于检测认知障碍包括轻度认知障碍和阿尔茨海默氏病。同时，本发明目的是提出用于认知障碍和非精神病学疾病和方法新颖的生物标志物用于检测使用被测生物标记物的认知缺损。具体地，用于从所述组蛋白由SEQ ID NO过表达的氨基酸序列中的选定精神病学疾病或认知障碍，其包括蛋白质片段，或由至少一种蛋白质或肽所产生的不小于5个氨基酸残基的肽的诊断的生物标志物： 1，3，6，8，10，13，15，18，和20以及从该组中的合成蛋白质由SEQ ID NO过表达的氨基酸序列的部分肽选自：2，4，5，7，9， 22，用于制备肽特异性抗体的使用在：11，12，14，16，17，19，和21和进一步的目的使用这些生物标志物和进一步的目的呈现由SEQ ID NO过表达合成抗原肽呈现诊断方法诊断方法。

6. 发明授权

EP2312312B1 Detection of conformationally altered proteins and prions 有权
标题翻译：蛋白质和朊蛋白
公开(公告)号：EP2312312B1
公开(公告)日：2016-03-02
申请号：EP10188900.4
申请日：2004-12-03
申请人： System of Systems Analytics, Inc.
发明人： Orser, Cindy S. , Grosset, Anne , Davidson, Eugene
IPC分类号： G01N33/68 , G01N33/542
CPC分类号： G01N33/6896 , C07K14/4711 , G01N33/542 , G01N33/582 , G01N2800/2828
摘要： The invention provides methods and kits for detecting conformationally altered proteins and prions in a sample. In one embodiment, the conformationally altered proteins and prions are associated with amyloidogenic diseases.
摘要翻译：本发明提供用于检测样品中构象改变的蛋白质和朊病毒的方法和试剂盒。在一个实施方案中，构象改变的蛋白质和朊病毒与淀粉样变性疾病相关。

7. 发明公开

EP2963421A1 Process for diagnosis of neurodegenerative diseases 审中-公开
标题翻译： Verfahren zur诊断神经退行性病变Erkrankungen
公开(公告)号：EP2963421A1
公开(公告)日：2016-01-06
申请号：EP14175677.5
申请日：2014-07-03
申请人： SeNostic GmbH
发明人： SeNostic GmbH
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N1/04 , G01N1/286 , G01N21/6428 , G01N2021/6439 , G01N2800/2828 , G06F19/00 , G06F19/10 , G06F19/18 , Y02A90/26
摘要： The invention provides an analytical process for analysing the presence of at least one aggregated conformation prion protein in a sample of body fluid or a sample of tissue and uses the dependency of the amplification of the aggregated conformation on the shear-force intensity applied to the native conformation prion protein, which is also dependent on the specific seed present in the admixture with native conformation prion protein, for specifically analysing for the presence of an aggregated conformation prion protein in the sample. The process of the invention contains the step of determining the content of aggregated conformation prion protein generated in admixture with the sample to be analysed using one shear-force intensity, preferably using least at two different shear-force intensities and the step of comparing data on these contents of generated prion protein having an aggregated conformation with data on the content of aggregated prion protein that is pre-determined, each at the same shear-force intensity for a mixture of the same native conformation prion protein with a reference sample as a seed.
摘要翻译：本发明提供了一种分析方法，用于分析体液或组织样品中至少一种聚集的构象朊病毒蛋白的存在，并且使用聚集构象的扩增对应用于天然的剪切力强度的依赖性构象朊病毒蛋白也依赖于与天然构象朊病毒蛋白混合物中存在的特定种子，用于特异性分析样品中聚集的构象朊病毒蛋白的存在。本发明的方法包括以下步骤：使用一种剪切力强度，优选使用至少两种不同的剪切力强度来确定与待分析样品混合产生的聚集构象朊病毒蛋白的含量，以及将数据进行比较生成的朊病毒蛋白的内含物具有聚集构象，其中预先确定了聚集的朊病毒蛋白质含量的数据，每种化合物的相同剪切力强度用于相同天然构象朊病毒蛋白与参照样品作为种子的混合物。

8. 发明授权

EP1668369B1 EPITOPE PROTECTION ASSAY AND METHOD FOR DETECTING PROTEIN CONFORMATIONS 有权
标题翻译： EPITOPSCHUTZTEST和方法检测蛋白构象
公开(公告)号：EP1668369B1
公开(公告)日：2016-01-06
申请号：EP04761667.7
申请日：2004-08-20
申请人： ProMIS Neurosciences Inc.
发明人： CASHMAN, Neil , LEHTO, Marty
IPC分类号： G01N33/68 , G01N33/53 , G01N33/569
CPC分类号： G01N33/6896 , A61K38/00 , C07K16/18 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/626 , G01N33/58 , G01N33/581 , G01N33/68 , G01N33/6845 , G01N2333/90283 , G01N2800/28 , G01N2800/2828
摘要： The invention relates to a composition for eliciting an immune response in an animal to produce an antibody that binds selectively to an amyotrophic lateral sclerosis (ALS)-specific epitope.

9. 发明授权

EP1478931B1 BINDING OF PATHOLOGICAL FORMS OF PRION PROTEINS 有权
标题翻译：约束力的朊蛋白PATOLOGISCHER表格
公开(公告)号：EP1478931B1
公开(公告)日：2015-12-30
申请号：EP03709945.4
申请日：2003-02-28
申请人： Microsens Biophage Limited
发明人： LANE, Amin, Reza , STANLEY, Christopher, J. , WILSON, Stuart, Mark
IPC分类号： G01N33/68
CPC分类号： G01N33/6803 , G01N33/54326 , G01N33/68 , G01N33/6896 , G01N2333/968 , G01N2800/2828
摘要： Infective aggregating forms of proteins such as PrP, amyloid, and tau are bound selectively in the presence of the normal form protein using a polyionic binding agent such as dextran sulphate or pentosan (anionic), or polyamine compounds such as pDADMAC (cationic) under selective binding conditions including the use of n-lauroylsarcosine at mildly alkaline pH, and may then be assayed.

10. 发明授权

EP2616815B1 ASSAY FOR PRIONS 有权
标题翻译：检测朊蛋白
公开(公告)号：EP2616815B1
公开(公告)日：2015-11-18
申请号：EP11773304.8
申请日：2011-09-13
申请人： D-Gen Limited
发明人： JACKSON, Graham Stuart , COLLINGE, John , EDGEWORTH, Julie Ann
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N33/6893 , G01N2333/70596 , G01N2800/2828

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