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91. 发明授权

US08236280B2 Polyamides for nucleic acid delivery 有权
标题翻译：用于核酸输送的聚酰胺
公开(公告)号：US08236280B2
公开(公告)日：2012-08-07
申请号：US13044969
申请日：2011-03-10
申请人： Theresa M. Reineke
发明人： Theresa M. Reineke
IPC分类号： A61K51/00 , C12N15/00 , C07H21/04 , A01K61/00 , D06M14/22
CPC分类号： C12N15/113 , C12N2310/13 , C12N2310/51
摘要： A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells are also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.
摘要翻译：提供了可用于体内和体外应用的新一类非病毒转导载体，包括与病毒载体具有可比效的基因转移载体，而不具有危及生命的免疫应答潜力。还提供了包括可以促进复合物或其部分转运到细胞中的细胞递送分子或试剂的复合物。细胞递送分子可以包括一种或多种聚合物，例如聚酰胺，树枝状大分子和含碳水化合物的可降解聚酯。

92. 发明授权

US08202692B2 Expression profile of thyroid cancer 有权
标题翻译：甲状腺癌的表达谱
公开(公告)号：US08202692B2
公开(公告)日：2012-06-19
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供与甲状腺癌相关的基因表达谱。使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。此外，这些基因为癌症药物筛选和治疗应用提供了靶标。

93. 发明申请

US20120053125A1 PHOSPHATASE INHIBITOR PROTEIN-1 AS A REGULATOR OF CARDIAC FUNCTION 有权
标题翻译：磷酸酶抑制剂蛋白-1作为心脏功能的调节剂
公开(公告)号：US20120053125A1
公开(公告)日：2012-03-01
申请号：US13196450
申请日：2011-08-02
申请人： EVANGELIA KRANIAS , PATRICIA RODRIGUEZ , BRYAN MITTON
发明人： EVANGELIA KRANIAS , PATRICIA RODRIGUEZ , BRYAN MITTON
IPC分类号： A61K38/17 , A61K31/7088 , A61K31/711 , A61P9/00 , C07H21/04 , G01N33/566 , A61P9/04 , C07K14/47 , C07K16/18
CPC分类号： C07K14/4703 , A61K38/00
摘要： The present invention relates to novel nucleic acids which encode novel mutant forms of Inhibitor Protein-1 (I-1). In particular, the I-1 mutant forms comprise altered phosphorylation sites of PKC-α. In addition, the present invention relates to methods of regulating cardiac contractility and function, and for treatment of cardio myopathy and heart failure, which employ the novel nucleic acids and polypeptides. Vectors comprising the novel nucleic acids, Antibodies to the novel proteins, and diagnostic and screening methods associated therewith, are also provided.
摘要翻译：本发明涉及编码新型突变型抑制蛋白-1（I-1）的新型核酸。特别地，I-1突变体形式包含PKC-α的改变的磷酸化位点。此外，本发明涉及调节心脏收缩力和功能以及使用新型核酸和多肽的治疗心脏肌病和心力衰竭的方法。还提供了包含新型核酸，新型蛋白质的抗体以及与其相关的诊断和筛选方法的载体。

94. 发明授权

US08118916B2 High capacity materials for capture of metal vapors from gas streams 有权
标题翻译：用于从气流捕获金属蒸气的高容量材料
公开(公告)号：US08118916B2
公开(公告)日：2012-02-21
申请号：US11550927
申请日：2006-10-19
申请人： Neville R. deGouvea-Pinto , Malyuba Abu-Daabes
发明人： Neville R. deGouvea-Pinto , Malyuba Abu-Daabes
IPC分类号： B01D53/14
CPC分类号： B01D53/64 , B01D53/82 , B01D2257/602 , B82Y30/00 , B82Y40/00
摘要： Metal ions are adsorbed or absorbed by a combination of a binding ligand and an ionic liquid effective to dissolve the metal complex. The ligand is preferably bound to a solid surface which is coated with the ionic liquid. This method is particularly suitable for adsorbing gaseous mercury, lead, zinc and cadmium.
摘要翻译：金属离子被结合配体和有效溶解金属络合物的离子液体的组合吸附或吸收。配体优选与被离子液体涂覆的固体表面结合。该方法特别适用于吸附气态汞，铅，锌，镉。

95. 发明授权

US08012374B2 Slow-release inhibitor for corrosion control of metals 有权
标题翻译：用于金属腐蚀控制的缓释抑制剂
公开(公告)号：US08012374B2
公开(公告)日：2011-09-06
申请号：US10981017
申请日：2004-11-04
申请人： William J. van Ooij , Hrishikesh Manian , Lin Yang , Hai Yang
发明人： William J. van Ooij , Hrishikesh Manian , Lin Yang , Hai Yang
IPC分类号： C23F11/00 , C23F11/18 , B32B5/00
CPC分类号： C23F11/149 , C09D5/002 , C09D5/082 , C23F11/08 , C23F11/185 , Y10T428/2989 , Y10T428/2991 , Y10T428/2998
摘要： The present invention provides for a slow-release inhibitor that is applied to a metal surface, such as by way of a paint or primer coating, for corrosion control of the metal. An exemplary embodiment of the slow-release corrosion inhibitor includes a water-soluble particle, or pigment, and an organic polymeric film that encapsulates the particle. This water-soluble particle may be either organic or inorganic and, preferably, is non-carcinogenic and non-toxic. An additional water-soluble particle having an encapsulating, organic polymeric film further may be provided along with a water-soluble, organic compound to form the corrosion inhibitor. The polymeric film(s) are of a desired hydrophobicity and permeability to permit, upon interaction of the particle(s) with water, controlled diffusion of particle ions therethrough.
摘要翻译：本发明提供了一种缓释抑制剂，其被应用于金属表面，例如通过涂料或底漆涂层，用于金属的腐蚀控制。缓释缓蚀剂抑制剂的一个示例性实施方案包括水溶性颗粒或颜料，以及包封颗粒的有机聚合物膜。该水溶性颗粒可以是有机的或无机的，优选是非致癌的和无毒的。还可以与水溶性有机化合物一起提供另外具有包封的有机聚合物膜的水溶性颗粒以形成腐蚀抑制剂。聚合物膜具有所需的疏水性和渗透性，以便在颗粒与水相互作用时允许颗粒离子通过其控制扩散。

96. 发明申请

US20110183329A1 PROTEIN PHOSPHATASE-1 INHIBITOR-1 POLYMORPHISM AND METHODS OF USE 审中-公开
标题翻译：蛋白磷酸化酶-1抑制剂-1多态性及其使用方法
公开(公告)号：US20110183329A1
公开(公告)日：2011-07-28
申请号：US12911634
申请日：2010-10-25
申请人： Anand Pathak , Evangelia Kranias , Guoli Chen
发明人： Anand Pathak , Evangelia Kranias , Guoli Chen
IPC分类号： C12Q1/68 , C12N5/10 , C12N15/85 , C07K14/47 , C07H21/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N2800/325 , G01N2800/52
摘要： A method for diagnosing the presence of a G147D polymorphism of human phosphatase-1 inhibitor-1 protein is provided, wherein the method involves determining the presence of the polymorphism in a biological sample from a human subject by means which detect the presence of the polymorphism, wherein the presence of the polymorphism is indicative of a predisposition to impaired functioning of the β-adrenergic signaling pathway.
摘要翻译：提供了一种用于诊断人磷酸酶-1抑制剂-1蛋白的G147D多态性的存在的方法，其中所述方法包括通过检测多态性的存在的方式确定来自人受试者的生物样品中多态性的存在，其中所述多态性的存在指示所述β-肾上腺素能信号传导途径功能受损的倾向。

97. 发明授权

US07959935B2 Simulated vernix compositions for skin cleansing and other applications 有权
标题翻译：用于皮肤清洁和其他应用的模拟vernix组合物
公开(公告)号：US07959935B2
公开(公告)日：2011-06-14
申请号：US11038362
申请日：2005-01-19
申请人： Steven B. Hoath , William L. Pickens , Martha O. Visscher , Anyarporn Tansirikongkol , Richard Randall Wickett
发明人： Steven B. Hoath , William L. Pickens , Martha O. Visscher , Anyarporn Tansirikongkol , Richard Randall Wickett
IPC分类号： A61K9/00
CPC分类号： A61Q19/007 , A61K8/0295 , A61K8/046 , A61K8/14 , A61K8/31 , A61K8/36 , A61K8/375 , A61K8/553 , A61K8/63 , A61K8/68 , A61K8/985 , A61Q17/00 , A61Q19/10
摘要： A composition and a method of producing a composition which simulates hydration, cleansing and other properties of native vernix. The composition contains, in one embodiment, hydrated synthetic cells in a lipid matrix to provide properties which are substantially similar to those of native vernix, and may also contain proteins. In one embodiment, the composition contains water-in-oil emulsified particles providing water vapor transport and evaporative water loss properties simulating native vernix. In one embodiment, the composition contains cubosomes/water with up to 30% protein and about 5% lipid to about 30% lipid. The composition may be used to cleanse newborn skin, compromised skin surfaces, as well as normal skin, to provide hydration/barrier function, and other applications.
摘要翻译：一种组合物和一种制备模拟水合，清洁和其它天然植物性质的组合物的方法。在一个实施方案中，组合物在脂质基质中含有水合的合成细胞，以提供与天然叶绿体基本相似的性质，并且还可以含有蛋白质。在一个实施方案中，组合物含有油包水乳化颗粒，其提供模拟天然蕨类植物的水蒸汽输送和蒸发水分损失性质。在一个实施方案中，组合物含有具有高达30％蛋白质和约5％脂质至约30％脂质的cub体/水。该组合物可用于清洁新生皮肤，损伤的皮肤表面以及正常皮肤，以提供水合/屏障功能以及其它应用。

98. 发明授权

US07898740B2 Tunable optical array device comprising liquid cells 失效
标题翻译：包括液体电池的可调谐光学阵列装置
公开(公告)号：US07898740B2
公开(公告)日：2011-03-01
申请号：US12100032
申请日：2008-04-09
申请人： Jason Heikenfeld , Joachim Bradl
发明人： Jason Heikenfeld , Joachim Bradl
IPC分类号： G02B1/06 , G02B3/12
CPC分类号： G02B26/005 , G02B5/045 , G02B26/06 , G09G3/3433 , G09G3/3648 , G09G2300/0439 , G09G2300/0842 , G09G2320/028
摘要： A tunable optical component includes comprises a plurality of individual tunable liquid cells regularly arranged and integrated to at least one cell structure forming an array on the supporting substrate. A single liquid cell comprises several integrated cell walls, the cell walls projecting away from the supporting substrate and having a closed base area and an open cell surface at the cell wall edges. The liquid cell is filled with at least two liquids or fluids to provide at least one tunable interface area for varying the optical characteristic of the liquid cell.
摘要翻译：可调谐光学部件包括多个单独的可调谐液体单元，其规则地布置并集成到在支撑基板上形成阵列的至少一个单元结构。单个液体池包括几个集成的细胞壁，细胞壁远离支撑基底突出，并且在细胞壁边缘处具有封闭的基部区域和开放的细胞表面。液体池填充有至少两种液体或流体，以提供用于改变液体池的光学特性的至少一个可调谐界面区域。

99. 发明申请

US20110025668A1 Display Apparatus Comprising Electrofluidic Cells 有权
标题翻译：包含电流体细胞的显示装置
公开(公告)号：US20110025668A1
公开(公告)日：2011-02-03
申请号：US12723330
申请日：2010-03-12
申请人： Hjalmar Edzer Ayco Huitema , Jason Charles Heikenfeld
发明人： Hjalmar Edzer Ayco Huitema , Jason Charles Heikenfeld
IPC分类号： G09G3/34 , G09G5/00
CPC分类号： G09G3/3433 , G09G3/348
摘要： A display apparatus is described comprising a plurality of electrofluidic chromatophore (EFC) pixel cells. Each pixel cell comprises a fluid holder for holding a polar fluid and a non-polar fluid having differing display properties. The fluid holder comprises a fluid reservoir with a geometry having a small visible area onto the polar fluid, and a channel with a geometry having a large visible area onto the polar fluid. The channel is connected to the reservoir to enable free movement of the polar fluid and non-polar fluid between the channel and the reservoir. At least part of a surface of the channel comprises a wetting property responsive to a supply voltage. The pixel cell comprises at least one further pixel cell terminal that is coupled to a further electrode to supply a direct voltage to the pixel cell.
摘要翻译：描述了一种显示装置，其包括多个电流体色差（EFC）像素单元。每个像素单元包括用于保持极性流体的流体保持器和具有不同显示特性的非极性流体。流体保持器包括具有在极性流体上具有小可见区域的几何形状的流体储存器，以及具有在极性流体上具有大的可见区域的几何形状的通道。通道连接到储存器，以使极性流体和非极性流体在通道和储存器之间自由移动。通道的表面的至少一部分包括响应于电源电压的润湿特性。像素单元包括至少一个另外的像素单元端子，其耦合到另一电极以向像素单元提供直接电压。

100. 发明授权

US07872790B2 Display capable electrowetting light valve 有权
标题翻译：可显示电润湿光阀
公开(公告)号：US07872790B2
公开(公告)日：2011-01-18
申请号：US11570920
申请日：2005-07-08
申请人： Andrew J. Steckl , Jason C. Heikenfeld
发明人： Andrew J. Steckl , Jason C. Heikenfeld
IPC分类号： G02F1/07
CPC分类号： G02B26/004 , G02B5/02
摘要： The invention relates to light transmissive, transflective, or reflective flat panel display devices and, more specifically, to light emissive flat panel displays constructed from high performance electrowetting light valve (ELV) devices (10a-g). An array of ELV devices (10a-g) is mounted on or adjacent to a backlight (11), employing a reflector (13) allowing for improved transmission. The backlight (11) may be partially diffusely reflective or translucent as to also allow for creation of a transflective display panel.
摘要翻译：本发明涉及透光，半透反射或反射平板显示装置，更具体地说，涉及由高性能电润湿光阀（EL-V）装置（10a-g）构成的发光平板显示器。 ELV装置阵列（10a-g）安装在背光源（11）上或与背光源（11）相邻，采用允许改进透射的反射器（13）。背光（11）可以是部分地漫反射或半透明的，以便也可以创建透反射显示面板。

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