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1. 发明授权

US06258263B1 Liquid chromatograph on a chip 有权
标题翻译：液相色谱仪在芯片上
公开(公告)号：US06258263B1
公开(公告)日：2001-07-10
申请号：US09398847
申请日：1999-09-17
申请人： H. Thurman Henderson , Neville R. deGouvea-Pinto
发明人： H. Thurman Henderson , Neville R. deGouvea-Pinto
IPC分类号： B01D1508
CPC分类号： G01N30/6095 , G01N30/60 , G01N30/6043 , G01N30/466
摘要： A chromatograph fabricated using microelectromechanical techniques. The chromatograph includes a first layer superimposed over a second layer. At least one micro-channel is etched into the second layer to provide the separation column of the chromatograph. The surfaces of the micro-channel are chemically activated in order to separate the components of a sample flowing through the micro-channel by bonded phase chemistry. A third layer is placed in superimposed relationship with the second layer. At least one pair of electrodes is formed to the third layer with at least a portion of the electrodes internal to the micro-channel of the second layer. The electrodes detect separated components flowing through the micro-channel and identify them by their electrical conductivity. The depth of the micro-channel is greater than the width, thereby minimizing pressure drop across the device and allowing the chromatograph to operate with a high degree of speed, sensitivity and accuracy. Good resolution is obtained with narrow integrated electrodes for sensing the separated components of the sample.
摘要翻译：使用微机电技术制造的色谱仪。色谱仪包括叠加在第二层上的第一层。将至少一个微通道蚀刻到第二层中以提供色谱仪的分离柱。微通道的表面被化学活化，以通过键合相化学分离流过微通道的样品的组分。第三层与第二层叠加放置。至少一对电极形成到第三层，其中至少一部分电极在第二层的微通道内部。电极检测流过微通道的分离的组分，并通过其电导率来识别它们。微通道的深度大于宽度，从而使器件上的压降最小化，并允许色谱仪以高度的速度，灵敏度和精度运行。通过窄的集成电极获得良好的分辨率，用于感测样品的分离组分。

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