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91. 发明授权

US6017977A Methods for embolizing blood vessels 失效
标题翻译：栓塞栓塞方法
公开(公告)号：US6017977A
公开(公告)日：2000-01-25
申请号：US868931
申请日：1997-06-04
申请人： Scott Evans , John Perl, II , Richard Greff
发明人： Scott Evans , John Perl, II , Richard Greff
IPC分类号： A61B17/12 , A61K49/04 , A61L24/00 , A61L24/02 , A61L24/04 , A61L31/02 , C08L29/04 , A61K31/765 , C08K5/41
CPC分类号： A61L24/0015 , A61L24/001 , A61L24/02 , A61L24/04 , A61L31/02 , A61L2300/418 , A61L2300/44 , A61L2430/36
摘要： Disclosed are methods useful for treating vascular lesions wherein a non-particulate agent such as a metal coil is introduced into a vascular site (e.g., an aneurysm cavity) in conjunction with an embolizing composition comprising a biocompatible polymer and a biocompatible solvent.The biocompatible solvent is miscible or soluble in blood and also solubilizes the polymer during delivery. The biocompatible polymer is selected to be soluble in the biocompatible solvent but insoluble in blood. Upon contact with the blood, the biocompatible solvent dissipates from the embolic composition whereupon the biocompatible polymer precipitates. Precipitation of the polymer in the presence of the non-particulate agent permits the agent to act as a structural lattice for the growing polymer precipitate.In another embodiment, the biocompatible polymer composition can be replaced with a biocompatible prepolymer composition containing a biocompatible prepolymer.
摘要翻译：公开了可用于治疗血管损伤的方法，其中将非颗粒剂如金属盘管与包含生物相容性聚合物和生物相容性溶剂的栓塞组合物一起引入血管部位（例如，动脉瘤腔）。生物相容性溶剂是可混溶的或可溶于血液，并且在递送过程中也溶解聚合物。选择生物相容性聚合物可溶于生物相容性溶剂，但不溶于血液。当与血液接触时，生物相容性溶剂从栓塞组合物中消散，因此生物相容性聚合物沉淀。聚合物在非颗粒剂存在下的析出使得该试剂作为生长聚合物沉淀物的结构晶格。在另一个实施方案中，生物相容性聚合物组合物可以用含有生物相容性预聚物的生物相容性预聚物组合物代替。

92. 发明授权

US5997624A Self-setting calcium phosphate cements and methods for preparing and using them 失效
标题翻译：自制磷酸钙水泥及其制备和使用方法
公开(公告)号：US5997624A
公开(公告)日：1999-12-07
申请号：US61577
申请日：1998-04-16
申请人： Laurence C. Chow , Shozo Takagi
发明人： Laurence C. Chow , Shozo Takagi
IPC分类号： A61L27/00 , A61F2/00 , A61K6/033 , A61L24/02 , A61L27/12 , C04B12/02 , C09K3/00
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L27/12 , A61F2310/00293
摘要： The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
摘要翻译：本发明包括与磷酸钙水泥相关的方法和组合物，当与水性介质接触时，其在环境温度下自身硬化成羟基磷灰石。更具体地说，水泥包括除磷酸四钙之外的一种或多种微溶磷酸钙与用碱调节的水溶液以保持约12.5或更高的pH并具有足够溶解的磷酸盐以产生具有磷酸盐浓度的溶液混合物的组合等于或大于约0.2mol / L。

93. 发明授权

US5962028A Carbonated hydroxyapatite compositions and uses 失效
公开(公告)号：US5962028A
公开(公告)日：1999-10-05
申请号：US963481
申请日：1992-10-16
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , A61K9/00 , A61K33/06 , A61K33/42
CPC分类号： A61L24/02 , A61K6/0067 , A61K6/0085 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293
摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.

94. 发明授权

US5954867A Self setting calcium phosphate cements and methods for preparing and using them 失效
标题翻译：自制磷酸钙水泥及其制备和使用方法
公开(公告)号：US5954867A
公开(公告)日：1999-09-21
申请号：US845316
申请日：1997-04-25
申请人： Laurence C. Chow , Shozo Takagi
发明人： Laurence C. Chow , Shozo Takagi
IPC分类号： A61L27/00 , A61F2/00 , A61K6/033 , A61L24/02 , A61L27/12 , C04B12/02 , C09K3/00
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/0067 , A61K6/033 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61L27/12 , A61F2310/00293
摘要： The invention includes methods and compositions relating to calcium phosphate cements, which self-harden substantially to hydroxyapatite at ambient temperature when in contact with an aqueous medium. More specifically the cements comprise a combination of one or more sparingly soluble calcium phosphates other than tetracalcium phosphate with an aqueous solution adjusted with a base to maintain a pH of about 12.5 or above and having sufficient dissolved phosphate salt to yield a solution mixture with phosphate concentration equal to or greater than about 0.2 mol/L.
摘要翻译：本发明包括与磷酸钙水泥相关的方法和组合物，当与水性介质接触时，其在环境温度下自身硬化成羟基磷灰石。更具体地说，水泥包括除磷酸四钙之外的一种或多种微溶磷酸钙与用碱调节的水溶液以保持约12.5或更高的pH并具有足够溶解的磷酸盐以产生具有磷酸盐浓度的溶液混合物等于或大于约0.2mol / L。

95. 发明授权

US5914356A Bioactive load bearing bone bonding compositions 失效
标题翻译：生物活性负荷骨粘合组合物
公开(公告)号：US5914356A
公开(公告)日：1999-06-22
申请号：US77709
申请日：1998-06-05
申请人： Erik M. Erbe
发明人： Erik M. Erbe
IPC分类号： A61K6/083 , A61L24/00 , A61L24/02 , C03C10/00 , A61K6/06 , C08K3/40
CPC分类号： A61K6/083 , A61L24/0089 , A61L24/02 , C03C10/0009 , C03C4/0021
摘要： Novel fillers comprising combeite glass-ceramic are provided, along with filled polymerizable resin composites. Further provided are methods for making the combeite crystallite-containing novel fillers for use in hardenable, biocompatible bone restorations. Hard, shaped bodies or orthopaedic, dental and other uses are also provided.
摘要翻译： PCT No.PCT / US96 / 19368 Sec。 371日期：1998年6月5日 102（e）1998年6月5日PCT 1996年12月6日PCT PCT。公开号WO97 / 20521 日期：1997年6月12日提供了包含组合玻璃 - 陶瓷的新型填料，以及填充的可聚合树脂复合材料。还提供了用于制备用于可硬化，生物相容性骨修复体的含有微结晶的新型填料的方法。还提供硬的，成形的身体或矫形，牙科和其他用途。

96. 发明授权

US5900254A Carbonated hydroxyapatite compositions and uses 失效
标题翻译：碳酸羟基磷灰石组合物及用途
公开(公告)号：US5900254A
公开(公告)日：1999-05-04
申请号：US670514
申请日：1996-06-27
申请人： Brent R. Constantz
发明人： Brent R. Constantz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61K6/033 , A61L24/02 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/455 , A61K33/06 , A61K33/42 , C01F11/02
CPC分类号： A61L24/02 , A61K6/0067 , A61K6/0085 , A61L27/12 , A61L27/46 , A61L27/50 , A61L27/58 , C01B25/16 , C01B25/32 , C01B25/322 , C01B25/327 , C01B25/455 , A61F2002/2817 , A61F2002/30062 , A61F2210/0004 , A61F2310/00293
摘要： Carbonated hydroxyapatite compositions and their preparation are described. The compositions are biologically resorbable and are prepared as flowable masses which can be administered by syringe to set in situ to serve as a support structure, filler, prosthesis or the like. Optionally the compositions may include proteins or serve as a depot for compositions of phrarmacological interest.
摘要翻译：描述了碳酸化羟基磷灰石组合物及其制备方法。组合物是生物可吸收的并且被制备成可流动的质量，其可以通过注射器施用以原位置换以用作支撑结构，填充物，假体等。任选地，组合物可以包括蛋白质或用作用于药理学兴趣的组合物的贮库。

97. 发明授权

US5821265A Inhibitors of cell-mediated disorders 失效
标题翻译：抑制细胞介导的疾病
公开(公告)号：US5821265A
公开(公告)日：1998-10-13
申请号：US872901
申请日：1997-06-11
申请人： Paul H. Schlesinger , Steven L. Teitelbaum , Harry C. Blair
发明人： Paul H. Schlesinger , Steven L. Teitelbaum , Harry C. Blair
IPC分类号： A61K31/198 , A61K31/28 , A61L24/02 , A61L27/02 , A61K31/555
CPC分类号： A61L27/025 , A61K31/198 , A61K31/28 , A61L24/02
摘要： The present invention provides a method for blocking a cellular proton pump that comprises contacting a cell with a cellular proton pump-blocking effective quantity of In-EDTA or Tl-EDTA. The present invention also provides a method of treating or preventing cell-mediated disorders in a vertebrate animal by administering In-EDTA or Tl-EDTA to the vertebrate animal, as well as a method for stopping the cellular proton pump-blocking effect of Group IIIa metals such as Ga, In, and Tl, through use of suitable chelating agents. Suitable compositions for use in the aforementioned methods are provided as well.
摘要翻译：本发明提供了一种阻断细胞质子泵的方法，该方法包括使细胞与细胞质子泵阻断有效量的In-EDTA或T-EDTA接触。本发明还提供了一种通过向脊椎动物施用In-EDTA或T1-EDTA来治疗或预防脊椎动物中的细胞介导的疾病的方法，以及用于停止IIIa组细胞质子泵阻断作用的方法金属如Ga，In和Tl，通过使用合适的螯合剂。也提供了用于上述方法的合适的组合物。

98. 发明授权

US5691397A Isolation of the calcium-phosphate crystals of bone 失效
标题翻译：骨的磷酸钙晶体的分离
公开(公告)号：US5691397A
公开(公告)日：1997-11-25
申请号：US728820
申请日：1996-10-10
申请人： Melvin J. Glimcher , Hyun-Man Kim , Christian Rey
发明人： Melvin J. Glimcher , Hyun-Man Kim , Christian Rey
IPC分类号： A61F2/00 , A61L24/02 , A61L27/12 , A61L27/32 , A61L27/36 , B01J20/04 , C01B25/32 , C01F11/18 , C08K3/32 , A61F2/02 , A61F2/28 , C08K3/36
CPC分类号： A61L24/02 , A61L27/12 , A61L27/32 , A61L27/3604 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3843 , A61L27/3847 , B82Y30/00 , C01B25/32 , C01F11/185 , A61F2310/00293 , A61F2310/00796 , C01P2004/20 , C01P2004/62 , C01P2004/64
摘要： The present invention is a process for first removing and isolating the calcium-phosphate crystals of bone from a substantial amount of the organic matrix and cellular constituents of bone without significant physical, chemical or structural alterations in the crystals. The crystals can then be further treated to remove the remaining amount of organic material associated with the crystals, leaving them essentially free of any of the organic constituents of bone, without significant physical, chemical or structural alterations in the crystals.
摘要翻译：本发明是首先从大量的有机基质和骨的细胞组分中去除和分离骨的磷酸钙晶体的方法，而在晶体中没有明显的物理，化学或结构改变。然后可以进一步处理晶体以除去与晶体相关的剩余量的有机材料，使得它们基本上不含骨的任何有机成分，而晶体没有明显的物理，化学或结构改变。

99. 发明授权

US5683667A Reactive tricalcium phosphate compositions 失效
标题翻译：活性磷酸三钙组合物
公开(公告)号：US5683667A
公开(公告)日：1997-11-04
申请号：US570237
申请日：1995-12-11
申请人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
发明人： Mark Fulmer , Brent R. Constantz , Ira C. Ison , Bryan M. Barr
IPC分类号： A61L24/00 , A61F2/00 , A61L24/02 , A61L27/12 , C01B25/32 , C04B12/02 , C04B28/34
CPC分类号： C01B25/32 , A61L24/02 , A61L27/12 , C01B25/321 , C04B12/02 , C04B12/025 , C04B28/34 , C04B28/344 , C04B28/346 , A61F2310/00293 , C04B2111/00836
摘要： Methods for producing a room temperature stable, phase pure .alpha.-C.sub.3 P product, and compositions derived therefrom, are provided. In the subject method, a tricalcium phosphate source is heated to a temperature sufficient to convert substantially all of said tricalcium phosphate source to a substantially phase pure .alpha.-C.sub.3 P product. The temperature of the resultant product is rapidly cooled to a temperature below about 700.degree. C., resulting in a room temperature stable, reactive .alpha.-C.sub.3 P product. The resultant .alpha.-C.sub.3 P product may be milled to provide an .alpha.-C.sub.3 P composition which may find use in the preparation of calcium phosphate cements.
摘要翻译：提供了制备室温稳定的纯相α-C3P产物及其衍生物的方法。在本发明方法中，磷酸三钙源被加热到足以将基本上所有的所述磷酸三钙源转化为基本相纯α-C3P产物的温度。将所得产物的温度快速冷却至低于约700℃的温度，得到室温稳定的反应性α-C3P产物。所得到的α-C3P产物可以被研磨以提供可用于制备磷酸钙水泥的α-C3P组合物。

100. 发明授权

US5530037A Sterilized cyanoacrylate adhesive composition, and a method of making such a composition 失效
标题翻译：灭菌的氰基丙烯酸酯粘合剂组合物，以及制备这种组合物的方法
公开(公告)号：US5530037A
公开(公告)日：1996-06-25
申请号：US360511
申请日：1994-12-21
申请人： Patrick F. McDonnell , Robert J. Lambert
发明人： Patrick F. McDonnell , Robert J. Lambert
IPC分类号： A61L20060101 , A61L2/08 , A61L24/02 , A61L24/06 , C09J20060101 , C09J4/00 , C09J4/04 , C08J3/28 , C08K5/13
CPC分类号： A61L2/081 , A61L24/06 , C09J4/00
摘要： A curable cyanoacrylate adhesive composition intended for medical and/or veterinary uses is sterilized in liquid form by gamma irradiation. The composition comprisesa) a cyanoacrylate monomerb) a combination of an anionic stabilizer and a free-radical stabilizer in amounts effective to stabilize the composition during irradiation and to stabilize the sterilized composition during storage prior to cure, wherein the free radical stabilizer is a selected phenolic antioxidant (but not including hydroquinone).The preferred free radical stabilizer is butylated hydroxyanisole. After irradiation the cyanoacrylate monomer is substantially ungelled.
摘要翻译：用于医疗和/或兽医用途的可固化的氰基丙烯酸酯粘合剂组合物通过γ辐射以液体形式灭菌。组合物包含a）氰基丙烯酸酯单体b）阴离子稳定剂和自由基稳定剂的组合，其量有效地在照射期间稳定组合物，并且在固化之前储存期间稳定灭菌组合物，其中自由基稳定剂是选择酚类抗氧化剂（但不包括氢醌）。优选的自由基稳定剂是丁基化羟基苯甲醚。在辐射后，氰基丙烯酸酯单体基本上未凝胶化。

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