专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US5510497A Polymerizable aliphatic cyclobutene compositions 失效
标题翻译：可聚合的脂族环丁烯组合物
公开(公告)号：US5510497A
公开(公告)日：1996-04-23
申请号：US969654
申请日：1992-10-30
申请人： Larry S. Corley
发明人： Larry S. Corley
IPC分类号： C07C49/617 , C07C69/753 , C07D209/70 , C08G61/06 , H05K1/03 , C07D209/56 , C07C49/613 , C07C69/74
CPC分类号： C07C49/617 , C07C69/753 , C07D209/70 , C08G61/06 , H05K1/032
摘要： Aliphatic cyclobutene compositions according to the formula ##STR1## can be homopolymerized or copolymerized with a variety of comonomers, including bismaleimides, to produce tough, low dielectric constant resins.
摘要翻译：根据式“IMAGE”的脂族环丁烯组合物可以与各种共聚单体（包括双马来酰亚胺）均聚或共聚，以产生坚韧的低介电常数树脂。

92. 发明授权

US5438135A Water-soluble tetraazaporphins and fluorochrome for labeling 失效
标题翻译：水溶性四氮杂菲和荧光染料进行标记
公开(公告)号：US5438135A
公开(公告)日：1995-08-01
申请号：US846169
申请日：1992-03-05
申请人： Seiji Tai , Mitsuo Katayose , Hiroo Watanabe
发明人： Seiji Tai , Mitsuo Katayose , Hiroo Watanabe
IPC分类号： C07F5/06 , C07F7/02 , C07F7/08 , C07F9/6561 , C09B47/04 , C09B47/06 , G01N33/533 , C07D209/56 , G01N33/58
CPC分类号： G01N33/533 , C07F5/069 , C07F7/025 , C07F7/0858 , C07F9/6561 , C09B47/045 , C09B47/063
摘要： Water-soluble tetraazaporphins with novel structure is suitable as a fluorochrome for labeling and provides a reagent usable for fluorescence analysis process.
摘要翻译：具有新结构的水溶性四氮杂萘适用于标记荧光染料，并提供可用于荧光分析过程的试剂。

93. 发明授权

US5428152A Bis(trialkylsiloxy)silicon naphthalocyanine compounds wherein all the alkyl groups are the same and have 1-3 carbon atoms 失效
标题翻译：其中所有烷基相同且具有1-3个碳原子的双（三烷基甲硅烷氧基）硅萘酞菁化合物
公开(公告)号：US5428152A
公开(公告)日：1995-06-27
申请号：US74975
申请日：1993-06-10
申请人： Shigeru Hayashida , Seiji Tai
发明人： Shigeru Hayashida , Seiji Tai
IPC分类号： C07F7/04 , C07F7/08 , C09B47/04 , C09B47/073 , G03G5/06 , C07D209/56 , G03C1/72
CPC分类号： C09B47/045 , C07F7/045 , C07F7/0859 , C09B47/073 , G03G5/0696
摘要： Disclosed are naphthalocyanine compounds having siloxy groups bonded to a central metal silicon. The compounds can be used as a charge generating substance of an electrophotographic plate having high sensitivity to the longer wavelength light of about 800 nm without conducting a special treatment. The naphthalocyanine compounds are represented by the formula: ##STR1## wherein L is a group of the formula R.sub.1 R.sub.2 R.sub.3 SiO--, and R.sub.1, R.sub.2 and R.sub.3 are each a same alkyl group having 1-3 carbon atoms.
摘要翻译：公开了具有与中心金属硅键合的甲硅烷氧基的萘酞菁化合物。这些化合物可以用作对大约800nm的较长波长光具有高灵敏度的电子照相平板的电荷产生物质，而不进行特殊处理。萘酞菁化合物由下式表示：其中L是式R1R2R3SiO-基团，R1，R2和R3各自是具有1-3个碳原子的相同烷基。

94. 发明授权

US5409949A Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith 失效
标题翻译：亚甲基羟吲哚衍生物组合物和酪氨酸激酶抑制
公开(公告)号：US5409949A
公开(公告)日：1995-04-25
申请号：US987280
申请日：1993-03-12
申请人： Franco Buzzetti , Antonio Longo , Maristella Colombo
发明人： Franco Buzzetti , Antonio Longo , Maristella Colombo
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61P9/00 , A61P9/08 , A61P9/10 , A61P35/00 , A61P43/00 , C07D209/04 , C07D209/34 , C07D209/56 , C07D487/08 , C07D401/06
CPC分类号： C07D209/34
摘要： The invention provides new methylen-indole derivatives of formula (I) ##STR1## wherein R is a group ##STR2## in which R.sub.4 is hydrogen, hydroxy, C.sub.1 -C.sub.6 alkoxy, C.sub.2 -C.sub.6 alkanoyloxy, carboxy, nitro or NHR.sub.7, wherein R.sub.7 is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.5 is hydrogen, C.sub.1 -C.sub.6 alkyl or halogen; andR.sub.6 is hydrogen or C.sub.1 -C.sub.6 alkyl;n is zero, 1 or 2;R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl;R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen, cyano, carboxyl, nitro or --NHR.sub.7 in which R.sub.7 is as defined above;R.sub.3 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; and the pharmaceutically acceptable salts thereof; and wherein, when, at the same time, R.sub.2 is hydrogen, C.sub.1 -C.sub.6 alkyl, halogen or cyano and R.sub.3 is hydrogen, R.sub.1 and n being as defined above, then at least one of R.sub.4, R.sub.5 and R.sub.6 is other than hydrogen, which are useful as tyrosine kinase inhibitors.
摘要翻译： PCT No.PCT / EP92 / 01569 Sec。 371日期1993年3月12日 102（e）1993年3月12日PCT PCT 1991年7月10日PCT公布。公开号WO93 / 01182 日本公开日1993年1月21日。本发明提供式（I）的新的亚甲基 - 吲哚衍生物其中R是一个基团，其中R 4是氢，羟基，C 1 -C 6烷氧基，C 2 -C 6 烷酰氧基，羧基，硝基或NHR7，其中R7是氢或C1-C6烷基; R5是氢，C1-C6烷基或卤素; 并且R 6是氢或C 1 -C 6烷基; n为零，1或2; R1是氢，C1-C6烷基或C2-C6烷酰基; R2是氢，C1-C6烷基，卤素，氰基，羧基，硝基或-NHR7，其中R7如上定义; R3是氢，C1-C6烷基或C2-C6烷酰基; 及其药学上可接受的盐; 并且其中当R2同时为氢时，C1-C6烷基，卤素或氰基，R3为氢，R1和n定义如上，则R4，R5和R6中的至少一个不是氢，其可用作酪氨酸激酶抑制剂。

95. 发明授权

US5366890A Hapalosiphon hibernicus 失效
公开(公告)号：US5366890A
公开(公告)日：1994-11-22
申请号：US135931
申请日：1993-10-13
申请人： Roseanne Bonjouklian , Richard E. Moore , Gregory M. L. Patterson , Tim A. Smitka
发明人： Roseanne Bonjouklian , Richard E. Moore , Gregory M. L. Patterson , Tim A. Smitka
IPC分类号： A61K31/40 , A01N43/38 , A01N43/90 , A61K31/403 , A61P31/04 , A61P35/00 , C07D209/56 , C07D209/70 , C07D209/80 , C07D491/06 , C07D491/08 , C12N1/12 , C12P17/08 , C12P17/10 , C12P17/18 , C12R1/89 , C12N1/20
CPC分类号： C07D209/56 , A01N43/38 , A01N43/90 , C07D209/80 , C07D491/06 , C12N1/12 , C12P17/10 , C12P17/18 , Y10S435/822 , Y10S435/946
摘要： New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.
摘要翻译：称为A89271A-F和I的新的hapalindole型生物碱是抗真菌剂和抗肿瘤剂。提供了通过培养蓝绿藻Fischerella ambigua ATCC 55210制备它们和制备hapalindoles G和H的方法。还提供了通过培养蓝绿藻Hapalosiphon hibernicus ATCC 55225和这种藻类的生物学纯培养物来制备A89271因子B和F的方法。还提供了抑制真菌生长和易感性肿瘤治疗的方法和组合物。

96. 发明授权

US5318966A Method of inhibiting aretylcholine esterase using 2,3,3a,4,5,9b-hexahydro-1H-benzo[e]indole derivatives 失效
标题翻译：使用2,3,3a，4,5,9b-六氢-1H-苯并[e]吲哚衍生物抑制鸟苷酸酯酶的方法
公开(公告)号：US5318966A
公开(公告)日：1994-06-07
申请号：US93412
申请日：1993-07-16
申请人： Hans Bruderer , Thierry Godel , Rene Imhof , Roland Jakob-Roetne
发明人： Hans Bruderer , Thierry Godel , Rene Imhof , Roland Jakob-Roetne
IPC分类号： A61K31/40 , A61K20060101 , A61K31/403 , A61K31/405 , A61K31/435 , A61K31/4427 , A61K31/445 , A61K31/535 , A61P25/28 , C07D20060101 , C07D209/00 , C07D209/04 , C07D209/08 , C07D209/56 , C07D209/60 , C07D209/90 , C07D401/04 , C07D401/06 , C07D403/06 , C07D413/04 , C07D413/06
CPC分类号： C07D209/60
摘要： The invention relates to cis-2,3,3a,4,5,9b-Hexahydro-1H-benzo[b]indole derivatives of the formula ##STR1## wherein R.sup.1 is a residue of the formula --O--CO--NR.sup.4 R.sup.5, R.sup.2 is lower alkyl, lower cycloalkyl or lower alkyl substituted by lower cycloalkyl, aryl, aroyl, aroylamino, amino or by a cyclic amino, amide or imide group, R.sup.3 is hydrogen or lower alkyl, R.sup.4 is lower alkyl and R.sup.5 is hydrogen or lower alkyl,the corresponding trans isomers or cis-trans isomeric mixtures and pharmaceutically acceptable salts thereof. These compounds and salts are especially suitable for the treatment or prophylaxis of cognitive disorders and senile dementia particularly, Alzheimer's disease, and for the improvement of memory capacity.
摘要翻译：本发明涉及式a--CO-NR4R5的顺式-2,3,3a，4,5,9b-六氢-1H-苯并[b]吲哚衍生物，R2是低级烷基，低级环烷基或低级烷基取代的芳基，芳酰基，芳酰基氨基，氨基或环状氨基，酰胺或酰亚胺基，R3是氢或低级烷基，R4是低级烷基，R5是氢或低级烷基，相应的反式异构体或顺反异构体其混合物和药学上可接受的盐。这些化合物和盐特别适用于治疗或预防认知障碍和老年性痴呆，特别是阿尔茨海默氏病，以及改善记忆能力。

97. 发明授权

US5250563A Inhibitors of HIV protease 失效
标题翻译： HIV蛋白酶抑制剂
公开(公告)号：US5250563A
公开(公告)日：1993-10-05
申请号：US951927
申请日：1992-09-25
申请人： Shieh-Shung T. Chen , George A. Doss , Russell B. Lingham
发明人： Shieh-Shung T. Chen , George A. Doss , Russell B. Lingham
IPC分类号： C07D209/54 , A61K31/40 , C07D209/56
CPC分类号： C07D209/54
摘要： Novel cytochalasins are the biotransformed products after incubation with a substrate in a culture of the microorganism Kibdelosporangium sp. (Merck Culture Collection MA 6559), ATCC No. 53771. The compounds of the present invention inhibit HIV protease and are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as a compound, pharmaceutically acceptable salt, pharmaceutical composition ingredient, whether or not as a prodrug or as a combination with other antivirals, anti-infectives, immunomodulators, antibiotics or vaccines.
摘要翻译：新型细胞松弛素是在微生物克氏弧菌培养物中与底物孵育后的生物转化产物。（Merck Culture Collection MA 6559），ATCC编号53771.本发明的化合物抑制HIV蛋白酶，可用于预防或治疗HIV的感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合成分，无论作为前药还是作为其他抗病毒药，抗感染剂，免疫调节剂，抗生素或疫苗的组合。

98. 发明授权

US5100891A Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds 失效
标题翻译：取代的1,2,3,4-四氢环戊二烯并[b]吲哚，1,2,3,3a，4,8a-六氢环戊二烯并[B]吲哚和相关化合物
公开(公告)号：US5100891A
公开(公告)日：1992-03-31
申请号：US642952
申请日：1991-01-18
申请人： Helen H. Ong , Gerard J. O'Malley , Michael C. Merriman , Mark G. Palermo
发明人： Helen H. Ong , Gerard J. O'Malley , Michael C. Merriman , Mark G. Palermo
IPC分类号： A61K31/40 , A61K31/403 , A61K31/405 , A61P25/24 , A61P25/26 , A61P25/28 , C07D207/04 , C07D209/04 , C07D209/56 , C07D209/58 , C07D209/70 , C07D209/80 , C07D209/82 , C07D209/88 , C07D209/94 , C07D211/06 , C07D241/04 , C07D265/30
CPC分类号： C07D209/80
摘要： There are disclosed various compounds of the formula below, ##STR1## where n, X and R.sub.1 through R.sub.4 are as defined in the specification, which are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.Compound of this invention also inhibit monoamine oxidase and/or act at central .alpha..sub.2 -adrenergic receptors, and hence are useful as antidepressants.

99. 发明授权

US5043456A 6-oxa and thiabicyclo [3.1.0.] compounds 失效
标题翻译： 6-氧杂和硫杂双环[3.1.0。]化合物
公开(公告)号：US5043456A
公开(公告)日：1991-08-27
申请号：US516141
申请日：1990-04-27
申请人： Mitsuaki Ohtani , Fumihiko Watanabe , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
发明人： Mitsuaki Ohtani , Fumihiko Watanabe , Susumu Kamata , Nobuhiro Haga , Tatsuo Tsuri , Tadahiko Tsushima , Kenji Kawada
IPC分类号： C07D493/08 , A61K31/00 , A61K31/335 , A61K31/336 , A61K31/34 , A61K31/557 , A61P7/02 , A61P9/08 , A61P11/08 , C07C20060101 , C07C67/00 , C07C301/00 , C07C311/00 , C07C311/02 , C07C311/07 , C07C311/10 , C07C311/13 , C07C311/15 , C07C311/20 , C07C311/37 , C07C313/00 , C07C323/52 , C07D209/52 , C07D209/56 , C07D213/34 , C07D213/71 , C07D221/22 , C07D303/40 , C07D303/46 , C07D331/02 , C07D491/044 , C07D493/04 , C07D495/04
CPC分类号： C07D493/08 , C07D213/34 , Y02P20/55
摘要： There are provided compounds of the formula: ##STR1## wherein R.sub.1 is a hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 is an C.sub.1 -C.sub.10 alkyl, aryl, aralkyl, or pyridyl, where the aryl, aralkyl, or pyridyl are unsubstituted or are substituted by C.sub.1 -C.sub.5 alkyl, C.sub.1 -C.sub.5 alkoxy, nitro, hydroxy, carboxy, amino, C.sub.1 -C.sub.5 alkylamino, C.sub.1 -C.sub.5 dialkyamino whose two alkyl groups may be different from each other, C.sub.2 -C.sub.3 alkanoylamino, or halogen and X is an C.sub.1 -C.sub.7 alkylene, C.sub.2 -C.sub.7 alkenylene, --CH(F)CH.dbd.CH(CH.sub.2).sub.3 --, --(CH.sub.2).sub.3 --S--(CH.sub.2).sub.2 --, --(CH.sub.2).sub.2 --S--(CH.sub.2).sub.3 --, --C.sub.6 H.sub.4 -O--CH.sub.2 -- or --CH.sub.2 CH.dbd.CH--m--C.sub.6 H.sub.4 --, or their pharmaceutically accepatble salts. The compounds are useful as antithrombotic, anti-vasconstricting and anti-bronchoconstricting drugs.

100. 发明授权

US4985454A Process for the preparation of optically-active carbazole derivatives, new R- and S-carbazole derivatives and pharmaceutical compositions containing these compounds 失效
标题翻译：用于制备光学活性咔唑衍生物，新型R-和S-咔唑衍生物的方法和含有这些化合物的药物组合物
公开(公告)号：US4985454A
公开(公告)日：1991-01-15
申请号：US299750
申请日：1989-01-19
申请人： Herbert Leinert
发明人： Herbert Leinert
IPC分类号： A61K31/40 , A61K31/403 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/08 , A61P9/12 , A61P25/02 , C07C29/09 , C07D209/56 , C07D209/88 , C07D303/08 , C07D303/12 , C07D303/14 , C07D303/16 , C07D317/20 , C07D401/12 , C07D405/12 , C07D491/056
CPC分类号： C07D405/12 , C07C309/00 , C07D209/88 , C07D303/14 , C07D303/16 , C07D317/20 , Y10S514/913 , Y10S514/929
摘要： A process for the preparation of S- or R-carbazole derivatives of the general formula: ##STR1## in which R is an unsubstituted or substituted amino radical and pharmacologically acceptable salts, by either reacting R-(-)-epichlorohydrin (for the S-carbazole derivative); or reacting an S-epoxide derivative of the general formula: ##STR2## in which R.sub.1 is the residue of a substituted sulphonic acid derivative (for the R-carbazole derivative); with 4-hydroxycarbazole and then with ammonia or a substituted amine of the general formula RH, and recovering the compound or converting it to a pharmacologically acceptable salt.The new R-(+)- and S(-)-carbazole derivatives provided by the inventive process have unexpected beta blocking and vasodilatory properties and are useful in pharmaceutical compositions. R-(+)-carbazole derivatives are also useful for the treatment of glaucoma.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式