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1. 发明授权

US07994357B2 Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase 有权
标题翻译：用于抑制组蛋白脱乙酰酶的Cinamic化合物及其衍生物
公开(公告)号：US07994357B2
公开(公告)日：2011-08-09
申请号：US12418373
申请日：2009-04-03
申请人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
发明人： Chung-Yang Huang , Chia-Nan Chen , Wei-Jan Huang , Chia-Wei Lin , Jing-Shi Huang , Li-Ling Chi , Ai-Ling Chen , Chi-Yun Lee , Yu-Chen Huang
IPC分类号： C07C303/00 , C07C313/00 , C07C259/04 , C07D307/00
CPC分类号： A61K31/16 , A61K31/192 , A61K31/343 , C07C69/734 , C07C235/38 , C07C259/06 , C07D307/86 , C07D311/16 , C07D493/04
摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-cancer, anti-diabetic, and anti-neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, Spinocerebellar Ataxias (SCA), and human spinal muscular atrophy (SMA).
摘要翻译：本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。特别地，本发明的化合物可以用作抗癌，抗糖尿病和抗神经变性疾病如阿尔茨海默病，亨廷顿氏病，脊髓小脑性共济失调（SCA）和人脊髓性肌萎缩（SMA）的药物。。

2. 发明授权

US07732633B2 Arylsulfinate salts in photoinitiator systems for polymerization reactions 有权
标题翻译：用于聚合反应的光引发剂体系中的芳基亚磺酸盐
公开(公告)号：US07732633B2
公开(公告)日：2010-06-08
申请号：US12428634
申请日：2009-04-23
申请人： Rajdeep S. Kalgutkar , Michael C. Palazzotto
发明人： Rajdeep S. Kalgutkar , Michael C. Palazzotto
IPC分类号： C07C313/00
CPC分类号： A61K6/083 , A61K6/0017 , A61K6/0023 , A61K6/0052 , B33Y70/00 , C07C313/02 , C08F2/50 , G03F7/029 , C08L33/04
摘要： Compositions are provided that include an electron donor and a sensitizing compound. More specifically, the electron donor is an arylsulfinate salt. Methods of polymerization are also provided that can be used to prepare polymeric material from a photopolymerizable composition that includes ethylenically unsaturated monomers and a photoinitiator system. The photoinitiator system includes an electron donor and a sensitizing compound.
摘要翻译：提供了包括电子给体和敏化化合物的组合物。更具体地，电子给体是芳基亚磺酸盐。还提供聚合方法，其可用于由包含烯属不饱和单体和光引发剂体系的可光聚合组合物制备聚合物材料。光引发剂体系包括电子给体和增感化合物。

3. 发明授权

US07250446B2 Mercaptophenyl naphthyl methane compounds and synthesis thereof 有权
标题翻译：甲基邻苯基萘甲烷化合物及其合成
公开(公告)号：US07250446B2
公开(公告)日：2007-07-31
申请号：US10809845
申请日：2004-03-26
申请人： Sangita , Atul Kumar , Man Mohan Singh , Girish Kumar Jain , Puvvada Sri Ramanchandra Murthy , Suprabhat Ray
发明人： Sangita , Atul Kumar , Man Mohan Singh , Girish Kumar Jain , Puvvada Sri Ramanchandra Murthy , Suprabhat Ray
IPC分类号： A61K31/18 , C07C313/00 , C07C315/00
CPC分类号： C07D295/088 , C07C317/22 , C07C317/24 , C07C323/19 , C07C323/22 , C07C323/25
摘要： Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications associated with estrogen dependent diseases or syndromes related to osteoporosis, bone loss, bone formation, cardiovascular disorders, neurodegenerative disorders, menopausal disorders, physiological disorders, diabetes disorders, prostatic carcinoma, cancer of breast, cancer of uterus, cancer of the cervix and cancer of the colon, threatened or habitual abortion, obesity, ovarian development or function, post-partum lactation and depression.
摘要翻译：新的巯基苯基萘基甲烷化合物，其药学上可接受的盐和组合物可用于预防或治疗与与雌激素依赖性疾病或与骨质疏松症，骨丢失，骨形成，心血管疾病，神经变性疾病，绝经障碍相关的综合征相关的各种医学适应症，生理障碍，糖尿病，前列腺癌，乳腺癌，子宫癌，宫颈癌和结肠癌，威胁或习惯性流产，肥胖，卵巢发育或功能，产后泌乳和抑郁症。

4. 发明授权

US07145035B2 Methods of ortho alkylation 失效
标题翻译：邻位烷基化方法
公开(公告)号：US07145035B2
公开(公告)日：2006-12-05
申请号：US10468637
申请日：2002-03-14
申请人： Gary David Annis , Richard James Brown , Albert Loren Casalnuovo , Stephen Ernest Jacobson , Philip Osborne Moss
发明人： Gary David Annis , Richard James Brown , Albert Loren Casalnuovo , Stephen Ernest Jacobson , Philip Osborne Moss
IPC分类号： C07C313/00 , C07D211/72
CPC分类号： C07D213/73 , C07C67/297 , C07C68/06 , C07C209/68 , C07C211/52 , C07C213/08 , C07C227/16 , C07C231/12 , C07C231/14 , C07C233/25 , C07C317/28 , C07C319/14 , C07C323/29 , C07C381/10 , C07D213/64 , C07D213/68 , C07D213/75 , C07D213/76 , C07C69/017 , C07C69/24 , C07C69/96 , C07C233/15 , C07C69/63 , C07C69/157 , C07C69/16
摘要： The present invention pertains to methods for preparing a compound of Formula (I), wherein A is O or N-L; each L is independently H or an acyl group; K is, together with the two contiguous linking carbon atoms, a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system wherein each ring or ring system is optionally substituted; R1 is H, C1 to C4 alkyl or CO2R3; R2 is H or C1 to C4 alkyl; and R3 is C1 to C4 alkyl; comprising hydrogenating a compound of Formula (II), wherein n is 0, 1 or 2 in the presence of a catalyst comprising palladium to form the compound of Formula (I). This invention further pertains to methods for preparing compounds of Formula (II) useful for preparing compounds of Formula (I). This invention also pertains to compounds used in these methods
摘要翻译：本发明涉及制备式（I）化合物的方法，其中A为O或N-L; 每个L独立地是H或酰基; K与两个相邻的连接碳原子连同苯环，5或6元杂芳环或芳族8,9-或10元稠合的碳双环或杂双环系统，其中每个环或环系是任选取代; R 1是H，C 1至C 4烷基或CO 2 R 3 O 3 >; R 2是H或C 1至C 4烷基; 且R 3是C 1至C 4烷基的C 1至C 4。包括在包含钯的催化剂存在下氢化式（II）化合物，其中n为0,1或2，以形成式（I）化合物。本发明还涉及制备可用于制备式（I）化合物的式（II）化合物的方法。本发明还涉及用于这些方法的化合物

5. 发明授权

US07009077B2 Aromatic sulfonation reactions 失效
标题翻译：芳香磺化反应
公开(公告)号：US07009077B2
公开(公告)日：2006-03-07
申请号：US10398531
申请日：2001-10-05
申请人： Martyn John Earle , Suhas Prabhakar Katdare
发明人： Martyn John Earle , Suhas Prabhakar Katdare
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C313/00
CPC分类号： C07C303/10 , C07C303/06 , C07C303/08 , C07C303/32 , C07C309/39 , C07C309/86 , C07C309/30 , C07C309/29
摘要： A process for the sulfonation of an aromatic compound wherein the aromatic compound and sulfonating agent are admixed in the presence of an ionic liquid is described. The method for the sulfonation of aromatic compounds in (e.g. water stable) ionic liquids offers advantages over conventional sulfonation reactions. These are that no by-products form, the ionic liquid is not consumed, and the sulfonating agent (e.g. SO3) is relatively inexpensive.
摘要翻译：描述了芳族化合物磺化的方法，其中芳族化合物和磺化剂在离子液体存在下混合。芳族化合物在（例如水稳定）离子液体中磺化的方法提供了优于常规磺化反应的优点。这些是没有副产物形式，离子液体不被消耗，并且磺化剂（例如SO 3 3）相对便宜。

6. 发明申请

US20020128383A1 COMBINATORIAL ACTIVE COMPOUND SYNTHESIS AND ITS INTERMEDIATES 无效
标题翻译：组合活性化合物合成及其中间体
公开(公告)号：US20020128383A1
公开(公告)日：2002-09-12
申请号：US08948557
申请日：1997-10-10
发明人： KLAUS HAAF , LOTHAR WILLMS
IPC分类号： C08F008/36 , C07C313/00
CPC分类号： C07C303/40 , C40B40/00 , C07C311/51
摘要： The invention relates to a resin-bound synthesis process for the preparation of chemical compounds of the formula (I)R1nullSO2nullNHnullCOnullR2nullnull(I)in which R1 and R2 each are an organic radical, which comprises a) reacting a resin-linker compound of the formula nullresin polymernull-nullL-Nucnulln (II) in which nucleofugic groups Nuc are bonded to a resin nullnullresin polymernull via the linker L, with an acylsulfonamide of the formula E1nullSO2nullNHnullCOnullE2 (III) in which E1 and E2 independently of one another in each case are an organic radical suitable for the preparation of the radicals R1 and R2 in compound (I), in the presence of a condensing agent to give a resin-bound adduct of the formula (IV) 1 in which nullresin polymernull, L, n, E1 and E2 are as defined in formula (II) or formula (III), b) derivatizing the adduct (IV) obtained in one or more further reaction steps on the organic radicals E1 or E2 to give the radicals R1 or R2, and c) cleaving the compound of the formula (I) from the resin-linker adduct of the formula (IVnull) obtained.
摘要翻译：本发明涉及一种用于制备式（I）的化合物的树脂结合合成方法，该方法涉及式（I）的化合物，其中式（I）

7. 发明授权

US5527824A Substituted Di-T-Butlyphenols useful for inhibiting leukotriene synthesis 失效
标题翻译：用于抑制白三烯合成的取代的二叔丁基酚
公开(公告)号：US5527824A
公开(公告)日：1996-06-18
申请号：US437143
申请日：1995-05-05
申请人： Robert A. Scherrer
发明人： Robert A. Scherrer
IPC分类号： C07C229/52 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/41 , A61P11/00 , A61P17/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C215/76 , C07C227/00 , C07C229/42 , C07C229/44 , C07C229/54 , C07C229/60 , C07C229/64 , C07C237/34 , C07C237/36 , C07C237/44 , C07C241/00 , C07C251/22 , C07C251/24 , C07C253/00 , C07C255/59 , C07C311/02 , C07C311/03 , C07C313/00 , C07C323/57 , C07C323/63 , C07D257/04 , C07D257/06
CPC分类号： C07D257/04 , C07C255/00
摘要： Substituted Di-T-Butylphenols useful for inhibiting the synthesis of leukotrienes are disclosed.
摘要翻译：公开了用于抑制白细胞三烯合成的取代的二叔丁基酚。

8. 发明授权

US5498745A Substituted di-t-butylphenols 失效
公开(公告)号：US5498745A
公开(公告)日：1996-03-12
申请号：US435582
申请日：1995-05-05
申请人： Robert A. Scherrer
发明人： Robert A. Scherrer
IPC分类号： C07C229/52 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/41 , A61P11/00 , A61P17/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C215/76 , C07C227/00 , C07C229/42 , C07C229/44 , C07C229/54 , C07C229/60 , C07C229/64 , C07C237/34 , C07C237/36 , C07C237/44 , C07C241/00 , C07C251/22 , C07C251/24 , C07C253/00 , C07C255/59 , C07C311/02 , C07C311/03 , C07C313/00 , C07C323/57 , C07C323/63 , C07D257/04 , C07D257/06 , C07C255/42
CPC分类号： C07D257/04 , C07C255/00
摘要： Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.

9. 发明授权

US5431900A Ester-substituted diaminedithiols and radiolabeled complexes thereof 失效
标题翻译：酯取代的二硫代二醇及其放射性标记的复合物
公开(公告)号：US5431900A
公开(公告)日：1995-07-11
申请号：US139894
申请日：1993-10-20
申请人： Paul L. Bergstein , Edward H. Cheesman , Alan D. Watson
发明人： Paul L. Bergstein , Edward H. Cheesman , Alan D. Watson
IPC分类号： A61K51/00 , A61K51/04 , C07B59/00 , C07C67/00 , C07C313/00 , C07C323/25 , C07C323/34 , C07C323/58 , C07C323/62 , C07D521/00 , C07F11/00 , C07F13/00 , C07F15/00 , C07C321/00
CPC分类号： C07F13/005 , A61K51/04 , A61K2123/00
摘要： Radiopharmaceuticals consisting essentially of a lipophilic, charge neutral radionuclide complex of a diaminedithiol ligand having 1-4 ester groups of the formula --A--COOR where A is a straight or branched chain alkylene of 0-10 carbon atoms and R is an alkyl group of 1-10 carbon atoms are useful in radioimaging brain perfusion in primates. Ester-substituted diaminedithiols in sterile, pharmaceutically acceptable form, and kits of the diaminedithiols and sterile, non-pyrogenic reducing agents for reducing preselected radionuclides are also provided. Technetium-99m is a preferred radionuclide.
摘要翻译：基本上由具有1-4个式-A-COOR的酯基的二硫代二醇配体的亲脂性电荷中性放射性核素复合物组成的放射性药物，其中A是0-10个碳原子的直链或支链亚烷基，R是 1-10个碳原子可用于放射性成像在灵长类动物中的脑灌注。还提供了无菌，药学上可接受的形式的酯取代的二硫代二醇和用于还原预选的放射性核素的二硫代二醇和无菌非致热原还原剂的试剂盒。锝-99m是优选的放射性核素。

10. 发明授权

US5416113A Substituted di-t-butylphenols 失效
标题翻译：取代的二叔丁基酚
公开(公告)号：US5416113A
公开(公告)日：1995-05-16
申请号：US263390
申请日：1994-06-22
申请人： Robert A. Scherrer
发明人： Robert A. Scherrer
IPC分类号： C07C229/52 , A61K31/18 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/235 , A61K31/24 , A61K31/41 , A61P11/00 , A61P17/00 , A61P37/08 , A61P43/00 , C07C67/00 , C07C215/76 , C07C227/00 , C07C229/42 , C07C229/44 , C07C229/54 , C07C229/60 , C07C229/64 , C07C237/34 , C07C237/36 , C07C237/44 , C07C241/00 , C07C251/22 , C07C251/24 , C07C253/00 , C07C255/59 , C07C311/02 , C07C311/03 , C07C313/00 , C07C323/57 , C07C323/63 , C07D257/04 , C07D257/06
CPC分类号： C07D257/04 , C07C255/00
摘要： Novel compounds which are 2,6-di-t-butylphenols substituted on the 4 position by an anilino group, which anilino group is substituted by a carboxyl substituent, a tetrazolyl substituent or an N-methyltetrazolyl substituent, are useful antiallergic agents. Pharmaceutical compositions containing and pharmacological methods of using such compounds are also disclosed, as are synthetic intermediates for preparing such compounds. Certain of the synthetic intermediates also exhibit useful antiallergic activity.
摘要翻译：通过苯胺基取代4位上的2,6-二叔丁基酚的新型化合物，其中苯胺基被羧基取代基取代，四唑基取代基或N-甲基四唑基取代基是有用的抗过敏剂。还公开了含有药物组合物和使用这些化合物的药理学方法，以及制备这些化合物的合成中间体。某些合成中间体也表现出有用的抗过敏活性。

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