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11. 发明授权

US08620047B2 Viewing three dimensional digital slides 有权
标题翻译：查看三维数字幻灯片
公开(公告)号：US08620047B2
公开(公告)日：2013-12-31
申请号：US13482869
申请日：2012-05-29
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images (“3D digital slides”) are provided. An image library module provides access to the imagery data in a 3D digital slide and constructs 3D image objects that are coextensive with the 3D digital slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D digital slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像（“3D数字幻灯片”）中检索，操纵和查看3D图像对象的系统和方法。图像库模块提供对3D数字幻灯片中的图像数据的访问，并且构建与3D数字幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D数字幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

12. 发明授权

US08582849B2 Viewing digital slides 有权
标题翻译：查看数字幻灯片
公开(公告)号：US08582849B2
公开(公告)日：2013-11-12
申请号：US13184362
申请日：2011-07-15
申请人： Ole Eichhorn , Anne Brumme
发明人： Ole Eichhorn , Anne Brumme
IPC分类号： G06K9/00
CPC分类号： H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F17/241 , G06F17/30905 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.
摘要翻译：虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。客户端查看器以特定分辨率请求图像数据。图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。然后将图像数据发送到客户端查看器。在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。

13. 发明授权

US08565480B2 Creating and viewing three dimensional virtual slides 有权
公开(公告)号：US08565480B2
公开(公告)日：2013-10-22
申请号：US12979996
申请日：2010-12-28
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional digital slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. These two dimensional digital slide images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.

14. 发明授权

US08189891B2 Viewing three dimensional digital slides 有权
标题翻译：查看三维数字幻灯片
公开(公告)号：US08189891B2
公开(公告)日：2012-05-29
申请号：US12871676
申请日：2010-08-30
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images (“3D digital slides”) are provided. An image library module provides access to the imagery data in a 3D digital slide and constructs 3D image objects that are coextensive with the 3D digital slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D digital slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像（“3D数字幻灯片”）中检索，操纵和查看3D图像对象的系统和方法。图像库模块提供对3D数字幻灯片中的图像数据的访问，并且构建与3D数字幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D数字幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

15. 发明授权

US07689024B2 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US07689024B2
公开(公告)日：2010-03-30
申请号：US12330370
申请日：2008-12-08
申请人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Dirk Soenksen , Steven Hashagen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

16. 发明授权

US07602524B2 Image processing and analysis framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US07602524B2
公开(公告)日：2009-10-13
申请号：US11536985
申请日：2006-09-29
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06F15/00 , G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“virtual slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微镜数字图像（“虚拟幻灯片”）的系统和方法。该系统包括维护或访问多个图像处理和分析例程的算法服务器。算法服务器还可以访问多个虚拟幻灯片。算法服务器在识别的虚拟幻灯片上执行所选择的例程，并提供所得到的数据。虚拟幻灯片可以通过网络在本地或远程访问。类似地，图像处理例程可以从本地存储器或网络或两者获得。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程获得的例程中。图像处理和分析的访问可能会通过对进程或查看虚拟幻灯片的请求进行身份验证的监视进程来限制。图像限制的变化提供了访问级别丰富的多样性，允许共享虚拟幻灯片和图像处理算法的演示。

17. 发明申请

US20090028414A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
标题翻译：基于线性阵列的显微镜幻灯片扫描仪中的数据管理
公开(公告)号：US20090028414A1
公开(公告)日：2009-01-29
申请号：US12235479
申请日：2008-09-22
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.
摘要翻译：提供了用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速生成的超大图像数据的系统和方法。该系统接收，处理和存储由线性扫描仪产生的图像数据作为一系列重叠的图像条纹，并将数据组合成无缝和连续的基线图像。基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。该系统能够在扫描和捕获新的图像条纹时消除与存储未压缩图像条纹相关的开销的动态图像数据压缩。该系统还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。该系统有助于虚拟幻灯片在诸如远程医疗，远程病理学，显微镜教育等应用中的使用，以及对组织阵列等高价值标本的分析。

18. 发明授权

US07463761B2 Systems and methods for creating and viewing three dimensional virtual slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US07463761B2
公开(公告)日：2008-12-09
申请号：US11140265
申请日：2005-05-27
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

19. 发明申请

US20080065645A1 System and Method for Managing Images Over a Network 有权
标题翻译：通过网络管理图像的系统和方法
公开(公告)号：US20080065645A1
公开(公告)日：2008-03-13
申请号：US11770499
申请日：2007-06-28
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06F17/30
CPC分类号： G06F17/30277 , G06F17/30106 , G06F17/3028 , Y10S707/915 , Y10S707/966
摘要： Images created by one or more image acquisition devices are initially stored in remote data bases at one or more remote or satellite locations and copies of the images are subsequently transferred to a central server at a central storage location over a network and stored in a central data base. A common catalog listing local image files stored at the central data base and remote image files stored at one or more remote data bases is stored at the central location and is accessed by users to search for images. User requests for images associated with local image files result in transfer of the requested images by the central server to the user. User requests for images associated with remote image files are relayed by the central server to the associated remote location, and the requested images are then relayed to the user from the remote location via the central server.
摘要翻译：由一个或多个图像采集设备创建的图像最初存储在一个或多个远程或卫星位置的远程数据库中，并且图像的副本随后通过网络传输到中央存储位置的中央服务器并存储在中央数据基础。列出存储在中央数据库的本地图像文件和存储在一个或多个远程数据库中的远程图像文件的公共目录存储在中央位置，并被用户访问以搜索图像。对与本地图像文件相关联的图像的用户请求导致中央服务器向用户传送所请求的图像。对与远程图像文件相关联的图像的用户请求由中央服务器中继到相关联的远程位置，然后所请求的图像经由中央服务器从远程位置中继给用户。

20. 发明申请

US20070030529A1 Image Processing and Analysis Framework 有权
标题翻译：图像处理与分析框架
公开(公告)号：US20070030529A1
公开(公告)日：2007-02-08
申请号：US11536985
申请日：2006-09-29
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images (“virtual slides”) is provided. The system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of virtual slides. The algorithm server executes a selected routine on an identified virtual slide and provides the resulting data. The virtual slide can be accessed locally or remotely across a network. Similarly, the image processing routines can be obtained from local storage or across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely obtained routines. Access to image processing and analysis may be restricted through a monitor process that authenticates requests to process or view virtual slides. Variations in restrictions to images provide a rich diversity in access levels that allow sharing of virtual slides and demonstrations of image processing algorithms.
摘要翻译：提供了一种用于处理和分析虚拟显微镜数字图像（“虚拟幻灯片”）的系统和方法。该系统包括维护或访问多个图像处理和分析例程的算法服务器。算法服务器还可以访问多个虚拟幻灯片。算法服务器在识别的虚拟幻灯片上执行所选择的例程，并提供所得到的数据。虚拟幻灯片可以通过网络在本地或远程访问。类似地，图像处理例程可以从本地存储器或网络或两者获得。有利地，某些公共子例程可以被本地存储以包含在其他本地或远程获得的例程中。图像处理和分析的访问可能会通过对进程或查看虚拟幻灯片的请求进行身份验证的监视进程来限制。图像限制的变化提供了访问级别丰富的多样性，允许共享虚拟幻灯片和图像处理算法的演示。

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