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1. 发明授权

US08467083B2 Framework for processing the content of a digital image of a microscope sample 有权
标题翻译：用于处理显微镜样品的数字图像的内容的框架
公开(公告)号：US08467083B2
公开(公告)日：2013-06-18
申请号：US13494715
申请日：2012-06-12
申请人： Ole Eichhorn , Allen Olson
发明人： Ole Eichhorn , Allen Olson
IPC分类号： G06K15/00 , G06F3/12
CPC分类号： G06K9/46 , G06T1/00
摘要： A system and method for processing and analyzing virtual microscopy digital images. In an embodiment, identifications of one or more algorithms and one or more digital slide images are received over a network. In addition, one or more parameter data are received that constrain the execution of the algorithm(s) to defined sub-region(s) of the digital slide image(s). The digital slide image(s) are retrieved, and the identified algorithm(s) are executed to analyze the defined sub-region(s) of the digital slide image(s).
摘要翻译：一种用于处理和分析虚拟显微镜数字图像的系统和方法。在一个实施例中，通过网络接收一个或多个算法和一个或多个数字幻灯片图像的标识。另外，接收一个或多个参数数据，这些参数数据将算法的执行限制到数字幻灯片图像的定义的子区域。检索数字幻灯片图像，并且执行识别的算法来分析数字幻灯片图像的确定的子区域。

2. 发明申请

US20120275671A1 System and Method to Determine Slide Quality of a Digitized Microscope Slide 有权
标题翻译：确定数字化显微镜幻灯片幻灯片质量的系统和方法
公开(公告)号：US20120275671A1
公开(公告)日：2012-11-01
申请号：US13515073
申请日：2011-06-03
申请人： Ole Eichhorn , Cindy Perz
发明人： Ole Eichhorn , Cindy Perz
IPC分类号： G06K9/34
CPC分类号： G06K9/00127 , G06T7/0004 , G06T2207/10056 , G06T2207/20021 , G06T2207/30024 , G06T2207/30168 , H04N19/60 , H04N19/86
摘要： A system that determines the quality of a digital microscope slide by analyzing digital slide images based on complexity and spatial frequencies. An example embodiment detailed in the application may provide visual feedback on the whole slide quality by overlaying the image with a color coded “heat map” of local area quality. A user provided with the overlap image may obtain both an absolute quality measurement for the whole image and quickly identity the quality variability within the slide.
摘要翻译：通过基于复杂性和空间频率分析数字幻灯片图像来确定数字显微镜幻灯片的质量的系统。应用中详细描述的示例实施例可以通过用局部区域质量的颜色编码热图覆盖图像来提供关于整个幻灯片质量的视觉反馈。提供重叠图像的用户可以获得整个图像的绝对质量测量，并且快速识别幻灯片内的质量变异性。

3. 发明申请

US20120235994A1 Viewing Three Dimensional Digital Slides 有权
标题翻译：查看三维数字幻灯片
公开(公告)号：US20120235994A1
公开(公告)日：2012-09-20
申请号：US13482869
申请日：2012-05-29
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06T15/00
CPC分类号： G06T15/00 , G02B21/34 , G02B21/367 , G06T5/50 , G06T15/08 , G06T15/10 , G06T2207/20212 , G06T2207/20224 , G06T2207/30024 , G06T2207/30056
摘要： Systems and methods for retrieving, manipulating, and viewing 3D image objects from 3D virtual microscope slide images (“3D digital slides”) are provided. An image library module provides access to the imagery data in a 3D digital slide and constructs 3D image objects that are coextensive with the 3D digital slide or a 3D sub-portion thereof. From within the 3D image object, cross layer planar views spanning various depths of the 3D digital slide are constructed as well as 3D prisms and other shaped image areas. The image library module allows a 3D image object to be sliced into horizontal and vertical views, skewed cross layer views and regular and irregular shaped 3D image areas for viewing by a user.
摘要翻译：提供了从3D虚拟显微镜幻灯片图像（“3D数字幻灯片”）中检索，操纵和查看3D图像对象的系统和方法。图像库模块提供对3D数字幻灯片中的图像数据的访问，并且构建与3D数字幻灯片或其3D子部分共同延伸的3D图像对象。从3D图像对象中，构建跨越3D数字幻灯片的各种深度的跨层平面视图以及3D棱镜和其他形状图像区域。图像库模块允许3D图像对象被切割成水平和垂直视图，倾斜的交叉层视图和规则和不规则形状的3D图像区域以供用户观看。

4. 发明申请

US20120099769A1 STORING AND RETRIEVING LARGE IMAGES VIA DICOM 有权
标题翻译：通过DICOM存储和检索大图
公开(公告)号：US20120099769A1
公开(公告)日：2012-04-26
申请号：US13337882
申请日：2011-12-27
申请人： Ole Eichhorn
发明人： Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06F17/30244 , G06F17/3028 , G06F19/00 , G06F19/321 , G06T3/40 , G06T7/0012 , G06T7/30 , G06T2207/20021 , G06T2207/30004
摘要： Systems and methods that acquire digital slides and other large images and store these images into commercially available PACS systems using DICOM-standard messaging are provided. A digital slide or other large two-dimensional image is acquired and each separate resolution level of the digital slide or large image is divided into a series of regions that are each identified as a DICOM image. All of the regions at the same resolution in the digital slide or other large image are collectively identified as a DICOM series. A plurality of DICOM series, representing multiple resolution levels in a digital slide are collectively identified and stored as a DICOM study.
摘要翻译：提供了获取数字幻灯片和其他大图像并将这些图像存储到使用DICOM标准消息传递的市售PACS系统中的系统和方法。获取数字幻灯片或其他大的二维图像，并且将数字幻灯片或大图像的每个单独的分辨率级别划分为每个被识别为DICOM图像的一系列区域。数字幻灯片或其他大图像中相同分辨率的所有区域被统称为DICOM系列。在数字幻灯片中表示多个分辨率级别的多个DICOM系列被集体地识别并存储为DICOM研究。

5. 发明申请

US20120014576A1 Signal to Noise Ratio in Digital Pathology Image Analysis 有权
标题翻译：数字病理图像分析中的信噪比
公开(公告)号：US20120014576A1
公开(公告)日：2012-01-19
申请号：US13259562
申请日：2010-12-10
申请人： Allen Olson , Ole Eichhorn
发明人： Allen Olson , Ole Eichhorn
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06F19/00 , G06F19/321 , G06T2207/10056 , G06T2207/30024
摘要： A digital slide analysis system comprises an algorithm server that maintains or has access to a plurality of image processing and analysis routines. The algorithm server additionally has access to a plurality of digital slide images. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. Prior to the application of selected routine, the system employs a digital pre-processing module to create a metadata mask that reduces undesirable image data such that the image data processed by the selected routine has an improved signal to noise ratio. The pre-processing module uses a classifier that may be implemented as a pattern recognition module, for example. Undesirable image data is therefore excluded from the image data that is processed by the digital pathology image processing and analysis routine, which significantly improves the digital pathology image analysis.
摘要翻译：数字幻灯片分析系统包括维护或者可以访问多个图像处理和分析程序的算法服务器。算法服务器还可以访问多个数字幻灯片图像。算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。在应用所选程序之前，系统采用数字预处理模块来创建一个减少不需要的图像数据的元数据掩码，使得由所选程序处理的图像数据具有改善的信噪比。预处理模块使用例如可以被实现为模式识别模块的分类器。因此，不希望的图像数据被排除在由数字病理图像处理和分析程序处理的图像数据中，这显着地改善了数字病理图像分析。

6. 发明申请

US20110044518A1 Data Management in a Linear-Array-Based Microscope Slide Scanner 有权
公开(公告)号：US20110044518A1
公开(公告)日：2011-02-24
申请号：US12914356
申请日：2010-10-28
申请人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
发明人： Greg J. Crandall , Ole Eichhorn , Allen H. Olson , Dirk G. Soenksen
IPC分类号： G06K9/00
CPC分类号： G02B21/367 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/14 , G02B21/245 , G02B21/26 , G02B21/32 , G02B21/34 , G02B21/365 , G06F19/00 , H04N1/053 , H04N1/1903 , H04N1/193 , H04N1/19573 , H04N5/2256 , H04N5/23206 , H04N7/18 , H04N7/183 , H04N2201/04727 , H04N2201/04755
摘要： Systems and methods for processing, storing, and viewing extremely large imagery data rapidly produced by a linear-array-based microscope slide scanner are provided. The system receives, processes, and stores imagery data produced by the linear scanner as a series of overlapping image stripes and combines the data into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The system enables dynamic imagery data compression while scanning and capturing new image stripes that eliminates the overhead associated with storing uncompressed image stripes. The system also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The system facilitates the use of virtual slides in applications such as telemedicine, telepathology, microscopy education, and analysis of high value specimens like tissue arrays.

7. 发明授权

US07844125B2 Systems and methods for image pattern recognition 有权
标题翻译：图像模式识别的系统和方法
公开(公告)号：US07844125B2
公开(公告)日：2010-11-30
申请号：US12400981
申请日：2009-03-10
申请人： Ole Eichhorn , Dirk G. Soenksen
发明人： Ole Eichhorn , Dirk G. Soenksen
IPC分类号： G06K9/00 , G06K9/68
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (“TMAs”).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合的词汇相关联来实现图像的候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（“TMA”）。

8. 发明授权

US07738688B2 System and method for viewing virtual slides 有权
标题翻译：用于查看虚拟幻灯片的系统和方法
公开(公告)号：US07738688B2
公开(公告)日：2010-06-15
申请号：US10787773
申请日：2004-02-26
申请人： Ole Eichhorn , Anne Brumme
发明人： Ole Eichhorn , Anne Brumme
IPC分类号： G06K9/00
CPC分类号： H04L65/403 , G02B21/26 , G02B21/32 , G06F3/1454 , G06F17/241 , G06F17/30905 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.
摘要翻译：虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。客户端查看器以特定分辨率请求图像数据。图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。然后将图像数据发送到客户端查看器。在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。

9. 发明申请

US20090116733A1 Systems and Methods for Creating and Viewing Three Dimensional Virtual Slides 有权
标题翻译：用于创建和查看三维虚拟幻灯片的系统和方法
公开(公告)号：US20090116733A1
公开(公告)日：2009-05-07
申请号：US12330370
申请日：2008-12-08
申请人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
发明人： Ole Eichhorn , Greg Crandall , Steven Hashagen , Dirk Soenksen , Mark Wrenn
IPC分类号： G06K9/00
CPC分类号： G02B27/2278 , G02B21/367 , G06K9/00201 , H04N13/395
摘要： Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
摘要翻译：提供了用于创建和查看三维虚拟幻灯片的系统和方法。将一个或多个显微镜载片放置在图像采集装置中，扫描载玻片上的标本，并以中等或高分辨率制作二维图像。该二维图像被提供给图像查看工作站，在那里它们被操作者观看，该操作者平移和缩放二维图像并选择感兴趣的区域以在多个深度级别（Z平面）进行扫描。图像采集装置接收包括位置和深度的多个深度级扫描的一组参数。然后，图像获取装置在一系列Z平面图像中的位置处扫描样本，其中每个Z平面图像对应于深度参数内的样本的深度级部分。

10. 发明申请

US20070274603A1 Systems and Methods for Image Pattern Recognition 有权
标题翻译：图像模式识别系统与方法
公开(公告)号：US20070274603A1
公开(公告)日：2007-11-29
申请号：US11836713
申请日：2007-08-09
申请人： Ole Eichhorn , Dirk Soenksen
发明人： Ole Eichhorn , Dirk Soenksen
IPC分类号： G06K9/36
CPC分类号： G06K9/6218 , G06K9/00147 , G06T9/008 , G06T9/40 , H04N19/94 , H04N19/96
摘要： Systems and methods for image pattern recognition comprise digital image capture and encoding using vector quantization (“VQ”) of the image. A vocabulary of vectors is built by segmenting images into kernels and creating vectors corresponding to each kernel. Images are encoded by creating a vector index file having indices that point to the vectors stored in the vocabulary. The vector index file can be used to reconstruct an image by looking up vectors stored in the vocabulary. Pattern recognition of candidate regions of images can be accomplished by correlating image vectors to a pre-trained vocabulary of vector sets comprising vectors that correlate with particular image characteristics. In virtual microscopy, the systems and methods are suitable for rare-event finding, such as detection of micrometastasis clusters, tissue identification, such as locating regions of analysis for immunohistochemical assays, and rapid screening of tissue samples, such as histology sections arranged as tissue microarrays (TMAs).
摘要翻译：用于图像模式识别的系统和方法包括使用图像的矢量量化（“VQ”）的数字图像捕获和编码。通过将图像分割为内核并创建与每个内核相对应的向量来构建向量的词汇表。通过创建具有指向存储在词汇表中的向量的索引的向量索引文件对图像进行编码。向量索引文件可用于通过查找存储在词汇表中的向量来重建图像。可以通过将图像向量与包括与特定图像特征相关的向量的预先训练的矢量集合词汇相关联来实现图像候选区域的模式识别。在虚拟显微镜中，系统和方法适用于罕见事件发现，例如检测微转移簇，组织鉴定，例如免疫组织化学测定的分析区域以及组织样品的快速筛选，例如排列成组织的组织切片微阵列（TMA）。

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