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1. 发明申请

US20190219808A1 OBSERVATION DEVICE 审中-公开
公开(公告)号：US20190219808A1
公开(公告)日：2019-07-18
申请号：US16366214
申请日：2019-03-27
申请人： OLYMPUS CORPORATION
发明人： Shintaro TAKAHASHI , Shinichi TAKIMOTO , Yohei TANIKAWA , Akira MATSUSHITA , Masaru MIZUNAKA , Tsuyoshi MOCHIZUKI
IPC分类号： G02B21/08 , G02B21/36 , G02B21/33
CPC分类号： G02B21/086 , C12M1/34 , G01N21/17 , G02B21/06 , G02B21/26 , G02B21/33 , G02B21/36 , G02B21/361 , G02B21/367
摘要： An observation device includes: a housing having, in a top surface, a glass window on which a vessel accommodating samples is placed and through which illumination light is transmitted; and an image acquisition unit accommodated in the housing and configured to capture transmitted light obtained after illumination light is transmitted through the samples from above, is transmitted through the glass window, and enters the housing.

2. 发明申请

US20190187453A1 DEVICE AND METHOD FOR OBSERVING A SAMPLE WITH A CHROMATIC OPTICAL SYSTEM 审中-公开
公开(公告)号：US20190187453A1
公开(公告)日：2019-06-20
申请号：US16223511
申请日：2018-12-18
申请人： Commissariat a l'energie atomique et aux energies alternatives
发明人： Ondrej Mandula , Cedric Allier
IPC分类号： G02B21/36 , G02B21/16 , G02B21/06 , G01N21/64 , G06K9/00
CPC分类号： G02B21/367 , G01N21/4788 , G01N21/6458 , G01N21/6486 , G01N2021/6491 , G02B21/06 , G02B21/16 , G03H1/0443 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0452 , G06K9/00127
摘要： The invention relates to a method for observing a fluorescent sample (10), lying in a plane (P10), called the sample plane, the sample comprising a fluorescent agent (10f) able to emit a fluorescence light wave (Δf), in a fluorescence spectral band (Δλf), when it is illuminated by an excitation light wave (Δe), in an excitation spectral band (Δλe), the method comprising the following steps: a) illuminating the sample (10) using a first light source (11), in a first illumination spectral band (Δλ1), in the excitation spectral band (Δλe0, and acquiring a first image (I1) of the sample, in the fluorescence spectral band, using an image sensor (30); b) illuminating the sample (10) using a second light source (12), in a second spectral band (Δλ2), outside of the fluorescence spectral band, and acquiring a second image (I2) of the sample, in the second apectral band, using the image sensor; the image sensor (30) being coupled to an optical system (20) such that: in the fluorescence spectral band (αλf), the object focal plane (P1) of the optical system is coincident with the plane (P10) of the sample; in the second spectral band, the object focal plane (P2) of the optical system is offset with respect to the plane (P10) of the sample, the offset being larger than 20 μm.

3. 发明申请

US20190187161A1 Methods for Visualization and Quantification of Fiber-Like Structures 审中-公开
公开(公告)号：US20190187161A1
公开(公告)日：2019-06-20
申请号：US16301086
申请日：2017-05-24
申请人： Karl A. Deisseroth , Li Ye , Jennifer McNab , Qiyuan Tian
发明人： Karl A. Deisseroth , Li Ye , Jennifer McNab , Qiyuan Tian
IPC分类号： G01N33/92 , G06T7/13 , G02B21/36 , A61B5/00
CPC分类号： G01N33/92 , A61B5/0042 , A61B5/0059 , G01N33/48 , G02B21/367 , G06T7/13 , G06T2207/30016
摘要： Aspects of the present disclosure include a method for visualizing a fiber-like structure in a biological specimen, the method comprising: clearing the biological specimen comprising a fiber-like structure, wherein the fiber-like structure is detectably labeled; illuminating the cleared biological specimen with two light sheets from a first side and a second side to produce an image volume, wherein the second side is opposite to the first side and wherein the image volume comprises a representation of the fiber-like structure; defining a plurality of voxels within the representation of the fiber-like structure; processing each of the plurality of voxels to estimate a plurality of principal fiber-like structure orientations; and defining a starting point on the representation of the fiber-like structure and propagating a plurality of stream-lines from the starting point, according to the plurality of principal fiber-like structure

4. 发明申请

US20190174079A1 Circular Scanning Technique For Large Area Imaging 审中-公开
公开(公告)号：US20190174079A1
公开(公告)日：2019-06-06
申请号：US16322296
申请日：2017-09-19
申请人： Massachusetts Institute of Technology
发明人： Brian W. ANTHONY , Xian DU
IPC分类号： H04N5/341 , H04N3/30 , H04N5/349
CPC分类号： H04N5/3415 , G02B21/367 , G02B27/58 , G06T3/4053 , G06T2207/10056 , H04N3/30 , H04N5/349
摘要： A system for generating an image of a region of interest (ROI) of a target object, the system including a camera, a target stage configured to receive the target object, the target stage configured to provide a translational movement and a rotational movement of the target object, and a controller. The controller is configured to control the camera and target stage to iteratively shift the target along scan trajectories of sample locations to capture images of each of a plurality of concentric rings and sub-rings of a predefined radial pitch over the ROI, the sample locations represented by polar coordinates defining sectors of each of the sub-rings. The controller is further configured to extract super resolution (SR) pixels from the images to reconstruct an SR image of each of the rings in the polar coordinates, and project the SR images into Cartesian coordinate images.

5. 发明申请

US20190129156A1 METHOD AND MICROSCOPE FOR EXAMINING A SAMPLE 审中-公开
公开(公告)号：US20190129156A1
公开(公告)日：2019-05-02
申请号：US16091522
申请日：2017-04-07
申请人： Leica Microsystems CMS GmbH
发明人： Werner Knebel , Florian Fahrbach
IPC分类号： G02B21/16 , G02B21/00
CPC分类号： G02B21/16 , G02B21/0032 , G02B21/0036 , G02B21/367
摘要： The invention relates to a method for examining a sample. The method is distinguished by the fact that the sample is illuminated with an illumination light beam in each case simultaneously in a plurality of mutually different sample planes in each case along an illumination line, and wherein each sample region illuminated along an illumination line is scanned in each case with a dedicated detection PSF and the detection light emanating from the illuminated sample regions is detected simultaneously and spatially separately from one another. The invention additionally relates to a microscope, in particular for performing such a method.

6. 发明申请

US20190049713A1 ORGANISM SAMPLE OBSERVATION DEVICE 审中-公开
公开(公告)号：US20190049713A1
公开(公告)日：2019-02-14
申请号：US16163125
申请日：2018-10-17
申请人： NIKON CORPORATION
发明人： Hideo KURODA , Hirotada Watanabe , Yoichi Wada , Yasujiro Kiyota , Takayuki Uozumi , Ryuji Koshiba
IPC分类号： G02B21/36 , G06K9/00 , G01N21/64 , G02B21/16
CPC分类号： G02B21/367 , G01N21/6486 , G02B21/16 , G02B21/365 , G06K9/00134 , G06K9/0014
摘要： A biological specimen observation apparatus whereby observation of a biological specimen can be performed accurately. In macro observation, a biological change region is extracted from a macro image, a micro observation point corresponding to an extracted biological change region is registered, and an object for tracking is identified. In micro observation, it is judged from the micro image whether or not biological change has continued in the biological change region at the micro observation point, and the registered micro observation point is updated on the basis of this judgment result. It is possible to carry out both macro observation for detecting a biological change region and micro observation for observing the progress of growth of a partial minute region where biological change has been exhibited, and to carry out accurate observation of a biological specimen.

7. 发明申请

US20190037158A1 IMAGE ACQUSITION DEVICE, AND IMAGING DEVICE 审中-公开
公开(公告)号：US20190037158A1
公开(公告)日：2019-01-31
申请号：US16149642
申请日：2018-10-02
申请人： HAMAMATSU PHOTONICS K.K.
发明人： Eiji TODA , Takuo KAMEYAMA
IPC分类号： H04N5/353 , G02B21/36 , H04N5/378 , H04N5/225 , H04N5/232 , H04N3/14 , G02B21/00 , H04N5/341 , H04N5/235 , G02B21/16 , H04N5/359
CPC分类号： H04N5/3532 , G02B21/002 , G02B21/0036 , G02B21/008 , G02B21/16 , G02B21/365 , G02B21/367 , H04N3/1512 , H04N5/225 , H04N5/2256 , H04N5/232 , H04N5/2354 , H04N5/341 , H04N5/359 , H04N5/378
摘要： An image acquisition system 1 includes: a light source 3 which outputs illumination light; an optical scanner 7 which scans a sample S with the illumination light; an optical scanner control unit 9; a detection optical system 15, 17 which focuses fluorescence from the sample S; an imaging device 19 which has a light receiving surface 19c in which a plurality of pixel rows 19d are arranged, and an imaging control section 19b, and which can perform signal readout of each of the plurality of pixel rows 19d from the light receiving surface 19c; and a calculation unit 21 which calculates an interval of signal readout between adjacent pixel rows 19d, based on a moving speed of an illuminated region on the light receiving surface 19c; the imaging control section 19b controls signal readout of each pixel row 19d, based on the interval of the signal readout thus calculated.

8. 发明申请

US20180348500A1 SCANNING MICROSCOPE WITH REAL TIME RESPONSE 审中-公开
公开(公告)号：US20180348500A1
公开(公告)日：2018-12-06
申请号：US15774881
申请日：2016-11-10
申请人： SCOPIO LABS LTD.
发明人： Erez NAAMAN, III , Michael Shimon ILUZ , Itai HAYUT
IPC分类号： G02B21/36 , H04N5/232
CPC分类号： G02B21/367 , G06F19/00 , G06K9/00134 , G06K9/2081 , G06T3/4053 , G16H10/40
摘要： Microscopes and methods for processing images of a sample are disclosed. In one implementation, a microscope includes an illumination assembly configured to illuminate the sample under two or more different illumination conditions. The microscope further includes at least one image capture device configured to capture image information associated with the sample and at least one controller. The at least one controller is programmed to receive, from the at least one image capture device, a plurality of images associated with the sample. At least a first portion of the plurality of images is associated with a first region of the sample, and a second portion of the plurality of images is associated with a second region of the sample. The at least one controller is further programmed to initiate a first computation process to generate a high resolution image of the first region by combining image information selected from the first portion of the plurality of images; receive, after initiating the first computation process and before completing the first computation process, a request associated with prioritizing a second computation process for generating a high resolution image of the second region; and initiate, after receiving the request, the second computation process to generate the high resolution image of the second region by combining image information selected from the second portion of the plurality of images.

9. 发明申请

US20180341099A1 METHOD FOR OBSERVING A SAMPLE BY LENS-FREE IMAGING 审中-公开
公开(公告)号：US20180341099A1
公开(公告)日：2018-11-29
申请号：US16051891
申请日：2018-08-01
申请人： Commissariat A L'Energie Atomique et aux Energies Alternatives
发明人： Sophie Morel , Cedric Allier
IPC分类号： G02B21/36 , G03H1/04 , G01N21/25 , G01N21/45 , G01N33/483 , G03H1/08 , G02B21/33 , G03H1/00 , G01N15/14 , G01N15/10 , G01B9/021
CPC分类号： G02B21/367 , G01B9/021 , G01N15/1463 , G01N21/255 , G01N21/455 , G01N33/4833 , G01N2015/1006 , G01N2201/0627 , G02B21/33 , G03H1/0005 , G03H1/0443 , G03H1/0465 , G03H1/0866 , G03H2001/005 , G03H2001/0447 , G03H2001/0454 , G03H2001/0471
摘要： The invention relates to a method for observing a sample, in particular an anatomopathological slide formed from a thin thickness of a sampled biological tissue. It includes a step of illuminating the sample with a light source and acquiring, with an image sensor, an image representing the light transmitted by the sample. The image undergoes holographic reconstruction, so as to obtain a representation, in the plane of the sample, of the light wave transmitted by the latter. The method includes applying an impregnating fluid to the sample, such that the sample is impregnated with said impregnating liquid, said impregnating liquid having a refractive index strictly higher than 1.

10. 发明申请

US20180316855A1 VARIABLE-ILLUMINATION FOURIER PTYCHOGRAPHIC IMAGING DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20180316855A1
公开(公告)日：2018-11-01
申请号：US15963966
申请日：2018-04-26
申请人： California Institute of Technology
发明人： Xiaoze Ou , Roarke W. Horstmeyer , Guoan Zheng , Changhuei Yang
IPC分类号： H04N5/232 , G02B27/58 , G02B27/10 , G02B21/36 , H04N5/32 , G02B21/08 , G02B21/06 , H04N5/225 , G02B21/12
CPC分类号： H04N5/23232 , G02B21/06 , G02B21/084 , G02B21/086 , G02B21/125 , G02B21/361 , G02B21/367 , G02B27/1066 , G02B27/58 , H04N5/2256 , H04N5/32
摘要： Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.

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