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11. 发明申请

US20040214043A1 Organic electroluminescence device 审中-公开
标题翻译：有机电致发光器件
公开(公告)号：US20040214043A1
公开(公告)日：2004-10-28
申请号：US10847307
申请日：2004-05-18
申请人： Idemitsu Kosan Co., Ltd.
发明人： Sanae Tagami , Hidetsugu Ikeda , Chishio Hosokawa , Takashi Arakane
IPC分类号： B32B019/00 , G03C005/16
CPC分类号： H01L51/0056 , C07C13/62 , C07C13/70 , C07C211/61 , C07C217/92 , C07C217/94 , C07C229/68 , C07C255/42 , C07C255/58 , C07C2601/14 , C07C2603/54 , C07D219/14 , C07D223/14 , C07D223/26 , C07D223/28 , C07D279/26 , C07D295/02 , C07D295/135 , C07D295/155 , C07D471/06 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1037 , H01L51/0054 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/5012 , H01L51/5048 , H05B33/14 , Y10S428/917
摘要： An organic electroluminescence device which exhibits an excellent purity of color and a high efficiency of light emission, has a long life and emits reddish light and a novel compound having these characteristics are provided. The organic electroluminescence device comprises an organic layer disposed between at least one pair of electrodes, wherein the organic layer comprises a compound having a fluoranthene skeleton structure substituted at least with an amine group or an alkenyl group.
摘要翻译：具有优异的颜色纯度和高发光效率的有机电致发光元件具有使用寿命长并发出红光，并具有这些特性的新型化合物。有机电致发光器件包括设置在至少一对电极之间的有机层，其中有机层包含具有至少被胺基或烯基取代的荧蒽骨架结构的化合物。

12. 发明申请

US20030144323A1 Phenylalkynes 有权
公开(公告)号：US20030144323A1
公开(公告)日：2003-07-31
申请号：US10307870
申请日：2002-12-02
发明人： Richard Apodaca , Wei Xiao , Jill A. Jablonowski
IPC分类号： A61K031/445 , A61K031/40 , A61K031/137 , C07D207/04
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D213/38 , C07D215/06 , C07D273/00 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/12 , C07D471/10 , C07D491/10
摘要： Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.

13. 发明申请

US20030082403A1 Organic electroluminescent elements 有权
标题翻译：有机电致发光元件
公开(公告)号：US20030082403A1
公开(公告)日：2003-05-01
申请号：US09952215
申请日：2001-09-13
发明人： Shuit-Tong Lee , Chun-Sing Lee , Liang-Sun Hung , Bao-Xiu Mi , Zhi-Qiang Gao
IPC分类号： H05B033/14 , C09K011/06
CPC分类号： C09K11/06 , C07C15/20 , C07C15/56 , C07C25/22 , C07C211/61 , C07C255/52 , C07C265/12 , C07C2601/14 , C07C2602/10 , C07C2603/54 , C07D295/02 , H01L51/0056 , H01L51/0058 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/50 , Y10S428/917
摘要： An electroluminescent element has an anode, a cathode, and an organic layer structure between the two electrodes. The layer structure has a luminescent zone containing 1,9-perinaphtylene-10-1null-naphthylanthracene or derivatives as dopant. The luminescent material utilized as dopant has the following structure called pNNA or pNNA derivatives: 1 Wherein: R3 R1, R2, R3, R4 are individual substituents or a group of substituents, and they may be identical or different. Each substituent is individually selected from the following groups consisting of: H, alkyl (nullR), halogen (nullX), aryl (nullAr), alkenyl (RCHnullCHnull), allyl(CH2nullCHCH2null), cyano (NCnull), isocyano (CNnull), amino (H2Nnull), tertiary amino (R2Nnull or Ar1Ar2Nnull), amide (RCONRnull), nitro (N2Onull), acyl (RCOnull), carboxyl (nullCO2H), alkoxyl (ROnull), alkylsulfonyl (RSO2null), hydroxy (HOnull) and single or fused aromatic heterocyclic rings.
摘要翻译：电致发光元件在两个电极之间具有阳极，阴极和有机层结构。该层结构具有包含1,9-围烷基-10-1'-萘基蒽或其衍生物作为掺杂剂的发光区。用作掺杂剂的发光材料具有称为pNNA或pNNA衍生物的以下结构：其中：R 1，R 2，R 3，R 4是各自的取代基或一组取代基，它们可以相同或不同。每个取代基分别选自：H，烷基（-R），卤素（-X），芳基（-Ar），烯基（RCH = CH-），烯丙基（CH 2 = CHCH 2 - ），氰基（ NC-），异氰基（CN-），氨基（H2N-），叔氨基（R2N-或Ar1Ar2N-），酰胺（RCONR-），硝基（N2O-），酰基（RCO-），羧基（-CO2H）烷氧基（RO-），烷基磺酰基（RSO2-），羟基（HO-）和单或稠合芳族杂环。

14. 发明申请

US20030054200A1 Organic electroluminescence device 有权
标题翻译：有机电致发光器件
公开(公告)号：US20030054200A1
公开(公告)日：2003-03-20
申请号：US10244164
申请日：2002-09-16
申请人： Idemitsu Kosan Co., Ltd.
发明人： Sanae Tagami , Hidetsugu Ikeda , Chishio Hosokawa , Takashi Arakane
IPC分类号： H05B033/12 , C09K011/06
CPC分类号： H01L51/0056 , C07C13/62 , C07C13/70 , C07C211/61 , C07C217/92 , C07C217/94 , C07C229/68 , C07C255/42 , C07C255/58 , C07C2601/14 , C07C2603/54 , C07D219/14 , C07D223/14 , C07D223/26 , C07D223/28 , C07D279/26 , C07D295/02 , C07D295/135 , C07D295/155 , C07D471/06 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1037 , H01L51/0054 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/5012 , H01L51/5048 , H05B33/14 , Y10S428/917
摘要： An organic electroluminescence device which exhibits an excellent purity of color and a high efficiency of light emission, has a long life and emits reddish light and a novel compound having these characteristics are provided. The organic electroluminescence device comprises an organic layer disposed between at least one pair of electrodes, wherein the organic layer comprises a compound having a fluoranthene skeleton structure substituted at least with an amine group or an alkenyl group.
摘要翻译：具有优异的色纯度和高发光效率的有机电致发光元件具有使用寿命长，发出微红光，并具有这些特性的新化合物。有机电致发光器件包括设置在至少一对电极之间的有机层，其中有机层包含具有至少被胺基或烯基取代的荧蒽骨架结构的化合物。

15. 发明授权

US5811241A Method for preparing and identifying N-substitued 1,4-piperazines and N-substituted 1,4-piperazinediones 失效
标题翻译：制备和鉴定N-取代的1,4-哌嗪和N-取代的1,4-哌嗪二酮的方法
公开(公告)号：US5811241A
公开(公告)日：1998-09-22
申请号：US527407
申请日：1995-09-13
申请人： Val S. Goodfellow , Donald A. McLeod , James Ivan Gerrity , Christopher P. Laudeman , Michael R. Burkard
发明人： Val S. Goodfellow , Donald A. McLeod , James Ivan Gerrity , Christopher P. Laudeman , Michael R. Burkard
IPC分类号： C07D241/08 , C07D295/02 , G01N33/53 , G01N33/543 , G01N33/566
CPC分类号： C07D295/02 , C07D241/08
摘要： The invention provides a method of synthesizing N-substituted 1,4-piperazines and N-substituted 1,4-piperazinediones. The invention also provides a method for synthesing combinatorial libraries of piperazine derivatives which can be assayed for biological activity in pre-specified ligand binding or enzymatic activity screens.
摘要翻译：本发明提供合成N-取代的1,4-哌嗪和N-取代的1,4-哌嗪二酮的方法。本发明还提供了合成哌嗪衍生物的组合文库的方法，其可以在预先指定的配体结合或酶活性筛选中测定生物活性。

16. 发明授权

US4883797A Derivatives of piperazine, method for making the same 失效
标题翻译：哌嗪衍生物，制作方法
公开(公告)号：US4883797A
公开(公告)日：1989-11-28
申请号：US143214
申请日：1988-01-07
申请人： Rafael Foguet , Jose A. Ortiz , Santiago Gubert , Manuel M. Raga , Aurelio Sacristan
发明人： Rafael Foguet , Jose A. Ortiz , Santiago Gubert , Manuel M. Raga , Aurelio Sacristan
IPC分类号： A61K31/42 , A61K31/421 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P9/00 , A61P9/06 , C07D207/27 , C07D263/18 , C07D263/20 , C07D263/22 , C07D263/28 , C07D295/02 , C07D295/03 , C07D295/06 , C07D295/067 , C07D295/10 , C07D295/108 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/145 , C07D295/18 , C07D295/192 , C07D317/28 , C07D333/22
CPC分类号： C07D263/20 , C07D263/28 , C07D295/02 , C07D295/03 , C07D295/067 , C07D295/108 , C07D295/13 , C07D295/145 , C07D295/192 , C07D317/28 , C07D333/22
摘要： Derivatives of piperazine having the general formula ##STR1## wherein R.sub.1 is benzhydryl or cinnamyl and R.sub.2 is selected from the group consisting of ##STR2## --(CH.sub.2).sub.3 --R.sub.8, --CH.sub.2 NHR.sub.9, --CH.sub.2 NH.sub.2 and --COR.sub.10 ; wherein R.sub.3 is hydrogen, chloromethyl, (4-benzhydryl-1-piperazinyl) methyl, 4-morpholinylmethyl or 1-piperidinylmethyl, R.sub.4 is hydrogen, chloromethyl or carbethoxy, R.sub.5 and R.sub.6 taken together are an oxygen atom or the radical --O--(CH.sub.2).sub.2 --O--, R.sub.7 is methyl, phenyl or 2-thienyl, R.sub.8 is 4-morpholinyl, 1-piperidinyl or 4-benzhydryl-1-piperazinyl, R.sub.9 is 2-oxo-1- (pyrrolidinyl) acetyl, 2-hydroxybenzoyl or 4-sulfamoylbenzoyl, R.sub.10 is 2-oxo-1-(pyrrolidinyl)methyl or 4-sulfamoylphenyl and X is oxygen or NH; as well as methods for making the same and their use in a pharmaceutical composition is proposed. The compounds have cardiovascular properties and increasing effects on cerebral flow.
摘要翻译：其中R 1是二苯甲基或肉桂基，R 2选自CH 2 CR 3 CHR 4， - （CH 2）3 -R 8，-CH 2 NHR 9，-CH 2 NH 2和-COR 10; 其中R 3是氢，氯甲基，（4-二苯甲基-1-哌嗪基）甲基，4-吗啉基甲基或1-哌啶基甲基，R 4是氢，氯甲基或乙氧羰基，R 5和R 6一起是氧原子或-O- CH2）2-O-，R7是甲基，苯基或2-噻吩基，R8是4-吗啉基，1-哌啶基或4-二苯甲基-1-哌嗪基，R9是2-氧代-1-（吡咯烷基）乙酰基，羟基苯甲酰基或4-氨磺酰基苯甲酰基，R 10是2-氧代-1-（吡咯烷基）甲基或4-氨磺酰基苯基，X是氧或NH; 以及其制备方法及其在药物组合物中的应用。该化合物具有心脑血管性质和对脑流量的增加作用。

17. 发明授权

US4703099A Novel product and process 失效
标题翻译：新产品和工艺
公开(公告)号：US4703099A
公开(公告)日：1987-10-27
申请号：US909543
申请日：1986-09-22
申请人： Dale F. Regelman
发明人： Dale F. Regelman
IPC分类号： C07D295/02 , C08G18/02 , C08G18/16 , C08G18/79 , C08G18/08
CPC分类号： C07D295/02 , C07C255/00 , C07C265/00 , C07C265/12 , C08G18/022 , C08G18/168 , C08G18/791 , C08G2105/02 , Y10S521/902
摘要： Disclosed are novel compositions capable of catalytically trimerizing organic isocyanates said compositions comprising solutions of the reaction products obtained by reacting in an inert solvent in substantially equimolar proportions electron-rich ketene-aminals with electron-poor olefins having the respective formulae (I) and (II) ##STR1## The variously substituted electron-rich ketene-aminals (I), as the name implies, have high electron density associated with the double bond because of the two tertiary amine groups while the electron-poor olefins (II) have the opposite situation due to the presence of electron withdrawing substituents R.sub.9 and R.sub.10.Also disclosed is an improved process for trimerizing organic isocyanates using the above catalyst compositions including the preparation of polyisocyanurate polymers and isocyanurate-modified polyisocyanates.
摘要翻译：公开了能够催化三聚有机异氰酸酯的新型组合物，所述组合物包含通过在惰性溶剂中基本上等摩尔比例的富含电子的乙烯酮 - 胺与具有各自式（I）和（II）的电子不足烯烃反应而获得的反应产物的溶液（I）如下所述，不同取代的富电子酮乙烯酮（I）由于两个叔胺基团而具有与双键相关的高电子密度，而电子由于吸电子取代基R9和R10的存在，α-烯烃（II）具有相反的情况。还公开了使用上述催化剂组合物三聚有机异氰酸酯的改进方法，包括制备聚异氰脲酸酯聚合物和异氰脲酸酯改性的多异氰酸酯。

18. 发明授权

US4312831A Quaternaries of tertiary amino-substituted thiazines 失效
标题翻译：叔氨基取代噻嗪的季铵盐
公开(公告)号：US4312831A
公开(公告)日：1982-01-26
申请号：US166437
申请日：1980-07-07
申请人： Patrick M. Quinlan
发明人： Patrick M. Quinlan
IPC分类号： A01N43/84 , C07D295/02 , C07D295/13 , C23F11/16 , C23F11/14
CPC分类号： C07D295/02 , A01N43/84 , C07D295/13 , C23F11/16 , Y10S507/939
摘要： This invention relates to quaternaries of tertiary amino-substituted thiazines; the process of preparing such quaternary thiazines; and uses thereof, for example, as corrosion inhibitors, microbiocides, etc.
摘要翻译：本发明涉及叔氨基取代的噻嗪的季胺; 制备这种季噻嗪的方法; 及其用途，例如腐蚀抑制剂，杀微生物剂等

19. 发明授权

US4062955A Analgesic basic naphthalene derivatives 失效
标题翻译：镇痛碱性萘衍生物
公开(公告)号：US4062955A
公开(公告)日：1977-12-13
申请号：US625863
申请日：1975-10-28
申请人： Derek Burn , Richard J. Coles
发明人： Derek Burn , Richard J. Coles
IPC分类号： C07D295/12 , A61K31/13 , A61K31/135 , A61K31/165 , A61K31/215 , C07C17/12 , C07C17/14 , C07C63/72 , C07C65/24 , C07C67/00 , C07C209/00 , C07C209/08 , C07C209/16 , C07C209/50 , C07C209/62 , C07C211/30 , C07C211/44 , C07C213/00 , C07C215/14 , C07C215/74 , C07C217/08 , C07C217/78 , C07C219/04 , C07C219/34 , C07D211/14 , C07D211/70 , C07D265/30 , C07D295/02 , C07D295/073 , C07D295/096 , C07D295/135
CPC分类号： C07D295/02 , A61K31/165 , C07C17/12 , C07C17/14 , C07C63/72 , C07C65/24 , C07D211/14 , C07D211/70 , C07D265/30 , C07D295/073 , C07D295/096 , C07D295/135
摘要： Compounds of the general formula: ##STR1## wherein the groups CHR.sup.1 NR.sup.2 R.sup.3 and CHR.sup.4 NR.sup.5 R.sup.6 may be the same or different and where the group CHR.sup.4 NR.sup.5 R.sup.6 is in either the 1 or the 3 position and R.sup.1 and R.sup.4 independently represent a hydrogen atom or an aryl group;R.sup.2, r.sup.3, r.sup.5 and R.sup.6 which may be the same or different are each a hydrogen atom or an alkyl group or an aryl group both of which may in turn be substituted by one or more hydroxy, alkoxy, acyloxy, dialkylamino or aryl groups or the groups --NR.sup.2 R.sup.3 and/or NR.sup.5 R.sup.6 represent a heterocyclic ring containing one or more hetero atoms and which ring may optionally be substituted by an alkyl, aryl or aralkyl group and in which either aromatic ring of the naphthalene nucleus may be further substituted; with the proviso that when R.sup.1, R.sup.4, R.sup.2 and R.sup.5 are hydrogen, then R.sup.3 and R.sup.6 cannot both be benzyl, when the second substituent is in the 1 position; and when R.sup.1 and R.sup.4 are hydrogen, then R.sup.2, R.sup.3, R.sup.5 and R.sup.6 cannot all be methyl when the second substituent is in the 1 position; and when R.sup.1 and R.sup.4 are hydrogen, then R.sup.2 and R.sup.3 and R.sup.5 and R.sup.6 together with the nitrogen atom cannot both be piperidino when the second substituent is in the 3 position and the naphthalene nucleus is further substituted by hydroxy in the 1 and 4 positions; and pharmaceutically acceptable salts of such compounds; and hydrates of such compounds and such salts. The compounds have activity on the central nervous system in particular as analgesics.
摘要翻译：通式：其中CHR1NR2R3和CHR4NR5R6基团可以相同或不同，并且其中CHR4NR5R6基团在1或3位且R1和R4独立地表示氢原子或芳基的化合物组; R 2，R 3，R 5和R 6可以相同或不同，分别为氢原子或烷基或芳基，二者可以依次被一个或多个羟基，烷氧基，酰氧基，二烷基氨基或芳基取代，或基团-NR2R3和/或NR5R6表示含有一个或多个杂原子的杂环，并且该环可以任选地被烷基，芳基或芳烷基取代，并且其中萘核的任一个芳环可以进一步被取代; 条件是当R 1，R 4，R 2和R 5是氢时，则当第二取代基在1位时，R 3和R 6不能都是苄基; 当R 1和R 4为氢时，当第二取代基在1位时，R 2，R 3，R 5和R 6不能全部为甲基; 当R1和R4为氢时，当第二个取代基位于3位，R2和R3与R5和R6与氮原子一起不能同时为哌啶子基，而萘环在1和4位进一步被羟基取代; 和这些化合物的药学上可接受的盐; 和这些化合物的水合物和这些盐。该化合物对中枢神经系统具有活性，特别是作为镇痛药。

20. 发明授权

US3988457A Novel compounds and compositions for treating Parkinson's disease 失效
标题翻译：用于治疗帕金森氏病3型疾病的新型化合物和组合物
公开(公告)号：US3988457A
公开(公告)日：1976-10-26
申请号：US596872
申请日：1975-07-17
申请人： Harlan F. Hill , John J. Lafferty
发明人： Harlan F. Hill , John J. Lafferty
IPC分类号： C07D295/02 , C07D295/073 , C07D295/096 , A61K31/495
CPC分类号： C07D295/073 , C07D295/02 , C07D295/096
摘要： .beta.-Naphthylmethyl piperazinyl derivates having anti-Parkinsonism activity prepared by condensation of .beta.-chloromethylnaphthalene with the appropriate substituted piperazine.
摘要翻译：具有通过β-氯甲基萘与适当的取代哌嗪的缩合制备的具有抗帕金森综合征活性的β-萘基甲基哌嗪衍生物。

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