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1. 发明授权

US09493353B2 Process for producing pyrophosphate 有权
标题翻译：焦磷酸盐生产工艺
公开(公告)号：US09493353B2
公开(公告)日：2016-11-15
申请号：US14652797
申请日：2014-02-14
申请人： ADEKA CORPORATION
发明人： Genta Harada , Yutaka Yonezawa , Michio Nakamura , Yuri Okamoto , Kohei Omori
IPC分类号： C07D251/14 , C07D251/42 , C07D251/48 , C07D251/54 , C07F9/6521 , C01B25/42 , C07D295/02 , C07F9/6509
CPC分类号： C01B25/42 , C07D251/54 , C07D295/02 , C07F9/6509
摘要： A process for producing a pyrophosphate, particularly melamine pyrophosphate useful as a flame retardant, efficiently in high yield is provided. The process includes firing an orthophosphate, preferably melamine orthophosphate, in the presence of a silicone oil, preferably methylphenyl silicone oil preferably at 120° to 350° C. Examples of useful firing equipment include a hot air dryer, a kneader, a Henschel mixture, a fluidized bed dryer, a rotary kiln, a paddle dryer, an extruder, a vibrating dryer, a far-infrared conveyor furnace, and a microwave firing furnace.
摘要翻译：提供了以高产率有效地生产焦磷酸盐，特别是可用作阻燃剂的焦磷酸三聚氰胺的方法。该方法包括在硅油，优选甲基苯基硅油存在下，优选在120-350℃下焙烧正磷酸盐，优选正磷酸三聚氰胺。有用的焙烧设备的实例包括热空气干燥器，捏合机，亨舍尔混合物，流化床干燥机，回转窑，桨式干燥机，挤出机，振动干燥机，远红外传送炉和微波烧制炉。

2. 发明授权

US09238628B2 Phenyl amino pyrimidine compounds and uses thereof 有权
公开(公告)号：US09238628B2
公开(公告)日：2016-01-19
申请号：US13913362
申请日：2013-06-07
申请人： YM BIOSCIENCES AUSTRALIA PTY LTD
发明人： Christopher John Burns , Andrew Donohue , John Thomas Feutrill , Thao Lien Thi Nguyen , Andrew Frederick Wilks , Jun Zeng
IPC分类号： C07D413/00 , A61K31/535 , C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D401/14
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

3. 发明授权

US09233934B2 Phenyl amino pyrimidine compounds and uses thereof 有权
公开(公告)号：US09233934B2
公开(公告)日：2016-01-12
申请号：US13913369
申请日：2013-06-07
申请人： YM BIOSCIENCES AUTRALIA PTY LTD
发明人： Christopher John Burns , Andrew Craig Donohue , John Thomas Feutrill , Thao Lien Thi Nguyen , Andrew Frederick Wilks , Jun Zeng
IPC分类号： A61K31/535 , A61K31/54 , A61K31/505 , C07D413/00 , C07D417/00 , C07D239/02 , C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D401/14
CPC分类号： C07D239/42 , C07D295/02 , C07D295/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

4. 发明授权

US09012690B2 Method for producing alcohol and/or amine from amide compound 有权
标题翻译：从酰胺化合物制备醇和/或胺的方法
公开(公告)号：US09012690B2
公开(公告)日：2015-04-21
申请号：US13825449
申请日：2011-09-01
申请人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
发明人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
IPC分类号： C07C209/00 , C07C209/50 , C07B41/02 , C07B43/04 , C07C29/149 , C07C209/62 , C07D295/18 , C07C29/36 , C07D295/02
CPC分类号： C07C209/50 , B01J31/1805 , B01J31/189 , B01J31/20 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B41/02 , C07B43/04 , C07C29/149 , C07C29/36 , C07C209/62 , C07D295/02 , C07D295/18 , C07C211/04 , C07C211/46 , C07C211/48 , C07C211/55 , C07C31/125 , C07C33/22
摘要： Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.
摘要翻译：本文公开了一种在氢气氛下由酰胺制备醇和胺的方法，其中使用易于制备，易于处理和相对便宜地获得的钌络合物作为催化剂。具体地说，该方法是使用作为催化剂的氢气气氛下的酰胺化合物制备醇和/或胺的方法，由以下通式（1）表示的羰基钌络合物：RuXY（CO ）（L）（1）其中X和Y可以相同或不同，各自表示阴离子配体，L表示含有两个膦基和-NH-基团的三齿氨基二膦配体。

5. 发明申请

US20130172619A1 METHOD FOR PRODUCING ALCOHOL AND/OR AMINE FROM AMIDE COMPOUND 有权
标题翻译：从酰胺化合物生产醇和/或胺的方法
公开(公告)号：US20130172619A1
公开(公告)日：2013-07-04
申请号：US13825449
申请日：2011-09-01
申请人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
发明人： Osamu Ogata , Wataru Kuriyama , Takaji Matsumoto
IPC分类号： C07C209/50 , C07C29/36
CPC分类号： C07C209/50 , B01J31/1805 , B01J31/189 , B01J31/20 , B01J31/24 , B01J2231/643 , B01J2531/821 , C07B41/02 , C07B43/04 , C07C29/149 , C07C29/36 , C07C209/62 , C07D295/02 , C07D295/18 , C07C211/04 , C07C211/46 , C07C211/48 , C07C211/55 , C07C31/125 , C07C33/22
摘要： Disclosed herein is a method for producing an alcohol and an amine from an amide under an atmosphere of hydrogen with the use of, as a catalyst, a ruthenium complex that is easily prepared, easy to handle, and relatively cheaply obtained. Specifically, the method is a method for producing an alcohol and/or an amine from an amide compound under an atmosphere of hydrogen with the use of as a catalyst, a ruthenium carbonyl complex represented by the following general formula (1): RuXY(CO)(L) (1) wherein X and Y may be the same or different from each other and each represents an anionic ligand and L represents a tridentate aminodiphosphine ligand containing two phosphino groups and a —NH— group.
摘要翻译：本文公开了一种在氢气氛下由酰胺制备醇和胺的方法，其中使用易于制备，易于处理和相对便宜地获得的钌络合物作为催化剂。具体地说，该方法是使用作为催化剂的氢气气氛下的酰胺化合物制备醇和/或胺的方法，由以下通式（1）表示的羰基钌络合物：RuXY（CO ）（L）（1）其中X和Y可以相同或不同，各自表示阴离子配体，L表示含有两个膦基和-NH-基团的三齿氨基二膦配体。

6. 发明申请

US20110054167A1 METHOD FOR PRODUCING AN AMINE 有权
标题翻译：生产氨的方法
公开(公告)号：US20110054167A1
公开(公告)日：2011-03-03
申请号：US12809653
申请日：2008-12-10
申请人： Petr Kubanek , Wolfgang Mägerlein , Ekkehard Schwab , Johann-Peter Melder , Manfred Julius
发明人： Petr Kubanek , Wolfgang Mägerlein , Ekkehard Schwab , Johann-Peter Melder , Manfred Julius
IPC分类号： C07D295/023 , C07C209/16 , B01J23/72
CPC分类号： B01J23/835 , B01J23/002 , B01J37/03 , B01J37/18 , B01J2523/00 , C07C209/16 , C07C213/02 , C07D295/02 , C07D295/06 , C07C217/08
摘要： Processes for preparing an amine, which processes comprise: reacting a reactant selected from the group consisting of primary alcohols, secondary alcohols, aldehydes, ketones, and mixtures thereof, with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary amines, secondary amines and mixtures thereof, in the presence of a zirconium dioxide-, copper- and nickel-containing catalyst; wherein the catalyst comprises a catalytically active composition which comprises, before reduction with hydrogen, oxygen compounds of zirconium, copper, nickel and tin, and 0.5 to 8.0% by weight of an oxygen compound of cobalt, calculated as CoO, and wherein the catalytically active composition does not comprise any ruthenium.
摘要翻译：用于制备胺的方法，该方法包括：将选自伯醇，仲醇，醛，酮及其混合物的反应物与氢和选自以下的氮化合物反应：氨，伯胺，仲胺及其混合物，在二氧化锆，含铜和镍的催化剂存在下; 其中所述催化剂包含催化活性组合物，所述催化活性组合物在用氢还原之前包括锆，铜，镍和锡的氧化合物和0.5至8.0重量％的作为CoO计算的钴的氧化合物，并且其中催化活性组合物不包含任何钌。

7. 发明申请

US20070072837A1 Phenylalkynes 审中-公开
标题翻译：苯基炔
公开(公告)号：US20070072837A1
公开(公告)日：2007-03-29
申请号：US11556941
申请日：2006-11-06
申请人： Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
发明人： Richard Apodaca , Xiaohu Deng , Jill Jablonowski , Neelakandha Mani , Chennagiri Pandit , Wei Xiao
IPC分类号： A61K31/54 , A61K31/5375 , A61K31/513 , A61K31/496 , A61K31/495 , A61K31/396 , A61K31/444 , A61K31/4545
CPC分类号： C07D239/42 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D203/12 , C07D209/14 , C07D209/16 , C07D211/14 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D211/78 , C07D213/38 , C07D215/06 , C07D273/00 , C07D273/01 , C07D277/04 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/205 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D413/10 , C07D417/10 , C07D471/10 , C07D491/10 , C07D491/113
摘要： Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要翻译：取代的式（I）的苯炔基，含有它们的组合物，以及制备和使用它们来治疗组胺介导的病症的方法。

8. 发明申请

US20060167256A1 High purity piperazine pyrophosphate and process of producing same 有权
标题翻译：高纯度哌嗪焦磷酸盐及其制备方法
公开(公告)号：US20060167256A1
公开(公告)日：2006-07-27
申请号：US10563478
申请日：2004-08-27
申请人： Ryoji Kimura , Masaru Nagahama , Tetsuo Kamimoto , Shinji Nakano
发明人： Ryoji Kimura , Masaru Nagahama , Tetsuo Kamimoto , Shinji Nakano
IPC分类号： C07F9/6509
CPC分类号： C09K21/12 , C07D295/02
摘要： The present invention provides piperazine pyrophosphate represented by chemical formula (I) which has a sodium content of 10 ppm or lower and a process of producing the same. The piperazine pyrophosphate has high purity and provides a flame retardant composition exhibiting excellent flame retardancy. The process includes dehydration condensation of piperazine diphosphate and is able to produce the piperazine pyrophosphate at low cost.
摘要翻译：本发明提供了钠含量为10ppm以下的化学式（I）所示的焦磷酸哌嗪及其制造方法。焦磷酸哌嗪具有高纯度，并提供阻燃性优异的阻燃组合物。该方法包括哌嗪二磷酸酯的脱水缩合，能够以低成本生产焦磷酸哌嗪。

9. 发明申请

US20060040938A1 Substituted fullerene compositions and their use as antioxidants 审中-公开
标题翻译：取代的富勒烯组合物及其作为抗氧化剂的用途
公开(公告)号：US20060040938A1
公开(公告)日：2006-02-23
申请号：US11256359
申请日：2005-10-21
申请人： Uwe Hartnagel , Andreas Hirsch , Russ Lebovitz
发明人： Uwe Hartnagel , Andreas Hirsch , Russ Lebovitz
IPC分类号： A61K31/535 , A61K31/495
CPC分类号： B82Y40/00 , A61K8/19 , A61K2800/522 , A61Q19/00 , B82Y30/00 , C01B32/15 , C01B32/152 , C07D295/02 , C07D295/023 , C07D295/037
摘要： This patent discloses a substituted fullerenes, compositions comprising the same, and their use as antioxidants. The substituted fullerenes comprise a fullerene core (Cn), wherein n is an even integer greater than or equal to 60, and (i) t —X3 groups bonded to the fullerene core, wherein: (i-a) t is an integer from 1 to 12, inclusive; and (i-b) each —X3 is inependently selected from wherein each R10 is independently >O, >C(R2)(R3), >CN+(R2)(R3)(R4), or >CHN+(R2)(R3)(R8), wherein R2, R3, and R4 are independently —H or —(CH2)d—CH3, wherein d is an integer from 0 to about 20, and each R8 is independently —(CH2)f—SO3−, —(CH2)f—PO4−, or —(CH2)f—COO−, wherein f is an integer from 1 to about 20; and (ii) u>O groups bonded to the fullerene core, wherein u is an integer from 0 to 12, inclusive
摘要翻译：该专利公开了一种取代的富勒烯，包含它们的组合物及其作为抗氧化剂的用途。取代的富勒烯包含富勒烯核（Cn），其中n是大于或等于60的偶数整数，和（i）与富勒烯核键合的t -X 3+基团，其中：（ia ）t为1〜12的整数，包括1和12; 和（ib）各自独立地选自其中每个R 10独立地为O，C（R 2）（R 2）（R 3）（R 3）（R 3）（R 3）（R 3）（R 8）和（CH 3）（R 3）（R 8）），或其中 R 2，R 3，R 4和R 4独立地是-H或 - （CH 2 CH 2）其中d为0至约20的整数，并且每个R 8独立地为 - （CH 2）2 N - ） - （CH 2） - - - （CH 2）n - 或者 - （CH 2 - ） - - - - - - - - - - - - （CH 2）其中f为1至约20的整数; 和（ii）键合到富勒烯核心的u> O基团，其中u是0至12的整数，包括0和12

10. 发明申请

US20040214043A1 Organic electroluminescence device 审中-公开
标题翻译：有机电致发光器件
公开(公告)号：US20040214043A1
公开(公告)日：2004-10-28
申请号：US10847307
申请日：2004-05-18
申请人： Idemitsu Kosan Co., Ltd.
发明人： Sanae Tagami , Hidetsugu Ikeda , Chishio Hosokawa , Takashi Arakane
IPC分类号： B32B019/00 , G03C005/16
CPC分类号： H01L51/0056 , C07C13/62 , C07C13/70 , C07C211/61 , C07C217/92 , C07C217/94 , C07C229/68 , C07C255/42 , C07C255/58 , C07C2601/14 , C07C2603/54 , C07D219/14 , C07D223/14 , C07D223/26 , C07D223/28 , C07D279/26 , C07D295/02 , C07D295/135 , C07D295/155 , C07D471/06 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1037 , H01L51/0054 , H01L51/0059 , H01L51/006 , H01L51/0081 , H01L51/5012 , H01L51/5048 , H05B33/14 , Y10S428/917
摘要： An organic electroluminescence device which exhibits an excellent purity of color and a high efficiency of light emission, has a long life and emits reddish light and a novel compound having these characteristics are provided. The organic electroluminescence device comprises an organic layer disposed between at least one pair of electrodes, wherein the organic layer comprises a compound having a fluoranthene skeleton structure substituted at least with an amine group or an alkenyl group.
摘要翻译：具有优异的颜色纯度和高发光效率的有机电致发光元件具有使用寿命长并发出红光，并具有这些特性的新型化合物。有机电致发光器件包括设置在至少一对电极之间的有机层，其中有机层包含具有至少被胺基或烯基取代的荧蒽骨架结构的化合物。

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