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21. 发明授权

US10208131B2 Artificially produced polyclonal immunoglobulin preparation 有权
公开(公告)号：US10208131B2
公开(公告)日：2019-02-19
申请号：US13716469
申请日：2012-12-17
申请人： National University Corporation Chiba University
发明人： Kazuo Suzuki
IPC分类号： C07K16/00 , C07K16/46 , A61K39/00
摘要： The present invention intended to provide an artificial polyclonal immunoglobulin composition having a high therapeutic effect and high safety, and being capable of stable supply in a large amount. Specifically provided is an artificial polyclonal immunoglobulin composition containing, as active ingredients, 204 polypeptides represented by amino acid sequences set forth in SEQ ID NOS: 1 to 204 of the sequence listing, the polypeptides being plural kinds of single chain variable fragments (also referred to as ScFvs) each comprised of a heavy chain variable region, heavy chain constant region 1, and hinge region (VH-CH1-hinge) of an immunoglobulin, in which the heavy chain variable regions are different each other.

22. 发明授权

US09872833B2 Liposome composite body 有权
公开(公告)号：US09872833B2
公开(公告)日：2018-01-23
申请号：US14349871
申请日：2012-10-03
申请人： National University Corporation Tottori University , National University Corporation Chiba University
发明人： Yoshiharu Okamoto , Yutaka Tamura , Akiko Suganami , Hideki Hayashi , Tomoyuki Madono , Hisahiro Matsubara , Taro Toyota
IPC分类号： A61K9/127 , A61K41/00 , A61K49/00 , A61K31/403 , A61K31/675
CPC分类号： A61K9/127 , A61K31/403 , A61K31/675 , A61K41/0052 , A61K41/0057 , A61K49/0021 , A61K49/0034 , A61K49/0052 , A61K49/0084
摘要： An object of the present invention is to provide a drug delivery system capable of sustainedly releasing a drug noninvasively at any given point in time. The present invention relates to a liposome complex comprising a liposome membrane-constituting substance bonded to a light-absorbing compound having an absorption wavelength in the near-infrared region, selected from the group consisting of indocyanine green dyes, phthalocyanine dyes, squarylium dyes, croconium dyes, and diimmonium dyes.

23. 发明申请

US20170191103A1 Method For Producing Carotenoids Each Having 50 Carbon Atoms 有权
公开(公告)号：US20170191103A1
公开(公告)日：2017-07-06
申请号：US15384420
申请日：2016-12-20
申请人： National University Corporation Chiba University
发明人： Daisuke Umeno , Maiko Furubayashi , Norihiko Misawa , Shinichi Takaichi
IPC分类号： C12P23/00 , C12N15/52
CPC分类号： C12P23/00 , C12N9/001 , C12N15/52 , C12P5/026 , C12Y103/99029 , C12Y205/0101 , C12Y205/01096 , Y02P20/52
摘要： The present invention provides a method of producing a carotenoid having 50 carbon atoms which comprises culturing, in a medium, a cell transformed with a mutant phytoene desaturase gene and obtaining the carotenoid having 50 carbon atoms from the culture. The mutant phytoene desaturase gene has an introduced mutation to encode a mutant phytoene desaturase having an enhanced activity to desaturate a carotenoid backbone compound of 50 carbon atoms.

24. 发明授权

US09509124B2 Photoelectric conversion device and characteristic inspection method for same 有权
标题翻译：光电转换装置及其特性检验方法相同
公开(公告)号：US09509124B2
公开(公告)日：2016-11-29
申请号：US13394049
申请日：2011-03-14
申请人： Akihiko Yoshikawa , Yoshihiro Ishitani , Kazuhide Kusakabe
发明人： Akihiko Yoshikawa , Yoshihiro Ishitani , Kazuhide Kusakabe
IPC分类号： H01L29/49 , H01S5/343 , B82Y20/00 , H01L33/18 , H01L33/32 , H01L31/0304 , H01L31/0368 , H01L31/075 , H01L31/105 , H02S50/10 , H01L33/02
CPC分类号： H01S5/34333 , B82Y20/00 , H01L31/03046 , H01L31/0368 , H01L31/075 , H01L31/105 , H01L33/025 , H01L33/18 , H01L33/32 , H01S2301/17 , H02S50/10 , Y02E10/544 , Y02E10/548 , Y02P70/521
摘要： A photoelectric conversion device which inhibits characteristic degradation caused by crystal defects, and an inspection method for crystal defects in photoelectric conversion devices. The photoelectric conversion device is provided with an active layer, and a deactivator contained in the active layer.
摘要翻译：抑制由晶体缺陷引起的特性劣化的光电转换装置，以及光电转换装置中的晶体缺陷检查方法。光电转换装置设置有活性层和包含在活性层中的钝化剂。

25. 发明授权

US09494594B2 Method of determining administration effect in cancer chemotherapy with S-1 有权
标题翻译：用S-1测定癌症化疗药物治疗效果的方法
公开(公告)号：US09494594B2
公开(公告)日：2016-11-15
申请号：US13853137
申请日：2013-03-29
申请人： National University Corporation Chiba University
发明人： Hideki Tanzawa , Atsushi Kasamatsu , Katsuhiro Uzawa
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： G01N33/68 , G01N2333/4722 , G01N2800/52 , G01N2800/7028
摘要： Provided is a method of determining a therapeutic effect of cancer chemotherapy with an anticancer drug obtained by blending three ingredients, i.e., tegafur, gimeracil, and oteracil potassium as active ingredients (hereinafter abbreviated as S-1) quickly, simply, and accurately before carrying out the cancer chemotherapy. Specifically, provided is a method of determining an administration effect in chemotherapy with S-1, the method comprising: a step (a) of measuring expression level of a decorin gene in a biological sample collected from a subject to be diagnosed; and a step (b) of determining an administration effect of S-1 based on the expression level of the gene obtained from the measurement.
摘要翻译：本发明提供了一种通过以下方式确定癌症化学疗法的治疗效果的方法：通过将三种成分即替加氟，吉莫斯特和奥替卡尔钾作为活性成分（以下简称为S-1），通过简单地和准确地混合三种成分获得的抗癌药物出了癌症化疗。具体地说，提供了一种用S-1测定化疗药物的给药效果的方法，所述方法包括：测定从待诊断对象收集的生物样品中的核心蛋白聚糖基因的表达水平的步骤（a）以及基于从测定得到的基因的表达水平确定S-1的给药效果的步骤（b）。

26. 发明申请

US20150164987A1 Wnt Signaling Inhibitor Comprising Insulin-Like Growth Factor-Binding Protein 有权
标题翻译：包含胰岛素样生长因子结合蛋白的Wnt信号抑制剂
公开(公告)号：US20150164987A1
公开(公告)日：2015-06-18
申请号：US14633155
申请日：2015-02-27
申请人： National University Corporation Chiba University
发明人： Issei Komuro , Ichiro Shiojima , Weidong Zhu
IPC分类号： A61K38/17 , C12N5/09
CPC分类号： A61K38/1754 , A61K31/7088 , A61K38/00 , A61K48/005 , C07K14/4743 , C12N5/0693 , C12N15/113 , C12N15/1138 , C12N2310/14 , C12N2501/105
摘要： Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.
摘要翻译：提供了调节形态发生和细胞增殖的新型可溶性因子，例如心脏发育和/或心肌细胞分化。具体提供的是：Wnt信号传导的抑制剂，其包含与Wnt受体结合的胰岛素样生长因子结合蛋白（IGFBP）和/或编码该蛋白的多核苷酸; 用于预防和/或治疗由于增强的Wnt信号传导引起的疾病的药物，其包含Wnt信号传导的抑制剂和用于诱导心肌细胞分化的药物; 以及由于Wnt信号传导增强而引起的疾病的预防和/或治疗的方法以及诱导心肌细胞分化的方法，所述方法包括使用Wnt信号传导抑制剂和心肌细胞，所述心肌细胞通过诱导心肌细胞分化的方法获得，及其用途。

27. 发明授权

US09042422B2 Tunable external resonator laser 有权
标题翻译：可调外部谐振器激光器
公开(公告)号：US09042422B2
公开(公告)日：2015-05-26
申请号：US13519463
申请日：2010-12-30
申请人： Kiyohumi Muro , Tomohisa Endo , Yasutaka Shimada , Daisuke Fukuoka
发明人： Kiyohumi Muro , Tomohisa Endo , Yasutaka Shimada , Daisuke Fukuoka
IPC分类号： H01S3/08 , H01S5/06 , H01S5/14 , H01S5/022 , H01S5/028 , H01S5/10
CPC分类号： H01S5/06 , H01S3/025 , H01S3/0815 , H01S3/1055 , H01S5/02 , H01S5/02248 , H01S5/02252 , H01S5/02415 , H01S5/02438 , H01S5/0286 , H01S5/1085 , H01S5/143 , H01S2301/02
摘要： Disclosed is an ASE-free continuously tunable external resonator laser in which reduction in tuning range and decrease in output are suppressed. The external resonator laser comprises: a fixed support body which has a half mirror that partially reflects incident light and partially transmits incident light fixed therein; and a rotatory support body which is rotatably supported by the fixed support body by way of a shaft, and which has a laser chip that emits light, a collimator lens that collimates light emitted from the laser chip, and a diffraction grating that diffracts light emitted from the laser chip, fixed therein.
摘要翻译：公开了一种无ASE连续可调谐的外部谐振器激光器，其中抑制了调谐范围的减小和输出的减小。外部谐振器激光器包括：固定支撑体，其具有部分地反射入射光并部分地透射固定在其中的入射光的半反射镜; 以及旋转支撑体，其通过轴由固定支撑体可旋转地支撑，并且具有发射光的激光芯片，准直激光芯片发射的光的准直透镜和衍射出的光的衍射光栅从激光芯片固定在其中。

28. 发明申请

US20150117041A1 OPTICAL APPARATUS AND AUTOMOBILE LIGHTING 有权
标题翻译：光学装置和汽车照明
公开(公告)号：US20150117041A1
公开(公告)日：2015-04-30
申请号：US14511016
申请日：2014-10-09
申请人： STANLEY ELECTRIC CO., LTD. , NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY
发明人： Hiroto FUKUSHIMA , Yasuo TOKO , Norihisa KOBAYASHI
IPC分类号： G02F1/163 , F21S8/10
CPC分类号： G02F1/163 , F21S41/28 , F21S41/285 , F21S41/645 , F21S43/255 , F21S43/26 , G02F1/1506
摘要： An optical apparatus includes first and second substrates disposed to oppose each other, the first substrate having a first electrode provided on a surface of the first substrate nearer to the second substrate, and the second substrate having a second electrode provided on a surface of the second substrate nearer to the first substrate, and an electrolyte layer sandwiched between the first and the second substrates, and containing electro-deposition material including silver, wherein when potential of the first electrode is used as reference, a first voltage of positive polarity is applied in a first period to the second electrode, and a second voltage of positive polarity lower than the first voltage is applied in a second period after the first period to the second electrode.
摘要翻译：光学装置包括彼此相对设置的第一和第二基板，第一基板具有设置在第一基板的表面上的第一电极，该第一电极更靠近第二基板，第二基板具有设置在第二基板的第二基板的表面上的第二电极基板，更靠近第一基板的基板和夹在第一和第二基板之间的电解质层，并且含有包含银的电沉积材料，其中当使用第一电极的电位作为参考时，施加正极性的第一电压在第一周期之后的第二周期内向第二电极施加第一周期，并且施加低于第一电压的正极性的第二电压。

29. 发明申请

US20140228199A1 AMMONIA-PRODUCING CATALYST 审中-公开
标题翻译：氨生产催化剂
公开(公告)号：US20140228199A1
公开(公告)日：2014-08-14
申请号：US14177479
申请日：2014-02-11
申请人： National University Corporation Chiba University , DENSO CORPORATION
发明人： Masaki Yoshinaga , Hiroaki Yotou , Takumi Okamoto , Miho Itoh , Katsuyoshi Hoshino
IPC分类号： B01J31/38
CPC分类号： B01J31/063 , B01J21/063 , B01J23/38 , B01J23/42 , B01J23/44 , B01J23/462 , B01J23/464 , B01J23/50 , B01J23/70 , B01J23/745 , B01J27/135 , B01J27/18 , B01J33/00 , B01J35/0013 , B01J35/004 , B01J35/006 , B01J35/008 , B01J37/0219 , B01J37/088 , B01J37/18 , B01J37/345 , B01J2231/62
摘要： An ammonia-producing catalyst includes a p-type semiconductor, an n-type semiconductor, and a metal fine particle having a function of adsorbing nitrogen. In the ammonia-producing catalyst including the metal fine particle, generation of ammonia is promoted, and the generated amount of ammonia is increased. An ammonia-producing catalyst includes a p-type semiconductor, an n-type semiconductor, and an ammonia-fixing compound for fixing ammonia. In the ammonia-producing catalyst including the ammonia-fixing compound, a fixed yield of ammonia is sufficiently increased.
摘要翻译：氨生产催化剂包括p型半导体，n型半导体和具有吸附氮功能的金属微粒。在包含金属微粒子的氨生成催化剂中，促进氨的产生，氨的产生量增加。氨生产催化剂包括p型半导体，n型半导体和用于固定氨的氨固定化合物。在含氨固定化合物的氨生成催化剂中，氨的固定收率充分提高。

30. 发明申请

US20140218781A1 LIGHT-ADJUSTING ELEMENT AND PRODUCT CONTAINING THE SAME 有权
标题翻译：光调节元件和含有它的产品
公开(公告)号：US20140218781A1
公开(公告)日：2014-08-07
申请号：US14001955
申请日：2012-03-02
申请人： Norihisa Kobayashi , Kazuki Nakamura , Shingo Araki
发明人： Norihisa Kobayashi , Kazuki Nakamura , Shingo Araki
IPC分类号： G02F1/155
CPC分类号： G02F1/155 , G02F2001/1552
摘要： Provided are a light-adjusting element and a product containing the same. The light-adjusting element usable even with a transmission display device, and has a high-quality mirror state capable of a high contrast ratio. A light-adjusting element, according to one embodiment of the present invention, is characterized by including: a pair of substrates; a pair of electrodes formed on opposing surfaces of the pair of substrates, with one electrode being a transparent electrode that has nanometer-scale depressions and protrusions; and en electrolyte layer, interposed between the pair of electrodes, which has electrolyte as well as a mediator and an electrochromic material that has silver. Furthermore, a device according to one embodiment of the present invention at least partially includes the light-adjusting element.
摘要翻译：提供了一种调光元件和包含该调光元件的产品。该调光元件即使使用透射显示装置也可以使用，并且具有能够具有高对比度的高品质镜像状态。根据本发明的一个实施例的调光元件的特征在于包括：一对基板; 形成在一对基板的相对表面上的一对电极，一个电极是具有纳米级凹陷和突起的透明电极; 和介于具有电解质的一对电极之间的电解质层以及具有银的电介质和电致变色材料。此外，根据本发明的一个实施例的装置至少部分地包括调光元件。

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