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21. 发明申请

US20220339183A1 TREATMENT OF TAUOPATHIES 有权
公开(公告)号：US20220339183A1
公开(公告)日：2022-10-27
申请号：US17754047
申请日：2020-09-23
申请人： MACQUARIE UNIVERSITY
发明人： Lars ITTNER , Arne ITTNER
IPC分类号： A61K31/713 , A61K39/395 , C07K14/47 , A61K47/64 , A61K9/28 , A61P25/28
摘要： The present invention relates to a method of treating a tauopathy in a subject, a method of improving cognitive ability in a subject suffering from cognitive impairment associated with a tauopathy, a method of reducing tau aggregates and neurofibrillary tangles. The method comprises administering an agent which promotes phosphorylation of tau at threonine in the sequence SSPGSPGTPGSRSR of the tau; and/or introduces a phosphomimetic of a phosphorylated tau, wherein the phosphorylated tau is tau that has been phosphorylated at threonine in the sequence SSPGSPGTPGSRSR of the tau.

22. 发明授权

US11421513B2 Triboelectric energy harvesting with pipe-in-pipe structure 有权
公开(公告)号：US11421513B2
公开(公告)日：2022-08-23
申请号：US16944745
申请日：2020-07-31
申请人： SAUDI ARABIAN OIL COMPANY , Macquarie University
发明人： Chinthaka Pasan Gooneratne , Subhas Mukhopadhyay , Bodong Li , Guodong Zhan , Arturo Magana-Mora , Timothy Eric Moellendick
IPC分类号： E21B41/00 , H02N1/04 , H02N2/18 , E21B47/01 , E21B47/12
摘要： An apparatus includes an outer structure body having a cavity and an inner structure body rotatably supported within the cavity. The inner structure body has a central bore. Movable elements are positioned along the inner surface and movably coupled to the outer structure body. Ball elements are positioned along the outer surface and coupled to the inner structure body for movement with the inner structure body. The ball elements are positioned to releasably contact and impart motion to the movable elements in response to relative motion between the inner structure body and the outer structure body. A plurality of triboelectric energy harvesters are positioned to generate electrical charges when motion is imparted to the movable elements by the ball elements.

23. 发明申请

US20220113363A1 DIRECTION OF ARRIVAL ESTIMATION 有权
公开(公告)号：US20220113363A1
公开(公告)日：2022-04-14
申请号：US17509543
申请日：2021-10-25
申请人： MACQUARIE UNIVERSITY
发明人： Sam Reisenfeld , Audri Biswas
IPC分类号： G01S3/04 , G01S3/72 , G01S3/80 , G01S3/48
摘要： Iterative methods for direction of arrival estimation of a signal at a receiver with a plurality of spatially separated sensor elements are described. A quantized estimate of the angle of arrival is obtained from a compressive sensing solution of a set of equations. The estimate is refined in a subsequent iteration by a computed error based a quantized estimate of the direction of arrival in relation to quantization points offset from the quantization points for the first quantized estimate of the angle of arrival. The iterations converge on an estimated direction of arrival.

24. 发明授权

US10944232B2 Terahertz lasers and terahertz extraction 有权
公开(公告)号：US10944232B2
公开(公告)日：2021-03-09
申请号：US16495598
申请日：2018-03-23
申请人： Macquarie University
发明人： Andrew Lee , Helen M. Pask , David James Spence
IPC分类号： H01S3/30 , H01S1/02 , H01S3/108 , H01S3/11 , H01S3/16
摘要： A frequency electromagnetic radiation generation system including: a non linear crystal producing THz frequency electromagnetic radiation; a fundamental beam that interacts with the non linear crystal thereby emitting a THz frequency electromagnetic radiation emission; a silicon intermediary coupled to the non linear crystal for output channeling the THz frequency electromagnetic radiation emission to an output environment; the system utilising a fundamental beam which has a photon energy below the bandgap energy of silicon.

25. 发明授权

US10655138B2 Thermostable Rubisco activase complexes 有权
公开(公告)号：US10655138B2
公开(公告)日：2020-05-19
申请号：US15545870
申请日：2016-01-22
申请人： Macquarie University
发明人： Andrew Scafaro , Brian Atwell
IPC分类号： C12N15/82 , C12N9/88 , C07K14/415
摘要： The present invention relates to Rubisco activase (RCA) and functionally equivalent polypeptides that confer thermostability to a complex comprising Rubisco activase and Ribulose-1,5-bis-phosphate carboxylase/oxygenase (Rubisco).

26. 发明申请

US20200037894A1 A PATIENT-SPECIFIC REMOTE ISCHEMIC PRECONDITIONING SYSTEM WITH MULTI-LAYER FEEDBACK CONTROL UNIT 审中-公开
公开(公告)号：US20200037894A1
公开(公告)日：2020-02-06
申请号：US16481329
申请日：2018-01-25
申请人： MacQuarie University
发明人： Ashkan Javadzadegan , Andy Yong , Abouzar Moshfegh
IPC分类号： A61B5/0225 , A61B5/026 , A61B5/0255 , A61B5/1455
摘要： The technology relates to a remote ischemic preconditioning system having a cuff configured to contract about a limb of a subject; an actuator connected to the cuff that, when actuated, causes the cuff to contract about the limb of the subject; a controller that controls the actuator to operate according to a treatment protocol that includes a plurality of treatment cycles of contracting and releasing the cuff about the limb of a subject; a first sensor for measuring oxygen saturation level in the blood of the limb; a second sensor for measuring a pulse property in the limb; and a feedback control unit in communication with the controller and configured to receive the oxygen saturation measurement from the first sensor and the pulse property from the second sensor; wherein the feedback control unit is further configured to: compare the oxygen saturation level to a first predetermined value and signal the controller to operate the actuator to further inflate the cuff if the oxygen saturation level is above the predetermined value; and compare the pulse property to a second predetermined value and signal the controller to operate the actuator to further inflate the cuff if the pulse rate or pulse strength is above the predetermined value.

27. 发明申请

US20180353114A1 Biological detection system 审中-公开
公开(公告)号：US20180353114A1
公开(公告)日：2018-12-13
申请号：US16061218
申请日：2016-12-16
申请人： Macquarie University
发明人： Ewa Patrick GOLDYS , Guozhen LIU
IPC分类号： A61B5/145 , A61B5/1473
CPC分类号： A61B5/14546 , A61B5/1473 , B82Y20/00 , B82Y30/00 , G01N33/53 , G01N33/54366 , G01N33/68 , G01N33/6863
摘要： A biological capture device including an elongate member configured to be inserted into a region of a body of a subject and having capture region on the surface of the elongate member containing a capture ligand capable of binding to a target biological material when the device is in the body, and methods of use of the device to detect and measure target biological materials in a body.

28. 发明申请

US20150325976A1 A LASER AND A METHOD OF CONTROLLING THE GENERATION OF A LIGHT 审中-公开
标题翻译：激光和控制光的产生的方法
公开(公告)号：US20150325976A1
公开(公告)日：2015-11-12
申请号：US14412402
申请日：2013-07-05
申请人： Macquarie University
发明人： David James Spence , Helen Margaret Pask , Andrew Lee
IPC分类号： H01S3/108 , H01S3/16 , H01S3/30 , H01S3/109
CPC分类号： H01S3/30 , H01S3/08059 , H01S3/09415 , H01S3/1086 , H01S3/109 , H01S3/1611 , H01S3/1671
摘要： A laser configured to optimise output power at a desired wavelength, by suppression of unwanted Stokes orders in a Raman cascade, the laser comprising a resonating structure configured to resonate precursor light and Raman light frequencies, having a Raman medium configured to interact with the precursor resonating light to generate the Raman light; a control nonlinear medium configured to reduce an extraction of power from the precursor resonating light by the Raman process; and an output nonlinear medium configured to interact with the precursor resonating light to generate a desired output light thereby extracting power from the precursor resonating light; whereby the control nonlinear medium reduces the extraction of power from the precursor resonating light by the Raman process to enhance the extraction of power from the precursor resonating light by the output nonlinear medium interacting with the precursor resonating light thereby increasing the power of desired output the light.
摘要翻译：激光器，被配置为通过抑制拉曼级联中的不期望的斯托克斯次数来优化在期望波长处的输出功率，所述激光器包括被配置为共振前驱光和拉曼光频率的谐振结构，所述谐振结构被配置为与前体谐振相互作用光产生拉曼光; 控制非线性介质，被配置为通过拉曼过程减少从所述前体谐振光的功率的提取; 以及输出非线性介质，其被配置为与前体谐振光相互作用以产生期望的输出光，从而从前体谐振光提取功率; 由此，控制非线性介质通过拉曼过程减少来自前体谐振光的功率的提取，以通过与前驱体谐振光相互作用的输出非线性介质增强从前体谐振光的功率提取，从而增加所需输出光的功率。

29. 发明申请

US20150185149A1 MULTIPLEX SUSPENSION ASSAY/ARRAY USING LIFETIME CODING 有权
标题翻译：多用途悬挂测定/使用寿命编码的阵列
公开(公告)号：US20150185149A1
公开(公告)日：2015-07-02
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilised for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct colour bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.
摘要翻译：用于多重测定的系统，装置和/或方法。在特定但非限制性的示例中，提供了多路复用阵列，例如悬架阵列。发光衰减寿命用于悬浮阵列中的探针，并对来自时间分辨光谱的代码进行编码/解码。可以在不同的色带上生成终身人口。一种新颖的时间技术或尺寸应用于常规光谱和强度组合，从而扩大了悬架阵列的复用能力。在一个示例形式中，悬挂阵列的复用容量可以扩展到大约58个数量级。这提供了可靠的，高通量的和相对便宜的解决方案，用于在各种应用领域中的多重测定，诸如生命科学，数据存储和安全。

30. 发明申请

US20140269787A1 WAVELENGTH VERSATILE VECSEL RAMAN LASER 有权
标题翻译：波长VERSSTILE VECSEL拉曼激光
公开(公告)号：US20140269787A1
公开(公告)日：2014-09-18
申请号：US14355734
申请日：2012-11-09
申请人： Macquarie University
发明人： Jipeng Lin , Helen M. Pask , David James Spence , Craig J. Hamilton , Graeme P. Malcolm
IPC分类号： H01S5/183 , H01S5/06 , H01S3/30
CPC分类号： H01S5/0604 , H01S3/08027 , H01S3/082 , H01S3/1086 , H01S3/109 , H01S3/30 , H01S5/041 , H01S5/141 , H01S5/142 , H01S5/183
摘要： A tunable lasing device including a vertical external cavity surface emitting laser, adapted to generate a fundamental laser beam in response to pumping from a pump source, said fundamental laser beam having a fundamental wavelength and a fundamental linewidth; a fundamental resonator cavity adapted to resonate the fundamental beam therein; a first optical element located within the fundamental resonator cavity for control of the fundamental linewidth of the fundamental beam; a Raman resonator located at least partially in said fundamental resonator adapted to receive the fundamental beam and comprising therein, a solid state Raman active medium located therein for generating at least a first Stokes beam from the fundamental beam wherein said Raman resonator cavity is adapted to resonate said Stokes beam therein and further adapted to emit an output beam; and further comprising a nonlinear medium located within the Raman resonator cavity for nonlinear frequency conversion of at least one of the beams present in the fundamental or the Raman resonator cavity; said tunable lasing device further comprising an output coupler adapted to emit an output beam, said output beam comprising at least a portion of said frequency converted beam being derived from at least one of the resonating beams in said fundamental or said Raman resonator cavities.
摘要翻译：一种可调谐激光装置，包括垂直外腔表面发射激光器，适于响应于泵浦源的泵浦产生基本激光束，所述基本激光束具有基本波长和基本线宽; 基本谐振腔，其适于在其中谐振基波束; 位于基本谐振腔内的第一光学元件，用于控制基波束的基线宽度; 至少部分地位于所述基本谐振器中的拉曼谐振器，其适于接收基波束并且在其中包括位于其中的固态拉曼有源介质，用于从基波束产生至少第一斯托克斯波束，其中所述拉曼谐振腔适于谐振所述斯托克斯光束在其中并进一步适于发射输出光束; 并且还包括位于拉曼谐振腔内的非线性介质，用于对存在于基波或拉曼谐振腔中的至少一个波束进行非线性频率转换; 所述可调谐激光装置还包括适于发射输出光束的输出耦合器，所述输出光束包括所述频率转换光束的至少一部分从所述基波或所述拉曼谐振腔中的至少一个谐振光束导出。

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