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1. 发明授权

US09816926B2 Multiplex suspension assay/array using lifetime coding 有权
公开(公告)号：US09816926B2
公开(公告)日：2017-11-14
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64 , C40B70/00 , C09K11/02 , C09K11/06 , C09D11/50 , C09K11/77 , B42D25/382 , B42D25/387 , G01N33/542 , G01N33/58
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilized for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct color bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.

2. 发明申请

US20150185149A1 MULTIPLEX SUSPENSION ASSAY/ARRAY USING LIFETIME CODING 有权
标题翻译：多用途悬挂测定/使用寿命编码的阵列
公开(公告)号：US20150185149A1
公开(公告)日：2015-07-02
申请号：US14410015
申请日：2013-06-21
申请人： Macquarie University
发明人： Dayong Jin , Yiqing Lu , Jiangbo Zhao
IPC分类号： G01N21/64
CPC分类号： G01N21/6408 , B42D25/382 , B42D25/387 , C09D11/50 , C09K11/02 , C09K11/025 , C09K11/06 , C09K11/7773 , C09K2211/182 , C40B70/00 , G01N21/6428 , G01N33/542 , G01N33/582
摘要： A system, device and/or method for multiplex assays. In a particular, but non-limiting, example there is provided a multiplex array, such as a suspension array. Luminescence decay lifetimes are utilised for probes in a suspension array, and coding/decoding the codes from time-resolved spectra. Lifetime populations can be generated at distinct colour bands. A novel temporal technique or dimension is applied over conventional spectral and intensity combinations, thereby expanding the multiplexing capacity of a suspension array. In one example form, the multiplexing capacity of a suspension array can be expanded to the order of about 58. This provides a reliable, high-throughput and relatively inexpensive solution for multiplex assays in various areas of application such as life sciences, data storage and security.
摘要翻译：用于多重测定的系统，装置和/或方法。在特定但非限制性的示例中，提供了多路复用阵列，例如悬架阵列。发光衰减寿命用于悬浮阵列中的探针，并对来自时间分辨光谱的代码进行编码/解码。可以在不同的色带上生成终身人口。一种新颖的时间技术或尺寸应用于常规光谱和强度组合，从而扩大了悬架阵列的复用能力。在一个示例形式中，悬挂阵列的复用容量可以扩展到大约58个数量级。这提供了可靠的，高通量的和相对便宜的解决方案，用于在各种应用领域中的多重测定，诸如生命科学，数据存储和安全。

3. 发明申请

US20150252259A1 ENHANCING UPCONVERSION LUMINESCENCE IN RARE-EARTH DOPED PARTICLES 审中-公开
标题翻译：增加稀土掺杂颗粒中的UPCONVERSION LUMINESCENCE
公开(公告)号：US20150252259A1
公开(公告)日：2015-09-10
申请号：US14427693
申请日：2013-09-17
申请人： Macquarie University
发明人： Dayong Jin , Jiangbo Zhao
IPC分类号： C09K11/77
CPC分类号： A61K49/0013 , A61K49/0058 , A61K49/0093 , B41M3/144 , B42D25/29 , B42D2035/34 , C09D11/30 , C09D11/50 , C09K11/025 , C09K11/7773 , G02F2/02
摘要： Disclosed is a method for enhancing upconversion luminescence of rare-earth doped particles comprising a host material, an enriched concentration of activator (emitter) and a sufficient concentration level of sensitiser, the method comprising subjecting the particles to increased irradiance. The increased irradiance is higher than presently used relatively low irradiance levels. Enhancing upconversion luminescence involves enhancing luminescence intensity, brightness and/or upconversion efficiency. Particles are preferably subjected to an irradiance power density sufficient to overcome or reverse concentration quenching. The activator preferably has an intermediate meta stable energy level which accepts resonance energy from the sensitiser excited state level. In another form, particles are designed to minimize or exclude quenchers from the upconversion system between sensitizer and activator, such as the core-shell particles wherein the core comprises the host material, sensitiser and the activator, and the shell comprises a material which prevents, retards or inhibits surface quenching.
摘要翻译：公开了一种用于增强包含主体材料，富集浓度的活化剂（发射体）和足够浓度的敏化剂的稀土掺杂颗粒的转换发光的方法，所述方法包括使颗粒经受增加的辐照度。增加的辐照度高于目前使用的相对低的辐照度水平。增强上变频发光涉及提高发光强度，亮度和/或上转换效率。颗粒优选经受足以克服或反向浓缩猝灭的辐照功率密度。优选地，活化剂具有从敏化剂激发态水平接受共振能的中间元稳定能级。在另一种形式中，颗粒被设计成使敏化剂和活化剂之间的上转换系统中的猝灭剂最小化或排除，例如核 - 壳颗粒，其中芯包含主体材料，敏化剂和活化剂，并且壳包含防止，延缓或抑制表面淬火。

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