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    • 28. 发明授权
    • Antibacterial and antifouling oxathiazines and their oxides
    • 抗菌和防污的恶噻嗪及其氧化物
    • US5712275A
    • 1998-01-27
    • US586690
    • 1996-01-25
    • Jozef Frans Elizabetha Van Gestel
    • Jozef Frans Elizabetha Van Gestel
    • A01N43/88A01P1/00C07D291/06C07D419/04C09D5/14C09D5/16A61K31/54A01N43/34A01N43/36A01N43/72
    • C07D419/04A01N43/88C07D291/06C09D5/1625
    • Use of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides having the formula ##STR1## wherein n is 0, 1 or 2; R.sup.1 is hydrogen, C.sub.1-4 alkyl or benzyl; and R represents (a) phenyl; phenyl substituted with 1 to 3 substituents independently selected from hydroxyl, halo, C.sub.1-12 alkyl, C.sub.5-6 cycloalkyl, trihalomethyl, phenyl, C.sub.1-5 alkoxy, C.sub.1-5 alkylthio, tetrahydropyranyloxy, phenoxy, C.sub.1-4 alkylcarbonyl, phenylcarbonyl, C.sub.1-4 alkylsulfinyl, C.sub.1-4 alkylsulfonyl, carboxy or its alkali metal salt, C.sub.1-4 alkyloxycarbonyl, C.sub.1-4 alkylaminocarbonyl, phenylaminocarbonyl, tolylaminocarbonyl, morpholinocarbonyl, amino, nitro, cyano, dioxolanyl or C.sub.1-4 alkyloxyiminomethyl; naphthyl; pyridinyl; thienyl, preferably when n is not 2; furanyl; or thienyl or furanyl substituted with one to three substituents independently selected from C.sub.1-4 alkyl, C.sub.1-4 alkyloxy, C.sub.1-4 alkylthio, halo, cyano, formyl, acetyl, benzoyl, nitro, C.sub.1-4 alkyloxycarbonyl, phenyl, phenylaminocarbonyl and C.sub.1-4 alkyloxyiminomethyl; or R represents a radical of formula ##STR2## wherein X is oxygen or sulfur; Y is nitrogen, CH or C(C.sub.1-4 alkyloxy); and R" is hydrogen or C.sub.1-4 alkyl, as an antibacterial, anti-yeast, antifungal, algicidal, anti-crustacean, molluscicidal and general antifouling agent and compositions containing the same.
    • PCT No.PCT / EP94 / 02784 Sec。 371日期:1996年1月25日 102(e)日期1996年1月25日PCT 1994年8月24日PCT公布。 公开号WO95 / 05739 日期1993年3月2日使用3-芳基-5,6-二氢-1,4,2-氧噻嗪及其具有式(I)的化合物,其中n为0,1或2; R1是氢,C1-4烷基或苄基; 且R表示(a)苯基; 被1至3个独立地选自羟基,卤素,C 1-12烷基,C 5-6环烷基,三卤甲基,苯基,C 1-5烷氧基,C 1-5烷硫基,四氢吡喃氧基,苯氧基,C 1-4烷基羰基,苯基羰基,C 1-4烷基亚磺酰基, 羧基或其碱金属盐,C 1-4烷氧基羰基,C 1-4烷基氨基羰基,苯基氨基羰基,甲苯基氨基羰基,吗啉代羰基,氨基,硝基,氰基,二氧戊环基或C 1-4烷氧基亚氨基甲基; 萘基; 吡啶基 噻吩基,优选当n不为2时; 呋喃基 或被一至三个独立地选自C 1-4烷基,C 1-4烷氧基,C 1-4烷硫基,卤素,氰基,甲酰基,乙酰基,苯甲酰基,硝基,C 1-4烷氧基羰基,苯基,苯氨基羰基和C 1-4烷氧基亚氨基甲基的取代基取代的噻吩基或呋喃基。 或R表示式(B)的基团,其中X为氧或硫; Y是氮,CH或C(C 1-4烷氧基); 和R“是氢或C 1-4烷基,作为抗菌,抗酵母,抗真菌,杀藻,抗甲壳素,杀软体动物和一般的防污剂及含有它们的组合物。