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1. 发明授权

US11535600B2 Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine 有权
公开(公告)号：US11535600B2
公开(公告)日：2022-12-27
申请号：US17297717
申请日：2019-11-27
申请人： H. Lundbeck A/S
发明人： Mikkel Fog Jacobsen , Morten Jørgensen
IPC分类号： C07D295/03 , C07D295/037
摘要： The present invention relates to prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine in the form of 1a and 1b; and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine in the form of 2a and 2b, wherein X—is a counter ion, or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising prodrugs, or pharmaceutically acceptable salts thereof, of the invention.

2. 发明申请

US20220033367A1 PRODRUGS OF 4-((1R, 3S)-6-CHLORO-3-PHENYL-2,3-DIHYDRO-1H-INDEN-1-Y)-1-,2,2-TRIMETHYLPIPERAZINE AND 4-((1R,3S)-6-CHLORO-3-(PHENYL-D5)-2,3-DIHYDRO-1H-INDEN-1YL)-2,2-DIMETHYL-1 (METHYL-D3)PIPERAZINE 有权
公开(公告)号：US20220033367A1
公开(公告)日：2022-02-03
申请号：US17297717
申请日：2019-11-27
申请人： H. Lundbeck A/S
发明人： MIkkel Fog Jacobsen , Morten Jørgensen
IPC分类号： C07D295/037
摘要： The present invention relates to prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine in the form of 1a and 1b; and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine in the form of 2a and 2b, wherein X—is a counter ion, or pharmaceutically acceptable salts thereof. The present invention also provides pharmaceutical compositions comprising prodrugs, or pharmaceutically acceptable salts thereof, of the invention.

3. 发明授权

US10301254B2 Substituted polycationic multi-quaternary ammonium salts as antimicrobial agents 有权
公开(公告)号：US10301254B2
公开(公告)日：2019-05-28
申请号：US15568555
申请日：2016-04-22
申请人： Temple University—Of The Commonwealth System of Higher Education , Villanova University
发明人： William M. Wuest , Kevin P. C. Minbiole
IPC分类号： C07D295/02 , C07C211/63 , A61K31/13 , A61K31/16 , A61K45/06 , C08G73/00 , C07D401/04 , C07D453/02 , C07D255/02 , C07D257/02 , C07D295/037 , C07D213/36 , A01N33/12 , A01N43/40 , A01N43/60 , A01N43/64 , A01N43/90 , C07C211/64 , C07D295/13 , C08F8/32 , C08F112/14 , C08F120/34 , C09D5/14
摘要： The present invention includes polycationic amphiphilic compounds of formula VII useful as antimicrobial agents. The present invention further includes novel polymers of polycationic amphiphilic compounds useful as antimicrobial agents. The present invention further includes methods useful for removing microorganisms and/or biofilm-embedded microorganisms from a surface. The present invention further includes compositions and methods useful for preventing or reducing the growth or proliferation of microorganisms and/or biofilm-embedded microorganisms on a surface.

4. 发明申请

US20180265486A1 ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS 审中-公开
公开(公告)号：US20180265486A1
公开(公告)日：2018-09-20
申请号：US15981148
申请日：2018-05-16
申请人： UOP LLC
发明人： Christopher P. Nicholas , Mark A. Miller , Melissa M. Galey , Benjamin D. Yuhas , Sesh Prabhakar
IPC分类号： C07D295/037 , C07D295/023 , C07D295/027
CPC分类号： C07D295/037 , C07D295/023 , C07D295/027
摘要： Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

5. 发明申请

US20180265485A1 ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS 审中-公开
公开(公告)号：US20180265485A1
公开(公告)日：2018-09-20
申请号：US15981084
申请日：2018-05-16
申请人： UOP LLC
发明人： Christopher P. Nicholas , Mark A. Miller , Melissa M. Galey , Benjamin D. Yuhas , Sesh Prabhakar
IPC分类号： C07D295/037 , C07D295/023 , C07D295/027
CPC分类号： C07D295/037 , C07D295/023 , C07D295/027 , C07D497/10
摘要： Novel 1-oxa-4-azonium cyclohexane salts are described. These compounds can be used as structure directing agents, and they overcome many of the typical problems associated with OSDA synthesis and subsequent zeolite synthesis. Methods for synthesis of the 1-oxa-4-azonium cyclohexane salts from a variety of starting materials are also described. A substituted hydrocarbon is added to water to form a mixture, and a 1-oxa-4-azacyclohexane derivative is then added. The reaction mixture stirred until a solution containing the 1-oxa-4-azonium cyclohexane salt is obtained.

6. 发明授权

US09676700B2 Preparation of fluorosulfonate esters and onium salts derived therefrom 有权
公开(公告)号：US09676700B2
公开(公告)日：2017-06-13
申请号：US14766092
申请日：2014-02-11
申请人： Trinapco, Inc.
发明人： Martin Reid Johnson
IPC分类号： C07C309/00 , C07C209/00 , C07C211/63 , C07C213/02 , C07D233/58 , C07D295/037 , C01B17/45
CPC分类号： C07C209/00 , C01B17/45 , C07C211/63 , C07C213/02 , C07D233/58 , C07D295/037
摘要： The present invention is directed to methods for preparing a fluorosulfonate ester or a salt thereof, through a reaction of a dissolved sulfonyl fluoride (RFSO2F) with alkoxide anion (RO−) optionally in the presence of an aprotic base (B), where RF is fluorine or a C1-C8 perfluoroalkyl group, and R is a primary alkyl or alkoxyalkyl. Alkoxide anion (RO−) can be generated from a precursor such as an alcohol or silyl ester.

7. 发明授权

US09637449B2 Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic-acid 有权
公开(公告)号：US09637449B2
公开(公告)日：2017-05-02
申请号：US15061931
申请日：2016-03-04
申请人： Pfizer Inc.
发明人： Joseph Francis Krzyzaniak , Jason Albert Leonard
IPC分类号： C07D207/34 , C07D295/037 , C07C211/07 , C07C215/08 , C07C229/26 , C07D295/027
CPC分类号： C07D207/34 , C07C211/07 , C07C215/08 , C07C229/26 , C07D295/027 , C07D295/037
摘要： Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.

8. 发明申请

US20160252808A1 PHOTOPOLYMER FORMULATION FOR PRODUCTION OF HOLOGRAPHIC MEDIA COMPRISING BORATES WITH LOW TG 有权
标题翻译：用于生产包含低TG的硼酸盐的全息介质的光聚合物配方
公开(公告)号：US20160252808A1
公开(公告)日：2016-09-01
申请号：US15029080
申请日：2014-10-13
申请人： COVESTRO DEUTSCHLAND AG
发明人： Horst BERNETH , Thomas RÖLLE , Friedrich-Karl BRUDER , Dennis HÖNEL , Marc-Stephan WEISER , Thomas FÄCKE , Rainer HAGEN , Günther WALZE
IPC分类号： G03F7/00 , C07C211/63 , C07D295/037 , C07D213/20 , C07D233/58 , G03F7/029 , C07F5/02
CPC分类号： G03F7/001 , C07C211/63 , C07D213/20 , C07D233/58 , C07D295/037 , C07F5/027 , G03F7/029 , G03F7/035 , G03H1/0248 , G03H2001/0264 , G03H2260/12
摘要： The invention relates to a photopolymer formulation comprising a component reactive toward isocyanates, a polyisocyanate component, a writing monomer and a photoinitiator containing at least one dye and a coinitiator, characterized in that the coinitiator contains at least one substance of the formula (Ia) The invention further provides a process for preparing the specific coinitiators and the coinitiators obtainable by this process, and additionally a process for producing a holographic medium using the specific coinitiators, and a holographic medium obtainable using the inventive photopolymer formulation. The invention further relates to a laminate structure comprising an inventive holographic medium and likewise specific borates suitable as coinitiators.
摘要翻译：本发明涉及包含对异氰酸酯反应的组分，多异氰酸酯组分，书写单体和含有至少一种染料和共引发剂的光引发剂的光聚合物配方，其特征在于共引发剂含有至少一种式（Ia）的物质。本发明还提供了一种制备可通过该方法获得的特定共引发剂和共引发剂的方法，另外提供了使用该特定共引发剂制备全息介质的方法，以及使用本发明的光聚合物制剂可获得的全息介质。本发明还涉及包含本发明的全息介质和适合作为共引发剂的特定硼酸盐的层压结构。

9. 发明授权

US09345653B2 Dye composition comprising a cationic meta-phenylenediamine 有权
标题翻译：包含阳离子间苯二胺的染料组合物
公开(公告)号：US09345653B2
公开(公告)日：2016-05-24
申请号：US14411841
申请日：2013-06-26
申请人： Aziz Fadli
发明人： Aziz Fadli
IPC分类号： A61Q5/10 , A61K8/49 , C07D233/61 , C07D295/037
CPC分类号： A61K8/494 , A61Q5/10 , C07D233/61 , C07D295/037
摘要： One subject of the invention is a meia-phenylenediamine compound having formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: • R represents a hydrogen or halogen atom; a C1-C4 alkyl group; a carboxyl group or a (C1-C4)alkoxycarbonyl group, • R1 represents a C1-C10(hydroxy)alkyl group, optionally interrupted with one or more non-adjacent oxygen atoms or non-adjacent NR′ substituents, substituted by a cationic CAT group, • R2 represents a hydrogen atom or a C1-C4(hydroxy)alkyl group, • R1 and R2 may form, together with the atom that bears them, a cationic heterocycle with 5 to 8 members, • R′ represents a hydrogen atom or a C1-C4(hydroxy)alkyl group; • An″ represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.
摘要翻译：本发明的一个主题是下式（I）的咪 - 苯二胺化合物，其与酸的加成盐及其溶剂合物：其中：R代表氢或卤素原子; C1-C4烷基; 羧基或（C1-C4）烷氧基羰基，R1表示C1-C10（羟基）烷基，任选地被一个或多个不相邻的氧原子或不相邻的NR'取代基间隔，被阳离子CAT 基团，R 2表示氢原子或C 1 -C 4（羟基）烷基，R 1和R 2可以与带有它们的原子一起形成具有5-8个成员的阳离子杂环，R'表示氢原子或C 1 -C 4（羟基）烷基; •“一个”表示阴离子或阴离子的混合物，它们是有机或无机和化妆品可接受的。

10. 发明授权

US09309195B2 Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-hepatanoic acid 有权
标题翻译： [R-（R *，R *）] - 2-（4-氟苯基） - （bgr），δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-乙酸
公开(公告)号：US09309195B2
公开(公告)日：2016-04-12
申请号：US14716361
申请日：2015-05-19
申请人： Pfizer Inc.
发明人： Joseph Francis Krzyzaniak , Jason Albert Leonard
IPC分类号： C07D207/34 , C07D295/037 , C07C211/07 , C07C215/08 , C07C229/26 , C07D295/027
CPC分类号： C07D207/34 , C07C211/07 , C07C215/08 , C07C229/26 , C07D295/027 , C07D295/037
摘要： Novel salt forms of [R—(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid characterized by their X-ray powder diffraction pattern and solid-state NMR spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and Alzheimer's Disease.
摘要翻译： [R-（R *，R *）] - 2-（4-氟苯基） - ，b-的新型盐形式，δ-二羟基-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基 ] -1H-吡咯-1-庚酸，其特征在于它们的X射线粉末衍射图和固态NMR光谱，以及其制备方法和药物组合物，其可用作治疗高脂血症的药剂，高胆固醇血症，骨质疏松症，良性前列腺增生症和阿尔茨海默病。

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