专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 外观设计

USD632156S1 Handle 有权
公开(公告)号：USD632156S1
公开(公告)日：2011-02-08
申请号：US29349310
申请日：2010-03-24
申请人： Chia Ling Huang
设计人： Chia Ling Huang

32. 外观设计

USD627533S1 Trash can 有权
公开(公告)号：USD627533S1
公开(公告)日：2010-11-16
申请号：US29307694
申请日：2008-05-06
申请人： Frank Yang , Tzu-Hao Wei , Po-Ling Huang
设计人： Frank Yang , Tzu-Hao Wei , Po-Ling Huang

33. 发明授权

US07786270B2 Humanized FcγRIIB-specific antibodies and methods of use thereof 有权
标题翻译：人源化FcγRIIB特异性抗体及其使用方法
公开(公告)号：US07786270B2
公开(公告)日：2010-08-31
申请号：US11754015
申请日：2007-05-25
申请人： Leslie S. Johnson , Ling Huang
发明人： Leslie S. Johnson , Ling Huang
IPC分类号： C12P21/08
CPC分类号： A61K39/39 , A61K2039/505 , A61K2039/55516 , C07K16/283 , C07K2317/24 , C07K2317/34 , C07K2317/52 , G01N33/564 , G01N33/6893 , G01N2800/24
摘要： The present invention relates to humanized FcγRIIB antibodies, fragments, and variants thereof that bind human FcγRIIB with a greater affinity than said antibody binds FcγRIIA. The invention encompasses the use of the humanized antibodies of the invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, such as cancer, autoimmune and inflammatory disease. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the humanized antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing the efficacy of a vaccine composition by administering the humanized antibodies of the invention. The invention encompasses methods for treating an autoimmune disease and methods for elimination of cancer cells that express FcγRIIB.
摘要翻译：本发明涉及以比所述抗体结合FcγRIIA更大的亲和力结合人FcγRIIB的人源化FcγRIIB抗体，其片段和变体。本发明包括本发明的人源化抗体用于治疗与Fc受体介导的信号传导的平衡丧失有关的任何疾病（例如癌症，自身免疫性和炎症性疾病）的用途。本发明提供了通过施用本发明的人源化抗体来增强治疗性抗体的治疗效果以增强治疗性抗体的效应子功能的方法。本发明还提供了通过施用本发明的人源化抗体来增强疫苗组合物的功效的方法。本发明包括治疗自身免疫性疾病的方法和用于消除表达FcγRIIB的癌细胞的方法。

34. 外观设计

USD622110S1 Bamboo napkin holder 有权
标题翻译：竹餐巾架
公开(公告)号：USD622110S1
公开(公告)日：2010-08-24
申请号：US29346643
申请日：2009-11-03
申请人： Frank Yang , Tzu-Hao Wei , Di-Fong Chang , Po-Ling Huang
设计人： Frank Yang , Tzu-Hao Wei , Di-Fong Chang , Po-Ling Huang

35. 发明授权

US07776617B2 Signal enhancement system with multiple labeled-moieties 有权
标题翻译：具有多个标记部分的信号增强系统
公开(公告)号：US07776617B2
公开(公告)日：2010-08-17
申请号：US10432036
申请日：2001-11-30
申请人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
发明人： Helen Lee , Ling Huang , Magda Anastassova Dineva , Hsiang Yun Hu
IPC分类号： C12Q1/00 , C12M1/34 , C12M3/00 , G01N33/53 , G01N21/00 , G01N21/75 , G01N21/76 , G01N21/77 , G01N33/566 , G01N33/543 , G01N33/551 , G01N33/544
CPC分类号： G01N33/558 , Y10S435/81 , Y10S436/807 , Y10S977/70 , Y10S977/773 , Y10S977/788 , Y10S977/918
摘要： Dipstick tests for detecting analyte are described. In a preferred embodiment, a multiple biotinylated antibody capable of binding analyte is bound to an anti-biotin antibody labelled with colloidal gold and wicked up the dipstick with test solution thought to contain analyte. Complex formed between analyte, biotinylated anti-analyte antibody, and colloidal gold labelled anti-biotin antibody is captured at a capture zone of the dipstick. Presence of colloidal gold label at the capture zone indicates the presence of analyte in the test solution. The sensitivity of analyte detection using such methods is an order of magnitude higher than for comparable methods in which biotinylated anti-analyte antibody bound to analyte is wicked up the dipstick in a first step, and a colloidal gold labelled anti-biotin antibody is wicked up the dipstick in a separate step. Kits for performing the tests of the invention are also described.
摘要翻译：描述了用于检测分析物的浸渍试验。在优选的实施方案中，能够结合分析物的多重生物素化抗体与由胶体金标记的抗生物素抗体结合，并且将被认为含有分析物的测试溶液弄脏。分析物，生物素化抗分析物抗体和胶体金标记的抗生物素抗体之间形成的复合物在量油尺的捕获区捕获。在捕获区存在胶体金标记表示测试溶液中存在分析物。使用这种方法的分析物检测的灵敏度比在第一步中将测得的与分析物结合的生物素化的抗分析物抗体被弄脏的可比较方法高一个数量级，并且胶体金标记的抗生物素抗体被恶化量油尺在一个单独的步骤。还描述了用于执行本发明的测试的套件。

36. 发明申请

US20100174053A1 COVALENT DIABODIES AND USES THEREOF 有权
标题翻译：同性双胞胎及其用途
公开(公告)号：US20100174053A1
公开(公告)日：2010-07-08
申请号：US12641095
申请日：2009-12-17
申请人： Leslie S. JOHNSON , Ling HUANG
发明人： Leslie S. JOHNSON , Ling HUANG
IPC分类号： C07K16/00
CPC分类号： C07K16/283 , C07K2317/34 , C07K2317/52 , C07K2317/626 , C07K2317/73
摘要： The present invention is directed to diabody molecules and uses thereof in the treatment of a variety of diseases and disorders, including immunological disorders, infectious disease, intoxication and cancers. The diabody molecules of the invention comprise two polypeptide chains that associate to form at least two epitope binding sites, which may recognize the same or different epitopes on the same or differing antigens. Additionally, the antigens may be from the same or different molecules. The individual polypeptide chains of the diabody molecule may be covalently bound through non-peptide bond covalent bonds, such as, but not limited to, disulfide bonding of cysteine residues located within each polypeptide chain. In particular embodiments, the diabody molecules of the present invention further comprise an Fc region, which allows antibody-like functionality to engineered into the molecule.
摘要翻译：本发明涉及双抗体分子及其在治疗各种疾病和病症（包括免疫学疾病，感染性疾病，中毒和癌症）中的用途。本发明的双抗体分子包含两个缔合以形成至少两个表位结合位点的多肽链，其可识别相同或不同抗原上相同或不同的表位。另外，抗原可以来自相同或不同的分子。双抗体分子的单个多肽链可以通过非肽键共价键共价结合，例如但不限于位于每个多肽链内的半胱氨酸残基的二硫键。在具体实施方案中，本发明的双抗体分子还包含Fc区，其允许抗体样功能被改造成分子。

37. 外观设计

USD617098S1 Tool box 有权
公开(公告)号：USD617098S1
公开(公告)日：2010-06-08
申请号：US29348224
申请日：2009-12-10
申请人： Chia-Ling Huang
设计人： Chia-Ling Huang

38. 发明申请

US20100129908A1 SPACED PROJECTION SUBSTRATES AND DEVICES FOR CELL CULTURE 审中-公开
标题翻译：间隔投影基质和细胞培养装置
公开(公告)号：US20100129908A1
公开(公告)日：2010-05-27
申请号：US12622079
申请日：2009-11-19
申请人： Ye Fang , Yi-Cheng Hsieh , Ling Huang , Ying Wei
发明人： Ye Fang , Yi-Cheng Hsieh , Ling Huang , Ying Wei
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12M25/02 , C12N2502/13 , C12N2533/54
摘要： An article for culturing cells includes a substrate on which cells can be cultured. The substrate has a base surface. An array of projections extends from the base surface. The projections have a height of about 1 micrometer to about 100 micrometers, and have a gap distance along the major surface from center to center between neighboring projections of about 10 micrometers to 80 micrometers. A plurality of arrays of projections may extend from the surface with gaps in the base surface between the arrays. Hepatocytes cultures on such microprojection array substrates maintained in vivo like morphology and membrane polarity. Hepatocytes co-cultured with helper cells on such substrates tended to grow in the area of the arrays, while the helper cells tended to grow in the areas between the arrays.
摘要翻译：培养细胞的制品包括可以培养细胞的底物。基板具有基面。一组突起从基面延伸出来。突起具有约1微米至约100微米的高度，并且在约10微米至80微米的相邻突起之间具有从中心到中心的主表面的间隙距离。多个突起阵列可以从阵列之间的基部表面中的间隙从表面延伸。在这样的微喷射阵列基板上的肝细胞培养物保持体内，如形态和膜极性。与这种底物上的辅助细胞共培养的肝细胞趋向于在阵列区域中生长，而辅助细胞趋向于在阵列之间的区域中生长。

39. 发明申请

US20100121219A1 Mouth Cell Collection Device with Mechanically Rinsible Scoop 审中-公开
标题翻译：具有机械可溶性勺子的口腔细胞收集装置
公开(公告)号：US20100121219A1
公开(公告)日：2010-05-13
申请号：US12614290
申请日：2009-11-06
申请人： Edward R.B. McCabe , Yao Hua Zhang , Bing Ling Huang , Nicole K. Henderson-MacLennan
发明人： Edward R.B. McCabe , Yao Hua Zhang , Bing Ling Huang , Nicole K. Henderson-MacLennan
IPC分类号： A61B10/02
CPC分类号： A61B10/0051 , A61B10/0096
摘要： The present invention provides a collection device for obtaining a sample from within the mouth of a subject. The collection device comprises a collection wand, having a hollow shaft and a scoop attached to the end of the shaft, and optionally, a bulb, a pipetting device, and a collection tube. Also provided are methods of using the collection device to obtain a sample from the mouth of a subject.
摘要翻译：本发明提供一种用于从受试者的嘴内获取样品的收集装置。收集装置包括收集棒，具有中空轴和连接到轴的端部的铲斗，以及可选地，灯泡，移液装置和收集管。还提供了使用收集装置从受试者的嘴中获取样品的方法。

40. 发明授权

US07713912B2 Nano photocatalytic sol and application thereof 有权
标题翻译：纳米光催化溶胶及其应用
公开(公告)号：US07713912B2
公开(公告)日：2010-05-11
申请号：US11512220
申请日：2006-08-30
申请人： Chia-Hung Huang , Yao-Ling Huang , Yao-Hsuan Tseng , Yu-Ming Lin , Shu-Ling Liu
发明人： Chia-Hung Huang , Yao-Ling Huang , Yao-Hsuan Tseng , Yu-Ming Lin , Shu-Ling Liu
IPC分类号： B01J23/00 , B01J23/06 , C01G23/047 , C01G9/02 , C01G19/02 , C09D1/00
CPC分类号： B01J35/004 , B01J35/023 , B01J35/026 , B01J37/0215 , B01J37/04
摘要： The present invention relates to a nano-sized photocatalytic sol and application thereof. The invention utilizes spherical nano-photocatalyst and non-spherical photocatalytic sol for coating a photocatalyst layer on a substrate. Because of the stereo, interlaced and composite structure between spherical photocatalyst and non-spherical photocatalyst, a hard and well adhesion coated layer of photocatalyst with good photocatalytic activity can be obtained without using binder.
摘要翻译：本发明涉及一种纳米级光催化溶胶及其应用。本发明利用球形纳米光催化剂和非球形光催化溶胶在基材上涂覆光催化剂层。由于球形光催化剂和非球形光催化剂之间的立体，交错和复合结构，可以在不使用粘合剂的情况下获得具有良好光催化活性的硬质和良好粘附的光催化剂层。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式