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31. 发明授权

US07369228B2 Compact spectrometer 有权
标题翻译：紧凑型光谱仪
公开(公告)号：US07369228B2
公开(公告)日：2008-05-06
申请号：US10544555
申请日：2003-12-19
申请人： Felix Kerstan , Ullrich Klarner , Nico Correns , Gregor Tumpach
发明人： Felix Kerstan , Ullrich Klarner , Nico Correns , Gregor Tumpach
IPC分类号： G01J3/36
CPC分类号： G01J3/02 , G01J3/0256 , G01J3/0291
摘要： The present invention is directed to a spectrometer in which the electrical and optical components are connected to one another in a compact construction. A minimal expenditure on assembly and adjustment is achieved through a small quantity of individual parts. The compact spectrometer comprises an entrance slit, an imaging grating, one or more detector elements in rows or matrices, and elements of a controlling and evaluating unit. The detector elements and the entrance slit are arranged on a shared support, the elements of the controlling and evaluating unit being arranged on the free surfaces of the support. The entrance slit and the detector elements and the imaging spherical grating recessed into the spectrometer housing are arranged symmetric to an imaginary center axis of the support. Due to its compact size and the minimized expenditure on adjustment and assembly for its manufacture, the inventive spectrometer has numerous applications.
摘要翻译：本发明涉及一种其中电气和光学部件以紧凑的结构相互连接的光谱仪。组装和调整的最小支出是通过少量的个别部件实现的。紧凑型光谱仪包括入口狭缝，成像光栅，行或矩阵中的一个或多个检测器元件，以及控制和评估单元的元件。检测器元件和入口狭缝布置在共享支撑件上，控制和评估单元的元件布置在支撑件的自由表面上。凹入光谱仪壳体的入射狭缝和探测器元件和成像球形光栅与支撑体的假想中心轴线对称。由于其紧凑的尺寸和用于其制造的调整和组装的最小化的支出，本发明的光谱仪具有许多应用。

32. 发明申请

US20140029091A1 MICROSCOPE AND METHOD FOR OPERATING A MICROSCOPE 有权
标题翻译：显微镜和操作微阵列的方法
公开(公告)号：US20140029091A1
公开(公告)日：2014-01-30
申请号：US14049683
申请日：2013-10-09
申请人： Carl Zeiss Microimaging GmbH
发明人： Ingo Kleppe , Mirko Liedtke
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/0076
摘要： The invention relates to a method for operating a microscope in which excitation light is focused on, or beamed to, different points of a specimen, in which an intensity of the excitation light is point-specifically varied and in which an intensity of the light reflected by said specimen in at least one spectral range is measured point-specifically and quantitatively. The method according to the invention is characterized in that the intensity and/or a spectral composition of the excitation light beamed to a specific point of said specimen is automatically adjusted by a regulating device on the basis of information previously gained from measured data of said specimen concerning an estimated or actual intensity of the light reflected in the spectral range by said point such that an integral of the intensity of the light reflected in the spectral range by this point during a pixel dwell time is within a predefined value interval. The invention also relates to a microscope.
摘要翻译：本发明涉及一种用于操作显微镜的方法，其中激发光聚焦在或被照射到样本的不同点，其中激发光的强度被特别地改变，并且其中光的强度被反射通过所述样本在至少一个光谱范围内被特别和定量地测量。根据本发明的方法的特征在于，通过调节装置基于先前从所述样本的测量数据获得的信息自动调节被发射到所述样本的特定点的激发光的强度和/或光谱组成涉及所述点在光谱范围内反射的光的估计或实际强度，使得在像素停留时间期间在该点处在光谱范围内反射的光的强度的积分在预定义的值间隔内。本发明还涉及一种显微镜。

33. 发明授权

US08503077B2 Tube unit for microscopes 有权
标题翻译：显微镜管单元
公开(公告)号：US08503077B2
公开(公告)日：2013-08-06
申请号：US12867864
申请日：2009-01-28
申请人： Rolf Wartmann , Hubert Wahl
发明人： Rolf Wartmann , Hubert Wahl
IPC分类号： G02B21/00
CPC分类号： G02B21/24 , G02B7/24
摘要： A tube unit for microscopes which has a tube lens, including two components with an intermediate, large air separation, and an overall positive refractive power. The air separation is at least half the size of the focal length f of the tube lens. A roof edge mirror or another suitable deflection element is arranged between the two components of the tube lens. The roof edge mirror includes two mirrors, which can be tilted with respect to one another, and which is able to be tilted around its roof edge. The tilting movement or the tilting angle of the tiltable mirror or deflection element corresponds to half the tilt or half the tilting angle of the tube or eyepiece viewing system.
摘要翻译：用于具有管透镜的显微镜的管单元，包括具有中间，大空气分离和总正折射力的两个部件。空气分离至少是管透镜焦距f的一半。在镜片的两个部件之间布置有屋顶镜或其它合适的偏转元件。屋顶边缘镜包括两个可相对于彼此倾斜的镜子，其能够围绕其屋顶边缘倾斜。可倾斜镜或偏转元件的倾斜运动或倾斜角度对应于管或目镜观察系统的倾斜角或倾斜角的一半。

34. 发明申请

US20120281264A1 MICROSCOPE 有权
标题翻译：显微镜
公开(公告)号：US20120281264A1
公开(公告)日：2012-11-08
申请号：US13498095
申请日：2010-09-17
申请人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
发明人： Helmut Lippert , Matthias Wald , Michael Goelles , Robert Hauschild
IPC分类号： G02B21/06 , G02B26/10
CPC分类号： G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B26/08 , G02B27/0911
摘要： A family of microscopes include an illumination device which produces a planar light sheet along an illumination axis of an illumination beam path and a transverse axis normal to the illumination axis. A detection device detects light emitted from the sample region along an axis of detection of a detection beam path. The illumination and detection axes as well as the transverse axis and the axis of detection being oriented relative each other at an angle unequal to zero. A light sheet generator also produces rotationally symmetrical light and includes structure and control for rapidly scanning the sample region along the transverse axis. The illumination device includes a second light sheet generator having a first astigmatically active optical element with at least one astigmatic lens for producing a static sheet of light. Selection elements used to select either the first or the second light sheet or both together to produce the sheet of light.
摘要翻译：显微镜系列包括照明装置，其沿着照明光束路径的照明轴线和垂直于照明轴线的横轴产生平面光片。检测装置沿着检测光束路径的检测轴检测从样本区域发射的光。照明和检测轴以及横轴和检测轴线以不等于零的角度相对定向。光片发生器还产生旋转对称的光，并且包括用于沿横轴快速扫描样品区域的结构和控制。照明装置包括具有第一散光活性光学元件的第二光片发生器，该光学元件具有用于产生静态光的至少一个散光透镜。用于选择第一或第二光照片或两者的选择元件一起产生光线。

35. 发明授权

US08294728B2 Process for generating display images from acquired recorded images, and means for carrying out the process 有权
标题翻译：用于从获取的记录图像生成显示图像的处理，以及用于执行该处理的装置
公开(公告)号：US08294728B2
公开(公告)日：2012-10-23
申请号：US11991999
申请日：2006-09-14
申请人： Jörg Steinert
发明人： Jörg Steinert
IPC分类号： G09G5/02
CPC分类号： G02B21/367
摘要： An image processing device comprising an acquisition interface for acquiring recorded image data or recorded image signals and a graphics interface for a display device is constructed in such a way that a temporal sequence of recorded images can be acquired via the acquisition interface and an image data acquisition device connected to the latter and a temporal sequence of display images can be generated from the recorded image sequence, preferably with a smaller quantity of display images over the period of time in which the recorded image sequence is acquired. A display image of the display image sequence is generated from a partial sequence of at least two already acquired recorded images of the recorded image sequence, this partial sequence being associated with the display image of the display image sequence, and the display images can be sent to the display device via the graphics interface.
摘要翻译：包括用于获取记录图像数据或记录图像信号的采集接口和用于显示装置的图形接口的图像处理装置被构造成使得可以经由采集接口和图像数据采集获取记录图像的时间序列连接到后者的装置和显示图像的时间序列可以从所记录的图像序列生成，优选地在获取记录图像序列的时间段内具有较少量的显示图像。从所记录的图像序列的至少两个已经获取的记录图像的部分序列生成显示图像序列的显示图像，该部分序列与显示图像序列的显示图像相关联，并且可以发送显示图像通过图形界面显示设备。

36. 发明申请

US20120249770A1 METHOD FOR AUTOMATICALLY FOCUSING A MICROSCOPE ON A PREDETERMINED OBJECT AND MICROSCOPE FOR AUTOMATIC FOCUSING 审中-公开
标题翻译：用于自动聚焦的预定对象和显微镜上的显微镜的自动聚焦方法
公开(公告)号：US20120249770A1
公开(公告)日：2012-10-04
申请号：US13395441
申请日：2010-08-20
申请人： Peter Hamm , Karl-Hans Englmeier , Thomas Waschulzik , Horst Wolff
发明人： Peter Hamm , Karl-Hans Englmeier , Thomas Waschulzik , Horst Wolff
IPC分类号： H04N7/18
CPC分类号： G02B21/244
摘要： A method for automatic focusing of a microscope on a predetermined object in a specimen to be examined may include a) producing a set of criteria to be satisfied for the predetermined object using at least one training image of the object, b) producing a first image of the specimen to be examined which contains the predetermined object with the microscope in a first focal position, c) ascertaining the section or sections of the first image, which in each case satisfies or satisfy the set of criteria according to step a), and defining each ascertained section as object area of the first image, d) producing further images of the specimen with the microscope in different focal positions, e) determining the optimum focal position(s) using the further images, wherein, for this purpose, in all images only the partial region or partial regions which correspond to the object area or object areas is/are evaluated, f) focusing the microscope on at least one of the optimum focal position(s) determined in step e).
摘要翻译：一种显微镜自动聚焦在待检查样本中的预定物体上的方法可以包括：a）使用该物体的至少一个训练图像来产生一组对于预定物体满足的标准，b）产生第一图像在第一焦点位置用显微镜包含预定物体的检查样本，c）确定在每一种情况下符合或满足根据步骤a）的一组标准的第一图像的部分或部分，以及将每个确定的部分定义为第一图像的对象区域，d）用不同焦点位置的显微镜产生样本的另外的图像，e）使用另外的图像确定最佳焦点位置，其中，为此目的，所有图像仅评估对应于对象区域或对象区域的部分区域或部分区域，f）将显微镜聚焦在最佳焦点位置抑制器中的至少一个上在步骤e）中开采。

37. 发明申请

US20120168623A1 OBSERVATION AND ANALYSIS UNIT 有权
标题翻译：观察和分析单位
公开(公告)号：US20120168623A1
公开(公告)日：2012-07-05
申请号：US13395636
申请日：2010-08-20
申请人： Martin Edelmann , Christian Thomas
发明人： Martin Edelmann , Christian Thomas
IPC分类号： H01J47/00
CPC分类号： G02B21/367 , G01N23/2252 , H01J37/165 , H01J37/228
摘要： An observation and analysis unit that magnifies an image of a sample and further accomplishes the evaluation and analysis thereof. The observation and analysis unit includes a light-microscopic device designed for the magnified imaging and optical evaluation of the sample and a sample analyzer that analyses selected regions of the sample. The sample analyzer includes an electron source from which an electron beam can be directed to a region of the sample selected by use of the light-microscopic device. The sample analyzer further includes an X-ray detector designed to detect X-ray radiation generated by the interaction of the electron beam with the sample material. The unit further includes an actuation and evaluation unit that generates control commands for the light-microscopic device and the electron source and spectrally analyzes the X-ray radiation.
摘要翻译：观察和分析单元，其放大样品的图像并进一步完成其评估和分析。观察和分析单元包括设计用于样品的放大成像和光学评估的光学装置和分析样品的选定区域的样品分析仪。样品分析仪包括电子源，电子束可以通过电子源被引导到通过使用光学显微镜装置选择的样品的区域。样品分析仪还包括设计用于检测由电子束与样品材料的相互作用产生的X射线辐射的X射线检测器。该单元还包括致动和评估单元，其产生用于光学微观装置和电子源的控制命令并且对X射线辐射进行光谱分析。

38. 发明授权

US08189897B2 Program-controlled microscope and method for externally controlling microscopes 有权
标题翻译：程控显微镜和外置显微镜的方法
公开(公告)号：US08189897B2
公开(公告)日：2012-05-29
申请号：US11628967
申请日：2005-06-15
申请人： Steffen Leidenbach
发明人： Steffen Leidenbach
IPC分类号： G06K9/00
CPC分类号： G02B21/365
摘要： The object in a program-controlled microscope and method for the external control of microscopes is to ensure the availability of externally generated data independent from the external control device generating the data. The microscope has an interface by which data which are generated externally by the control device and which are not provided in the control program internal to the microscope are stored in and/or read out from a storage internal to the microscope.
摘要翻译：程序控制显微镜中的对象和显微镜外部控制的方法是确保外部产生的数据的可用性与产生数据的外部控制设备无关。显微镜具有通过控制装置从外部生成的数据并且不在显微镜内部的控制程序中提供的数据存储在显微镜内部和/或从显微镜内部的存储器中读出的界面。

39. 发明授权

US08116543B2 System for and method of intelligently directed segmentation analysis for automated microscope systems 失效
标题翻译：用于自动显微镜系统的智能定向分割分析系统和方法
公开(公告)号：US08116543B2
公开(公告)日：2012-02-14
申请号：US12460079
申请日：2009-07-13
申请人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
发明人： Cynthia B. Perz , Robert T. Ellis , Jose De La Torre-Bueno
IPC分类号： G06K9/00
CPC分类号： G06K9/0014 , G06T7/11 , G06T2207/10056 , G06T2207/20016 , G06T2207/20021 , G06T2207/20076 , G06T2207/20132 , G06T2207/30024
摘要： The present disclosure includes systems and techniques relating to intelligently directed segmentation analysis for automated microscope systems. In general, in one implementation, the technique includes obtaining an image of at least a portion of a scan region including a biological specimen, partitioning the obtained image into zelles, determining one or more parameters of the zelles, performing a cluster analysis on the one or more parameters of the zelles, differentiating tissue of greater interest from tissue of lesser interest in the obtained image based on the cluster analysis and based on a test being performed for the biological specimen, and storing more information for the tissue of greater interest than information for the tissue of lesser interest. The cluster analysis can be a multivariate statistical cluster analysis, and the zelles can be test-dependent zelles (e.g., having dimensions defined according to the test being performed for the biological specimen).
摘要翻译：本公开包括与用于自动显微镜系统的智能定向分割分析有关的系统和技术。通常，在一个实施方式中，该技术包括获得包括生物样本的扫描区域的至少一部分的图像，将获得的图像划分为zelles，确定zell的一个或多个参数，对该图像执行聚类分析或更多参数，基于聚类分析，并且基于对生物样本进行的测试，并且比信息存储更多的感兴趣的组织的信息，将获得的图像中较不感兴趣的组织感兴趣的组织区分为更多的组织对于较不感兴趣的组织。聚类分析可以是多变量统计聚类分析，并且zelles可以是测试依赖性zelles（例如，具有根据为生物样本进行的测试而定义的维度）。

40. 发明授权

US08115164B2 Calibration device and laser scanning microscope with such a calibration device 有权
标题翻译：校准装置和激光扫描显微镜用这种校准装置
公开(公告)号：US08115164B2
公开(公告)日：2012-02-14
申请号：US12320599
申请日：2009-01-29
申请人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
发明人： Ralf Netz , Wolfgang Bathe , Joerg Steinert , Werner Kleinschmidt , Ingo Fahlbusch , Michael Brehm
IPC分类号： G01D18/00
CPC分类号： G02B21/34 , G01M11/0264 , G02B21/002 , G02B27/32
摘要： A calibration device for managing a variety of performance tests and/or calibration tasks in a laser scanning microscope. The calibration device, which has focusing optics and a test structure arranged in the focal plane of the focusing optics, with structural elements detectable in reflected and/or transmitted light aligned to each other in a common mounting, can be switched into the microscope beam path in a laser scanning microscope, so that the pupil of the focusing optics coincides with the objective pupil of the laser scanning microscope or lies in a plane conjugated to it.
摘要翻译：用于在激光扫描显微镜中管理各种性能测试和/或校准任务的校准装置。具有聚焦光学元件和布置在聚焦光学器件的焦平面中的测试结构的校准装置可以被转换成显微镜光束路径，该结构元件可在反射和/或透射的光中可检测到，在共同安装中彼此对准在激光扫描显微镜中，使得聚焦光学元件的瞳孔与激光扫描显微镜的客观瞳孔重合或位于与其共轭的平面中。

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