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41. 发明申请

US20120183563A1 IMINOTHIADIAZINE DIOXIDE COMPOUNDS AS BACE INHIBITORS, COMPOSITIONS AND THEIR USE 有权
标题翻译：三氮嗪二氧化物作为BACE抑制剂，组合物及其使用
公开(公告)号：US20120183563A1
公开(公告)日：2012-07-19
申请号：US13392297
申请日：2010-10-06
申请人： Jack D. Scott , Andrew W. Stamford , Eric J. Gilbert , Jared N. Cumming , Ulrich Iserloh , Jeffrey A. Misiaszek , Guoqing Li
发明人： Jack D. Scott , Andrew W. Stamford , Eric J. Gilbert , Jared N. Cumming , Ulrich Iserloh , Jeffrey A. Misiaszek , Guoqing Li
IPC分类号： A61K31/549 , C07D285/18 , C07D417/14 , C07D471/04 , C07D495/04 , A61K31/55 , A61K39/395 , A61K39/00 , A61P29/00 , A61P31/04 , A61P37/04 , A61P5/50 , A61P25/28 , A61P25/16 , A61P25/00 , A61P3/10 , C07D417/04 , A61P7/04 , A61P7/00 , C07D417/12
CPC分类号： A61K31/549 , A61K31/00 , A61K31/495 , A61K31/54 , A61K45/06 , C07C309/30 , C07D213/26 , C07D213/89 , C07D239/14 , C07D285/18 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , A61K2300/00
摘要： In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-,L2-, and L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (Aβ) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers disease, are also disclosed.
摘要翻译：在其许多实施方案中，本发明提供了某些亚氨基二嗪二氧化物化合物，包括式（I）：（I）的化合物并包括其立体异构体，以及所述化合物立体异构体的药学上可接受的盐，其中R1，R2，R3，R4，R5 ，R9，环A，环B，m，n，p，-L1-，L2-和L3-是独立选择和如本文所定义的。令人惊奇地发现本发明的新型亚氨基二嗪二氧化物化合物表现出预期使其作为BACE抑制剂和/或用于治疗和预防与β-淀粉样蛋白（A＆bgr）生产相关的各种病症的优点的性质。还公开了包含一种或多种这样的化合物（单独和与一种或多种其它活性剂组合）的药物组合物及其制备和用于治疗与包括阿尔茨海默氏病在内的淀粉样蛋白β（A＆bgr））蛋白相关的病理学的方法。

42. 发明申请

US20120083310A1 METHOD, DEVICE AND SYSTEM FOR REPORTING POWER HEADROM 有权
标题翻译：用于报告电源头的方法，装置和系统
公开(公告)号：US20120083310A1
公开(公告)日：2012-04-05
申请号：US13322273
申请日：2010-06-11
申请人： Yali Zhao , Li Chen , Guoqing Li
发明人： Yali Zhao , Li Chen , Guoqing Li
IPC分类号： H04W52/04
CPC分类号： H04W52/367 , H04L5/0007 , H04L5/001 , H04W24/08 , H04W52/34 , H04W52/365 , H04W52/54 , H04W72/1284
摘要： A method, device and system for reporting power headroom are provided, and the method includes the following steps: a user equipment determines whether it triggers power headroom reporting (PHR) (101); if triggering PHR, the user equipment reports power headroom independently or associatively basing on a component carrier (CC) or a power amplifier (PA) (102). The technical solution realizes power headroom reporting in a multi-carrier system by reporting power headroom independently or associatively basing on the CC or the PA, and can make a base station equipment process uplink scheduling better according to the power headroom coming from the user equipment.
摘要翻译：提供报告功率余量的方法，装置和系统，该方法包括以下步骤：用户设备确定是否触发功率余量报告（PHR）（101）; 如果触发PHR，则用户设备基于分量载波（CC）或功率放大器（PA）（102）独立地或相关地报告功率余量。该技术方案通过独立或相关地基于CC或PA报告功率余量来实现多载波系统中的功率余量报告，并且可以使基站设备根据用户设备的功率余量更好地进行上行调度。

43. 发明申请

US20120063425A1 Method and Apparatus for Uplink Synchronization Control 有权
标题翻译：上行同步控制方法与装置
公开(公告)号：US20120063425A1
公开(公告)日：2012-03-15
申请号：US13320537
申请日：2010-05-11
申请人： Zhixue Wang , Guoqing Li , Yi Zhao , Jiamin Liu , Yali Zhao , Fangli Xu
发明人： Zhixue Wang , Guoqing Li , Yi Zhao , Jiamin Liu , Yali Zhao , Fangli Xu
IPC分类号： H04W56/00
CPC分类号： H04W56/0045 , H04W92/10
摘要： The present invention discloses a method for uplink synchronization control, wherein network side and a user equipment (UE) maintain a timing alignment timer (TAT) for the UE, and maintain an uplink transmission timing adjustment amount for uplink component carriers, and the method includes following steps: the network side measuring uplink component carriers of the UE, and obtaining an uplink transmission TA amount of the uplink component carriers; and before the TAT expires, the network side transmitting to the UE an adjustment command comprising information of the uplink transmission TA amount for at least one of the uplink component carriers of the UE. Also disclosed in the embodiments of the present invention are a method for uplink synchronization control at the UE side, and a base station and a UE for implementing the above methods. The solution of the present invention enables accurate adjustment of the uplink synchronization for each component carrier in a carrier aggregation mechanism.
摘要翻译：本发明公开了一种上行链路同步控制方法，其中网络侧和用户设备（UE）维护用于UE的定时对准定时器（TAT），并维持上行链路分量载波的上行链路传输定时调整量，该方法包括以下步骤：网络侧测量UE的上行链路分量载波，并获得上行链路分量载波的上行链路传输TA量; 并且在TAT到期之前，网络侧向UE发送包括UE的上行链路分量载波中的至少一个的上行链路传输TA的信息的调整命令。在本发明的实施例中也公开了一种用于UE侧的上行链路同步控制的方法，以及用于实现上述方法的基站和UE。本发明的解决方案能够准确地调整载波聚合机制中的每个分量载波的上行链路同步。

44. 发明申请

US20120063376A1 METHOD AND SYSTEM OF MAPPING DISPLAYPORT OVER A WIRELESS INTERFACE 有权
标题翻译：在无线接口上绘制显示的方法和系统
公开(公告)号：US20120063376A1
公开(公告)日：2012-03-15
申请号：US12882506
申请日：2010-09-15
申请人： SRIKANTH KAMBHATLA , Guoqing Li
发明人： SRIKANTH KAMBHATLA , Guoqing Li
IPC分类号： H04W40/00
CPC分类号： G09G5/363 , G09G5/006 , G09G2370/04 , G09G2370/10 , G09G2370/12 , G09G2370/16
摘要： A method and system to facilitate the mapping of the DisplayPort standard over a wireless interface. The wireless interface uses a communication protocol that operates in accordance with, but is not limited to, a wireless gigabit alliance (WGA) standard, a Institute of Electrical and Electronics Engineers (IEEE) 802.11a/b/g, IEEE 802.11n, and other IEEE wireless standards, a Bluetooth standard, a Ultra-wideband (UWB) standard, and a 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) standard. In one embodiment of the invention, it provides a definition for mapping the DisplayPort standard over a wireless interface to enable wireless display usage model with existing or new DisplayPort sink devices. The definition for mapping the DisplayPort standard over a wireless interface allows end-to-end interoperability of DisplayPort based wireless devices and facilitates the adoption of the definition as an industry standard in one embodiment of the invention.
摘要翻译：一种便于通过无线接口映射DisplayPort标准的方法和系统。无线接口使用根据但不限于无线吉比特联盟（WGA）标准，电气和电子工程师协会（IEEE）802.11a / b / g，IEEE 802.11n和其他IEEE无线标准，蓝牙标准，超宽带（UWB）标准和第三代合作伙伴计划（3GPP）长期演进（LTE）标准。在本发明的一个实施例中，它提供了用于通过无线接口映射DisplayPort标准以使得能够利用现有的或新的DisplayPort宿设备实现无线显示使用模型的定义。通过无线接口映射DisplayPort标准的定义允许基于DisplayPort的无线设备的端到端互操作性，并且有助于在本发明的一个实施例中将定义作为工业标准采用。

45. 发明授权

US08040983B2 Device, system and method of mitigating interference in a wireless network 有权
标题翻译：减轻无线网络干扰的设备，系统和方法
公开(公告)号：US08040983B2
公开(公告)日：2011-10-18
申请号：US11865737
申请日：2007-10-02
申请人： Guoqing Li
发明人： Guoqing Li
IPC分类号： H03D1/04
CPC分类号： H04W24/08 , H04W16/14
摘要： System and method of locating an interferer and mitigating its effect for stations of a wireless local area network. Embodiments provide a protocol and mechanism to evaluate the interferer location relative to a wireless link and to take accurate actions to mitigate the interference effect for specific cases. A method includes classifying a location of an interferer relative to a wireless communication device based on a comparison with a clear-channel threshold and a noise-tolerability threshold of the device, categorizing a location of the interferer relative to a wireless link based on a combination of the interference categories for the transmitting and the receiving devices, and mitigating interference in the wireless network according to the categorization. For example, in some cases, mitigating includes adapting a noise-tolerability threshold of the transmitting device to allow transmission.
摘要翻译：定位干扰源并减轻其对无线局域网站的影响的系统和方法。实施例提供了一种用于评估相对于无线链路的干扰源位置的协议和机制，并采取准确的动作来减轻特定情况下的干扰效应。一种方法包括基于与清除信道阈值和设备的可容许噪声阈值的比较来相对于无线通信设备对干扰源的位置进行分类，基于组合对干扰源相对于无线链路的位置进行分类的发射和接收设备的干扰类别，并根据分类减轻无线网络中的干扰。例如，在一些情况下，减轻包括适配发射设备的可容许噪声阈值以允许传输。

46. 发明申请

US20110158145A1 METHOD AND SYSTEM TO SUPPORT WIRELESS MULTICAST TRANSMISSION 有权
标题翻译：支持无线多播传输的方法和系统
公开(公告)号：US20110158145A1
公开(公告)日：2011-06-30
申请号：US12647179
申请日：2009-12-24
申请人： Michelle Gong , Guoqing Li
发明人： Michelle Gong , Guoqing Li
IPC分类号： H04H20/71
CPC分类号： H04L12/185 , H04L12/189 , H04L69/325 , H04W4/06
摘要： A method and system may include a source station to provide wireless multicast transmission to a plurality of destination stations according to a protocol adaptation layer multicast management protocol. The protocol adaptation layer may lie above the MAC layer. The multicast management protocol includes formation, maintenance, and termination procedures. Other embodiments are described and claimed.
摘要翻译：方法和系统可以包括根据协议适配层多播管理协议向多个目的地站提供无线多播传输的源站。协议适配层可以位于MAC层之上。多播管理协议包括形成，维护和终止程序。描述和要求保护其他实施例。

47. 发明申请

US20110110957A1 PHENYL-SUBSTITUTED 2-IMINO-3-METHYL PYRROLO PYRIMIDINONE COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE 有权
标题翻译：作为BACE-1抑制剂，组合物及其使用的苯基取代的2-亚氨基-3-甲基吡咯啉吡啶酮化合物
公开(公告)号：US20110110957A1
公开(公告)日：2011-05-12
申请号：US12988461
申请日：2009-04-21
申请人： Andrew W. Stamford , Zhaoning Zhu , Mihirbaran Mandal , Yusheng Wu , Jared N. Cumming , Xiaoxiang Liu , Guoqing Li , Ulrich Iserloh
发明人： Andrew W. Stamford , Zhaoning Zhu , Mihirbaran Mandal , Yusheng Wu , Jared N. Cumming , Xiaoxiang Liu , Guoqing Li , Ulrich Iserloh
IPC分类号： A61K31/519 , C07D487/04 , A61K31/55 , A61K39/395 , A61K39/00 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/00 , A61P27/06 , A61P3/10 , A61P13/12
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides certain 2-imino-3-methyl pyrrolo pyrimidone compounds, including compounds Formula (II): and include tautomers, steroisomers, or pharmaceutically acceptable salts or solvates of said compounds, stereoisomers, or said tautomers, wherein R2, R3, R4, R5, R6, R7, R8, and R9 are each selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds, and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's Disease, are also disclosed.
摘要翻译：在其许多实施方案中，本发明提供某些2-亚氨基-3-甲基吡咯烷酮化合物，包括式（II）化合物：并且包括所述化合物，立体异构体或所述互变异构体的互变异构体，立体异构体或药学上可接受的盐或溶剂化物，其中R2，R3，R4，R5，R6，R7，R8和R9各自独立地并如本文所定义。还公开了包含一种或多种这样的化合物的药物组合物，及其制备和用于治疗与淀粉样蛋白β（A＆bgr））蛋白质（包括阿尔茨海默氏病）相关的病理学的方法。

48. 发明授权

US07822440B2 Method and apparatus for operating a communication station 有权
标题翻译：用于操作通信站的方法和装置
公开(公告)号：US07822440B2
公开(公告)日：2010-10-26
申请号：US11615955
申请日：2006-12-23
申请人： Minyoung Park , Guoqing Li , Liuyang Lily Yang
发明人： Minyoung Park , Guoqing Li , Liuyang Lily Yang
IPC分类号： H04M1/00
CPC分类号： H04W8/005 , H04W76/10 , H04W84/18 , H04W92/18
摘要： A method for operating a communication station in a communicating environment includes: (a) monitoring the environment to ascertain whether the station is receiving an unintended sensed signal not intended for the station from at least one signal source; (b) if the station has not received a predetermined number of unintended sensed signals during a predetermined time interval, operating the station in an omni-directional mode; and (c) if the station has received a predetermined number of sensed signals during the predetermined time interval, saving an indication of a reception direction from which arrived each unintended sensed signal; and operating the station in a directional mode. While in the directional mode, the station is sensitive to receiving signals arriving from a sensing direction other than from a reception direction, and the station transmits signals toward the sensing direction.
摘要翻译：一种用于在通信环境中操作通信站的方法包括：（a）监测环境以确定站是否正在从至少一个信号源接收不用于该站的非预期感测信号; （b）如果站在预定时间间隔内没有收到预定数量的非预期感测信号，则以全向模式操作站; （c）如果站在预定的时间间隔期间已接收到预定数量的感测信号，则保存从每个非预期的感测信号到达的接收方向的指示; 并以定向模式操作站。在方向模式中，站对从接收方向以外的感测方向到达的信号敏感，并且站向感测方向发送信号。

49. 发明授权

US07763609B2 Heterocyclic aspartyl protease inhibitors 有权
公开(公告)号：US07763609B2
公开(公告)日：2010-07-27
申请号：US11710582
申请日：2007-02-23
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mazzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K31/535 , C07D273/04
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein W is a bond, —C(═S)—, —S(O)—, —S(O)2—, —C(═O)—, —O—, —C(R6)(R7)—, —N(R5)— or —C(═N(R5))—; X is —O—, —N(R5)— or —C(R6)(R7)—; provided that when X is —O—, U is not —O—, —S(O)—, —S(O)2—, —C(═O)— or —C(═NR5)—; U is a bond, —S(O)—, —S(O)2—, —C(O)—, —O—, —P(O)(OR15)—, —C(═NR5)—, —(C(R6)(R7))b— or —N(R5)—; wherein b is 1 or 2; provided that when W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, U is not —S(O)—, —S(O)2—, —O—, or —N(R5)—; provided that when X is —N(R5)— and W is —S(O)—, —S(O)2—, —O—, or —N(R5)—, then U is not a bond; and R1, R2, R3, R4, R5, R6, and R7 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes.Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

50. 发明申请

US20100016341A1 ASPARTYL PROTEASE INHIBITORS CONTAINING A TRICYCLIC RING SYSTEM 审中-公开
标题翻译：含有三环系统的ASPARTYL蛋白酶抑制剂
公开(公告)号：US20100016341A1
公开(公告)日：2010-01-21
申请号：US12517740
申请日：2007-12-10
申请人： Zhaoning Zhu , Andrew Stamford , Guoqing Li , Mihirbaran Mandal
发明人： Zhaoning Zhu , Andrew Stamford , Guoqing Li , Mihirbaran Mandal
IPC分类号： A61K31/519 , C07D491/04 , C07D471/14 , A61P9/00
CPC分类号： C07D239/70 , C07D471/04 , C07D487/04 , C07D493/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof or wherein R1, R2, R3, R4, R6, R7, R14, W, V, X, Y, A and b are as described above in the specification. Also disclosed is a method of inhibiting aspartyl protease, methods of treating cardiovascular diseases, cognitive diseases, neurodegenerative diseases, and other biological processes and indications. Combination treatments and compositions are also disclosed.
摘要翻译：公开了式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，或其中R1，R2，R3，R4，R6，R7，R14，W，V，X，Y，A和b为在说明书中描述。还公开了抑制天冬氨酰蛋白酶的方法，治疗心血管疾病的方法，认知疾病，神经变性疾病以及其他生物过程和适应症。还公开了组合处理和组合物。

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