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1. 发明申请

US20230008022A1 NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS 有权
公开(公告)号：US20230008022A1
公开(公告)日：2023-01-12
申请号：US17295497
申请日：2019-11-25
申请人： Dane CLAUSEN , Ping CHEN , Xavier FRADERA , Liangqin GUO , Yongxin HAN , Shuwen HE , Xianhai HUANG , Joseph KOZLOWSKI , Guoqing LI , Theodore A. MARTINOT , Alexander PASTERNAK , Andreas VERRAS , Li XIAO , Wensheng YU , Rui ZHANG , Merck Sharp & Dohme Corp.
发明人： Dane Clausen , Ping Chen , Xavier Fradera , Liangqin Guo , Yongxin Han , Shuwen He , Xianhai Huang , Joseph Kozlowski , Guoqing Li , Theodore A. Martinot , Alexander Pasternak , Andreas Verras , Li Xiao , Feng Ye , Wensheng Yu , Rui Zhang
IPC分类号： C07D231/56 , C07D491/052 , C07D231/54 , A61K31/496 , C07D401/12 , C07D401/14 , C07D413/12 , A61K31/5377 , C07D498/10 , C07D491/107 , C07D498/08 , C07D471/10 , C07D403/12 , C07D405/12 , C07D498/04 , C07D487/04 , C07D487/10 , A61K31/541 , C07D413/14
摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

2. 发明授权

US11034661B2 Substituted N′-hydroxycarbamimidoyl-1,2,5-oxadiazole compounds as indoleamine 2,3-dioxygenase IDO inhibitors 有权
公开(公告)号：US11034661B2
公开(公告)日：2021-06-15
申请号：US16495883
申请日：2018-03-23
申请人： Merck Sharp & Dohme Corp. , Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
发明人： Liangqin Guo , Yongxin Han , Kun Liu , Shuwen He , Joseph Kozlowski , Ravi Nargund , Wensheng Yu , Hongjun Zhang , Qinglin Pu , Derun Li , Abdelghani Achab , Guoqing Li
IPC分类号： C07D271/08 , C07D413/12
摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

3. 发明授权

US09820261B2 Mapping method and apparatus for resource status process 有权
公开(公告)号：US09820261B2
公开(公告)日：2017-11-14
申请号：US13703316
申请日：2011-06-03
申请人： Dajun Zhang , Guoqing Li , Wei Bao
发明人： Dajun Zhang , Guoqing Li , Wei Bao
IPC分类号： H04W72/04 , H04B7/155 , H04W84/04 , H04W92/20
CPC分类号： H04W72/04 , H04B7/15542 , H04W84/047 , H04W92/20
摘要： The present invention discloses a mapping method and apparatus for resource status process, and the method comprises the following steps: DeNB receives resource status information from RN; said DeNB acquires the address of source eNB according to said resource status information and context information; said DeNB sends said resource status information to said source eNB according to the address of said source eNB. In the present invention, context information on DeNB is established for source eNB to enable DeNB to route resource status response message or resource status report to correct source eNB apparatus according to context information.

4. 发明授权

US09632968B2 Implementing an inter-processor communication in a multi-core system using mmWave radios 有权
公开(公告)号：US09632968B2
公开(公告)日：2017-04-25
申请号：US13993212
申请日：2011-12-15
申请人： Carlos Cordeiro , Guoqing Li , Bahareh Sadeghi
发明人： Carlos Cordeiro , Guoqing Li , Bahareh Sadeghi
IPC分类号： G06F13/00 , G06F13/42 , G06F15/163 , G06F15/167
CPC分类号： G06F13/42 , G06F15/163 , G06F15/167 , Y02D10/14 , Y02D10/151
摘要： A system and method are provided that implement the use of mmWave directional communications to replace wired interconnects for inter-processor communication in multi-core computing systems. Using highly directional, low interference mmWave transmissions in the 60 GHz frequency range, an alternative interconnect scheme is provided to support inter-processor communication in multi-core computing systems for operations and testing. Wired interconnects between the multiple cores and a bus interface are replaced with cooperating mmWave transmitting/receiving devices on each of the core side and the bus interface side. The ability to transmit and receive separate high data rate, directional low interference signals for individual core communication is thus facilitated between the bus interface and each of the multiple cores in the multi-core computing system.

5. 发明授权

US09629040B2 Method and device for configuring donor base station or donor cell for mobile relay node 有权
公开(公告)号：US09629040B2
公开(公告)日：2017-04-18
申请号：US13984907
申请日：2012-02-09
申请人： Wei Bao , Yali Zhao , Yi Yang , Guoqing Li
发明人： Wei Bao , Yali Zhao , Yi Yang , Guoqing Li
IPC分类号： H04W36/00 , H04W24/02 , H04W36/08 , H04W84/04 , H04W88/04 , H04W88/08 , H04W64/00 , H04W84/00
CPC分类号： H04W36/0083 , H04W24/02 , H04W36/08 , H04W64/003 , H04W84/005 , H04W84/047 , H04W88/04 , H04W88/08
摘要： Disclosed are a method and device for configuring a Donor base station or a Donor cell for a mobile relay node. The method includes: an operation administration and maintenance (OAM) system obtains position information about a mobile relay node (RN) and determines a standby Donor base station or a standby Donor cell which can be accessed by the mobile RN according to the position information thereof; and the OAM system indicates the standby Donor base station or the standby Donor cell to a serving Donor base station of the mobile RN or indicates the standby Donor base station or the standby Donor cell to the serving Donor base station of the mobile RN through the mobile RN, so that the serving Donor base station of the mobile RN selects a target Donor base station or a target Donor cell for the mobile RN. By way of the present invention, the DeNB or the Donor Cell can be configured for the mobile RN when the mobile RN is moving.

6. 发明授权

US09531446B2 Use of location information in multi-radio devices for mmWave beamforming 有权
标题翻译：在多无线电设备中使用位置信息进行mm波束成形
公开(公告)号：US09531446B2
公开(公告)日：2016-12-27
申请号：US13993218
申请日：2011-12-15
申请人： Bahareh Sadeghi , Carlos Cordeiro , Guoqing Li , Vallabhajosyula S. Somayazulu
发明人： Bahareh Sadeghi , Carlos Cordeiro , Guoqing Li , Vallabhajosyula S. Somayazulu
IPC分类号： H04B7/10 , H04B7/00 , H04W16/28 , G01S5/00 , H04W64/00 , H04W88/06
CPC分类号： H04B7/00 , G01S5/0072 , H04W16/28 , H04W64/00 , H04W88/06
摘要： A system and method are provided for using location services available from other radios in a multi-radio system to assist a beamforming mechanism, particularly in establishing and maintaining mmWave communication link. A majority of wireless client devices for use in a mmWave communication link are equipped with multiple radios. Many of the “other” radios include technologies that support location based services, including GPS, Wi-Fi and cellular communications. One or more non-mmWave in one device is used to provide relative location information regarding the other device with which the mmWave communication link is to be established. The relative location information is used to derive a direction for communication, and to compute beamforming parameters, in a limited set of transmit/receive sectors where the destination device is likely to be found, in order to streamline the beamforming process.
摘要翻译：提供了一种系统和方法，用于使用可从多无线电系统中的其他无线电获得的定位服务来协助波束成形机制，特别是在建立和维护毫米波通信链路中。用于mmWave通信链路的大多数无线客户端设备都配备有多个无线电。许多“其他”无线电包括支持基于位置的服务的技术，包括GPS，Wi-Fi和蜂窝通信。使用一个设备中的一个或多个非mm波形来提供关于要建立mmWave通信链路的另一个设备的相对位置信息。相对位置信息用于导出用于通信的方向，并且在可能找到目的地设备的发送/接收扇区的有限集合中计算波束成形参数，以便简化波束成形处理。

7. 发明授权

US09219801B2 Implementing a protocol adaptation layer over an internet protocol 有权
标题翻译：通过互联网协议实现协议适配层
公开(公告)号：US09219801B2
公开(公告)日：2015-12-22
申请号：US13995650
申请日：2011-12-22
申请人： Guoqing Li , Carlos Cordeiro , Bahareh Sadeghi , Ali S. Sadri
发明人： Guoqing Li , Carlos Cordeiro , Bahareh Sadeghi , Ali S. Sadri
IPC分类号： H04L29/06 , H04W80/04 , H04W80/06
CPC分类号： H04L69/08 , H04L69/168 , H04L69/169 , H04W80/04 , H04W80/06
摘要： A system and method are provided that allow WiGig protocol adaptation layers (PALs) to operate differently from the proposed WiGig standard on top of an Internet protocol (IP) layer in order to enhance routing options for communication of the data traffic between a transmitting (source) device and a receiving (sink) device. A layering architecture is provided that allows WiGig PALs, such as WDE, to operate on top of an IP layer. A signaling mechanism is also provided that allows a negotiation, or at least an indication, of the underlying layering structure for specific data communications. Recognizing that the next generation wireless display requires technology such as WiGig WDE to support the driving demand for a cable replacement user experience and richer wireless display use cases, this PAL over IP architecture optimizes alignment of the WiGig data communication technology with other data communication technologies.
摘要翻译：提供一种系统和方法，其允许WiGig协议适配层（PAL）与互联网协议（IP）层之上的所提出的WiGig标准不同地运行，以便增强用于在发送（源））设备和接收（接收）设备。提供了一种分层架构，允许WiGig PAL（如WDE）在IP层之上运行。还提供了一种信令机制，其允许用于特定数据通信的基础分层结构的协商或至少指示。认识到下一代无线显示器需要诸如WiGig WDE之类的技术来支持电缆更换用户体验的驱动需求和更丰富的无线显示用例，该PAL over IP架构优化了WiGig数据通信技术与其他数据通信技术的对准。

8. 发明申请

US20150274708A1 INHIBITORS OF IRAK4 ACTIVITY 有权
标题翻译： IRAK4活性抑制剂
公开(公告)号：US20150274708A1
公开(公告)日：2015-10-01
申请号：US14434348
申请日：2013-10-03
申请人： Michael W. SEGANISH , Jennifer HANISAK , Guoqing LI , Rui ZHANG , Haiqun TANG , MERCK SHARP & DOHME CORP.
发明人： W. Michael Seganish , Jennifer Hanisak , Guoqing Li , Rui Zhang , Haiqun Tang
IPC分类号： C07D409/14 , A61K31/444 , A61K31/4439 , A61K45/06 , A61K31/5377 , A61K31/496 , C07D405/14 , A61K31/497 , C07D401/14 , C07D401/12
CPC分类号： C07D409/14 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to inhibitors of IRAK4 of Formula (I) and provides compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.
摘要翻译：本发明涉及式（I）的IRAK4的抑制剂，并提供包含这些抑制剂的组合物，以及其用于治疗IRAK4介导的或相关的病症或疾病的方法。

9. 发明申请

US20140282753A1 Techniques for Transmitting Video Content to a Wirelessly Docked Device Having a Display 有权
标题翻译：将视频内容发送到具有显示器的无线对接设备的技术
公开(公告)号：US20140282753A1
公开(公告)日：2014-09-18
申请号：US13797861
申请日：2013-03-12
申请人： GUOQING LI , JEFFREY R. FOERSTER , YANIV FRISHMAN
发明人： GUOQING LI , JEFFREY R. FOERSTER , YANIV FRISHMAN
IPC分类号： H04N21/4363 , H04N21/41
CPC分类号： H04N21/2404 , G06F3/1462 , G06F11/08 , G06F11/1004 , G06K9/6215 , G09G5/00 , H03M13/09 , H04L1/0061 , H04N21/23418 , H04N21/4122 , H04N21/41407 , H04N21/43637 , H04N21/44008 , H04W84/12
摘要： Examples are disclosed for transmitting video content. In some examples, cyclic redundancy check (CRC) values may be added to video content for video frames to be presented or displayed in a given region of a display. Results of CRC functions for consecutive video frames that use the added CRC values may be compared to determine whether the video content for the consecutive video frames is static video content. Video content for at least one of the consecutive video frames may be withheld from being transmitted if the video content for the consecutive video frames is characterized as static video content. Multiple CRC values or different CRC values may be added to further determine whether video content for the consecutive video frames or for subsequent consecutive video frames is also characterized as static video content. Other examples are described and claimed.
摘要翻译：公开了用于发送视频内容的示例。在一些示例中，可以将循环冗余校验（CRC）值添加到要在显示器的给定区域中呈现或显示的视频帧的视频内容。可以比较使用添加的CRC值的连续视频帧的CRC功能的结果，以确定连续视频帧的视频内容是否是静态视频内容。如果用于连续视频帧的视频内容被表征为静态视频内容，则可以不连续传送连续视频帧中的至少一个的视频内容。可以添加多个CRC值或不同的CRC值，以进一步确定连续视频帧的视频内容还是后续的连续视频帧的视频内容也被表征为静态视频内容。其他的例子被描述和要求保护。

10. 发明授权

US08691831B2 Heterocyclic aspartyl protease inhibitors 有权
标题翻译：杂环天门冬氨酰蛋白酶抑制剂
公开(公告)号：US08691831B2
公开(公告)日：2014-04-08
申请号：US13416140
申请日：2012-03-09
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoxiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula I are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中式I中的每个变量如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

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