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1. 发明授权

US09115362B2 Mutant microorganism having high production of cadaverine, and preparation method of cadaverine using same 有权
标题翻译：具有高死亡率的突变体微生物及其使用的尸胺的制备方法
公开(公告)号：US09115362B2
公开(公告)日：2015-08-25
申请号：US13813949
申请日：2011-08-03
申请人： Sang Yup Lee , Zhi Gang Qian , Xiaoxia Xia , Min Young Kim
发明人： Sang Yup Lee , Zhi Gang Qian , Xiaoxia Xia , Min Young Kim
IPC分类号： C12N15/70 , C12N9/02 , C12N9/10 , C12N9/88 , C12N9/00 , C12P13/00 , C12N15/52
CPC分类号： C12N15/70 , C12N9/001 , C12N9/1029 , C12N9/104 , C12N9/1085 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/52 , C12P13/001 , C12Y103/01026 , C12Y203/01057 , C12Y205/01016 , C12Y206/01082 , C12Y401/0102 , C12Y402/01051 , C12Y403/03007
摘要： The present invention relates to a mutant microorganism having a high ability to produce cadaverine, and a method for producing cadaverine using the same. More specifically, the invention relates to a mutant microorganism having a high ability to produce cadaverine wherein a gene involved in the cadaverine degradation or utilization pathway is inactivated or deleted, and to a method for producing cadaverine in high yield by culturing the mutant microorganism under aerobic conditions. The mutant microorganism according to the present invention is useful for producing a high yield of cadaverine which can be widely used in various industrial applications.
摘要翻译：本发明涉及具有高的生产尸胺能力的突变微生物，以及使用该活性的生物化学品的方法。更具体地，本发明涉及具有高生产能力的突变体微生物，其中参与尸胺降解或利用途径的基因被失活或缺失，以及通过在需氧下培养突变型微生物而以高产率生产尸胺的方法条件。根据本发明的突变体微生物可用于生产可广泛用于各种工业应用中的高产量的尸胺。

2. 发明授权

US08593944B2 Method, apparatus and communication system for protecting signaling transmission 有权
标题翻译：用于保护信令传输的方法，装置和通信系统
公开(公告)号：US08593944B2
公开(公告)日：2013-11-26
申请号：US12901980
申请日：2010-10-11
申请人： Gang Qian
发明人： Gang Qian
IPC分类号： H04L12/26
CPC分类号： H04L41/147 , H04L41/06
摘要： The present invention discloses a method, an apparatus, and a communication system for protecting signaling transmission, relates to the communication field, and enables end-to-end signaling protection. In an embodiment of the present invention, a primary signaling path and at least one secondary signaling path are created between terminals; the transmission protocol of the primary signaling path is different from the transmission protocol of the secondary signaling path, and the secondary signaling path works instead when the primary signaling path is in an abnormal state. The embodiments of the present invention are primarily applied to communication systems, and in particular, to the communication systems that support multiple transmission modes, for example, WCDMA system that supports IP bearers.
摘要翻译：本发明公开了一种用于保护信令传输的方法，装置和通信系统，涉及通信领域，并实现端到端信令保护。在本发明的实施例中，在终端之间创建主信令路径和至少一个次信令路径; 主要信令路径的传输协议与二级信令路径的传输协议不同，当主信令路径处于异常状态时，二级信令路由工作。本发明的实施例主要应用于通信系统，特别是应用于支持多种传输模式的通信系统，例如支持IP承载的WCDMA系统。

3. 发明申请

US20130157323A1 MUTANT MICROORGANISM HAVING HIGH PRODUCTION OF CADAVERINE, AND PREPARATION METHOD OF CADAVERINE USING SAME 有权
标题翻译：具有高生产率的复方微生物，以及使用其的CADAVERINE的制备方法
公开(公告)号：US20130157323A1
公开(公告)日：2013-06-20
申请号：US13813949
申请日：2011-08-03
申请人： Sang Yup Lee , Zhi Gang Qian , Xiaoxia Xia , Min Young Kim
发明人： Sang Yup Lee , Zhi Gang Qian , Xiaoxia Xia , Min Young Kim
IPC分类号： C12N15/70 , C12P13/00
CPC分类号： C12N15/70 , C12N9/001 , C12N9/1029 , C12N9/104 , C12N9/1085 , C12N9/1096 , C12N9/88 , C12N9/93 , C12N15/52 , C12P13/001 , C12Y103/01026 , C12Y203/01057 , C12Y205/01016 , C12Y206/01082 , C12Y401/0102 , C12Y402/01051 , C12Y403/03007
摘要： The present invention relates to a mutant microorganism having a high ability to produce cadaverine, and a method for producing cadaverine using the same. More specifically, the invention relates to a mutant microorganism having a high ability to produce cadaverine wherein a gene involved in the cadaverine degradation or utilization pathway is inactivated or deleted, and to a method for producing cadaverine in high yield by culturing the mutant microorganism under aerobic conditions. The mutant microorganism according to the present invention is useful for producing a high yield of cadaverine which can be widely used in various industrial applications.
摘要翻译：本发明涉及具有高的生产尸胺能力的突变微生物，以及使用该活性的生物化学品的方法。更具体地，本发明涉及具有高生产能力的突变体微生物，其中参与尸胺降解或利用途径的基因被失活或缺失，以及通过在需氧下培养突变型微生物而以高产率生产尸胺的方法条件。根据本发明的突变体微生物可用于生产可广泛用于各种工业应用中的高产量的尸胺。

4. 发明授权

US6165869A Method to avoid dishing in forming trenches for shallow trench isolation 失效
标题翻译：避免形成沟槽进行浅沟槽隔离的方法
公开(公告)号：US6165869A
公开(公告)日：2000-12-26
申请号：US96047
申请日：1998-06-11
申请人： Gang Qian , Chock Hing Gan , Lap Hung Chan , Poh Suan Tan
发明人： Gang Qian , Chock Hing Gan , Lap Hung Chan , Poh Suan Tan
IPC分类号： H01L21/762 , H01L21/76
CPC分类号： H01L21/76224
摘要： A method is described for filling trenches with dielectric for shallow trench isolation which completely fills the trench and avoids problems due to dishing at the top of the trench. A trench is formed in a substrate having a second dielectric material formed thereon. The trench is lined with a third dielectric material. Sub atmospheric chemical vapor deposition, SACVD, of tetra-ethyl-ortho-silicate and ozone is used to grow a fourth dielectric on the surface of the second dielectric material and in the trench lined with the third dielectric material. The growth rate of fourth dielectric on the third dielectric is greater than the growth rate of the fourth dielectric on the second dielectric using SACVD of tetra-ethyl-ortho-silicate and ozone. The difference in growth rate assures that the trench is completely filled with fourth dielectric even for relatively thin layers of fourth dielectric grown on the second dielectric. This provides good planarity for a planarized substrate and avoids the problem of dishing at the top of the trench.
摘要翻译：描述了一种用于填充具有用于浅沟槽隔离的电介质的沟槽的方法，其完全填充沟槽并且避免了由于沟槽顶部的凹陷引起的问题。在其上形成有第二电介质材料的基板中形成沟槽。沟槽衬有第三介电材料。使用四乙基原硅酸盐和臭氧的次大气化学气相沉积，SACVD在第二介电材料的表面上和在第三介电材料内衬的沟槽中生长第四电介质。第四电介质的第四电介质的生长速率大于使用四乙基原硅酸盐和臭氧的SACVD的第二电介质上的第四电介质的生长速率。生长速率的差异确保即使对于在第二电介质上生长的第四电介质的较薄层，沟槽也完全填充第四电介质。这为平坦化衬底提供了良好的平面性，并且避免了在沟槽顶部的凹陷的问题。

5. 发明申请

US20150329521A1 PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS 有权
标题翻译：制备逆转录酶抑制剂的方法
公开(公告)号：US20150329521A1
公开(公告)日：2015-11-19
申请号：US14649837
申请日：2013-12-04
申请人： Tetsuji ITOH , Ingyu JEON , Ian MANGION , Gang QIAN , Benjamin D. SHERRY , Donald R. GAUTHIER , Yang CAO , MERCK SHARP & DOHME CORP.
发明人： Tetsuji Itoh , Ingyu Jeon , Ian Mangion , Gang QIAN , Benjamin D. Sherry , Donald R. Gauthier , Yang CAO
IPC分类号： C07D401/06
CPC分类号： C07D401/06
摘要： The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.
摘要翻译：本发明涉及一种合成3-（取代的苯氧基）-1 - [（5-氧代-4,5-二氢-1H-1,2,4-三唑-3-基）甲基]] - 吡啶-2（1H） - 酮衍生物。通过本发明的方法合成的化合物是可用于抑制逆转录酶，HIV复制和人类免疫缺陷病毒感染治疗的HIV逆转录酶抑制剂。

6. 发明申请

US20140206715A1 PREPARATION AND USE OF COMPOUNDS AS PROTEASE INHIBITORS 审中-公开
标题翻译：化合物作为蛋白酶抑制剂的制备和使用
公开(公告)号：US20140206715A1
公开(公告)日：2014-07-24
申请号：US14226338
申请日：2014-03-26
申请人： Andrew W. Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X.E. Le , Gang Qian , Yuefei Shao
发明人： Andrew W. Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X.E. Le , Gang Qian , Yuefei Shao
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07D209/44 , C07D487/04
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Q is a bond or —N(R5)—; T is a bond, —O—, —C(O)—; S, —N(R5)—, or —C(R6′R7′); U is a bond or —C(R6)(R7)— Y is C or N; Z is C or N; ring A, including variables Y and Z, is a three to nine membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, and heteroaryl ring having 0 to 4, preferably 0 to 2, heteroatoms independently selected from the group consisting of O, S, N and —N(R)—, wherein ring A is unsubstituted or substituted with 1 to 5 independently selected R1 moieties and/or oxo when ring A is cycloalkyl, cycloalkenyl, heterocyclyl or heterocyclenyl; and R, R1, R2, R3, R4, R5, R6, R6, R7 and R7′ are as defined in the specification; pharmaceutical compositions comprising the compounds of formula I and the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中Q是键或-N（R 5） - ; T是键，-O - ， - C（O） - ; S，-N（R 5） - 或-C（R 6'R 7'）; U是键或-C（R6）（R7）-Y是C或N; Z是C或N; 环A包括变量Y和Z是具有0至4个，优选0至2个杂原子的3至9元环烷基，环烯基，杂环基，杂环烯基，芳基和杂芳基环，其独立地选自O，S， N和-N（R） - ，其中当环A是环烷基，环烯基，杂环基或杂环烯基时，环A是未取代的或被1至5个独立选择的R 1部分和/或氧代取代。并且R，R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 7和R 7'如本说明书中所定义; 包含式I化合物的药物组合物和抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。

7. 发明授权

US08722708B2 Substituted isoindolines as aspartyl protease inhibitors 有权
标题翻译：取代的异吲哚啉作为天冬氨酰蛋白酶抑制剂
公开(公告)号：US08722708B2
公开(公告)日：2014-05-13
申请号：US11451065
申请日：2006-06-12
申请人： Andrew Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X. H. Le , Gang Qian , Yuefei Shao
发明人： Andrew Stamford , Guoqing Li , William Greenlee , Zhaoning Zhu , Brian McKittrick , Robert Mazzola , Ying Huang , Tao Guo , Thuy X. H. Le , Gang Qian , Yuefei Shao
IPC分类号： C07D487/04 , A61K31/519 , A61K31/4035 , A61K31/4406 , C07D487/14 , A61K31/437 , A61P25/28 , A61P9/00 , A61P31/14
CPC分类号： C07D471/04 , C07D209/44 , C07D487/04
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein Q is a bond or —N(R5)—; T is a bond, —O—, —C(O)—; S, —N(R5)—, or —C(R6′R7′); U is a bond or —C(R6)(R7)— Y is C or N; Z is C or N; ring A, including variables Y and Z, is a three to nine membered cycloalkyl, cycloalkenyl, heterocyclyl, heterocyclenyl, aryl, and heteroaryl ring having 0 to 4, preferably 0 to 2, heteroatoms independently selected from the group consisting of O, S, N and —N(R)—, wherein ring A is unsubstituted or substituted with 1 to 5 independently selected R1 moieties and/or oxo when ring A is cycloalkyl, cycloalkenyl, heterocyclyl or heterocyclenyl; and R, R1, R2, R3, R4, R5, R6, R6, R7 and R7′ are as defined in the specification; pharmaceutical compositions comprising the compounds of formula I and the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物，其中Q是键或-N（R 5） - ; T是键，-O - ， - C（O） - ; S，-N（R 5） - 或-C（R 6'R 7'）; U是键或-C（R6）（R7）-Y是C或N; Z是C或N; 环A包括变量Y和Z是具有0至4个，优选0至2个杂原子的3至9元环烷基，环烯基，杂环基，杂环烯基，芳基和杂芳基环，其独立地选自O，S， N和-N（R） - ，其中当环A是环烷基，环烯基，杂环基或杂环烯基时，环A是未取代的或被1至5个独立选择的R 1部分和/或氧代取代。并且R，R 1，R 2，R 3，R 4，R 5，R 6，R 6，R 7和R 7'如本说明书中所定义; 包含式I化合物的药物组合物和抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经变性疾病的方法。

8. 发明授权

US08691833B2 Heterocyclic aspartyl protease inhibitors 有权
标题翻译：杂环天门冬氨酰蛋白酶抑制剂
公开(公告)号：US08691833B2
公开(公告)日：2014-04-08
申请号：US13415404
申请日：2012-03-08
申请人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： Zhaoning Zhu , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voight , Corey O. Strickland , Elizabeth M. Smith , Andrew W. Stamford , William J. Greenlee , Robert D. Mazzola, Jr. , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X.E. Le , Kurt W. Saionz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
摘要翻译：公开了式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂化物，其中式1中的每个变量如说明书中所定义; 以及包含式I化合物的药物组合物。还公开了抑制天冬氨酰蛋白酶的方法，特别是治疗心血管疾病，认知和神经退行性疾病的方法，以及抑制人类免疫缺陷病毒，plasmepins，组织蛋白酶D和原生动物酶。还公开了使用式I化合物与胆碱酯酶抑制剂或毒蕈碱m1激动剂或m2拮抗剂组合治疗认知或神经变性疾病的方法。

9. 发明申请

US20120231017A1 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS 有权
公开(公告)号：US20120231017A1
公开(公告)日：2012-09-13
申请号：US13415404
申请日：2012-03-08
申请人： ZHAONING ZHU , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Sainoz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
发明人： ZHAONING ZHU , Brian McKittrick , Zhong-Yue Sun , Yuanzan C. Ye , Johannes H. Voigt , Corey O. Strickland , Elizabeth M. Smith , Andrew Stamford , William J. Greenlee , Robert D. Mozzola , John P. Caldwell , Jared N. Cumming , Lingyan Wang , Yusheng Wu , Ulrich Iserloh , Xiaoiang Liu , Tao Guo , Thuy X. E. Le , Kurt W. Sainoz , Suresh D. Babu , Rachael C. Hunter , Michelle L. Morris , Huizhong Gu , Gang Qian , Dawit Tadesse , Ying Huang , Guoqing Li , Jianping Pan , Jeffrey A. Misiaszek , Gaifa Lai , Jingqi Duo , Chuanxing Qu , Yuefei Shao
IPC分类号： A61K39/395 , C07D239/70 , C07F5/02 , C07D403/10 , A61K31/513 , A61K31/506 , C07D409/04 , C07D409/14 , C07D401/04 , C07D405/14 , C07D417/14 , C07D417/04 , C07D413/14 , C07D413/10 , A61K31/5377 , A61P29/00 , A61P9/00 , A61P25/28 , A61P31/10 , A61P33/02 , C07D495/04 , A61P25/00 , A61P31/04 , C07D239/22
CPC分类号： C07D233/88 , A61K31/4168 , A61K31/4178 , C07D239/22 , C07D401/06 , C07D401/10 , C07D403/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/10 , C07D417/14 , C07D495/10
摘要： Disclosed are compounds of the formula I or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein each variable in Formula 1 are as defined in the specification; and pharmaceutical compositions comprising the compounds of formula I. Also disclosed are methods of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases, and the methods of inhibiting of Human Immunodeficiency Virus, plasmepins, cathepsin D and protozoal enzymes. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.

10. 发明授权

US08123488B2 System and method for joining turbine blades 有权
标题翻译：用于连接涡轮叶片的系统和方法
公开(公告)号：US08123488B2
公开(公告)日：2012-02-28
申请号：US11856181
申请日：2007-09-17
申请人： Peter Michael Finnigan , Christophe Lanaud , Govindarajan Rengarajan , Gang Qian
发明人： Peter Michael Finnigan , Christophe Lanaud , Govindarajan Rengarajan , Gang Qian
IPC分类号： F03D1/06
CPC分类号： F03D1/0658 , F03D13/10 , F05B2230/60 , F05B2240/231 , F05B2240/302 , Y02E10/721 , Y02P70/523 , Y10T29/49337
摘要： A blade assembly including an outboard blade segment is provided. The outboard blade segment includes an outboard blade shell, first and second outboard bulkheads situated within the outboard blade shell, and an outer box supported by and aligned by the outboard bulkheads. The blade assembly also includes an inboard blade segment including an inboard blade shell, first and second inboard bulkheads situated within the inboard blade shell, and an inner box supported by and aligned by the inboard bulkheads. Further, the inner and the outer boxes are tapered to facilitate insertion of the inner box into the outer box and coupling of the inner and outer boxes.
摘要翻译：提供了包括外侧叶片段的叶片组件。外侧叶片段包括外侧叶片壳体，位于外侧叶片壳体内的第一和第二外侧舱壁，以及由外侧舱壁支撑并由外侧舱壁对准的外部箱体。叶片组件还包括内侧叶片段，其包括内侧叶片壳体，位于内侧叶片壳体内的第一和第二内侧舱壁以及由内侧舱壁支撑并由内侧舱壁对准的内部箱体。此外，内箱和外箱是锥形的，以便于将内箱插入外箱和内箱和外箱的联接。

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