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41. 发明申请

US20120190042A1 PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR OSTEOARTHRITIS 审中-公开
标题翻译：蛋白质生物标志物和治疗目标
公开(公告)号：US20120190042A1
公开(公告)日：2012-07-26
申请号：US13145796
申请日：2010-01-22
申请人： Reuben Gobezie , David M. Lee
发明人： Reuben Gobezie , David M. Lee
IPC分类号： G01N33/566 , G01N33/573
CPC分类号： G01N33/6896 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , G01N2800/105
摘要： The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis. In particular, the invention provides the identity of marker proteins whose expressions are correlated with OA, and/or OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
摘要翻译：本发明涉及与骨关节炎临床相关的蛋白质表达谱的鉴定和应用。特别地，本发明提供其表达与OA和/或OA进展相关的标记蛋白的身份。描述了在研究和/或诊断OA中使用这些蛋白质表达谱的方法和试剂盒，以确定OA的进展程度，以及在治疗方案的选择和/或监测中。本发明还涉及调节这些蛋白质或编码这些蛋白质的核酸分子的表达的药物的筛选，特别是用于发展改变疾病的OA剂。

42. 发明申请

US20100329254A1 MULTICAST SUPPORT ON A SWITCH FOR PCIe ENDPOINT DEVICES 有权
标题翻译：用于PCIe端点设备的交换机上的多播支持
公开(公告)号：US20100329254A1
公开(公告)日：2010-12-30
申请号：US12495487
申请日：2009-06-30
申请人： Chih-Cheh Chen , Michael T. Klinglesmith , David M. Lee , John Zulauf , Itay Franko , Peter J. Elardo , Mohan K. Nair , Christopher Van Beek
发明人： Chih-Cheh Chen , Michael T. Klinglesmith , David M. Lee , John Zulauf , Itay Franko , Peter J. Elardo , Mohan K. Nair , Christopher Van Beek
IPC分类号： H04L12/56
CPC分类号： H04L12/18 , H04L49/00
摘要： Devices and method with hardware configured to support phantom register programming. Where phantom register programming allows a device driver for an endpoint device to program multicast registers in the device without support of the operating system.
摘要翻译：硬件配置支持幻像寄存器编程的设备和方法。幻影寄存器编程允许端点设备的设备驱动程序在设备中对组播寄存器进行编程，而无需支持操作系统。

43. 发明授权

US07787934B2 Fiducial marker devices, tools, and methods 有权
标题翻译：基准标记设备，工具和方法
公开(公告)号：US07787934B2
公开(公告)日：2010-08-31
申请号：US10454145
申请日：2003-06-04
申请人： Rudy A. Mazzocchi , Matthew S. Solar , David M. Lee
发明人： Rudy A. Mazzocchi , Matthew S. Solar , David M. Lee
IPC分类号： A61B5/00
CPC分类号： A61B34/20 , A61B90/39 , A61B2034/107 , A61B2034/2055 , A61B2034/2068 , A61B2034/2072 , A61B2090/0801 , A61B2090/363 , A61B2090/3916 , A61B2090/3937 , A61B2090/3954 , A61B2090/3983 , A61B2090/3987
摘要： This document discusses, among other things, a fiducial marker assembly that includes an internally engagable base. The base is sized and shaped to be mounted flush to or recessed from an outer surface of a patient's skull, thereby reducing or avoiding patient discomfort. The fiducial marker assembly includes an imagable locator and a registration receptacle. A base insertion instrument is engaged to the base to attach the base to the patient's skull. In one example the base includes a faceted head, permitting a socket-like device to screw or unscrew the base into or out of the skull. In another example, the base includes at least one step or slot for engaging an insertion or extraction tool.
摘要翻译：本文件尤其讨论了包括内部可接合基座的基准标记组件。基座的尺寸和形状被安装成与患者头骨的外表面齐平或凹入安装，从而减少或避免患者的不适。基准标记组件包括可成像定位器和注册容器。基部插入器械接合到基座以将基部附接到患者的颅骨。在一个示例中，底座包括刻面的头部，允许套筒状的装置将基座拧入或旋出到头骨中或从头骨中旋出。在另一示例中，底座包括用于接合插入或取出工具的至少一个台阶或槽。

44. 外观设计

USD528211S1 Fiducial marker 失效
公开(公告)号：USD528211S1
公开(公告)日：2006-09-12
申请号：US29199249
申请日：2004-02-12
申请人： Matthew S. Solar , Thomas L. Bridges , David M. Lee , Mark Stephen Freas , Rudy A. Mazzocchi
设计人： Matthew S. Solar , Thomas L. Bridges , David M. Lee , Mark Stephen Freas , Rudy A. Mazzocchi

45. 发明授权

US07013360B2 Efficient use of multiple buses for a scalable and reliable high-bandwidth connection 失效
标题翻译：高效利用多个总线实现可扩展和可靠的高带宽连接
公开(公告)号：US07013360B2
公开(公告)日：2006-03-14
申请号：US10643347
申请日：2003-08-15
申请人： David M. Lee
发明人： David M. Lee
IPC分类号： G06F13/14
CPC分类号： G06F13/4269
摘要： In one embodiment, a system is disclosed having a first device, a second device, and two sets of bi-directional buses that couple the first and second devices. The devices are to perform transactions with each other over the buses, such that each set of buses has a dominant, but not exclusive, direction, for sending transaction information and data, that is opposite the other. Other embodiments are also described and claimed.
摘要翻译：在一个实施例中，公开了具有耦合第一和第二设备的第一设备，第二设备和两组双向总线的系统。这些设备将通过总线执行交互，使得每组总线具有主导但不排他的方向，用于发送与另一方相反的交易信息和数据。还描述和要求保护其他实施例。

46. 发明授权

US06733823B2 Method for electroless gold plating of conductive traces on printed circuit boards 失效
标题翻译：印刷电路板上导电迹线的无电镀金的方法
公开(公告)号：US06733823B2
公开(公告)日：2004-05-11
申请号：US10114211
申请日：2002-04-02
申请人： David M. Lee , Arthur S. Francomacaro , Seppo J. Lehtonen , Harry K. Charles, Jr.
发明人： David M. Lee , Arthur S. Francomacaro , Seppo J. Lehtonen , Harry K. Charles, Jr.
IPC分类号： B05D512
CPC分类号： H05K3/244 , C23C18/1651 , C23C18/1844 , C23C18/54
摘要： A method of electrolessly gold plating copper on a printed circuit board (PCB). Starting with a copper patterned PCB, steps include: clean with ultrasonic agitation with the PCB initially oriented vertically and gradually moved to a 45° angle; rinse; sulfuric acid bath with ultrasonic and mechanical agitation; rinse; another sulfuric acid bath with ultrasonic and mechanical agitation; plate the copper with palladium with ultrasonic agitation with the PCB initially oriented at a 45° angle and flipped half way through to opposing 45° angle; rinse; post dip in sulfuric acid; rinse; electrolessly nickel plate with mechanical agitation; rinse; nitrogen blow dry; visual inspection for nickel coverage of the copper; hydrochloric acid bath with manual agitation; rinse; if full nickel coverage was not achieved, repeat preceding steps starting with second sulfuric acid bath; gold flash plate to establish a first layer of gold; rinse; autocatalytic gold plate; rinse; and nitrogen blow dry.
摘要翻译：在印刷电路板（PCB）上无电镀金铜的方法。从铜图案化PCB开始，步骤包括：使用超声波搅拌清洁PCB，PCB最初垂直定向并逐渐移动到45°角; 冲洗; 硫酸浴用超声波和机械搅拌; 冲洗; 超声波和机械搅拌的另一种硫酸浴; 用钯超声波搅拌用铜板将铜最初定向成45°的角度，并以一半的方式翻转到相对的45°角; 冲洗; 硫酸后浸渍; 冲洗; 无电镀镍板机械搅拌; 冲洗; 氮吹干燥; 铜的镍覆盖目视检查; 手动搅拌的盐酸浴; 冲洗; 如果未达到全镍覆盖率，则从第二次硫酸浴开始重复前述步骤; 金闪盘建立第一层金; 冲洗; 自催化金板; 冲洗; 并吹氮。

47. 发明授权

US06622194B1 Efficient use of multiple buses for a scalable and reliable high-bandwidth connection 有权
标题翻译：高效利用多个总线实现可扩展和可靠的高带宽连接
公开(公告)号：US06622194B1
公开(公告)日：2003-09-16
申请号：US09650010
申请日：2000-08-28
申请人： David M. Lee
发明人： David M. Lee
IPC分类号： G06F1314
CPC分类号： G06F13/4269
摘要： In one embodiment, a system has a first device, a second device, and two sets of bi-directional buses that couple the first and second devices. The devices are to perform transactions with each other over the buses, such that each set of buses has a dominant, but not exclusive, direction, for sending transaction information and data, that is opposite the other. This configuration may allow the number of turnaround cycles on split transaction buses to be reduced, thus helping increase bandwidth.
摘要翻译：在一个实施例中，系统具有耦合第一和第二设备的第一设备，第二设备和两组双向总线。这些设备将通过总线执行交互，使得每组总线具有主导但不排他的方向，用于发送与另一方相反的交易信息和数据。该配置可以允许减少拆分事务总线上的周转周期数，从而有助于增加带宽。

48. 发明授权

US6078980A Regulating a data transfer time 有权
标题翻译：调整数据传输时间
公开(公告)号：US6078980A
公开(公告)日：2000-06-20
申请号：US222213
申请日：1998-12-29
申请人： Kenneth C. Holland , David M. Lee , Susan S. Meredith
发明人： Kenneth C. Holland , David M. Lee , Susan S. Meredith
IPC分类号： G06F13/36 , G06F11/16 , G06F13/42 , G06F13/00
CPC分类号： G06F13/4213 , G06F11/1679
摘要： A computer system includes a bus, a first bus device, a core circuit and a second circuit. The first bus device is coupled to the bus and adapted to finish a first indication of data to a portion of a bus beginning at a first clock cycle. The bus is capable of skewing the first indication to produce a second indication of the data at another portion of the bus beginning at another clock cycle. The second circuit is coupled to the bus and is adapted to receive an indication of a selected latency time. The second circuit is also adapted to transfer the data to the core circuit in response to the second indication and regulate the transfer so that the circuit receives the data beginning at the selected latency time after the first clock cycle.
摘要翻译：计算机系统包括总线，第一总线装置，核心电路和第二电路。第一总线设备耦合到总线并适于完成从第一时钟周期开始的总线的一部分的数据的第一指示。总线能够偏移第一指示，以在另一时钟周期开始的总线的另一部分产生数据的第二指示。第二电路耦合到总线并且适于接收所选择的等待时间的指示。第二电路还适于响应于第二指示将数据传送到核心电路并调节传输，使得电路在第一时钟周期之后的所选等待时间开始接收数据。

49. 发明授权

US5770303A Occluded composite-particle latex 失效
标题翻译：封闭的复合颗粒胶乳
公开(公告)号：US5770303A
公开(公告)日：1998-06-23
申请号：US583260
申请日：1996-01-05
申请人： Raymond J. Weinert , Satish C. Sharma , John P. Kovalchin , David M. Lee , Nick G. Triantafillopoulos , Ira John Westerman
发明人： Raymond J. Weinert , Satish C. Sharma , John P. Kovalchin , David M. Lee , Nick G. Triantafillopoulos , Ira John Westerman
IPC分类号： C08F263/04 , B32B5/16
CPC分类号： C08F263/04 , Y10T428/253 , Y10T428/254 , Y10T428/31855 , Y10T428/3188 , Y10T428/31888 , Y10T428/31891 , Y10T428/31895 , Y10T428/31899 , Y10T428/31902 , Y10T428/31906
摘要： A latex binder composition comprises occluded composite particles containing at least a vinyl ester homopolymer or a copolymer thereof polymerized from acrylate and/or ethylene monomers, and a polymer polymerized from conjugated diene and/or vinyl substituted aromatic monomers and desirably unsaturated carboxylic acid monomers. The occluded composite particles are produced in the absence of crosslinking agents by first polymerizing the vinyl esters and optional acrylate and/or ethylene monomers, and subsequently in situ polymerizing the conjugated diene and/or vinyl substituted aromatic, etc., monomers in the presence of the vinyl ester latex particles. The occluded composite-particle latex contains phase separated domains which are neither a core-shell nor an inverted core-shell particle and provide properties which are superior to physical blends of the two classes of polymers when utilized as binders in paper coating formulations. Such properties include excellent ink receptivity, low mottle, good blister resistance, good coating strength, good brightness, and the like.
摘要翻译：胶乳粘合剂组合物包含至少含有由丙烯酸酯和/或乙烯单体聚合的乙烯基酯均聚物或其共聚物的封闭复合颗粒和由共轭二烯和/或乙烯基取代的芳族单体和期望的不饱和羧酸单体聚合的聚合物。封闭的复合颗粒在不存在交联剂的情况下通过首先聚合乙烯基酯和任选的丙烯酸酯和/或乙烯单体，随后在共轭二烯和/或乙烯基取代的芳族等单体的存在下原位聚合，乙烯基酯胶乳颗粒。封闭的复合颗粒胶乳含有相分离的结构域，它们既不是核 - 壳也不是反核 - 壳 - 壳颗粒，并且提供了当用作纸涂布配方中的粘合剂时两种聚合物的物理共混物优异的性质。这些性质包括优异的油墨接受性，低斑点，良好的起泡性，良好的涂布强度，良好的亮度等。

50. 发明授权

US10087401B2 Water soluble compositions incorporating enzymes, and method of making same 有权
公开(公告)号：US10087401B2
公开(公告)日：2018-10-02
申请号：US13422709
申请日：2012-03-16
申请人： David M. Lee , Jennifer L. Sims
发明人： David M. Lee , Jennifer L. Sims
IPC分类号： B32B5/16 , C11D3/20 , C11D3/22 , C11D3/37 , C11D3/38 , C11D3/386 , C11D17/04
摘要： Disclosed herein are water soluble compositions, such as films, including a mixture of a first water-soluble resin, an enzyme, and an enzyme stabilizer which comprises a functional substrate for the enzyme, methods of making such compositions, and methods of using such compositions, e.g. to make packets containing functional ingredients. The enzymes can include proteases and mixtures of proteases with other enzymes, and the compositions provide good retention of enzyme function following film processing and storage.

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