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41. 发明授权

US11367608B2 Gridless ion mirrors with smooth fields 有权
公开(公告)号：US11367608B2
公开(公告)日：2022-06-21
申请号：US17049175
申请日：2019-04-23
申请人： Micromass UK Limited
发明人： Anatoly Verenchikov
IPC分类号： H01J49/40
摘要： An ion mirror 41 constructed of thin electrodes that are interconnected by resistive dividers 45 with potentials U1-U5 applied to knot electrodes to form segments 41-43 of linear potential distribution between the “knot” electrodes, yet without separating those field regions by meshes. Weak and controlled penetration of electric fields provide for a fine control over the field non linearity and over the equipotential line curvature, thus allowing to reach unprecedented level of ion optical quality: more than twice larger energy acceptance compared to thick electrode mirrors, up to sixth order time per energy focusing, ion spatial focusing and wide spatial acceptance. Novel mirrors can be formed very slim to arrange them into stacks for ion transverse displacement between ion reflections or for multiplexed mirror stacks. Printed circuit boards (PCB) are best suited for making novel ion mirrors, while novel ion mirrors are designed to suit PCB requirements.

42. 发明授权

US11355336B2 Time-resolved chemical studies via time-of-flight secondary ion mass spectrometry 有权
公开(公告)号：US11355336B2
公开(公告)日：2022-06-07
申请号：US17174968
申请日：2021-02-12
申请人： UT-BATTELLE, LLC , University of Tennessee Research Foundation
发明人： Anton V. Ievlev , Olga S. Ovchinnikova , Matthias Lorenz , Yongtao Liu
IPC分类号： H01J49/40 , H01J49/00 , H01J49/02
摘要： A method of performing time-of-flight secondary ion mass spectrometry on a sample includes the step of directing a beam of primary ions to the sample, and stimulating the migration of ions within the sample while the beam of primary ions is directed at the sample. The stimulation of the ions is cycled between a stimulation state and a lower stimulation state. Secondary ions emitted from the sample by the beam of primary ions are collected in a time-of-flight mass spectrometer. Time-of-flight secondary ion mass spectrometry is then performed on the secondary ions. A system for performing time-of-flight secondary ion mass spectrometry on a sample is also disclosed.

43. 发明申请

US20220148867A1 SELF-CALIBRATION OF HIGH RESOLUTION MASS SPECTRUM 有权
公开(公告)号：US20220148867A1
公开(公告)日：2022-05-12
申请号：US17435266
申请日：2020-03-02
申请人： Micromass UK Limited
发明人： Boris Kozlov , Vasiliy Makarov , Keith Richardson
IPC分类号： H01J49/00 , H01J49/40
摘要： A method of self-calibrating a mass spectrometer or mass spectral data is disclosed. At least some first observed mass to charge ratios are matched with or against a comprehensive reference set of possible or predicted elemental compositions having known precise mass to charge ratios. One or more calibration parameters of a calibration routine are then adjusted so as to optimise the match between one or more of the first observed mass to charge ratios and the corresponding known precise mass to charge ratios of one or more possible or predicted elemental compositions contained within the reference set.

44. 发明申请

US20220146527A1 METHOD OF CREATING CHARACTERISTIC PROFILES OF MASS SPECTRA AND IDENTIFICATION MODEL FOR ANALYZING AND IDENTIFYING FEATURES OF MICROORGANISMS 有权
公开(公告)号：US20220146527A1
公开(公告)日：2022-05-12
申请号：US17583418
申请日：2022-01-25
申请人： Jang-Jih Lu , Hsin-Yao Wang , Chia-Ru Chung , Jorng-Tzong Horng , Tzong-Yi Lee
发明人： Jang-Jih Lu , Hsin-Yao Wang , Chia-Ru Chung , Jorng-Tzong Horng , Tzong-Yi Lee
IPC分类号： G01N33/68 , G16B40/10 , H01J49/00 , H01J49/40
摘要： A method of creating characteristic profiles of mass spectra and identification model for analyzing and identifying microorganisms includes collecting m/z data of microorganisms having same features from MALDI-TOF MS; classifying the microorganisms; classifying the collected set of m/z data as a plurality of subsets; creating modified subsets by applying KDE to the subsets; creating first characteristic MS profiles based on the modified subsets; summarizing into a second characteristic MS profile; repeating above six steps to create second characteristic MS profiles; creating a training set comprising first matched vectors; training a machine learning system using the training set to establish a feature classification model; using MALDI-TOF MS to analyze microorganisms having unknown features; comparing m/z of MALDI-TOF MS spectrum of the microorganisms having unknown features with second characteristic MS profiles to obtain second matched vectors; using the feature classification model analyzing the second matched vectors; and identifying the microorganisms.

45. 发明申请

US20220128509A1 OPTIMISED ION MOBILITY SEPARATION TIMESCALES FOR TARGETED IONS 有权
公开(公告)号：US20220128509A1
公开(公告)日：2022-04-28
申请号：US17570581
申请日：2022-01-07
申请人： Micromass UK Limited
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： G01N27/622 , H01J49/00 , G01N30/72 , G01N27/624 , H01J49/42 , H01J49/28 , H01J49/26 , H01J37/05 , H01J49/02 , H01J49/06 , H01J49/40
摘要： An analytical device for analysing ions is provided comprising a separator 2 for separating ions according to a physico-chemical property and an interface 3 comprising one or more ion guides. A quadrupole rod set mass filter 4 is arranged downstream of the interface 3. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator 2 through the interface 3 with a first transit time t1 and (ii) to transmit a second group of ions which subsequently emerges from the separator 2 through the interface 3with a second different transit time t2.

46. 发明授权

US11295944B2 Printed circuit ion mirror with compensation 有权
公开(公告)号：US11295944B2
公开(公告)日：2022-04-05
申请号：US16636936
申请日：2018-07-26
申请人： Micromass UK Limited
发明人： Anatoly Verenchikov
IPC分类号： H01J49/40 , H05K1/02
摘要： Improved ion mirrors (10) are proposed for multi-reflecting TOF MS and electrostatic traps at various analyzer topologies. Ion mirrors (10) are constructed of printed circuit boards (11) with improved precision and flatness. To compensate for the remaining geometrical imperfections of mirror electrodes there are proposed electrode sets (17) and field structures in the ion retarding region for electronically adjusting of the ion packets time fronts, for improving the ion injection into the analyzer and for reversing the ion motion in the drift direction.

47. 发明授权

US11289318B2 Mass spectrometry analysis method and mass spectrometry system 有权
公开(公告)号：US11289318B2
公开(公告)日：2022-03-29
申请号：US17212168
申请日：2021-03-25
申请人： Shimadzu Corporation
发明人： Xinfeng Zhou , Ran Qiu , Wenjian Sun
IPC分类号： H01J49/00 , H01J49/42 , H01J49/40 , G01N30/72 , G01N30/02
摘要： The invention provides a mass spectrometry analysis method and a mass spectrometry system. During implementation of the mass spectrometry analysis method, intensity data of the daughter ions, a first parameter of the daughter ions associated with the first physicochemical property, and a second parameter of the daughter ions associated with the second physicochemical property are all recorded to form a spectrogram data set. In a deconvolution step, the spectrogram data set is deconvoluted to categorize the daughter ions from the same parent ion according to two-dimensional features including the first parameter and the second parameter. In the above manner, the mass spectrometry analysis method and the mass spectrometry system provided by the invention can detect ions that partially overlap spectral peaks of other ions significantly, thereby improving the qualitative and quantitative ability of data analysis for data independent acquisition.

48. 发明申请

US20220065884A1 ANALYTICAL OPERATION ASSISTING DEVICE AND NON-TRANSITORY COMPUTER READABLE MEDIUM RECORDING ANALYTICAL OPERATION ASSISTING PROGRAM 有权
公开(公告)号：US20220065884A1
公开(公告)日：2022-03-03
申请号：US17376776
申请日：2021-07-15
申请人： SHIMADZU CORPORATION
发明人： Tomonori OSHIKAWA , Yuko KOBAYASHI , Yoshiki TAINAKA , Tatsuki OKUBO , Kohei SUZUKI
IPC分类号： G01N35/00 , H01J49/16 , H01J49/40 , G01N33/49
摘要： In a device (4) for assisting in analytical operations for correctly arranging samples in a plurality of sample-placement portions and implementing multiple protocols in the correct order, a storage section (41) holds sample information and analysis parameters for each protocol as well as the order of implementation. A protocol-selection-input receiver (42) receives an input of the selection of a protocol. A sample-position displayer (43) displays, on a display unit (6), sample information in the selected protocol along with the positions of the sample-placement portions. A protocol-implementation-information collector (45) collects information concerning the state of implementation of the protocols. A determiner (46) determines whether a protocol which must be implemented earlier was already implemented, based on the state of implementation and order of implementation of the protocols. A batch-file creator (47) creates a batch file when it is confirmed that the protocol which must be implemented earlier was already implemented.

49. 发明授权

US11255817B2 Optimised ion mobility separation timescales for targeted ions 有权
公开(公告)号：US11255817B2
公开(公告)日：2022-02-22
申请号：US16909796
申请日：2020-06-23
申请人： Micromass UK Limited
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： G01N27/622 , H01J49/00 , G01N30/72 , G01N27/624 , H01J49/42 , H01J49/28 , H01J49/26 , H01J37/05 , H01J49/02 , H01J49/06 , H01J49/40 , G01N15/10 , G01N15/00
摘要： An analytical device for analysing ions is provided comprising a separator 2 for separating ions according to a physico-chemical property and an interface 3 comprising one or more ion guides. A quadrupole rod set mass filter 4 is arranged downstream of the interface 3. A control system is arranged and adapted: (i) to transmit a first group of ions which emerges from the separator 2 through the interface 3 with a first transit time t1; and (ii) to transmit a second group of ions which subsequently emerges from the separator 2 through the interface 3 with a second different transit time t2.

50. 发明授权

US11239069B2 Mass spectrometer 有权
公开(公告)号：US11239069B2
公开(公告)日：2022-02-01
申请号：US17053128
申请日：2018-05-31
申请人： SHIMADZU CORPORATION
发明人： Kazuma Maeda , Daisuke Okumura
IPC分类号： H01J49/42 , H01J49/02 , H01J49/06 , H01J49/40
摘要： When a Q-TOF type mass spectrometer is operated in an MS1 mode, a controller (40), at the time of measurement, controls voltage generators (31 to 33) such that only a V voltage (radio-frequency voltage for mass separation) and a direct-current bias voltage are applied to main rod electrodes of a quadrupole mass filter (12) without application of a U voltage (direct-current voltage for mass separation). During a measurement preparation period between a plurality of measurements to obtain one mass spectrum, the controller (40) controls a U voltage generator (31) so as to apply the U voltage to the main rod electrodes of the quadrupole mass filter (12). Accordingly, a direct-current electric field is formed between adjacent main rod electrodes around an ion optical axis (C) due to a potential difference, and electric charges accumulated in rod holders (122) holding the main rod electrodes are rapidly removed by an effect of this electric field. As a result, it is possible to eliminate a charge-up that has not been eliminated by a conventional method in which a polarity of a direct-current bias voltage applied to the rod electrodes is merely reversed.

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