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51. 发明申请

US20070055077A1 CHEMICAL PROCESS 审中-公开
标题翻译：化学工艺
公开(公告)号：US20070055077A1
公开(公告)日：2007-03-08
申请号：US11554076
申请日：2006-10-30
申请人： Stephen Brown , James Muxworthy
发明人： Stephen Brown , James Muxworthy
IPC分类号： C07C313/26
CPC分类号： C07C201/08 , C07C303/40 , C07C311/51 , C07C205/59
摘要： A process for the preparation of a compound of general formula I: wherein: R1 is hydrogen or C1-C6 alkyl, C2-C6 alkenyl or C2-C6 alkynyl (any of which may optionally be substituted with one or more substituents selected from halogen and OH) or COOH, COH, COOR , COR6, CONR4R5 or CONHSO2R4; R4 and R5 are each independently hydrogen or C1-C4 alkyl optionally substituted with one or more halogen atoms; R6 is a halogen atom or a group R4; R2 is hydrogen or halo; R3 is C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl, any of which may optionally be substituted with one or more halogen atoms, or halo; the process comprising reacting a compound of general formula II: wherein R1, R2 and R3 are as defined for general formula I; with a nitrating agent comprising nitric acid or a mixture of nitric and sulphuric acids in the presence of an organic solvent and in the presence of acetic anhydride, characterised in that the molar ratio of acetic anhydride to compound of general formula I is from about 1:1 to 3:1.
摘要翻译：制备通式I化合物的方法：其中：R 1是氢或C 1 -C 6烷基，C 1 -C 6烷基，其中任何一个可以任选被一个或多个C 1 -C 6亚烷基取代，选自卤素和OH的更多取代基）或COOH，COH，COOR，COR 6，CONR 4，R 5或CONHSO 2， / 4> 4 R 4和R 5各自独立地为氢或任选被一个或多个C 1 -C 4烷基取代的C 1 -C 4烷基卤原子; R 6是卤素原子或基团R 4; R 2是氢或卤素; R 3是C 1 -C 4烷基，C 2 -C 4烷基，C 1 -C 4烷基，C 2 -C 4烷基，烯基或C 2 -C 4炔基，其中任何一个可以任选被一个或多个卤素原子或卤素取代; 该方法包括使通式II化合物：其中R 1，R 2和R 3与通式I所定义的反应; 在硝酸和硝酸和硫酸的混合物的存在下，在有机溶剂存在下和在乙酸酐存在下，硝酸化剂的特征在于乙酸酐与通式I的化合物的摩尔比为约1： 1到3：1。

52. 发明授权

US07186839B2 Chemical process for the extraction of 2-hydroxy pyridine derivatives, 2-hydroxyquinoline, and 2-hydroxybenzothiazole 有权
标题翻译：用于萃取2-羟基吡啶衍生物，2-羟基喹啉和2-羟基苯并噻唑的化学方法
公开(公告)号：US07186839B2
公开(公告)日：2007-03-06
申请号：US10332105
申请日：2001-06-14
申请人： Raymond Vincent Heavon Jones , Joanne Emma Murray , Jennifer Ann White , Alastair Iain Currie Stewart , Susan Thomson Hamilton , Alan John Whitton , Julie Forrester
发明人： Raymond Vincent Heavon Jones , Joanne Emma Murray , Jennifer Ann White , Alastair Iain Currie Stewart , Susan Thomson Hamilton , Alan John Whitton , Julie Forrester
IPC分类号： A61K31/44 , A61K31/47 , A61K31/428 , C07D215/18 , C07D213/61 , C07D277/68
CPC分类号： C07D213/64 , C07D215/227 , C07D277/68
摘要： A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiasole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating the solvent phase containing the alkali metal or calcium salt and water from the aqueous phase, the ratio of solvent to water in the separated solvent phase being from 0.5:1 to 10:1 w/w.
摘要翻译：从水溶液中提取卤素或卤代烷基取代的2-羟基吡啶或2-羟基喹啉或2-羟基苯并噻唑的碱金属盐或钙盐的方法，其包括使碱金属或钙盐的碱性或中性水溶液与溶解碱金属氟化物，氯化物，溴化物，氢氧化物，硫酸盐，亚硫酸盐，氰酸盐，氰化物，硫氰酸盐，硫代硫酸盐，硫化物，磷酸盐，磷酸氢盐，碳酸盐，碳酸氢盐，硼酸盐，氯酸盐，次氯酸盐，高氯酸盐，亚硝酸盐，铬酸盐，重铬酸盐或高锰酸盐或氯化钙，溴化物，硝酸盐，亚硝酸盐，氯酸盐，次氯酸盐，高氯酸盐，硫氰酸盐，硫代硫酸盐，铬酸盐，二铬酸盐或高锰酸盐，与部分水混溶性有机溶剂混合，以将碱金属或钙盐的水溶液 2-羟基吡啶，2-羟基喹啉或2-羟基苯并噻吩进入溶剂，同时保留分开的水相和溶剂相，然后从水相中分离出含有碱金属或钙盐和水的溶剂相，溶剂相中的溶剂相与水的比例为0.5:1至10:1w / w。

53. 发明申请

US20070011773A1 Method of resistance management for transgenic crops 审中-公开
标题翻译：转基因作物抗性管理方法
公开(公告)号：US20070011773A1
公开(公告)日：2007-01-11
申请号：US10551894
申请日：2004-03-03
申请人： Martin Clough , Alan McCaffery
发明人： Martin Clough , Alan McCaffery
IPC分类号： A01H1/00 , A01H3/00
CPC分类号： C12N15/8286 , A01N63/02 , C12N15/8279 , Y02A40/162 , A01N25/00 , A01N2300/00
摘要： The present invention provides a method for reducing the incidence of resistance of pests to pesticidal plants. In particular, there is provided a locus at which plant pests feed comprising at least two regions, characterised in that: a) a first region comprises plants which produce at least a first pesticidal toxin; and b) a second region comprises plants which produce at least a second pesticidal toxin; wherein a pest which can develop resistance to the first toxin does not develop resistance to the second toxin, and the first region comprises plants which produce the first toxin but not the second toxin when the plants of the second region produce the second toxin but not the first toxin. In one aspect of the invention, the plant pests are insects. The invention also provides a method for controlling insects.
摘要翻译：本发明提供了一种降低害虫对杀虫植物的抗性发生率的方法。特别地，提供了一种植物害虫进入的场所，其包含至少两个区域，其特征在于：a）第一区域包括产生至少第一种杀虫毒素的植物; 和b）第二区域包括产生至少第二种杀虫毒素的植物; 其中可以产生对第一毒素的抗性的害虫不产生对第二毒素的抗性，并且第一区域包含产生第一毒素而不是第二毒素的植物，当第二区域的植物产生第二毒素而不是第二毒素时第一毒素在本发明的一个方面，植物害虫是昆虫。本发明还提供了一种控制昆虫的方法。

54. 发明授权

US07122672B2 Quinolin-, isoquinolin-, and quinazolin-oxyalkylamides and their use as fungicides 失效
标题翻译：喹啉，异喹啉和喹唑啉 - 烷氧基酰胺及其作为杀真菌剂的用途
公开(公告)号：US07122672B2
公开(公告)日：2006-10-17
申请号：US10536475
申请日：2003-10-27
申请人： Roger Salmon , Patrick Jelf Crowley
发明人： Roger Salmon , Patrick Jelf Crowley
IPC分类号： C07D217/22 , C07D239/72
CPC分类号： C07D403/12 , A01N43/42 , A01N43/54 , C07D215/20 , C07D215/54 , C07D215/60 , C07D217/02 , C07D239/74 , C07D409/12
摘要： Fungicidal compounds of the general formula (1) wherein one of X and Y is N or N-oxide and the other is CR or both of X and Y are N
摘要翻译：通式（1）的杀菌化合物，其中X和Y中的一个是N或N-氧化物，另一个是CR或X和Y两者都是N

55. 发明授权

US07033784B1 Method of producing an erythroid cell which is undifferentiated yet capable of expressing a heterologous protein 失效
标题翻译：产生未分化但能表达异源蛋白质的红细胞的方法
公开(公告)号：US07033784B1
公开(公告)日：2006-04-25
申请号：US10009231
申请日：2000-04-05
申请人： Marie-Marthe Suner , John Windass , Fergus Gerard Paul Earley , Stuart John Dunbar , Judith Lesley Blythe
发明人： Marie-Marthe Suner , John Windass , Fergus Gerard Paul Earley , Stuart John Dunbar , Judith Lesley Blythe
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , C12N5/00 , C12N15/09
CPC分类号： G01N33/5094 , G01N33/5008 , G01N33/502 , G01N33/5023
摘要： A method of producing an erythroid cell which is substantially undifferentiated but which is capable of expressing a heterologous protein under the control of a globin promoter thereof, which method comprises maintaining growing uninduced erythroid cells in culture for sufficient period of time that the protein is expressed, and isolating a subclone which expresses said protein. Erythroid cells produced by the method, and methods of detecting the interaction of an insect G-protein coupled receptor with an endogenous signaling cascade of erythroid cells are also described and claimed.
摘要翻译：一种生产基本上未分化但能够在其珠蛋白启动子控制下表达异源蛋白质的红细胞的方法，该方法包括在培养物中保持生长未诱导的红细胞足够的时间以使蛋白质表达，并分离表达所述蛋白质的亚克隆。通过该方法产生的红细胞细胞和检测昆虫G蛋白偶联受体与红细胞内源性信号级联的相互作用的方法也被描述和要求保护。

56. 发明授权

US07015177B2 Solid formulation 失效
标题翻译：固体制剂
公开(公告)号：US07015177B2
公开(公告)日：2006-03-21
申请号：US10471704
申请日：2002-03-13
申请人： Richard David Knott , Rowena Roshanthi Landham , Eric Van Der Drift
发明人： Richard David Knott , Rowena Roshanthi Landham , Eric Van Der Drift
IPC分类号： A01N25/10 , A01N25/14 , A01N25/34
CPC分类号： A01N25/34 , A01N25/10 , A01N25/14 , Y10S514/961
摘要： A solid formulation of an agrochemical is prepared by forming a melt containing at least one agrochemical and at least one thermoplastic binder having a melting point or glass temperature of greater than 35° C., briquetting the melt by dividing it into drops in a first step and solidifying these drops by cooling in a second step, characterized in that the melt additionally comprises a liquid non-volatile solvent for the agrochemical.
摘要翻译：通过形成含有至少一种农用化学品和至少一种具有大于35℃的熔点或玻璃温度的热塑性粘合剂的熔融物来制备农药的固体制剂，在第一步骤中将熔融物分成几滴并通过在第二步骤中冷却来固化这些液滴，其特征在于熔体还包含用于农用化学品的液体非挥发性溶剂。

57. 发明授权

US06894195B2 Preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol 失效
标题翻译：制备4-甲基-2,3,5,6-四氟苄醇
公开(公告)号：US06894195B2
公开(公告)日：2005-05-17
申请号：US10415262
申请日：2001-10-18
申请人： Raymond Vincent Heavon Jones , Stephen Martin Brown
发明人： Raymond Vincent Heavon Jones , Stephen Martin Brown
IPC分类号： C07B61/00 , C07C29/09 , C07C29/86 , C07C33/46 , C07C67/14 , C07C69/747 , C07C209/48 , C07C211/29 , C07L33/46
CPC分类号： C07C209/48 , C07C29/09 , C07C211/29 , C07C33/46
摘要： A process for the preparation of 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol comprising hydrogenating 4-methyl-2,3,5,6-tetrafluorobenzonitrile to 4-methyl-2,3,5,6-tetrafluorobenzylamine and converting 4-methyl-2,3,5,6-tetrafluorobenzylamine to 4-methyl-2,3,5,6-tetrafluorobenzyl alcohol. The process optionally also comprises the further step of reacting 4-Methyl-2,3,5,6-tetrafluobenzyl alcohol with cis-Z-3-(2-chloro-1,1,1-trifluoro-2-propenyl)-2,2-dimethylcyclopropanecarbonyl chloride to the form tefluthrin. 4-Methyl-2,3,5,6-tetrafluorobenzylamine and salts thereof are also claimed.
摘要翻译：一种制备4-甲基-2,3,5,6-四氟苄醇的方法，包括将4-甲基-2,3,5,6-四氟苄腈氢化成4-甲基-2,3,5,6-四氟苄胺和将4-甲基-2,3,5,6-四氟苄胺转化为4-甲基-2,3,5,6-四氟苄醇。该方法任选地还包括使4-甲基-2,3,5,6-四氟苄醇与顺式Z-3-（2-氯-1,1,1-三氟-2-丙烯基）-2 ，2-二甲基环丙烷甲酰氯，形成三氟菊酯。还要求保护4-甲基-2,3,5,6-四氟苄胺及其盐。

58. 发明授权

US06888008B2 Process for preparing 3-isochromanone 失效
标题翻译： 3-异色满酮的制备方法
公开(公告)号：US06888008B2
公开(公告)日：2005-05-03
申请号：US09810458
申请日：2001-03-16
申请人： Raymond Vincent Heavon Jones , Alan John Whitton , Jennifer Ann White , David John Ritchie , Robin Fieldhouse , Kirstin Maccormick , Logan Thomson Nisbet , Paul Richard Evans , Colin John Bennie
发明人： Raymond Vincent Heavon Jones , Alan John Whitton , Jennifer Ann White , David John Ritchie , Robin Fieldhouse , Kirstin Maccormick , Logan Thomson Nisbet , Paul Richard Evans , Colin John Bennie
IPC分类号： B01J31/28 , C07B61/00 , C07D311/76 , C07D311/74
CPC分类号： C07D311/76
摘要： A process for the preparation of 3-isochromanone which comprises contacting an o-xylene-α,α′-dihalide with carbon monoxide, in the presence of a catalyst and a hindered amine base in a liquid medium comprising water and a tertiary alcohol.
摘要翻译：一种制备3-异色满酮的方法，其包括使邻二甲苯-α，α'-二卤化物与一氧化碳在催化剂和受阻胺碱存在下在包含水和叔醇的液体介质中接触。

59. 发明授权

US06867293B2 Polynucleotide constructs having at least one transcriptional enhancer and encoding a modified rice EPSPS enzyme 失效
标题翻译：具有至少一个转录增强子并编码修饰的水稻EPSPS酶的多核苷酸构建体
公开(公告)号：US06867293B2
公开(公告)日：2005-03-15
申请号：US10012070
申请日：2001-10-29
申请人： Christopher John Andrews , Satvinder Bachoo , Timothy Robert Hawkes , Andrew Paul Pickerill , Simon Anthony James Warner
发明人： Christopher John Andrews , Satvinder Bachoo , Timothy Robert Hawkes , Andrew Paul Pickerill , Simon Anthony James Warner
IPC分类号： A01H5/00 , A01N57/20 , C12N5/10 , C12N9/10 , C12N15/09 , C12N15/29 , C12N15/31 , C12N15/54 , C12N15/82
CPC分类号： C12N9/1092 , C07K2319/00 , C12N15/8209 , C12N15/8216 , C12N15/8275 , C12Y205/01019
摘要： The invention is directed to polynucleotide constructs having at least one transcriptional enhancer operably liked to a rice EPSPS promoter and to a sequence encoding the rice EPSPS chloroplast transit peptide and rice EPSPS enzyme, the encoded enzyme having a modified region that confers herbicide resistance.
摘要翻译：本发明涉及具有至少一种可操作地喜欢水稻EPSPS启动子的转录增强子和编码水稻EPSPS叶绿体转运肽和水稻EPSPS酶的序列的多核苷酸构建体，该编码的酶具有赋予除草剂抗性的修饰区域。

60. 发明申请

US20020187934A1 Peptide derivatives 审中-公开
标题翻译：肽衍生物
公开(公告)号：US20020187934A1
公开(公告)日：2002-12-12
申请号：US10078458
申请日：2002-02-21
申请人： Syngenta Limited
发明人： Richard William Arthur Luke , Ronald Cotton
IPC分类号： A61K038/10 , A61K038/08 , A61K038/07 , C07K007/08 , C07K007/06 , C07K005/10
CPC分类号： C07K7/02 , A61K38/00 , C07K14/70539 , C12N2799/026
摘要： The invention concerns pharmaceutically useful peptide derivatives of the formula (I): PnullR1nullR2nullR3nullR4, in which P, R1, R2, R3 and R4 have various meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel peptide derivatives are of value in treating MHC class II dependent T-cell medicated autoimmune or inflammatory diseases, such as rheumatoid arthritis. The invention further concerns processes for the manufacture of the novel peptide derivatives and the use of the compounds in medical treatment.
摘要翻译：本发明涉及式（I）的药学上有用的肽衍生物：其中P，R 1，R 2，R 3和R 4具有本文定义的各种含义的P-R 1 -R 2 -R 3 -R 4及其药学上可接受的盐和药物组合物包含它们新型肽衍生物在治疗MHC II类依赖性T细胞药物自身免疫性或炎症性疾病如类风湿性关节炎中具有价值。本发明还涉及制备新型肽衍生物的方法和该化合物在医疗中的用途。

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