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51. 发明申请

US20220260580A1 METHOD FOR EVALUATING STATE OF CELL DIFFERENTIATION 有权
公开(公告)号：US20220260580A1
公开(公告)日：2022-08-18
申请号：US17628023
申请日：2019-07-19
申请人： TOKYO ELECTRON LIMITED , SHIMADZU CORPORATION , FOUNDATION FOR BIOMEDICAL RESEARCH AND INNOVATION AT KOBE
发明人： Keisuke HARA , Shinichi GOMI , Tomohisa NAGATA , Kenichi KAGAWA , Yasuhiro OSHIMA , Takashi SUZUKI , Masatoshi TAKAHASHI , Takako YAMAMOTO , Shin KAWAMATA
IPC分类号： G01N33/68 , C12N5/0735
摘要： The present invention relates to a method for evaluating the state of cell differentiation during the process of inducing differentiation of human induced pluripotent stem cells (iPS cells) into retinal pigment epithelial cells. The present invention further relates to a method for evaluating the state of cell differentiation during the process of inducing differentiation of human embryonic stem cells (ES cells) into retinal pigment epithelial cells.

52. 发明申请

US20220259542A1 CELL COLLECTING DEVICE AND CELL COLLECTING METHOD 有权
公开(公告)号：US20220259542A1
公开(公告)日：2022-08-18
申请号：US17628528
申请日：2019-07-26
申请人： SHIMADZU CORPORATION
发明人： Yamato MAEDA , Akari TAKEDA , Yoshitake YAMAMOTO , Yoshitaka NODA , Takashi INOUE
IPC分类号： C12M1/26 , C12M1/00
摘要： A cell collecting device include a pipette tip that sucks substances in a cell culture container, a first valve connected to the pipette tip through a first flow path, a first pump connected to the first valve through a second flow path, and a second pump connected to the first valve through a third flow path. In a remove mode, the first valve is switched to connect the first flow path and the second flow path to each other and disconnect the third flow path, and the first pump is driven to discharge waste in the cell culture container, that has been sucked from the pipette tip, from a drain of the first pump through the first flow path and the second flow path, and in a picking mode, the first valve is switched to connect the first flow path and the third flow path to each other and disconnect the second flow path, and the second pump is driven to suck cells in the cell culture container using the pipette tip.

53. 发明授权

US11415596B2 Scanning probe microscope and analysis method 有权
公开(公告)号：US11415596B2
公开(公告)日：2022-08-16
申请号：US16959392
申请日：2018-01-29
申请人： Shimadzu Corporation
发明人： Hiroshi Arai , Masato Hirade
IPC分类号： G01Q30/06
摘要： A scanning probe microscope 1 is provided with a control unit 15. The control unit 15 includes a signal acquisition processing unit 151, an image acquisition processing unit 152, a scanning condition change processing unit 154, a scanning processing unit 155, and a noise determination processing unit 156. In the scanning probe microscope 1, when removing noise included in a surface image of a sample, the scanning condition change processing unit 154 changes a scanning condition. And, the signal acquisition processing unit 151 acquires an output signal from a detection unit 12. The image acquisition processing unit 152 acquires a surface image of a sample S based on the output signal. The noise determination processing unit 156 determines whether or not noise is inclined in the output signal contains noise based on the change in the output signal or the change in the surface image of the sample S when the scanning condition is changed by the scanning condition change processing unit 154. Therefore, if noise is included in the output signal, it is possible to correctly determinate the fact.

54. 发明授权

US11415529B2 X-ray phase imaging apparatus and X-ray phase contrast image generation method 有权
公开(公告)号：US11415529B2
公开(公告)日：2022-08-16
申请号：US16834694
申请日：2020-03-30
申请人： Shimadzu Corporation
发明人： Takahiro Doki , Kenji Kimura , Taro Shirai , Satoshi Sano , Akira Horiba , Naoki Morimoto
IPC分类号： G01N23/041 , G06T5/00
摘要： The X-ray phase imaging apparatus includes an imaging system, a position switching mechanism for switching between a retracted position and an imaging position, a control unit for controlling switching between the retracted position and the imaging position, and an image processing unit for generating an X-ray phase contrast image based on the first image and the second image. The control unit is configured to control sequentially imaging at the retracted position and imaging at the imaging position.

55. 发明授权

US11413555B2 Liquid delivery device and liquid chromatograph equipped with liquid delivery device 有权
公开(公告)号：US11413555B2
公开(公告)日：2022-08-16
申请号：US16611331
申请日：2017-05-10
申请人： Shimadzu Corporation
发明人： Jun Yanagibayashi
IPC分类号： B01D15/10 , G01N30/88 , F04B23/04 , G01N30/34 , G01N30/32
摘要： A liquid delivery device includes at least one liquid delivery pump that delivers liquid, at least one main channel communicating with an outlet of the liquid delivery pump, at least one branch channel branched from the main channel, and a switching valve that has, as a port for connecting channels, at least a port to which the main channel is connected, a port to which the branch channel is connected, at least one output port for outputting liquid delivered by the liquid delivery pump through the main channel, and at least one drain port leading to a drain, and is configured to be selectively switched to a first state, in which the main channel is connected to the output port while the branch channel is not connected to any channel, and a second state in which the branch channel is connected to the drain port while the main channel is not connected to any channel.

56. 发明申请

US20220253508A1 CONSECUTIVE APPROXIMATION CALCULATION METHOD, CONSECUTIVE APPROXIMATION CALCULATION DEVICE, AND PROGRAM 有权
公开(公告)号：US20220253508A1
公开(公告)日：2022-08-11
申请号：US17294181
申请日：2019-11-14
申请人： SHIMADZU CORPORATION
发明人： Yusuke TAGAWA , Akira NODA , Wataru TAKAHASHI , Tetsuya KOBAYASHI
IPC分类号： G06F17/17 , G06T11/00
摘要： A computer calculates interference fringe phase estimated value data (30) of a phase-restored object image by performing iterative approximation calculation using interference fringe intensity data (10) measured by a digital holography apparatus and interference fringe phase initial value data (20), which is an estimated initial phase value of the image of the object. The interference fringe phase initial value data (20) is calculated by an initial phase estimator (300). The initial phase estimator (300) is constructed by implementing machine learning using interference fringe intensity data and the like for learning. The computer acquires reconfigured intensity data (40) and reconfigured phase data (50) by performing optical wave propagation calculation using the interference fringe phase estimation value data (30) of the image of the object acquired through phase restoration, and the interference fringe intensity data (10) used as input data for the initial phase estimator (300). This provides an iterative approximation calculation method and the like capable of making an initial value of a solution used in the iterative approximation calculation method a value close to the true value.

57. 发明申请

US20220252557A1 SUPERCRITICAL FLUID CHROMATOGRAPH AND SAMPLE SUPPLY METHOD USED IN SUPERCRITICAL FLUID CHROMATOGRAPH 有权
公开(公告)号：US20220252557A1
公开(公告)日：2022-08-11
申请号：US17617494
申请日：2019-06-11
申请人： SHIMADZU CORPORATION
发明人： Katsuhiro TANAKA
IPC分类号： G01N30/38 , G01N30/20 , G01N30/30 , G01N30/32
摘要： A supercritical fluid chromatograph includes a suction discharger that sucks and discharges a sample, a first sample loop connected to the suction discharger through a first flow path, a first flow path switcher that is connected to the first sample loop through a second flow path, a sample container connected to the second flow path through a third flow path when the first flow path switcher is in a first switch state, and a second flow path switcher connected to the second flow path through a fourth flow path when the first flow path switcher is in a second switch state. The fourth flow path is connected to a second sample loop when the second flow path switcher is in a third switch state, and the second sample loop is connected to an analysis flow path to which a solvent is supplied as a supercritical fluid when the second flow path switcher is in a fourth switch state.

58. 发明申请

US20220252556A1 BINARY PUMP AND LIQUID CHROMATOGRAPH 有权
公开(公告)号：US20220252556A1
公开(公告)日：2022-08-11
申请号：US17615561
申请日：2019-06-26
申请人： SHIMADZU CORPORATION
发明人： Jun YANAGIBAYASHI
IPC分类号： G01N30/32 , F04B49/06 , F04B41/06
摘要： A binary pump in which an operation controller causes each of two liquid delivery pumps to execute, while a secondary discharge process is executed, a suction process, a first pre-pressurizing process, and a standby process. The operation controller causes each of the two liquid delivery pumps to execute a second pre-pressurizing process before proceeding from the secondary discharge process to the primary discharge process. Furthermore, the operation controller causes, as long as continuous liquid delivery by each of the two liquid delivery pumps is not interrupted, at least one of the two liquid delivery pumps to execute avoidance operation of interrupting the standby process and proceeding to the second pre-pressurizing process by using the operation state of each of the two liquid delivery pumps, so as to avoid overlap of execution time zones of the primary discharge processes of the two liquid delivery pumps.

59. 发明申请

US20220244223A1 DETECTOR FOR LIQUID CHROMATOGRAPH 有权
公开(公告)号：US20220244223A1
公开(公告)日：2022-08-04
申请号：US17576254
申请日：2022-01-14
申请人： SHIMADZU CORPORATION
发明人： Yuki IIJIMA
IPC分类号： G01N30/30 , G01N30/62
摘要： A detector for a liquid chromatograph includes a detector that detects components in liquid, and a heat exchanger that adjusts a temperature of liquid introduced into the detector, wherein the heat exchanger includes a pipe having a winding portion, and a cast in which the winding portion is embedded, the pipe is formed of resin, and the cast is formed of an alloy having a melting point lower than a continuous use temperature of the resin.

60. 发明申请

US20220244163A1 LIGHT SCATTERING DETECTION APPARATUS 有权
公开(公告)号：US20220244163A1
公开(公告)日：2022-08-04
申请号：US17166758
申请日：2021-02-03
申请人： Shimadzu Corporation
发明人： Toru YAMAGUCHI , Atsushi KASATANI
IPC分类号： G01N15/14
摘要： Disclosed in a light scattering detection apparatus, including a sample cell for holding a liquid sample therein, a light source for irradiating the sample cell with coherent light, a detector for detecting light that coming from the sample cell, and a pair of holders for holding ends of the sample cell. Either or both of the holders has a double flange structure. The double flange structure includes a first flange configured to receiving the sample cell and a second flange configured to hold a tube connected to the sample cell. The second flange is detachably attached to the first flange.

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