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61. 发明授权

US10388499B2 Confirmation using multiple collision cross section (“CCS”) measurements 有权
公开(公告)号：US10388499B2
公开(公告)日：2019-08-20
申请号：US15125363
申请日：2015-03-10
申请人： Micromass UK Limited
发明人： Kevin Giles , Martin Raymond Green , Keith Richardson , Jason Lee Wildgoose
IPC分类号： H01J49/36 , H01J49/00 , G01N27/62
摘要： A method of identifying ions or confirming the identity of ions is disclosed comprising determining a physico-chemical or other property of first ions under first conditions, determining the physico-chemical or other property of the first ions or second ions derived from the first ions under second different conditions, and identifying or confirming the identity of the first ions or determining a class of the first or the second ions on the basis of the physico-chemical or other property of the first ions as determined under the first conditions and on the basis of the physico-chemical or other property of the first ions or second ions derived from the first ions as determined under the second conditions.

62. 发明申请

US20190244800A1 MINIATURE ION SOURCE OF FIXED GEOMETRY 审中-公开
公开(公告)号：US20190244800A1
公开(公告)日：2019-08-08
申请号：US16256687
申请日：2019-01-24
申请人： Micromass UK Limited
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
IPC分类号： H01J49/16 , H01J49/04 , H01J49/00
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature ≥100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

63. 发明申请

US20190237317A1 ION GUIDE 审中-公开
公开(公告)号：US20190237317A1
公开(公告)日：2019-08-01
申请号：US16382714
申请日：2019-04-12
申请人： Micromass UK Limited
发明人： Kevin Giles , David Gordon
IPC分类号： H01J49/06 , H01J49/00
CPC分类号： H01J49/062 , H01J49/0027 , H01J49/065
摘要： An ion guide comprises a first ion guide portion that forms a first ion guiding path and a second ion guide portion that forms a second ion guiding path. A first device applies a plurality of different first voltages or potentials to the electrodes of the first ion guide portion in order to generate an electric field that directs ions from the first ion guiding path of the first ion guide portion into the second ion guiding path of the second ion guide portion. The use of plural different first voltages can provide a controlled transfer of ions from the first ion guiding path into the second ion guiding path.

64. 发明申请

US20190234901A1 METHOD OF CHARGE STATE SELECTION 审中-公开
公开(公告)号：US20190234901A1
公开(公告)日：2019-08-01
申请号：US16375513
申请日：2019-04-04
申请人： Micromass UK Limited
发明人： Martin Raymond Green , Keith Richardson , Jason Lee Wildgoose
IPC分类号： G01N27/447 , H01J49/00 , H01J49/04 , G01N27/62
CPC分类号： G01N27/44717 , G01N27/4473 , G01N27/44782 , G01N27/44791 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0404
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.

65. 发明授权

US10325766B2 Method of optimising spectral data 有权
公开(公告)号：US10325766B2
公开(公告)日：2019-06-18
申请号：US15301172
申请日：2015-04-01
申请人： Micromass UK Limited
发明人： Richard Moulds , Keith Richardson , Jason Lee Wildgoose , Martin Raymond Green
IPC分类号： H01J49/26 , H01J49/00 , G01N27/62 , H01J49/40
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed. The method comprises: providing a plurality of species of ions; analyzing the ions during a plurality of sequential acquisition periods so as to obtain spectral data relating to the ions; varying the value of an operational parameter of the spectrometer such that it has different values during the different acquisition periods, wherein the spectral data obtained for a given ion varies depending on the value of the operational parameter; storing the spectral data obtained during the different acquisition periods separately; selecting a target ion; and then interrogating the spectral data so as to identify a set of first acquisition periods that include data corresponding to said target ion. Selecting spectral data from only a subset of the first acquisition periods allows the selection of the optimal spectral data for the target ion, while discarding less optimal data.

66. 发明授权

US10260632B2 Chamber seal for mass spectrometer 有权
公开(公告)号：US10260632B2
公开(公告)日：2019-04-16
申请号：US15023053
申请日：2014-09-17
申请人： Micromass UK Limited
发明人： Stephen O'Brien , Ian Trivett
IPC分类号： F16J15/02 , H01J49/24 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a first component, an annular vacuum chamber seal and a second component. The first component has a groove. The annular vacuum chamber seal comprises a main body portion and one or more blade or rib portions which protrude from the main body portion. The main body portion is located in the groove and the one or more blade or rib portions protrude above or beyond a surface of the first component. The second component is slid, in use, along the surface of the first component thereby deforming the one or more blade or rib portions so that the one or more blade or rib portions form a radial, diametric or piston seal between the first and second components.

67. 发明授权

US10242851B2 Using theoretical collision cross section (“CCS”) in sample identification 有权
公开(公告)号：US10242851B2
公开(公告)日：2019-03-26
申请号：US15125328
申请日：2015-03-10
申请人： Micromass UK Limited
发明人： Martin Raymond Green , Kevin Giles , Keith Richardson , Jason Lee Wildgoose
IPC分类号： H01J49/00 , G01N27/62
摘要： A method of mass spectrometry is disclosed that comprises predicting 1 one or more first reaction products which may result from subjecting an analyte to one or more reactions of interest, calculating 2 one or more first masses or mass to charge ratios and one or more first ion mobility values, collision cross sections or interaction cross sections of at least some first reaction product ions which may be generated from the one or more first reaction products under first conditions, and calculating one or more second masses or mass to charge ratios and one or more second ion mobility values, collision cross sections or interaction cross sections of at least some second reaction product ions which may be generated from the one or more first reaction products under second different conditions. The method further comprises generating third ions from a sample under the first conditions, generating fourth ions from the sample under the second conditions, experimentally determining 3 one or more third masses or mass to charge ratios and one or more third ion mobility values, collision cross sections or interaction cross sections of at least some of the third ions, and experimentally determining one or more fourth masses or mass to charge ratios and one or more fourth ion mobility values, collision cross sections or interaction cross sections of at least some of the fourth ions. The first, second, third and/or fourth mass or mass to charge ratios and/or the first, second, third and/or fourth ion mobility values, collision cross sections or interaction cross sections are compared 4 in order to confirm the presence and/or absence of one or more reaction products of interest in the sample.

68. 发明授权

US10217623B2 Secondary electrospray ionization at reduced pressure 有权
公开(公告)号：US10217623B2
公开(公告)日：2019-02-26
申请号：US15317731
申请日：2015-06-12
申请人： Micromass UK Limited
发明人： Jeffery Mark Brown , David Gordon , Daniel James Kenny , Paul Murray
IPC分类号： H01J49/16 , H01J49/14 , G01N27/62 , H01J49/00 , H01J49/24
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing gas phase analyte in a vacuum housing; electrospraying a reagent solution outside of the vacuum housing so as to form charged droplets of reagent solution and/or reagent ions; conveying the charged droplets and/or reagent ions into the vacuum housing and reacting them with the analyte so as to form analyte ions; and analyzing the analyte ions with a mass analyzer and/or ion mobility analyzer. Reacting the droplets of reagent solution and/or reagent ions with the analyte in sub-atmospheric pressures improved the reaction conditions.

69. 发明授权

US10199205B2 Compact mass spectrometer 有权
公开(公告)号：US10199205B2
公开(公告)日：2019-02-05
申请号：US15852412
申请日：2017-12-22
申请人： Micromass UK Limited
发明人： David Gordon , Daniel James Kenny
IPC分类号： H01J49/00 , H01J49/24 , H01J49/10 , H01J49/40 , H01J49/14 , H01J49/06
摘要： A miniature mass spectrometer is disclosed comprising an atmospheric pressure ionization source and a first vacuum chamber having an atmospheric pressure sampling orifice or capillary, a second vacuum chamber located downstream of the first vacuum chamber and a third vacuum chamber located downstream of the second vacuum chamber. An ion detector is located in the third vacuum chamber. A first RF ion guide is located within the first vacuum chamber and a second RF ion guide is located within the second vacuum chamber. The ion path length from the atmospheric pressure sampling orifice or capillary to an ion detecting surface of the ion detector is ≤400 mm. The mass spectrometer further comprises a tandem quadrupole mass analyzer, a 3D ion trap mass analyzer, a 2D or linear ion trap mass analyzer, a Time of Flight mass analyzer, a quadrupole-Time of Flight mass analyzer or an electrostatic mass analyzer arranged in the third vacuum chamber. The product of the pressure P1 in the vicinity of the first RF ion guide and the length L1 of the first RF ion guide is in the range 10-100 mbar-cm and the product of the pressure P2 in the vicinity of the second RF ion guide and the length L2 of the second RF ion guide is in the range 0.05-0.3 mbar-cm.

70. 发明申请

US20180358216A1 PROBE ASSEMBLY FOR ATTACHING A CHROMATOGRAPHY DEVICE TO A MASS SPECTROMETER 审中-公开
公开(公告)号：US20180358216A1
公开(公告)日：2018-12-13
申请号：US16045010
申请日：2018-07-25
申请人： Micromass UK Limited
发明人： Steve O'Brien , Ian Trivett
IPC分类号： H01J49/04 , H01J47/00 , G01N27/62 , G01N30/72 , H01J43/24
CPC分类号： H01J49/0404 , G01N27/622 , G01N30/7233 , G01N30/7266 , H01J43/24 , H01J47/005 , H01J49/0431
摘要： A probe assembly is disclosed comprising an inlet for receiving an eluent from a chromatography device; an outlet for delivering the eluent to an ion source of a mass spectrometer; and an attachment device for attaching the outlet to the mass spectrometer. The outlet comprises an electrically conductive capillary and an electrically conductive member surrounding at least part of the electrically conductive capillary. The electrically conductive member is arranged to receive a voltage upon connection of the attachment device to the mass spectrometer and the electrically conductive member is arranged to provide an electrical connection from the electrically conductive member to the electrically conductive capillary.

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