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61. 发明授权

US07075046B2 Objective lens reference system and method 有权
公开(公告)号：US07075046B2
公开(公告)日：2006-07-11
申请号：US11190995
申请日：2005-07-27
申请人： Guy G. Kennedy , David M. Warshaw
发明人： Guy G. Kennedy , David M. Warshaw
IPC分类号： G02B27/64 , G02B27/40 , G02B7/04
CPC分类号： G02B21/245
摘要： A system and method for referencing an objective lens to a desired plane of focus. In one embodiment, a dichroic element is utilized to reflect energy of one or more wavelengths that has passed through an objective lens to a detector for determining a position of the objective lens to a desired plane of focus. The objective lens may be manually and/or automatically focused to the desired plane of focus.

62. 发明申请

US20060013772A1 Method and device to recover diagnostic and therapeutic agents 审中-公开
标题翻译：恢复诊断和治疗药物的方法和装置
公开(公告)号：US20060013772A1
公开(公告)日：2006-01-19
申请号：US11169516
申请日：2005-06-29
申请人： Martin LeWinter , Harold Dauerman , Daniel Lustgarten , Markus Meyer
发明人： Martin LeWinter , Harold Dauerman , Daniel Lustgarten , Markus Meyer
IPC分类号： A61K48/00 , A61M31/00
CPC分类号： A61M1/3621 , A61M1/0058 , A61M1/3613 , A61M1/3615 , A61M2025/1052
摘要： The invention relates to a method and device for recovering therapeutic and diagnostic agents from the venous outflow of a tissue or organ. A method for recovering an agent includes inserting a catheter into a vascular outflow of a tissue or organ, occluding the flow of blood/fluid through the vascular outflow, and withdrawing blood/fluid in the vascular outflow into the catheter to recover at least a portion of the agent administered to the vascular inflow of the organ or tissue. Also provided is a device to capture an agent administered to a vascular inflow, the device having a catheter having an expandable occlusion device to occlude a flow of fluid through the vascular outflow, a pump operably coupled to the catheter for withdrawing from the vascular outflow at least a portion of the agent administered to a vascular inflow of the organ or tissue, and an automated controller in signal communication with the catheter to control the expandable occlusion device and the pump to withdraw at least a portion of the agent from the vascular outflow.
摘要翻译：本发明涉及从组织或器官的静脉流出中回收治疗剂和诊断剂的方法和装置。用于回收试剂的方法包括将导管插入组织或器官的血管流出物中，阻断通过血管流出物的血液/流体的流动，以及将血管流出物中的血液/流体抽出到导管中以回收至少一部分的给药剂给予器官或组织的血管流入。还提供了一种用于捕获施用于血管流入物的药剂的装置，所述装置具有导管，所述导管具有可扩张的闭塞装置，以阻塞通过所述血管流出物的流体流动;泵，可操作地联接到所述导管，用于从血管流出物施用于器官或组织的血管流入物的药剂的至少一部分，以及与导管信号通信的自动化控制器，以控制可扩张闭塞装置和泵从血管流出物中抽出至少一部分药剂。

63. 发明授权

US06903135B2 Methods and products related to 16-HETE analogs 失效
标题翻译：与16-HETE类似物相关的方法和产品
公开(公告)号：US06903135B2
公开(公告)日：2005-06-07
申请号：US10375287
申请日：2003-02-27
申请人： John R. Falck , Martin M. Bednar , Cordell E. Gross , Michael Balazy
发明人： John R. Falck , Martin M. Bednar , Cordell E. Gross , Michael Balazy
IPC分类号： A61P7/02 , A61K31/18 , A61K31/202 , A61K31/215 , A61K38/00 , A61K38/49 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P43/00 , C07C49/24 , C07C59/42 , C07C69/732 , C07C311/51 , A61K31/23
CPC分类号： C07C311/51 , A61K31/18 , A61K31/202 , A61K38/49 , Y02A50/402
摘要： The present invention includes 16-HETE analogs which are agonists and antagonists of 16-HETE. The compositions may be formulated in pharmaceutically acceptable formulations. The invention also includes methods and products for inhibiting neutrophil adhesion and neutrophil aggregation using the 16-HETE agonists. One method of the invention involves the administration of a 16-HETE agonist in combination with a thrombolytic agent to a patient suffering from, thromboembolic stroke.
摘要翻译：本发明包括16-HETE类似物，其是16-HETE的激动剂和拮抗剂。组合物可以配制成药学上可接受的制剂。本发明还包括使用16-HETE激动剂抑制嗜中性粒细胞粘附和嗜中性粒细胞聚集的方法和产品。本发明的一种方法涉及将16-HETE激动剂与血栓溶解剂组合给患有血栓栓塞性中风的患者。

64. 发明授权

US06902926B1 Toxoplasma gondii apical membrane antigen-1 失效
公开(公告)号：US06902926B1
公开(公告)日：2005-06-07
申请号：US10039770
申请日：2001-11-09
申请人： Gary E. Ward , Carolyn G. Conant , Brian Ward
发明人： Gary E. Ward , Carolyn G. Conant , Brian Ward
IPC分类号： A61K39/00 , A61K39/002 , A61K39/012 , C07K14/45 , C07K16/20 , C12N1/10 , C12Q1/68
CPC分类号： A61K39/012 , A61K39/00 , A61K39/002 , C07K14/45 , C07K16/20 , C07K2319/00
摘要： The invention provides polypeptide fragments derived from TgAMA-1, nucleic acids that encode the polypeptide fragments, and TgAMA-binding polypeptides such as antibodies. Methods for using the polypeptide and nucleic acid molecules to produce vaccines are also provided. In addition the invention provides methods involving use of the polypeptides, nucleic acids, and binding polypeptides, such as antibodies, for the prevention and treatment of Toxoplasmosis.

65. 发明申请

US20050048055A1 Use of CD40 engagement to alter T cell receptor usage 审中-公开
标题翻译：使用CD40参与来改变T细胞受体的使用
公开(公告)号：US20050048055A1
公开(公告)日：2005-03-03
申请号：US10939652
申请日：2004-09-13
申请人： Martha Newell , Evan Newell , David Wagner
发明人： Martha Newell , Evan Newell , David Wagner
IPC分类号： C12N15/09 , A61K35/12 , A61K35/17 , A61K38/17 , A61K38/20 , A61K39/00 , A61K39/002 , A61K39/02 , A61K39/118 , A61K39/12 , A61K39/395 , A61K45/00 , A61K45/06 , A61P1/00 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/10 , A61P13/12 , A61P17/00 , A61P17/06 , A61P21/04 , A61P27/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07K16/28 , C12N5/02 , C12N5/078 , C12N5/08
CPC分类号： C12N5/065 , A61K35/17 , A61K38/00 , C07K16/2878 , C12N2501/52
摘要： The invention relates to methods for altering and enhancing the immune response toward an antigen. More specifically, the present invention relates to methods of using CD40 engagement on T cells to induce T cell receptor gene rearrangement and enhance T cell affinity for a particular antigen. The invention also relates to methods for promoting developmental maturation of an immature cell of the T cell lineage.
摘要翻译：本发明涉及用于改变和增强针对抗原的免疫应答的方法。更具体地，本发明涉及在T细胞上使用CD40接合以诱导T细胞受体基因重排并增强对特定抗原的T细胞亲和力的方法。本发明还涉及促进T细胞谱系未成熟细胞发育成熟的方法。

66. 发明申请

US20030216309A1 Binding peptides specific for the extracellular domain of ErbB2 and uses therefor 失效
标题翻译：特异于ErbB2细胞外结构域的结合肽并用于此
公开(公告)号：US20030216309A1
公开(公告)日：2003-11-20
申请号：US10272437
申请日：2002-10-15
申请人： University of Vermont and State Agricultural College
发明人： David N. Krag , Stephanie C. Pero , Lyn Oligino
IPC分类号： A61K051/00 , A61K038/17
CPC分类号： C07K14/475 , A61K38/00 , A61K47/64
摘要： The invention provides methods and compositions for diagnosing and treating subjects using EBPs. Specifically disclosed are peptides and peptidomimetics that bind selectively to the extracellular domain of ErbB2. These compositions are useful in the prevention and treatment of disorders characterized by ErbB2 overexpression (e.g., breast cancer).
摘要翻译：本发明提供用于使用EBP诊断和治疗受试者的方法和组合物。具体公开的是与ErbB2细胞外结构域选择性结合的肽和肽模拟物。这些组合物可用于预防和治疗以ErbB2过表达为特征的疾病（例如乳腺癌）。

67. 发明申请

US20020192714A1 Single polymer matrix unit chromatography 审中-公开
标题翻译：单聚合物基质单元色谱
公开(公告)号：US20020192714A1
公开(公告)日：2002-12-19
申请号：US10153434
申请日：2002-05-22
申请人： University of Vermont and State Agricultural College
发明人： David W. Maughan
IPC分类号： G01N033/53 , G01N033/558
CPC分类号： C07K1/36 , A61K38/00 , C07K1/20
摘要： A method and apparatus for physically separating polypeptide constituents of a sample fluid by (a) providing a sample fluid comprising a mixture of polypeptides of differing physical and/or chemical properties; (b) contacting the fluid with at least two individual polymer matrix units, each polymer matrix unit preferentially accepting a different set of polypeptides on the basis of one or more physical and/or chemical properties; and (c) extracting the set of polypeptides from each polymer matrix unit.
摘要翻译：（a）提供包含不同物理和/或化学性质的多肽的混合物的样品流体的用于物理分离样品流体的多肽成分的方法和装置; （b）使流体与至少两个单独的聚合物基质单元接触，每个聚合物基质单元优选地基于一种或多种物理和/或化学性质接受不同组的多肽; 和（c）从每个聚合物基质单元提取该组多肽。

68. 发明申请

US20020102475A1 Method of curing a photosensitive material using evanescent wave energy 审中-公开
标题翻译：使用ev逝波能固化感光材料的方法
公开(公告)号：US20020102475A1
公开(公告)日：2002-08-01
申请号：US10022067
申请日：2001-12-18
申请人： The University of Vermont and State Agricultural College
发明人： Brian Esser , Dryver R. Huston , Noel V. Pelczarski , Wolfgang Sauter
IPC分类号： G03F007/20 , G03F007/24
CPC分类号： B82Y10/00 , G02B27/56 , G03F7/201 , G03F7/2022 , G03F7/70383
摘要： A method of curing a photosensitive material (10) having a critical electrical field amplitude at which photoinitiation occurs. The method includes contacting the photosensitive material, e.g., a photoinitiator/monomer resin system, with a substrate (18), such as an optical element, so as to form an interface (20) between the photosensitive material and the substrate. A light beam (12) is directed into the substrate such that the light beam is totally internally reflected from the interface within the substrate so that an evanescent wave is created in the photosensitive material. In order for curing to occur, the electric field amplitude of the evanescent wave at the interface must be at least equal to the critical electric field amplitude of the photosensitive material.
摘要翻译：一种固化具有发生光引发的临界电场振幅的感光材料（10）的方法。该方法包括使感光材料（例如光引发剂/单体树脂体系）与诸如光学元件的基材（18）接触，以在感光材料和基材之间形成界面（20）。将光束（12）引导到基板中，使得光束从基板内的界面全内反射，使得在感光材料中产生ev逝波。为了固化发生，界面处的消逝波的电场振幅必须至少等于感光材料的临界电场振幅。

69. 发明授权

US6140364A Arachidonic acid metabolite, 16-HETE 失效
标题翻译：花生四烯酸代谢物，16-HETE
公开(公告)号：US6140364A
公开(公告)日：2000-10-31
申请号：US194166
申请日：1999-11-26
申请人： John R. Falck , Martin M. Bednar , Cordell E. Gross , Michael Balazy
发明人： John R. Falck , Martin M. Bednar , Cordell E. Gross , Michael Balazy
IPC分类号： A61K31/20 , A61K31/202 , A61K31/23 , A61K31/35 , A61K31/415 , A61K31/445 , A61K31/525 , A61K31/60 , A61K38/49 , A61K45/06
CPC分类号： A61K31/525 , A61K31/20 , A61K31/202 , A61K31/23 , A61K31/35 , A61K31/415 , A61K31/445 , A61K31/60 , A61K38/49 , A61K45/06
摘要： The present invention provides methods and products for inhibiting neutrophil adhesion and neutrophil aggregation. The invention includes a method for treating a subject to inhibit neutrophil adhesion and neutrophil aggregation by administering 16-hydroxyeicosatetraenoic acid (16-HETE) to the subject. 16-HETE is an arachidonic acid metabolite. The invention also includes a pharmaceutical preparation of 16-HETE. Methods and products are also provided for treating thromboembolic stroke. The method involves the administration of 16-HETE in combination with a thrombolytic agent to a patient suffering from thromboembolic stroke. Preferably, the 16-HETE is 16(R)-HETE and the thrombolytic agent is tPA. The product is a pharmaceutical preparation of 16-HETE and a thrombolytic agent and a pharmaceutically acceptable carrier.
摘要翻译： PCT No.PCT / US97 / 08865 Sec。 371日期1999年11月26日 102（e）1999年11月26日PCT PCT 1997年5月22日PCT公布。公开号WO97 / 4402400 日期1997年11月27日本发明提供了抑制嗜中性粒细胞粘附和嗜中性粒细胞聚集的方法和产品。本发明包括通过向受试者施用16-羟基二十碳四烯酸（16-HETE）来治疗受试者以抑制嗜中性粒细胞粘附和嗜中性粒细胞聚集的方法。 16-HETE是花生四烯酸代谢物。本发明还包括16-HETE的药物制剂。还提供了治疗血栓栓塞中风的方法和产品。该方法涉及将16-HETE与血栓溶解剂组合施用于患有血栓栓塞性中风的患者。优选地，16-HETE是16（R）-HETE，溶栓剂是tPA。该产品是16-HETE和溶栓剂和药学上可接受的载体的药物制剂。

70. 发明授权

US5770591A Bis-platinum complexes as chemotherapeutic agents 失效
标题翻译：双铂络合物作为化学治疗剂
公开(公告)号：US5770591A
公开(公告)日：1998-06-23
申请号：US339291
申请日：1994-11-10
申请人： Nicholas Farrell
发明人： Nicholas Farrell
IPC分类号： C07F15/00 , A61K31/555
CPC分类号： C07F15/0093
摘要： A bis(platinum) complex having the structure: ##STR1## wherein X, Y, Z, X', Y', and Z' are the same or different ligands and are halide, sulphate, phosphate, nitrate, carboxylate, substituted carboxylate, dicarboxylate, substituted dicarboxylate primary or secondary amine, sulfoxide, phosphine, pyridine-type nitrogen and the like; preferably, there is at least one Pt-anion bond on each Pt molecule; and A is a diamine or polyamine. Complexes of trans geometry �PtX.sub.2 (L)(L')! where at least L is a planar ligand such as pyridine but preferably quinoline and L' may be amine, sulfoxide or substituted sulfoxide and X is a chloride, nitrate or carboxylate. A process for obtaining bis(platinum) complexes where the two platinum coordination spheres may contain different ligands in each sphere and where the geometry of each platinum coordination sphere may be the same or different.
摘要翻译：具有以下结构的双（铂）络合物：其中X，Y，Z，X'，Y'和Z'是相同或不同的配体，并且是卤化物，硫酸盐，磷酸盐，硝酸盐，羧酸盐，取代的羧酸盐，二羧酸酯，取代的二羧酸酯伯或仲胺，亚砜，膦，吡啶型氮等; 优选在每个Pt分子上存在至少一个Pt-阴离子键; A是二胺或多胺。其中至少L是平面配体如吡啶但优选喹啉和L'的反式几何[PtX2（L）（L'）]的复合物可以是胺，亚砜或取代的亚砜，X是氯，硝酸酯或羧酸酯。一种获得双（铂）络合物的方法，其中两个铂配位球可以在每个球体中含有不同的配体，并且每个铂配位球的几何形状可以相同或不同。

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