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1. 发明授权

US09946058B2 Microscope apparatus and observation method 有权
公开(公告)号：US09946058B2
公开(公告)日：2018-04-17
申请号：US13157805
申请日：2011-06-10
申请人： Ichiro Sase
发明人： Ichiro Sase
IPC分类号： G02B21/16 , G01N21/64 , G02B21/36 , G02B21/06 , G02B27/56
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/06 , G02B21/367 , G02B27/56
摘要： A microscope apparatus comprises: a distribution measurement apparatus which—with respect to an observation region wherein a sample is arranged which comprises a fluorescent material that is activated when irradiated with an activating light of a prescribed wavelength, and that emits fluorescence when irradiated in an activated condition with an exciting light of a wavelength that differs from that of the activating light—obtains a fluorescent picture image by conducting irradiation with the exciting light, and measures a fluorescent intensity distribution of the observation region; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by multiply repeating operations comprising an operation wherein the observation region is irradiated with the activating light at the irradiation intensities that have been set in the respective portions, and an operation wherein a fluorescent picture image is obtained by irradiating the observation region with the exciting light after the activating light irradiation, and which generates a sample picture image from the plurality of the fluorescent picture images.

2. 发明授权

US09575282B2 Apparatus for fixing solid immersion lens 有权
标题翻译：固定浸没透镜的装置
公开(公告)号：US09575282B2
公开(公告)日：2017-02-21
申请号：US14389443
申请日：2013-09-13
申请人： KOREA BASIC SCIENCE INSTITUTE
发明人： Geon Hee Kim , Ha Yeong Sung , Woo Kang Kim , Kye Sung Lee , Ki Soo Chang , Ki Ju Yee
IPC分类号： G02B7/02 , G02B27/56 , G02B7/04 , G01Q60/22
CPC分类号： G02B7/023 , G01Q60/22 , G02B7/025 , G02B7/04 , G02B27/56
摘要： Provided is an apparatus for fixing a solid immersion lens (SIL) in an optical system. The apparatus includes a first adapter; a second adapter screw-coupled to the inner surface of the first adapter and screw-coupled to the outer surface of a third adapter to pressurize a first O-ring; the third adapter screw-coupled to the inner surfaces of the second adapter and a fourth adapter; the fourth adapter screw-coupled to the outer surface of the third adapter to pressurize a second O-ring; the first and second O-rings elastically fixing an outer surface of a barrel of an infrared ray (IR) objective lens; and an SIL holder mounting the SIL onto the first adapter.
摘要翻译：提供了一种用于将固体浸没透镜（SIL）固定在光学系统中的装置。该装置包括第一适配器; 第二适配器，其螺纹联接到所述第一适配器的内表面，并且螺纹连接到第三适配器的外表面以对第一O形环加压; 所述第三适配器螺纹连接到所述第二适配器的内表面和第四适配器; 所述第四适配器螺纹连接到所述第三适配器的外表面以加压第二O形环; 所述第一和第二O形环弹性地固定红外线（IR）物镜的镜筒的外表面; 以及将SIL安装到第一适配器上的SIL保持架。

3. 发明申请

US20160306157A1 MICROSCOPIC APPARATUS FOR CREATING SUPER-RESOLUTION IMAGES OF AN ORGANISM OR BIOLOGICAL MATTER AND METHOD FOR CREATING SUPER-RESOLUTION IMAGES OF AN ORGANISM OR BIOLOGICAL MATTER USING THE SAME 有权
标题翻译：用于创建有机体或生物物质的超分辨率图像的微观装置以及使用其生成有机物或生物物质的超分辨率图像的方法
公开(公告)号：US20160306157A1
公开(公告)日：2016-10-20
申请号：US15077377
申请日：2016-03-22
申请人： POSTECH Academy-Industry Foundation
发明人： Junsuk RHO , Minkyung Kim
IPC分类号： G02B21/36 , G01N33/483 , G02B27/58 , H04N7/18 , G02B27/56
CPC分类号： G02B21/361 , G01N33/4833 , G02B1/002 , G02B27/56 , G02B27/58
摘要： An optical microscopic apparatus for creating a super-resolution image of an organism or biological matter, the optical microscopic apparatus includes a light source configured to provide visible light including evanescent waves, a hyper-lens unit including a front surface on which a specimen is placed, the hyper-lens unit including a multi-layered structure to convert at least part of the evanescent waves incident on the front surface into propagating waves, an objective lens for collecting visible light emitted from a rear surface of the hyper-lens unit, and an image capturing unit to capture visible light emitted from the objective lens and to create an image of the specimen.
摘要翻译：一种用于产生生物或生物物质的超分辨率图像的光学显微镜装置，所述光学显微镜装置包括被配置为提供包括ev逝波的可见光的光源，超透镜单元，其包括其上放置试样的前表面所述超透镜单元包括将入射在前表面上的至少部分瞬逝波转换为传播波的多层结构，用于收集从超透镜单元的后表面发射的可见光的物镜，以及图像捕获单元，用于捕获从物镜发射的可见光并创建样本的图像。

4. 发明申请

US20160131583A1 FLUORESCENCE IMAGING SYSTEM FOR TISSUE DETECTION 审中-公开
标题翻译：用于组织检测的荧光成像系统
公开(公告)号：US20160131583A1
公开(公告)日：2016-05-12
申请号：US14892527
申请日：2014-05-28
申请人： VENTANA MEDICAL SYSTEMS, INC.
发明人： Pascal Bamford , Lou Dietz , Elizabeth Little
IPC分类号： G01N21/64 , G01N33/50 , G02B21/34
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/648 , G01N33/5005 , G01N2021/6419 , G01N2021/6439 , G01N2021/6441 , G01N2201/062 , G01N2458/00 , G02B21/16 , G02B21/34 , G02B27/56
摘要： An imaging system (100) is capable of detecting of tissue situated on a microscope slide (180). The imaging system (100) includes a light source (150), an image capturing device (160) including a camera, and an imaging lens (170). The light source (150) directs light (154) towards one or more of the edges of the slide (180) such that the light (154) undergoes total internal reflection between a surface of the slide (180) and a coverslip (182) carried by the slide (180). The light (154) has a wavelength or waveband designed to stimulate one or more specimens carried on the slide (180). The imaging lens (170) is positioned to direct radiation emitted from the tissue and/or fluorophore onto the camera. The image capturing device (160) can capture an image of the whole slide (180) or a portion thereof.
摘要翻译：成像系统（100）能够检测位于显微镜载片（180）上的组织。成像系统（100）包括光源（150），包括相机的图像捕获装置（160）和成像透镜（170）。光源（150）将光（154）引向滑动件（180）的一个或多个边缘，使得光（154）在滑动件（180）的表面和盖玻片（182）之间经历全内反射，由幻灯片（180）承载。光（154）具有被设计成刺激载玻片（180）上的一个或多个样本的波长或波段。成像透镜（170）被定位成将从组织和/或荧光团发射的辐射引导到相机上。图像捕获装置（160）可以捕获整个幻灯片（180）或其一部分的图像。

5. 发明授权

US09285652B2 Point-wise phase matching for nonlinear frequency generation in dielectric resonators 有权
标题翻译：介质谐振器非线性频率产生的点相位匹配
公开(公告)号：US09285652B2
公开(公告)日：2016-03-15
申请号：US13924401
申请日：2013-06-21
申请人： Nan Yu , Dmitry V. Strekalov , Guoping Lin
发明人： Nan Yu , Dmitry V. Strekalov , Guoping Lin
IPC分类号： G02F1/37 , G02F1/35 , G02F1/355 , G02B27/56 , G02B5/04
CPC分类号： G02F1/37 , G02B5/04 , G02B27/56 , G02F1/3501 , G02F1/3544 , G02F1/3551 , G02F2001/3509
摘要： An optical resonator fabricated from a uniaxial birefringent crystal, such as beta barium borate. The crystal is cut with the optical axis not perpendicular to a face of the cut crystal. In some cases the optical axis lies in the plane of the cut crystal face. An incident (input) electromagnetic signal (which can range from the infrared through the visible to the ultraviolet) is applied to the resonator. An output signal is recovered which has a frequency that is an integer multiple of the frequency of the input signal. In some cases a prism is used to evanescently couple the input and the output signals to the resonator.
摘要翻译：由单轴双折射晶体制造的光学谐振器，例如硼酸钡。晶体被切割，光轴不垂直于切割晶体的表面。在某些情况下，光轴位于切割晶面的平面内。谐振器施加入射（输入）电磁信号（其可以从红外到可见光到紫外线）。恢复输出信号，该输出信号的频率是输入信号频率的整数倍。在某些情况下，使用棱镜将输入信号和输出信号瞬时耦合到谐振器。

6. 发明申请

US20140104680A1 Total Internal Reflectance Fluorescence (TIRF) Microscopy Across Multiple Wavelengths Simultaneously 有权
标题翻译：全内反射荧光（TIRF）显微镜同时跨多个波长
公开(公告)号：US20140104680A1
公开(公告)日：2014-04-17
申请号：US14052824
申请日：2013-10-14
申请人： Spectral Applied Research Inc.
发明人： Richard Berman , Peter Maclean Sinclair , John Oreopoulos
IPC分类号： G02B21/00
CPC分类号： G02B21/0076 , G01N21/6458 , G01N21/648 , G02B21/16 , G02B27/56
摘要： A multiple wavelength total internal reflection fluoresence (TIRF) microscopy system has an objective. A dispersion unit of the system comprises a high-dispersion optical element. The dispersion unit receives illumination light having at least a first wavelength λ1 and a second wavelength λ2, where λ1≠λ2, and splits the illumination light into a first monochromatic beam having the first wavelength λ1 and a second monochromatic beam having the second wavelength λ2. The monochromatic beams are focused onto a back focal plane of the objective, near an outer edge of the objective, at different radial distances from an optical axis of the objective. The dispersion unit is rotatable in order to adjust angles of incidence of the monochromatic beams onto an interface between a substrate and a sample to be imaged, wherein the angles of incidence are greater than the critical angle of the interface.
摘要翻译：多波长全内反射荧光（TIRF）显微镜系统有一个目标。该系统的色散单元包括高色散光学元件。色散单元接收具有至少第一波长λ1和第二波长λ2的照明光，其中λ1≠λ2，并将照明光分解成具有第一波长λ1的第一单色光束和具有第二波长λ2的第二单色光束。单色光束在与物镜的光轴不同的径向距离处聚焦在物镜的后焦平面上，靠近物镜的外边缘。色散单元是可旋转的，以便将单色光束的入射角度调整到衬底和待成像样品之间的界面上，其中入射角大于界面的临界角。

7. 发明授权

US08630044B2 Evanescent electromagnetic wave conversion methods III 有权
标题翻译：衰减电磁波转换方法III
公开(公告)号：US08630044B2
公开(公告)日：2014-01-14
申请号：US12460122
申请日：2009-07-13
申请人： Jeffrey A. Bowers , Roderick A. Hyde , Edward K. Y. Jung , John Brian Pendry , David Schurig , David R. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr.
发明人： Jeffrey A. Bowers , Roderick A. Hyde , Edward K. Y. Jung , John Brian Pendry , David Schurig , David R. Smith , Clarence T. Tegreene , Thomas A. Weaver , Charles Whitmer , Lowell L. Wood, Jr.
IPC分类号： G02B3/00 , H01P1/17
CPC分类号： G02B27/56
摘要： Apparatus, methods, and systems provide conversion of evanescent electromagnetic waves to non-evanescent electromagnetic waves and/or conversion of non-evanescent electromagnetic waves to evanescent electromagnetic waves. In some approaches the conversion includes propagation of electromagnetic waves within an indefinite electromagnetic medium, and the indefinite medium may include an artificially-structured material such as a layered structure or other metamaterial.
摘要翻译：装置，方法和系统提供了渐逝电磁波到不消逝的电磁波的转换和/或非消逝的电磁波转换成ev逝的电磁波。在一些方法中，转换包括电磁波在不确定的电磁介质中的传播，并且不定的介质可以包括人造结构的材料，例如层状结构或其他超材料。

8. 发明授权

US08432781B2 Method and apparatus for reading from a near-field optical recording medium, and near-field lens for the apparatus 失效
标题翻译：用于从近场光学记录介质读取的方法和装置以及用于该装置的近场透镜
公开(公告)号：US08432781B2
公开(公告)日：2013-04-30
申请号：US13517469
申请日：2010-12-07
申请人： Stephan Knappmann , Frank Przygodda
发明人： Stephan Knappmann , Frank Przygodda
IPC分类号： G11B7/00
CPC分类号： G02B27/56 , G11B7/1374 , G11B7/1387
摘要： A method and an apparatus for reading from a near-field optical recording medium are described. The apparatus includes: an optical system for generating a signal beam and a reference beam; a near-field lens for illuminating the signal beam onto the near-field optical recording medium, for collimating a reflected signal beam, and for reflecting the reference beam; and at least a first detector and a second detector for obtaining a homodyne detection signal from the reflected signal beam and the reflected reference beam.
摘要翻译：描述用于从近场光学记录介质读取的方法和装置。该装置包括：用于产生信号光束和参考光束的光学系统; 近场透镜，用于将信号光束照射到近场光学记录介质上，用于准直反射的信号光束，并用于反射参考光束; 以及至少第一检测器和第二检测器，用于从反射信号光束和反射参考光束获得零差检测信号。

9. 发明授权

US08378314B2 Device and method for the evanescent illumination of a sample 有权
标题翻译：样品瞬间照明的装置和方法
公开(公告)号：US08378314B2
公开(公告)日：2013-02-19
申请号：US12991108
申请日：2009-04-28
申请人： Manfred Matthae , Bruene Venus
发明人： Manfred Matthae , Bruene Venus
IPC分类号： G01N21/64
CPC分类号： G01N21/648 , G01N21/6458 , G01N2021/6419 , G01Q60/20 , G01Q60/22 , G02B27/56
摘要： A device for the evanescent illumination of a sample, including an optical illumination element with an optical corrective element and an objective arranged downstream from the corrective element, to evanescently illuminate the sample with a supplied ray beam containing optical radiation with at least two different wavelengths. The corrective optical element has a transverse chromatic aberration which, during the illumination, leads to the optical radiation penetrating the pupil of the objective at different heights relative to the optical axis varying according to the wavelength. The corrective optical element is selected in such a way that the wavelength-related difference of the penetration depths of the radiation into the sample is reduced during the evanescent illumination.
摘要翻译：一种用于样品的消逝照明的装置，包括具有光学校正元件的光学照明元件和布置在校正元件下游的物镜，以使包含具有至少两个不同波长的光学辐射的所提供的射线束ev逝照射样品。校正光学元件具有横向色差，其在照明期间导致相对于根据波长变化的光轴的不同高度穿透物镜的光瞳的光学辐射。选择校正光学元件，使得在渐逝照射期间辐射进入样品的穿透深度的波长相关差异减小。

10. 发明申请

US20120062722A1 MICROSCOPE APPARATUS AND OBSERVATION METHOD 有权
标题翻译： MICROSCOPE设备和观察方法
公开(公告)号：US20120062722A1
公开(公告)日：2012-03-15
申请号：US13157805
申请日：2011-06-10
申请人： Ichiro SASE
发明人： Ichiro SASE
IPC分类号： H04N7/18
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/06 , G02B21/367 , G02B27/56
摘要： A microscope apparatus comprises: a distribution measurement apparatus with respect to an observation region that comprises a fluorescent material that is activated when irradiated with an activating light, and that emits fluorescence when irradiated with an exciting light of a wavelength different from the activating light, obtains a fluorescent picture image through irradiation with the exciting light, and measures a fluorescent intensity distribution; an irradiation intensity setting apparatus which sets irradiation intensities of the activating light for respective portions of the observation region based on the fluorescent intensity distribution; and a picture image formation apparatus which obtains a plurality of the fluorescent picture images by repeating an operation wherein the observation region is irradiated with the activating light at the set irradiation intensities, and repeating an operation wherein a fluorescent picture image is obtained by irradiating with the exciting light after the activating light irradiation, generating a sample picture image.
摘要翻译：显微镜装置包括：关于观察区域的分布测量装置，其包括当用活化光照射时被激活的荧光材料，并且当用与激活光不同的激发光照射时发射荧光，获得荧光图像通过照射激发光，并测量荧光强度分布; 照射强度设定装置，其基于所述荧光强度分布来设定所述观察区域的各部分的激活光的照射强度; 以及图像形成装置，其通过重复以设定的照射强度照射激活光的观察区域的操作来获得多个荧光图像图像，并且重复其中通过照射所述荧光图像获得荧光图像图像的操作在激活光照射之后激发光，产生样本图像。

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