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71. 发明授权

US08415343B2 Compositions and methods for inhibiting the proliferation of cells 有权
标题翻译：抑制细胞增殖的组合物和方法
公开(公告)号：US08415343B2
公开(公告)日：2013-04-09
申请号：US11643614
申请日：2006-12-21
申请人： Gary D. Glick , Anthony W. Opipari
发明人： Gary D. Glick , Anthony W. Opipari
IPC分类号： A61K31/55 , A61K31/59 , A61K31/05
CPC分类号： C07D243/24 , A61K31/551 , A61K31/5513 , C07D243/14 , C07D401/12 , C07D403/12 , C07D413/12
摘要： The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
摘要翻译：本发明涉及化合物，其发现方法及其治疗用途。特别地，本发明提供了苯并二氮杂衍生物和使用苯并二氮杂衍生物作为治疗剂治疗与程序性细胞死亡，自身免疫，炎症和过度增殖等过程的错误调节相关的多种病症的方法。

72. 发明授权

US08403002B2 Directional control fluid valve 有权
标题翻译：定向控制液阀
公开(公告)号：US08403002B2
公开(公告)日：2013-03-26
申请号：US13023142
申请日：2011-02-08
申请人： Juergen Dettinger , Peter Borst
发明人： Juergen Dettinger , Peter Borst
IPC分类号： F15B13/044
CPC分类号： F16K31/0627 , F01N3/2066 , F01N2610/02 , F01N2610/14 , F01N2610/1493 , F16K11/044 , F16K27/0263 , F16K27/029 , Y02T10/24 , Y10T137/86622 , Y10T137/86839 , Y10T137/87217
摘要： A directional control fluid valve for establishing a first throughflow path, with which fluid is sucked in and supplied under pressure to a consumer, and a second throughflow path with which fluid is sucked out of the consumer. The valve has a housing which has a tank port, a pressure port for connecting to a pressure side of a pump, a suction port for connecting to a suction side of the pump, and a consumer port. The valve has at least one valve flap which is arranged within the housing and which can be moved between a first flap position for establishing the first throughflow path and a second flap position for establishing the second throughflow path. The housing has two parts on which are formed in each case at least two valve seats. The housing has a base part on which the tank port, the pressure port, the suction port and the consumer port are formed, and a cover part which has closed ducts. The closed ducts are connected to the associated valve seats.
摘要翻译：一种方向控制流体阀，用于建立流体被吸入并在压力下被供给到消费者的第一通流路径以及从消费者吸出流体的第二通流路径。阀具有壳体，其具有罐口，用于连接到泵的压力侧的压力端口，用于连接到泵的吸入侧的吸入口和消耗端口。阀具有至少一个阀瓣，其布置在壳体内并且可以在用于建立第一通流路径的第一挡板位置和用于建立第二通流路径的第二挡板位置之间移动。壳体具有两个部件，每个部件形成至少两个阀座。壳体具有形成有罐口，压力口，吸入口和消耗端口的基部，以及具有封闭导管的盖部。封闭的管道连接到相关的阀座。

73. 发明授权

US08343931B2 Methods of inhibiting photoreceptor apoptosis 有权
标题翻译：抑制感光细胞凋亡的方法
公开(公告)号：US08343931B2
公开(公告)日：2013-01-01
申请号：US12716986
申请日：2010-03-03
申请人： David Noam Zacks
发明人： David Noam Zacks
IPC分类号： A61P27/02 , C07K7/08
CPC分类号： A61K38/204 , A01K67/027 , A01K2207/30 , A01K2227/105 , A01K2267/035 , A61K9/0048 , A61K38/00 , A61K38/08 , A61K38/10 , A61K38/1761 , A61K38/179 , A61K48/00 , C07K14/4703 , C07K14/5412 , C12N2799/025
摘要： The present invention provides methods to prevent photoreceptor death. In particular, the present invention provides peptides which prevent FAS-mediated photoreceptor apoptosis.
摘要翻译：本发明提供了防止光感受器死亡的方法。特别地，本发明提供了预防FAS介导的感光细胞凋亡的肽。

74. 发明授权

US08324191B2 Combined calcium, magnesium and vitamin D supplements 有权
标题翻译：组合钙，镁和维生素D补充剂
公开(公告)号：US08324191B2
公开(公告)日：2012-12-04
申请号：US12218067
申请日：2008-07-11
申请人： Deanna Jean Nelson , Walter C. Holberg, III
发明人： Deanna Jean Nelson , Walter C. Holberg, III
IPC分类号： A01N37/36 , A01N45/00
CPC分类号： A61K31/59
摘要： The present invention relates to oral nutritional and therapeutic products which are useful for providing vitamins and minerals required for bone health. The present invention is an oral nutritional and therapeutic composition of calcium succinate, magnesium R-(+)-alpha-lipoate, and Vitamin D for use in the maintenance of bone health, the optimization of bone growth, reducing the risk of bone fracture, and the prevention and treatment of osteoporosis. The pharmaceutical products and methods of the present invention are particularly useful in building bone mass, quality, and density during growth, maintaining bone mass, quality, and density over time, reducing bone fracture risk, and treating osteoporosis in men and women.
摘要翻译：本发明涉及可用于提供骨骼健康所需的维生素和矿物质的口服营养和治疗产品。本发明是一种用于维持骨骼健康，优化骨骼生长，降低骨折风险的琥珀酸钙，R - （+） - α-硫辛酸镁和维生素D的口服营养和治疗组合物，并预防和治疗骨质疏松症。本发明的药物产品和方法特别可用于在生长期间建立骨量，质量和密度，保持骨质量，质量和随时间的密度，降低骨折风险，并治疗男性和女性的骨质疏松症。

75. 发明授权

US08251941B2 Selective cytopheresis devices and related methods thereof 有权
标题翻译：选择性细胞分离装置及其相关方法
公开(公告)号：US08251941B2
公开(公告)日：2012-08-28
申请号：US12201576
申请日：2008-08-29
申请人： H. David Humes , Deborah Buffington
发明人： H. David Humes , Deborah Buffington
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3687 , A61K31/34 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3633 , A61M1/3666 , A61M1/3667 , A61M1/3672 , A61M1/3679 , A61M2205/3331 , G01N33/56972
摘要： The present invention relates to systems and devices to treat and/or prevent inflammatory conditions within a subject and to related methods. More particularly, the invention relates to systems, devices, and related methods that sequester leukocytes and/or platelets and then inhibit their inflammatory action.
摘要翻译：本发明涉及用于治疗和/或预防受试者内的炎性病症的系统和装置及相关方法。更具体地，本发明涉及隔离白细胞和/或血小板然后抑制其炎症作用的系统，装置和相关方法。

76. 发明授权

US08202692B2 Expression profile of thyroid cancer 有权
标题翻译：甲状腺癌的表达谱
公开(公告)号：US08202692B2
公开(公告)日：2012-06-19
申请号：US12546278
申请日：2009-08-24
申请人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
发明人： Thomas Giordano , Ronald Koenig , Rork Kuick , Samir Hanish , Dafydd G. Thomas , Yuri Nikiforov
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N2333/96455
摘要： The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with thyroid cancers. Genes identified as cancer markers using the methods of the present invention find use in the diagnosis and characterization of thyroid cancer. In addition, the genes provide targets for cancer drug screens and therapeutic applications.
摘要翻译：本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。特别地，本发明提供与甲状腺癌相关的基因表达谱。使用本发明的方法鉴定为癌症标志物的基因可用于甲状腺癌的诊断和表征。此外，这些基因为癌症药物筛选和治疗应用提供了靶标。

77. 发明授权

US08178709B2 Iron preparation suitable for pharmaceutical formulation and process for the preparation thereof 失效
标题翻译：适用于药物制剂的铁制剂及其制备方法
公开(公告)号：US08178709B2
公开(公告)日：2012-05-15
申请号：US12506408
申请日：2009-07-21
申请人： Deanna Jean Nelson , Brian J. Mosley
发明人： Deanna Jean Nelson , Brian J. Mosley
IPC分类号： C07F9/09 , A61K31/295
CPC分类号： A61K31/194 , A61K33/26 , A61K33/42 , A61K45/06 , A61K2300/00 , A61K33/00
摘要： New iron preparations comprising stable, unpolymerized iron(III) citrate complex compositions and methods for their preparation are provided. Further, the invention involves the use stable, unpolymerized iron(III) citrate complex compositions of the invention as a food additive, nutritional supplement, dietary supplement, medical food, nutrient, iron fortificant, and source of iron in the fields of nutrition for humans, animals, fish, and birds and of diagnostics. The invention further involves the use of stable, unpolymerized iron(III) citrate complex compositions of the invention as a pharmaceutical and pharmacologically active ingredient for human clinical and veterinary applications.
摘要翻译：提供了包含稳定的未聚合的柠檬酸铁（III）络合物组合物的新铁制剂及其制备方法。此外，本发明涉及在人类营养领域中使用本发明的稳定的，未聚合的（III）柠檬酸铁配合物组合物作为食品添加剂，营养补充剂，膳食补充剂，医疗食品，营养物，铁的重要成分和铁源，动物，鱼和鸟以及诊断。本发明还涉及使用本发明的稳定的，未聚合的柠檬酸铁（III）络合物组合物作为用于人类临床和兽医应用的药物和药理学活性成分。

78. 发明授权

US08034833B2 Phosphorus binder for treatment of renal disease 有权
标题翻译：用于治疗肾脏疾病的磷结合剂
公开(公告)号：US08034833B2
公开(公告)日：2011-10-11
申请号：US12077777
申请日：2008-03-20
申请人： Deanna Jean Nelson
发明人： Deanna Jean Nelson
IPC分类号： A61K31/42
CPC分类号： A61K31/205 , A23L33/165 , A23L33/175 , A61K31/41 , A61K2300/00
摘要： The present invention relates to oral compositions which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of subjects. A method for binding phosphorus in ingesta and inhibiting its absorption from the gastrointestinal tract is also provided. The dietary supplements and pharmaceutical products and methods of the present invention are particularly useful in the treatment of hyperphosphatemia of chronic uremia and reducing serum phosphorus levels in patients requiring such therapy.
摘要翻译：本发明涉及口服组合物，其可用于结合摄入中的磷，并抑制磷从受试者的胃肠道吸收。还提供了一种在摄入中结合磷并抑制其从胃肠道吸收的方法。本发明的膳食补充剂和药物产品和方法特别可用于治疗需要这种治疗的患者中慢性尿毒症的高磷酸血症并降低血清磷水平。

79. 发明授权

US08017757B2 Kits and method for detecting human papilloma virus with oligo nucleotide bead array 失效
标题翻译：用寡核苷酸珠阵列检测人乳头瘤病毒的试剂盒和方法
公开(公告)号：US08017757B2
公开(公告)日：2011-09-13
申请号：US12095646
申请日：2007-02-23
申请人： Woong Shick Ahn , Byoung-Don Han , Yong Taek Oh , Su Mi Bae
发明人： Woong Shick Ahn , Byoung-Don Han , Yong Taek Oh , Su Mi Bae
IPC分类号： C07H21/04 , C12P19/34
CPC分类号： C12Q1/708
摘要： Provided are determining methods of human papillomavirus (HPV) genotypes with a high sensitivity. The method includes performing two-step PCRs on an HPV L1 gene in a sample to be analyzed as a biotin-labeled, single-stranded L1 gene, performing a hybridization reaction on the biotin-labeled, single-stranded L1 gene with a HPV genotype detection probe, reacting the hybridization reaction product with fluorescent substance combined with streptavidine, and measuring a fluorescent substance level to identify the HPV genotype. The detection method has high sensitivity enough to detect an extremely small amount of HPV in the sample. In addition, the high specificity exhibited by the detection method enables accurate diagnosis specific to HPV type.
摘要翻译：提供具有高灵敏度的人乳头瘤病毒（HPV）基因型的确定方法。该方法包括对作为生物素标记的单链L1基因进行分析的样品中的HPV L1基因进行两步PCR，对具有HPV基因型的生物素标记的单链L1基因进行杂交反应检测探针，使杂交反应产物与结合链霉亲和素的荧光物质反应，并测量荧光物质水平以鉴定HPV基因型。该检测方法具有足够高的灵敏度，可以检测样品中极少量的HPV。此外，通过检测方法表现出的高特异性能够对HPV类型进行准确诊断。

80. 外观设计

USD633411S1 Plaque 有权
公开(公告)号：USD633411S1
公开(公告)日：2011-03-01
申请号：US29361656
申请日：2010-05-13
申请人： Michael J. Smith
设计人： Michael J. Smith

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