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    • 72. 发明授权
    • Use of variable XIC widths of TOF-MSMS data for the determination of background interference in SRM assays
    • 使用TOF-MSMS数据的可变XIC宽度来确定SRM测定中的背景干扰
    • US09583323B2
    • 2017-02-28
    • US14123185
    • 2012-05-30
    • Stephen A. TateDavid M. Cox
    • Stephen A. TateDavid M. Cox
    • H01J49/02H01J49/00G06F19/00
    • H01J49/02G06F19/703H01J49/0031
    • Systems and methods identify a product ion that does not include an interference. A full product ion spectrum for a mass range of an analyte in a sample is received from a tandem mass spectrometer. A first set of one or more peak parameters is calculated for a product ion in the full product ion spectrum using a first XIC window width. A second set of one or more peak parameters is calculated for the product ion using a second XIC window width. The product ion is identified as not including an interference, if the first set of one or more peak parameters and the second set of one or more peak parameters are substantially the same. The product ion is further confirmed or determined to be from the analyte and not from a matrix of the sample by correlating the product to a precursor ion of the analyte.
    • 系统和方法识别不包括干扰的产物离子。 从串联质谱仪接收样品中分析物质量范围的完整产品离子谱。 使用第一XIC窗口宽度,对全产物离子谱中的产物离子计算第一组一个或多个峰参数。 使用第二XIC窗口宽度为产品离子计算第二组一个或多个峰值参数。 如果第一组一个或多个峰值参数和第二组一个或多个峰值参数基本上相同,则产物离子被识别为不包括干扰。 通过将产物与分析物的前体离子相关联,产物离子被进一步确认或确定为来自分析物而不是来自样品的基质。
    • 74. 发明授权
    • Method for triggering dependent spectra for data acquisition
    • 触发依赖光谱数据采集的方法
    • US09513232B2
    • 2016-12-06
    • US13995816
    • 2011-12-22
    • David M. CoxStephen A. TateMatthias Glueckmann
    • David M. CoxStephen A. TateMatthias Glueckmann
    • H01J49/00G01N23/00H01J49/02
    • G01N23/00H01J49/0031H01J49/0045H01J49/025
    • Methods and systems are provided for triggering an information dependent mass spectrometry scan in real time. A mass spectrometry scan of a separating sample mixture is performed by a mass spectrometer at each time interval of a time period. The mass spectrometer receives the separating sample mixture from a separation device. It is determined at a certain time interval that a received mass spectrometry scan at the time interval and one or more preceding received mass spectrometry scans include two or more time-varying ion signals that represent two or more fragment ion transitions of a known compound. If a characteristic of the two or more time-varying ion signals meets a selection criterion, the mass spectrometer is instructed to perform a dependent mass spectrometry scan of the separating sample mixture for a precursor ion of the known compound at the time interval.
    • 提供了实时触发信息依赖质谱扫描的方法和系统。 分离样品混合物的质谱扫描由质谱仪在每个时间段的每个时间间隔进行。 质谱仪从分离装置接收分离样品混合物。 在一定时间间隔确定在时间间隔和一个或多个先前接收质谱扫描的接收质谱扫描包括表示已知化合物的两个或更多个片段离子转变的两个或更多个时变离子信号。 如果两个或更多个时变离子信号的特征满足选择标准,则指示质谱仪以时间间隔对已知化合物的前体离子进行分离样品混合物的依赖性质谱扫描。
    • 77. 发明授权
    • Systems and methods for detecting ECG subwaveforms
    • 检测ECG子波形的系统和方法
    • US09339204B2
    • 2016-05-17
    • US14662996
    • 2015-03-19
    • Guangren Chen
    • Guangren ChenCheng Hong
    • A61B5/0452A61B5/04A61B5/044
    • A61B5/0452A61B5/0245A61B5/04012A61B5/04014A61B5/04017A61B5/0402A61B5/04028A61B5/042A61B5/044A61B5/6801A61B5/6869A61B5/7278A61B5/742A61B5/743
    • Systems and methods are provided to detect subwaveforms of an ECG waveform. Electrical impulses are detected between at least one pair of electrodes of two or more electrodes placed proximate to a beating heart and are converted to an ECG waveform for each heartbeat of the beating heart using the detector. One or more subwaveforms within P, Q, R, S, T, U, and J waveforms of the ECG waveform for each heartbeat or in an interval between the P, Q, R, S, T, U, and J waveforms that represent the depolarization or repolarization of an anatomically distinct portion of muscle tissue of the beating heart are detected using a signal processor. A processed ECG waveform that includes the one or more subwaveforms for each heartbeat is produced using the signal processor. The processed ECG waveform is received from the signal processor is displayed using a display device.
    • 提供系统和方法来检测ECG波形的子波形。 在靠近跳动心脏放置的两个或更多个电极的至少一对电极之间检测电脉冲,并且使用检测器将心跳波形转换为心跳波动。 在每个心跳的ECG波形的P,Q,R,S,T,U和J波形内或在表示P,Q,R,S,T,U和J波形之间的间隔内的一个或多个子波形 使用信号处理器检测跳动心脏的肌肉组织的解剖学上不同部分的去极化或复极化。 使用信号处理器产生包括每个心跳的一个或多个子波形的经处理的ECG波形。 从信号处理器接收的经处理的ECG波形使用显示装置显示。
    • 78. 发明授权
    • Gaze based communications for locked-in hospital patients
    • 锁定医院病人的凝视通讯
    • US09244528B2
    • 2016-01-26
    • US13857250
    • 2013-04-05
    • LC Technologies, Inc.
    • Nancy ClevelandDixon Cleveland
    • G06F3/01G06F3/048G06F19/00
    • G06F3/013G06F19/00G16H40/63
    • Effective patient-centered care in a hospital relies heavily on the ability of patients to communicate their physical needs to care givers. If a patient is unable to speak, he has limited means of communicating at a time when he needs it the most. The embodiments presented here, generally referred to as EyeVoice, include unobtrusive eye-operated communication systems for locked-in hospital patients who cannot speak or gesture. EyeVoice provides an alternate means of communication, allowing hospital patients to communicate with their care givers using their eyes in place of their voices. Simply by looking at images and cells displayed on a computer screen placed in front of them, patients are able to: answer questions posed by caregivers; specify locations, types and degrees of pain and discomfort; request specific forms of assistance; ask or answer care related questions, and help direct his own care.
    • 医院中以病人为中心的有效护理在很大程度上依赖于患者将其身体需求传达给护理人员的能力。 如果一个病人无法说话,他在最需要的时候,他的沟通方式有限。 这里呈现的通常被称为EyeVoice的实施例包括用于不能说话或手势的锁定医院病人的不引人注目的眼睛操作的通信系统。 EyeVoice提供了另一种沟通方式,使医院病人可以用他们的眼睛与他们的护理人员沟通,代替他们的声音。 通过查看放置在其前面的电脑屏幕上显示的图像和细胞,患者能够:回答看护者提出的问题; 指定疼痛和不适的位置,类型和程度; 要求具体形式的援助; 询问或回答有关护理的问题,并帮助指导自己的护理。