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1. 发明授权

US11693010B2 Method of characterization of visible and/or sub-visible particles in biologics 有权
公开(公告)号：US11693010B2
公开(公告)日：2023-07-04
申请号：US17505389
申请日：2021-10-19
申请人： Regeneron Pharmaceuticals, Inc.
发明人： Xiaobin Xu
IPC分类号： G01N33/68 , G01N1/28 , G01N21/65 , G01N30/72 , H01J49/00 , H01J49/02
CPC分类号： G01N33/6854 , G01N1/28 , G01N21/65 , G01N30/72 , G01N33/6848 , H01J49/0031 , H01J49/02 , G01N2560/00
摘要： A method for characterizing or quantifying one or more proteins in visible and/or sub-visible particles formed in a sample by detecting the at least one visible or sub-visible particle in the sample, isolating and capturing the at least one visible or sub-visible particle to identify a presence of a protein, and using a mass spectrometer to characterize the protein.

2. 发明申请

US20190164740A1 Electrostatic Trap 审中-公开
公开(公告)号：US20190164740A1
公开(公告)日：2019-05-30
申请号：US16262011
申请日：2019-01-30
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander A. MAKAROV , Eduard V. DENISOV , Gerhard JUNG , Wilko BALSCHUN , Stevan R. HORNING
IPC分类号： H01J49/42 , H01J49/02 , H01J49/00 , H01J49/28 , H01J49/40
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, ϕ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, ϕ, z) is the result of a perturbation W to an ideal field U(r, ϕ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, ϕ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2π radians over an ion detection period Tm.

3. 发明申请

US20180143332A1 Ion Filter 审中-公开
公开(公告)号：US20180143332A1
公开(公告)日：2018-05-24
申请号：US15813777
申请日：2017-11-15
申请人： Plasma-Therm LLC
发明人： Leslie Michael Lea , Linnell Martinez , Michael Morgan , Russell Westerman
IPC分类号： G01T1/28 , H01J49/02 , H01J3/14
CPC分类号： G01T1/28 , H01J3/14 , H01J37/32357 , H01J37/32422 , H01J37/32577 , H01J37/32633 , H01J37/32871 , H01J49/02 , H01L21/78
摘要： The present invention provides a method for using ion filtering to adjust the number of ions delivered to a substrate. The method comprising a process chamber being provided that is operatively connected to a plasma source. The substrate is provided on a substrate support that is provided within the process chamber. An electrical bias source is provided that is operatively connected to an aperture plate that is provided in the process chamber. The substrate on the substrate support is processed using a plasma generated using the plasma source. A variable bias voltage from the electrical bias source is applied to the aperture plate during the plasma processing of the substrate. The plasma processing of the substrate can further comprise exposing the substrate to a plasma time division multiplex process which alternates between deposition and etching on the substrate.

4. 发明申请

US20170236697A1 INTERACTIVE ANALYSIS OF MASS SPECTROMETRY DATA 审中-公开
公开(公告)号：US20170236697A1
公开(公告)日：2017-08-17
申请号：US15583752
申请日：2017-05-01
申请人： Christopher BECKER , Marshall BERN , Yong Joo KIL , Michael Taejong KIM , Boyan ZHANG
发明人： Christopher BECKER , Marshall BERN , Yong Joo KIL , Michael Taejong KIM , Boyan ZHANG
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G06T11/206 , H01J49/02
摘要： This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

5. 发明授权

US09640376B1 Interactive analysis of mass spectrometry data 有权
公开(公告)号：US09640376B1
公开(公告)日：2017-05-02
申请号：US14306020
申请日：2014-06-16
申请人： Protein Metrics Inc.
发明人： Christopher Becker , Marshall Bern , Yong Joo Kil , Michael Taejong Kim , Boyan Zhang
IPC分类号： H01J49/00 , G06T11/20 , H01J49/02
CPC分类号： H01J49/0036 , G06T11/206 , H01J49/02
摘要： This invention relates to graphical user-interactive displays for use in MS-based analysis of protein impurities, as well as methods and software for generating and using such. One aspect provides a user-interactive display comprising an extracted mass chromatogram (XIC), an MS1 spectrum and an MS2 spectrum, all simultaneously representing a user-selected peptide. Another aspect provides a user interactive display simultaneously presenting paired spectra (XIC, MS1 and/or MS2) for a variant peptide and its corresponding wildtype counterpart.

6. 发明申请

US20170117130A1 Electrostatic Trap 审中-公开
公开(公告)号：US20170117130A1
公开(公告)日：2017-04-27
申请号：US15398101
申请日：2017-01-04
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander A. MAKAROV , Eduard V. DENISOV , Gerhard JUNG , Wilko BALSCHUN , Stevan R. HORNING
IPC分类号： H01J49/42 , H01J49/28 , H01J49/40 , H01J49/00
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, Φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, Φ, z) is the result of a perturbation W to an ideal field U(r, Φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, Φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.

7. 发明申请

US20170089862A1 Mass Spectrometer 审中-公开
公开(公告)号：US20170089862A1
公开(公告)日：2017-03-30
申请号：US15231045
申请日：2016-08-08
申请人： Micromass UK Limited
发明人： Robert Harold Bateman , Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40 , H01J49/00
CPC分类号： G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/02 , H01J49/062 , H01J49/065 , H01J49/066 , H01J49/40 , H01J49/401 , H01J49/42
摘要： A mass spectrometer is disclosed comprising an ion mobility spectrometer or separator and an ion guide arranged downstream of the ion mobility spectrometer or separator. A plurality of axial potential wells are created in the ion guide so that ions received from the ion mobility spectrometer or separator become confined in separate axial potential wells. The potential wells maintain the fidelity and/or composition of ions received from the ion mobility spectrometer or separator. The potential wells are translated along the length of the ion guide.

8. 发明申请

US20160320341A1 METHOD AND APPARATUS FOR DETERMINING A MOBILITY OF IONS 有权
标题翻译：用于确定离子的移动性的方法和装置
公开(公告)号：US20160320341A1
公开(公告)日：2016-11-03
申请号：US15178941
申请日：2016-06-10
申请人： Tofwerk AG
发明人： Richard Knochenmuss
IPC分类号： G01N27/62 , H01J49/06 , H01J49/40
CPC分类号： G01N27/622 , H01J49/02 , H01J49/061 , H01J49/40
摘要： A method and an apparatus for determining a mobility of ions. The method includes the steps of modulating an ion beam with an ion gate which is controlled by a modulation function for generating a modulated ion beam, of guiding the modulated ion beam through a drifting region, of measuring a signal of the modulated ion beam after the modulated ion beam has passed the drifting region and of calculating a correlation of the modulation function and the signal in order to determine the mobility of the ions. The apparatus includes the ion gate, the drifting region through which the modulated ion beam is guidable, a detector by which the signal of the modulated ion beam is measurable after the modulated ion beam has passed the drifting region and a calculation unit by which the correlation of the modulation function and the signal is calculable in order to determine the mobility of the ions. An autocorrelation of the modulation function is a two-valued function.
摘要翻译：用于确定离子迁移率的方法和装置。该方法包括以下步骤：用离子门调制离子束，该离子门由用于产生调制离子束的调制功能控制，该调制离子束将经调制的离子束引导通过漂移区，测量经过调制离子束的信号调制离子束已经通过漂移区域并且计算调制函数和信号的相关性，以便确定离子的迁移率。该装置包括离子门，经调制的离子束可引导的漂移区域，经调制的离子束已经通过漂移区域之后可测量调制的离子束的信号的检测器，以及计算单元，的调制函数和信号是可计算的，以便确定离子的迁移率。调制函数的自相关是一个二值函数。

9. 发明授权

US09281175B2 First and second order focusing using field free regions in time-of-flight 有权
标题翻译：在飞行时间内使用无地区的一级和二级对焦
公开(公告)号：US09281175B2
公开(公告)日：2016-03-08
申请号：US14367234
申请日：2012-12-06
申请人： DH Technologies Development Pte. Ltd.
发明人： Robert E. Haufler , William Morgan Loyd
IPC分类号： H01J49/40 , H01J49/00 , B01D59/44 , H01J49/02
CPC分类号： H01J49/405 , H01J49/0027 , H01J49/02 , H01J49/406
摘要： In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions.
摘要翻译：在一些实施例中，飞行时间质谱仪可以包括用于接收离子的输入孔，用于沿着第一路径加速离子的第一离子加速器级，用于接收所述加速离子的至少一个离子反射器，并沿着第二路径重定向所述离子用于检测由所述至少一个离子反射器重定向的离子的至少一部分的检测器，以及设置在所述第一加速级与所述检测器之间的至少第一和第二场自由漂移区，其中所述第二无场区设置在检测器附近。在一些实施例中，可以选择场自由漂移区的长度，以便提供离子相对于其初始位置变化的飞行时间的1次和2次校正。

10. 发明授权

US09082600B1 Mass spectrometry methods and apparatus 有权
标题翻译：质谱法和仪器
公开(公告)号：US09082600B1
公开(公告)日：2015-07-14
申请号：US14153078
申请日：2014-01-13
申请人： Matthew Paul Greving , Trent R. Northen
发明人： Matthew Paul Greving , Trent R. Northen
IPC分类号： H01J49/02 , B65B5/04 , B01L3/00 , H01J49/04
CPC分类号： H01J49/02 , B01J2219/00315 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01L3/5085 , B01L3/5088 , B01L9/523 , B01L2200/141 , B01L2200/185 , B01L2300/041 , B01L2300/0819 , B01L2300/105 , B65B5/04 , C40B60/12 , H01J49/0418
摘要： Methods, apparatus, compositions, systems, and articles of manufacture useful in connection with performing offsite mass spectrometric (MS) analysis of samples are disclosed. In embodiments, library samples are arrayed on MS substrates in a blinded fashion and stability-packaged for transport to an off-site location where the MS substrate is de-packaged and MS analysis is performed, enabling off-site MS analysis without requiring transport of the sample library and without compromising the confidentiality of the library contents.
摘要翻译：公开了与进行样品的异地质谱（MS）分析有关的方法，装置，组合物，系统和制品。在实施方案中，将文库样品以无限制的方式排列在MS底物上，并稳定包装以便运输到MS基底被去包装和进行MS分析的非现场位置，从而实现异地MS分析，而不需要运输样本库，不影响图书馆内容的保密性。

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