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71. 发明申请

US20100030297A1 IMPLANTABLE OPTICAL PRESSURE SENSOR FOR SENSING URINARY SPHINCTER PRESSURE 有权
标题翻译：用于感应尿素压力的可植入光学压力传感器
公开(公告)号：US20100030297A1
公开(公告)日：2010-02-04
申请号：US12576881
申请日：2009-10-09
申请人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
发明人： Martin T. Gerber , Keith A. Miesel , Steven J. Shumaker
IPC分类号： A61N1/05
CPC分类号： A61B5/202 , A61B5/205 , A61N1/36007
摘要： The disclosure describes an optical fiber pressure sensor to measure sphincter pressure which may be incorporated into a therapeutic sphincter control system. The system senses sphincter pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of an optical fiber connected to flexible tube section placed through the sphincter, where properties of the emitted light are changed proportional to the pressure on the tube section. The light is returned to a light detector to measure light properties and create an electrical signal representative of the pressure on the tube section. The signal may then be sent by wireless telemetry to an implanted stimulator or external programmer.
摘要翻译：本公开描述了一种用于测量括约肌压力的光纤压力传感器，该压力传感器可并入治疗括约肌控制系统中。该系统感测括约肌压力，并将信息发送到能够刺激治疗的刺激器以控制括约肌收缩力，从而减少不必要的尿失禁。通过使用连接到通过括约肌放置的柔性管部分的光纤来实现测量括约肌压力，其中发射的光的性质与管部分上的压力成比例地变化。光返回到光检测器以测量光性质并产生代表管部分上的压力的电信号。然后可以通过无线遥测将信号发送到植入的刺激器或外部编程器。

72. 发明授权

US07590453B2 Collecting activity information to evaluate incontinence therapy 有权
标题翻译：收集活动信息以评估失禁治疗
公开(公告)号：US07590453B2
公开(公告)日：2009-09-15
申请号：US11796811
申请日：2007-04-30
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

73. 发明授权

US07395113B2 Collecting activity information to evaluate therapy 有权
标题翻译：收集活动信息以评估治疗
公开(公告)号：US07395113B2
公开(公告)日：2008-07-01
申请号：US10825965
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61N1/00
CPC分类号： A61M5/1723 , A61B5/0031 , A61B5/02055 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/1455 , A61B5/6814 , A61B5/6826 , A61B5/6831 , A61B5/6838 , A61B2562/0219 , A61M5/14276 , A61N1/36071 , A61N1/365 , A61N1/36521 , A61N1/36542 , A61N1/36557
摘要： A medical device delivers a therapy to a patient. The medical device may periodically determine an activity level of the patient, and associate each determined activity level with a current therapy parameter set. A value of at least one activity metric is determined for each of a plurality of therapy parameter sets based on the activity levels associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more activity metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of activity metrics, the list may be ordered according to the one of the activity metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。医疗设备可以周期性地确定患者的活动水平，并将每个确定的活动水平与当前治疗参数组相关联。基于与该治疗参数组相关联的活动水平，为多个治疗参数组中的每一个确定至少一个活动度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。该列表可以根据一个或多个活动度量值来排序以帮助评估治疗参数集。在确定多个活动度量的值的情况下，可以根据用户选择的活动度量中的一个排序列表。

74. 发明授权

US07328070B2 Multi-tube sensor for sensing urinary sphincter and urethral pressure 失效
标题翻译：用于感应尿路括约肌和尿道压力的多管传感器
公开(公告)号：US07328070B2
公开(公告)日：2008-02-05
申请号：US11117079
申请日：2005-04-28
申请人： Martin T. Gerber , Keith A. Miesel
发明人： Martin T. Gerber , Keith A. Miesel
IPC分类号： A61N1/00 , A61B5/00 , A61B5/103 , A61B5/117
CPC分类号： A61N1/36007 , A61B5/205 , A61B5/208
摘要： The disclosure describes a multi-tube pressure sensor to measure the pressure at two sites that may be used in a therapeutic incontinence control system. The system senses urinary sphincter pressure and urethral pressure and sends the information to a stimulator that is capable of stimulation therapy to control sphincter contractility, thus reducing unwanted urinary incontinence. Measuring sphincter pressure is accomplished through the use of a tube placed through the sphincter and urethral pressure is measured by a second tube placed within the urethra, both tubes may be attached to a single module implanted within the bladder. Pressure within the tube generates an electrical signal that is sent wirelessly to an implanted stimulator connected to a lead positioned near pelvic floor nerves. An external device may be used to wirelessly send information to the implanted stimulator and inhibit stimulation in order for the patient to empty the bladder. Additionally, the pressure information and stimulation information may be recorded and reviewed for continued patient monitoring.
摘要翻译：本公开描述了一种多管压力传感器，用于测量可用于治疗性失禁控制系统的两个位置处的压力。该系统感测尿括约肌压力和尿道压力，并将信息发送到能够刺激治疗以控制括约肌收缩力的刺激器，从而减少不必要的尿失禁。通过使用放置在括约肌中的管来实现测量括约肌压力，并且尿道压力通过放置在尿道内的第二管测量，两个管可以附接到植入膀胱内的单个模块。管内的压力产生电信号，其被无线发送到连接到位于骨盆底部神经附近的引线的植入刺激器。外部设备可以用于向植入的刺激器无线地发送信息并抑制刺激以使患者清空膀胱。此外，压力信息和刺激信息可被记录和审查，以便继续进行患者监测。

75. 发明授权

US07320676B2 Pressure sensing in implantable medical devices 有权
标题翻译：可植入医疗器械中的压力感测
公开(公告)号：US07320676B2
公开(公告)日：2008-01-22
申请号：US10836115
申请日：2004-04-30
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/16854 , A61M2205/3355 , A61M2205/3523
摘要： An implantable medical device for delivering a therapeutic substance to a delivery site in a patient. A reservoir holds a supply of the fluid therapeutic substance. A catheter has a proximal end, a delivery region and a lumen extending from the proximal end to the delivery region. The proximal end of the catheter is operatively coupled to the reservoir. The delivery region of the catheter is adapted to be placed proximate the delivery site in the patient. The therapeutic substance is adapted to be delivered through the lumen to the patient. A sensing device is operatively coupled with the lumen of the catheter being capable of detecting a pressure of the therapeutic substance in the lumen. A controller is operatively coupled to the sensing device, the controller being capable of taking an action in response to the pressure in the lumen.
摘要翻译：一种用于将治疗物质输送到患者的输送部位的可植入医疗装置。储存器容纳流体治疗物质的供应。导管具有近端，输送区域和从近端延伸到输送区域的内腔。导管的近端可操作地联接到储存器。导管的输送区域适于放置在患者体内的输送部位附近。治疗物质适于通过内腔输送给患者。感测装置与导管的内腔可操作地耦合，能够检测内腔中的治疗物质的压力。控制器可操作地耦合到感测装置，所述控制器能够响应于内腔中的压力而采取动作。

76. 发明授权

US06234973B1 Implantable medical device for sensing absolute blood pressure and barometric pressure 有权
标题翻译：用于感测绝对血压和大气压力的植入式医疗装置
公开(公告)号：US06234973B1
公开(公告)日：2001-05-22
申请号：US09442855
申请日：1999-11-18
申请人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
发明人： John T. Meador , Keith A. Miesel , Louis E. Halperin , Robert T. Taepke, II , Lee Stylos
IPC分类号： A61B502
CPC分类号： A61B5/0215 , A61B5/03 , A61B2560/0257 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/702
摘要： An implantable barometric pressure sensor coupled with an implantable medical device (IMD) provides a barometric pressure related, reference pressure value for use in combination with an absolute pressure value measured by an implantable absolute pressure sensor coupled to the IMD. In one embodiment, the barometric pressure sensor is implanted under the skin and subcutaneous tissue layer at or near the implant site of the IMD. In variations of this embodiment, the barometric pressure is formed as part of a connector module of the IMD or extends from the connector module. In a further embodiment, a percutaneous access device is provided which is adapted to be implanted to extend through the skin and subcutaneous tissue layer of the patient and is coupled with the barometric pressure sensor to provide for an air chamber extending between the atmosphere and the barometric pressure sensor. The barometric pressure sensor is preferably enclosed within an air chamber of the implantable medical device, and a catheter extends between the air chamber of the implantable medical device and the percutaneous access device. Or the barometric pressure sensor is enclosed within an air chamber of the percutaneous access device, and a lead extends between the barometric pressure sensor and the implantable medical device.
摘要翻译：与可植入医疗装置（IMD）耦合的可植入气压传感器提供与大气压相关的参考压力值，与由耦合到IMD的可植入绝对压力传感器测量的绝对压力值组合使用。在一个实施例中，将大气压力传感器植入在IMD的植入部位处或附近的皮肤和皮下组织层下方。在该实施例的变型中，大气压力形成为IMD的连接器模块的一部分或者从连接器模块延伸。在另一个实施例中，提供经皮进入装置，其适于植入以延伸通过患者的皮肤和皮下组织层，并与大气压力传感器耦合以提供在大气和气压之间延伸的空气室压力传感器。大气压力传感器优选地封装在可植入医疗装置的空气室内，并且导管在可植入医疗装置的空气室和经皮进入装置之间延伸。或者气压传感器被封闭在经皮进入装置的气室中，并且引线在大气压力传感器和可植入医疗装置之间延伸。

77. 发明授权

US06221024B1 Implantable pressure sensor and method of fabrication 失效
标题翻译：可植入式压力传感器及其制造方法
公开(公告)号：US06221024B1
公开(公告)日：2001-04-24
申请号：US09119095
申请日：1998-07-20
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61B500
CPC分类号： A61B5/0215
摘要： A body implantable pressure sensor attached to an endocardial lead for implantation in a heart chamber or cardiac blood vessel for sensing blood pressure and providing blood pressure signals to an implanted or external hemodynamic monitor and/or therapy delivery device and method of fabrication thereof. A pressure sensor module is formed of an elongated receptacle having an elongated receptacle cavity for receiving a calibrated, micro-machined pressure transducer having a pressure responsive element. The receptacle cavity is covered by a diaphragm disposed alongside the lead body and in parallel with the lead axis. The receptacle cavity is filled with a incompressible oil for transferring pressure forces that are applied to the diaphragm to the pressure transducer. The oil is introduced through a fill port, and the fill port is sealed after the oil is introduced to prevent leakage of the oil from the receptacle cavity and to complete the hermetic sealing of the receptacle cavity. The fill port further comprises a fill tube having a fill tube lumen extending outward of an end wall of the receptacle cavity to a fill tube end, and said sealing step further comprises the steps of crimping or otherwise obstructing the fill tube end to close the fill tube lumen, fitting a fill port cover having an abutting edge over the crimped fill tube end and against the end wall of the receptacle to enclose the sealed fill tube end within a fill port cover cavity, and sealing the abutting edge against the receptacle end wall to hermetically enclose the sealed fill tube end within the fill port cover cavity.
摘要翻译：身体可植入压力传感器，其附接到用于植入心室或心脏血管中的心内膜导管，用于感测血压并向植入或外部血液动力学监测器和/或治疗输送装置提供血压信号及其制造方法。压力传感器模块由具有细长插座空腔的细长插座形成，用于接收具有压力响应元件的经校准的微机械压力传感器。插座腔被设置在引线主体旁边并与引线轴平行的隔膜覆盖。容器腔填充有不可压缩的油，用于将施加到隔膜的压力传递到压力传感器。油通过填充口引入，并且在引入油之后填充口被密封以防止油从容器腔泄漏并完成容器腔的气密密封。填充口还包括填充管，其具有从容置腔的端壁向外延伸到填充管端的填充管内腔，并且所述密封步骤还包括以下步骤：压紧或阻碍填充管端部以封闭填充物管腔，装配填充口盖，其具有在卷曲的填充管端部上方并抵靠容器的端壁的邻接边缘，以将密封的填充管端封闭在填充端口盖腔内，并且将邻接边缘密封抵靠插座端壁将密封的填充管端气密地封闭在填充口盖腔内。

78. 发明授权

US6125291A Light barrier for medical electrical lead oxygen sensor 有权
标题翻译：医用电导线氧传感器的光栅
公开(公告)号：US6125291A
公开(公告)日：2000-09-26
申请号：US182764
申请日：1998-10-30
申请人： Keith A. Miesel , Eric M. Stetz
发明人： Keith A. Miesel , Eric M. Stetz
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/03 , A61N1/365 , A61N5/08
CPC分类号： A61B5/6864 , A61B5/0215 , A61B5/031 , A61B5/14539 , A61B5/1459 , A61B5/0031 , A61N1/36557
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译：公开了一种用于可植入医疗装置的植入式传感器组件。传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。

79. 发明授权

US6125290A Tissue overgrowth detector for implantable medical device 有权
标题翻译：用于可植入医疗器械的组织过度生长检测器
公开(公告)号：US6125290A
公开(公告)日：2000-09-26
申请号：US182972
申请日：1998-10-30
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61B5/00 , A61B5/03 , A61N1/05 , A61N1/365
CPC分类号： A61B5/6864 , A61B5/031 , A61B5/14539 , A61B5/1459 , A61N1/05 , A61N1/36557
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译：公开了一种用于可植入医疗装置的植入式传感器组件。传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。

80. 发明授权

US09192719B2 Implantable medical pump diagnostics 有权
标题翻译：植入式医疗泵诊断
公开(公告)号：US09192719B2
公开(公告)日：2015-11-24
申请号：US12916720
申请日：2010-11-01
申请人： Charles R. Rogers , Irfan Z. Ali , Ronald L. Mezera , Keith A. Miesel , Scott A. Sarkinen , Nicholas R. Whitehead
发明人： Charles R. Rogers , Irfan Z. Ali , Ronald L. Mezera , Keith A. Miesel , Scott A. Sarkinen , Nicholas R. Whitehead
IPC分类号： A61M5/168 , A61M5/142
CPC分类号： A61M5/16809 , A61M5/14216 , A61M5/14276 , A61M2005/16863 , A61M2005/16868 , A61M2005/16872
摘要： A method of detecting a fault condition within an implantable medical pump comprises delivering therapeutic fluid using a medical pump comprising an actuation mechanism configured to be energized to provide a pump stroke, detecting a property associated with energizing the actuation mechanism, and determining whether the property associated with energizing the actuation mechanism indicates that a fault condition exists with the medical pump.
摘要翻译：检测可植入医疗泵内的故障状况的方法包括使用医用泵递送治疗流体，所述医疗泵包括致动机构，所述致动机构被配置为通电以提供泵行程，检测与致动机构通电相关联的属性，以及确定属性是否相关联通过致动机构通电，指示医疗泵存在故障状况。

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